Incidental Mutation 'R4763:Atp2c1'
ID |
357039 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Atp2c1
|
Ensembl Gene |
ENSMUSG00000032570 |
Gene Name |
ATPase, Ca++-sequestering |
Synonyms |
ATP2C1A, D930003G21Rik, SPCA, 1700121J11Rik, PMR1 |
MMRRC Submission |
042404-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.371)
|
Stock # |
R4763 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
9 |
Chromosomal Location |
105288561-105398456 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 105295766 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 653
(T653A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000135802
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038118]
[ENSMUST00000085133]
[ENSMUST00000112558]
[ENSMUST00000163879]
[ENSMUST00000177293]
[ENSMUST00000176770]
[ENSMUST00000177074]
|
AlphaFold |
Q80XR2 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000038118
AA Change: T789A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000039103 Gene: ENSMUSG00000032570 AA Change: T789A
Domain | Start | End | E-Value | Type |
Cation_ATPase_N
|
25 |
99 |
1.85e-14 |
SMART |
Pfam:E1-E2_ATPase
|
105 |
339 |
2.3e-75 |
PFAM |
Pfam:Hydrolase
|
343 |
655 |
2.9e-31 |
PFAM |
Pfam:HAD
|
346 |
652 |
7.7e-15 |
PFAM |
Pfam:Hydrolase_like2
|
408 |
492 |
9.5e-20 |
PFAM |
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
Pfam:Cation_ATPase_C
|
725 |
897 |
4e-47 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000085133
AA Change: T823A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000082220 Gene: ENSMUSG00000032570 AA Change: T823A
Domain | Start | End | E-Value | Type |
Cation_ATPase_N
|
59 |
133 |
1.85e-14 |
SMART |
Pfam:E1-E2_ATPase
|
138 |
372 |
3.4e-62 |
PFAM |
Pfam:Hydrolase
|
377 |
689 |
2.6e-23 |
PFAM |
Pfam:HAD
|
380 |
686 |
7.8e-14 |
PFAM |
Pfam:Cation_ATPase
|
442 |
526 |
3.2e-19 |
PFAM |
low complexity region
|
740 |
755 |
N/A |
INTRINSIC |
Pfam:Cation_ATPase_C
|
759 |
931 |
3.8e-48 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000112557
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000112558
AA Change: T789A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000108177 Gene: ENSMUSG00000032570 AA Change: T789A
Domain | Start | End | E-Value | Type |
Cation_ATPase_N
|
25 |
99 |
1.85e-14 |
SMART |
Pfam:E1-E2_ATPase
|
105 |
339 |
2.3e-75 |
PFAM |
Pfam:Hydrolase
|
343 |
655 |
2.9e-31 |
PFAM |
Pfam:HAD
|
346 |
652 |
7.7e-15 |
PFAM |
Pfam:Hydrolase_like2
|
408 |
492 |
9.5e-20 |
PFAM |
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
Pfam:Cation_ATPase_C
|
725 |
897 |
4e-47 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000163879
|
SMART Domains |
Protein: ENSMUSP00000129617 Gene: ENSMUSG00000032570
Domain | Start | End | E-Value | Type |
Cation_ATPase_N
|
9 |
83 |
1.85e-14 |
SMART |
Pfam:E1-E2_ATPase
|
89 |
323 |
5.2e-76 |
PFAM |
Pfam:Hydrolase
|
327 |
639 |
5.6e-32 |
PFAM |
Pfam:HAD
|
330 |
636 |
1.4e-15 |
PFAM |
Pfam:Hydrolase_like2
|
392 |
476 |
3.2e-20 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175697
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176656
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000177293
AA Change: T653A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000135802 Gene: ENSMUSG00000032570 AA Change: T653A
Domain | Start | End | E-Value | Type |
Pfam:E1-E2_ATPase
|
1 |
203 |
6.7e-64 |
PFAM |
Pfam:Hydrolase
|
207 |
519 |
7.4e-32 |
PFAM |
Pfam:HAD
|
210 |
516 |
1.9e-15 |
PFAM |
Pfam:Hydrolase_like2
|
272 |
356 |
3.8e-20 |
PFAM |
transmembrane domain
|
564 |
586 |
N/A |
INTRINSIC |
Pfam:Cation_ATPase_C
|
589 |
761 |
1.2e-47 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000176770
AA Change: T784A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000134764 Gene: ENSMUSG00000032570 AA Change: T784A
Domain | Start | End | E-Value | Type |
Pfam:E1-E2_ATPase
|
100 |
334 |
8.9e-76 |
PFAM |
Pfam:Hydrolase
|
338 |
650 |
1.1e-31 |
PFAM |
Pfam:HAD
|
341 |
647 |
2.7e-15 |
PFAM |
Pfam:Hydrolase_like2
|
403 |
487 |
4.8e-20 |
PFAM |
low complexity region
|
701 |
716 |
N/A |
INTRINSIC |
Pfam:Cation_ATPase_C
|
720 |
892 |
1.6e-47 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000177074
AA Change: T789A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000135646 Gene: ENSMUSG00000032570 AA Change: T789A
Domain | Start | End | E-Value | Type |
Cation_ATPase_N
|
25 |
99 |
1.85e-14 |
SMART |
Pfam:E1-E2_ATPase
|
105 |
339 |
8.2e-76 |
PFAM |
Pfam:Hydrolase
|
343 |
655 |
1e-31 |
PFAM |
Pfam:HAD
|
346 |
652 |
2.5e-15 |
PFAM |
Pfam:Hydrolase_like2
|
408 |
492 |
4.5e-20 |
PFAM |
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
Pfam:Cation_ATPase_C
|
725 |
886 |
7e-44 |
PFAM |
|
Meta Mutation Damage Score |
0.6309 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
Validation Efficiency |
97% (73/75) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] PHENOTYPE: Mice homozygous for a knock-out allele show embryonic growth retardation, failure of rostral neural tube closure, Golgi and endoplasmic reticulum stress, increased apoptosis, accumulation of intracellular lipid droplets and midgestational lethality. Agedheterozygotes develop squamous cell tumors. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 64 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2610303G11Rik |
A |
G |
9: 98,069,176 (GRCm39) |
|
noncoding transcript |
Het |
Abhd2 |
A |
G |
7: 79,009,879 (GRCm39) |
E418G |
probably benign |
Het |
Acox2 |
G |
T |
14: 8,241,334 (GRCm38) |
H593N |
possibly damaging |
Het |
Adam17 |
A |
G |
12: 21,384,016 (GRCm39) |
Y495H |
probably benign |
Het |
Afg3l2 |
G |
T |
18: 67,554,329 (GRCm39) |
L458M |
probably damaging |
Het |
Arhgap44 |
A |
G |
11: 64,929,991 (GRCm39) |
I240T |
probably damaging |
Het |
Atxn7l1 |
G |
A |
12: 33,408,877 (GRCm39) |
|
probably benign |
Het |
Cacng8 |
T |
C |
7: 3,463,508 (GRCm39) |
V220A |
probably damaging |
Het |
Card14 |
A |
T |
11: 119,234,001 (GRCm39) |
S864C |
probably damaging |
Het |
Cfap58 |
C |
T |
19: 47,971,945 (GRCm39) |
A625V |
probably damaging |
Het |
Cfap61 |
T |
C |
2: 145,859,287 (GRCm39) |
V425A |
probably benign |
Het |
Cfap73 |
A |
G |
5: 120,768,294 (GRCm39) |
F155L |
probably damaging |
Het |
Cntrl |
G |
T |
2: 35,065,563 (GRCm39) |
R2235L |
probably damaging |
Het |
Cxxc1 |
A |
G |
18: 74,352,484 (GRCm39) |
K355E |
probably damaging |
Het |
Disc1 |
G |
A |
8: 125,851,277 (GRCm39) |
G387D |
probably damaging |
Het |
Dpf2 |
T |
C |
19: 5,952,480 (GRCm39) |
Y286C |
probably damaging |
Het |
E2f7 |
A |
T |
10: 110,616,710 (GRCm39) |
K650M |
probably damaging |
Het |
Fbln2 |
C |
T |
6: 91,246,982 (GRCm39) |
S1027F |
probably damaging |
Het |
Foxj2 |
G |
T |
6: 122,810,230 (GRCm39) |
Q196H |
probably benign |
Het |
Gm6811 |
A |
G |
17: 21,314,109 (GRCm39) |
|
noncoding transcript |
Het |
Gtf2i |
T |
C |
5: 134,284,818 (GRCm39) |
K409E |
probably damaging |
Het |
Hamp |
T |
A |
7: 30,641,989 (GRCm39) |
R55S |
probably damaging |
Het |
Heatr1 |
C |
T |
13: 12,445,811 (GRCm39) |
T1596I |
possibly damaging |
Het |
Hells |
T |
C |
19: 38,945,643 (GRCm39) |
V601A |
probably damaging |
Het |
Ighv5-8 |
A |
G |
12: 113,617,161 (GRCm39) |
S34P |
probably damaging |
Het |
Lig4 |
T |
C |
8: 10,022,955 (GRCm39) |
D275G |
probably damaging |
Het |
Meak7 |
A |
G |
8: 120,495,122 (GRCm39) |
V212A |
probably benign |
Het |
Med6 |
T |
C |
12: 81,629,435 (GRCm39) |
D59G |
probably damaging |
Het |
Men1 |
T |
C |
19: 6,385,102 (GRCm39) |
|
probably null |
Het |
Mlec |
G |
A |
5: 115,295,972 (GRCm39) |
A41V |
unknown |
Het |
Ncoa1 |
G |
A |
12: 4,325,297 (GRCm39) |
T927I |
probably damaging |
Het |
Neb |
T |
A |
2: 52,216,732 (GRCm39) |
K148* |
probably null |
Het |
Neb |
T |
A |
2: 52,127,052 (GRCm39) |
K378* |
probably null |
Het |
Or4b13 |
T |
A |
2: 90,082,807 (GRCm39) |
Y175F |
probably damaging |
Het |
Or4k41 |
T |
A |
2: 111,280,023 (GRCm39) |
C179* |
probably null |
Het |
Or5p73 |
G |
A |
7: 108,065,393 (GRCm39) |
M287I |
probably benign |
Het |
Or8g26 |
A |
G |
9: 39,096,256 (GRCm39) |
T261A |
probably benign |
Het |
Parp10 |
C |
T |
15: 76,117,627 (GRCm39) |
V920M |
probably damaging |
Het |
Parp6 |
C |
A |
9: 59,538,648 (GRCm39) |
P241H |
probably damaging |
Het |
Pcyox1l |
A |
G |
18: 61,830,850 (GRCm39) |
Y341H |
probably benign |
Het |
Pfas |
A |
T |
11: 68,881,020 (GRCm39) |
D1080E |
possibly damaging |
Het |
Pi4kb |
G |
T |
3: 94,911,720 (GRCm39) |
|
probably benign |
Het |
Piwil2 |
C |
T |
14: 70,614,227 (GRCm39) |
V846M |
probably damaging |
Het |
Pkd1l2 |
A |
G |
8: 117,746,168 (GRCm39) |
F1941L |
probably damaging |
Het |
Pot1b |
G |
A |
17: 56,002,160 (GRCm39) |
T138M |
possibly damaging |
Het |
Ppp4r1 |
T |
C |
17: 66,142,105 (GRCm39) |
I720T |
possibly damaging |
Het |
Prr12 |
A |
G |
7: 44,697,119 (GRCm39) |
L932S |
unknown |
Het |
Rnaseh2a |
T |
A |
8: 85,692,021 (GRCm39) |
E84V |
probably benign |
Het |
Rpl18a |
G |
A |
8: 71,348,330 (GRCm39) |
R118C |
probably benign |
Het |
Rprm |
C |
A |
2: 53,975,228 (GRCm39) |
C30F |
possibly damaging |
Het |
Sbf2 |
G |
T |
7: 110,020,124 (GRCm39) |
L579I |
probably damaging |
Het |
Sfn |
C |
A |
4: 133,328,656 (GRCm39) |
R142L |
probably benign |
Het |
St8sia6 |
T |
C |
2: 13,677,341 (GRCm39) |
K159E |
probably damaging |
Het |
Sugct |
A |
T |
13: 17,837,372 (GRCm39) |
F86L |
probably damaging |
Het |
Tmcc3 |
T |
C |
10: 94,415,173 (GRCm39) |
S292P |
probably damaging |
Het |
Tmem33 |
A |
T |
5: 67,443,479 (GRCm39) |
I219F |
probably benign |
Het |
Trav8-1 |
C |
A |
14: 53,707,492 (GRCm39) |
T44K |
possibly damaging |
Het |
U2surp |
A |
G |
9: 95,393,844 (GRCm39) |
|
probably benign |
Het |
Use1 |
T |
C |
8: 71,819,952 (GRCm39) |
L25P |
probably damaging |
Het |
Vmn1r221 |
G |
T |
13: 23,401,958 (GRCm39) |
|
noncoding transcript |
Het |
Vmn1r50 |
C |
T |
6: 90,085,062 (GRCm39) |
T269I |
probably benign |
Het |
Washc3 |
A |
G |
10: 88,055,185 (GRCm39) |
D125G |
probably damaging |
Het |
Zfp142 |
G |
A |
1: 74,615,671 (GRCm39) |
H278Y |
probably damaging |
Het |
Zfp418 |
A |
G |
7: 7,184,444 (GRCm39) |
N136D |
possibly damaging |
Het |
|
Other mutations in Atp2c1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00984:Atp2c1
|
APN |
9 |
105,295,778 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01682:Atp2c1
|
APN |
9 |
105,330,041 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01874:Atp2c1
|
APN |
9 |
105,326,024 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02299:Atp2c1
|
APN |
9 |
105,338,286 (GRCm39) |
unclassified |
probably benign |
|
IGL03186:Atp2c1
|
APN |
9 |
105,290,329 (GRCm39) |
missense |
probably benign |
0.10 |
IGL03212:Atp2c1
|
APN |
9 |
105,322,466 (GRCm39) |
missense |
probably damaging |
1.00 |
BB002:Atp2c1
|
UTSW |
9 |
105,319,969 (GRCm39) |
missense |
possibly damaging |
0.92 |
BB012:Atp2c1
|
UTSW |
9 |
105,319,969 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL02799:Atp2c1
|
UTSW |
9 |
105,290,242 (GRCm39) |
unclassified |
probably benign |
|
IGL03047:Atp2c1
|
UTSW |
9 |
105,398,206 (GRCm39) |
intron |
probably benign |
|
R0885:Atp2c1
|
UTSW |
9 |
105,298,772 (GRCm39) |
critical splice donor site |
probably null |
|
R1072:Atp2c1
|
UTSW |
9 |
105,336,943 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1469:Atp2c1
|
UTSW |
9 |
105,312,351 (GRCm39) |
nonsense |
probably null |
|
R1469:Atp2c1
|
UTSW |
9 |
105,312,351 (GRCm39) |
nonsense |
probably null |
|
R1611:Atp2c1
|
UTSW |
9 |
105,320,051 (GRCm39) |
missense |
probably damaging |
0.98 |
R1638:Atp2c1
|
UTSW |
9 |
105,309,897 (GRCm39) |
missense |
probably damaging |
0.96 |
R1667:Atp2c1
|
UTSW |
9 |
105,309,996 (GRCm39) |
missense |
probably null |
0.94 |
R1722:Atp2c1
|
UTSW |
9 |
105,316,599 (GRCm39) |
missense |
probably benign |
0.01 |
R1734:Atp2c1
|
UTSW |
9 |
105,291,854 (GRCm39) |
missense |
probably damaging |
1.00 |
R1782:Atp2c1
|
UTSW |
9 |
105,308,786 (GRCm39) |
missense |
probably damaging |
0.99 |
R1964:Atp2c1
|
UTSW |
9 |
105,323,322 (GRCm39) |
missense |
probably damaging |
1.00 |
R2008:Atp2c1
|
UTSW |
9 |
105,309,925 (GRCm39) |
missense |
probably benign |
0.00 |
R2093:Atp2c1
|
UTSW |
9 |
105,295,320 (GRCm39) |
nonsense |
probably null |
|
R3720:Atp2c1
|
UTSW |
9 |
105,300,175 (GRCm39) |
missense |
probably damaging |
1.00 |
R4118:Atp2c1
|
UTSW |
9 |
105,343,858 (GRCm39) |
missense |
probably damaging |
1.00 |
R4273:Atp2c1
|
UTSW |
9 |
105,312,339 (GRCm39) |
missense |
probably benign |
0.10 |
R4962:Atp2c1
|
UTSW |
9 |
105,320,149 (GRCm39) |
missense |
probably benign |
0.03 |
R5121:Atp2c1
|
UTSW |
9 |
105,326,024 (GRCm39) |
missense |
probably damaging |
1.00 |
R5458:Atp2c1
|
UTSW |
9 |
105,291,924 (GRCm39) |
nonsense |
probably null |
|
R5551:Atp2c1
|
UTSW |
9 |
105,336,936 (GRCm39) |
missense |
probably damaging |
1.00 |
R6198:Atp2c1
|
UTSW |
9 |
105,398,271 (GRCm39) |
missense |
probably benign |
0.00 |
R6414:Atp2c1
|
UTSW |
9 |
105,343,855 (GRCm39) |
missense |
probably damaging |
1.00 |
R6432:Atp2c1
|
UTSW |
9 |
105,322,512 (GRCm39) |
missense |
probably damaging |
1.00 |
R6675:Atp2c1
|
UTSW |
9 |
105,330,732 (GRCm39) |
critical splice donor site |
probably null |
|
R6719:Atp2c1
|
UTSW |
9 |
105,301,377 (GRCm39) |
missense |
probably damaging |
1.00 |
R6777:Atp2c1
|
UTSW |
9 |
105,295,799 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6847:Atp2c1
|
UTSW |
9 |
105,295,778 (GRCm39) |
missense |
probably damaging |
1.00 |
R6870:Atp2c1
|
UTSW |
9 |
105,347,261 (GRCm39) |
missense |
probably benign |
0.13 |
R7097:Atp2c1
|
UTSW |
9 |
105,341,850 (GRCm39) |
missense |
probably damaging |
1.00 |
R7120:Atp2c1
|
UTSW |
9 |
105,297,385 (GRCm39) |
nonsense |
probably null |
|
R7216:Atp2c1
|
UTSW |
9 |
105,344,930 (GRCm39) |
missense |
probably benign |
0.00 |
R7284:Atp2c1
|
UTSW |
9 |
105,398,008 (GRCm39) |
splice site |
probably null |
|
R7365:Atp2c1
|
UTSW |
9 |
105,300,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R7448:Atp2c1
|
UTSW |
9 |
105,329,982 (GRCm39) |
missense |
probably damaging |
0.98 |
R7818:Atp2c1
|
UTSW |
9 |
105,291,956 (GRCm39) |
missense |
probably benign |
0.06 |
R7921:Atp2c1
|
UTSW |
9 |
105,291,886 (GRCm39) |
missense |
probably damaging |
1.00 |
R7925:Atp2c1
|
UTSW |
9 |
105,319,969 (GRCm39) |
missense |
possibly damaging |
0.92 |
R8088:Atp2c1
|
UTSW |
9 |
105,329,768 (GRCm39) |
splice site |
probably null |
|
R8257:Atp2c1
|
UTSW |
9 |
105,308,756 (GRCm39) |
missense |
probably benign |
0.40 |
R8260:Atp2c1
|
UTSW |
9 |
105,295,778 (GRCm39) |
missense |
probably damaging |
1.00 |
R8265:Atp2c1
|
UTSW |
9 |
105,347,315 (GRCm39) |
missense |
probably benign |
0.01 |
R8307:Atp2c1
|
UTSW |
9 |
105,320,030 (GRCm39) |
missense |
probably benign |
|
R9052:Atp2c1
|
UTSW |
9 |
105,330,032 (GRCm39) |
missense |
probably damaging |
0.99 |
R9066:Atp2c1
|
UTSW |
9 |
105,330,845 (GRCm39) |
missense |
probably damaging |
1.00 |
R9177:Atp2c1
|
UTSW |
9 |
105,336,858 (GRCm39) |
critical splice donor site |
probably null |
|
R9257:Atp2c1
|
UTSW |
9 |
105,291,851 (GRCm39) |
nonsense |
probably null |
|
R9566:Atp2c1
|
UTSW |
9 |
105,343,828 (GRCm39) |
missense |
probably damaging |
0.97 |
R9779:Atp2c1
|
UTSW |
9 |
105,291,919 (GRCm39) |
missense |
probably damaging |
0.98 |
X0053:Atp2c1
|
UTSW |
9 |
105,295,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CAAACTTGCATGTACACGGTAC -3'
(R):5'- TCCCTAGCTAATAGATGCTAGTTAGG -3'
Sequencing Primer
(F):5'- CATGTACACGGTACTTTACTAAAGGC -3'
(R):5'- TAAGCCTTGGAGTAGAGC -3'
|
Posted On |
2015-11-11 |