Incidental Mutation 'R4747:Hfm1'
| ID |
357177 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hfm1
|
| Ensembl Gene |
ENSMUSG00000043410 |
| Gene Name |
HFM1, ATP-dependent DNA helicase homolog |
| Synonyms |
LOC381663, A330009G12Rik, Mer3, Sec63d1 |
| MMRRC Submission |
042029-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
R4747 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
106840192-106926321 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 106917523 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Tyrosine
at position 97
(H97Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142727
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112690]
[ENSMUST00000117588]
[ENSMUST00000148686]
[ENSMUST00000200249]
|
| AlphaFold |
D3Z4R1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112690
AA Change: H97Y
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000108310
Gene: ENSMUSG00000043410
AA Change: H97Y
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
276 |
490 |
3.66e-29 |
SMART |
|
HELICc
|
571 |
657 |
1.56e-14 |
SMART |
|
low complexity region
|
751 |
764 |
N/A |
INTRINSIC |
|
Sec63
|
775 |
1090 |
5.66e-60 |
SMART |
|
Blast:Sec63
|
1130 |
1188 |
2e-18 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117588
AA Change: H97Y
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000112590
Gene: ENSMUSG00000043410
AA Change: H97Y
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
276 |
490 |
3.66e-29 |
SMART |
|
HELICc
|
571 |
657 |
1.56e-14 |
SMART |
|
low complexity region
|
751 |
764 |
N/A |
INTRINSIC |
|
Sec63
|
775 |
1090 |
5.66e-60 |
SMART |
|
Blast:Sec63
|
1130 |
1188 |
2e-18 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134292
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148686
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200249
AA Change: H97Y
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000142727
Gene: ENSMUSG00000043410
AA Change: H97Y
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ResIII
|
260 |
410 |
9.9e-7 |
PFAM |
|
Pfam:DEAD
|
281 |
410 |
1.5e-19 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]
PHENOTYPE: Meiosis ais disrupted in homozygotes and bothe sexes are sterile [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810474O19Rik |
A |
T |
6: 149,326,894 (GRCm38) |
E479D |
probably damaging |
Het |
| 4933402D24Rik |
A |
G |
1: 63,756,409 (GRCm38) |
|
probably benign |
Het |
| Acadvl |
G |
T |
11: 70,012,508 (GRCm38) |
N340K |
probably damaging |
Het |
| Adgrl4 |
T |
A |
3: 151,507,440 (GRCm38) |
N372K |
probably benign |
Het |
| Adh1 |
G |
A |
3: 138,288,881 (GRCm38) |
G321S |
probably damaging |
Het |
| Ankrd26 |
G |
T |
6: 118,527,757 (GRCm38) |
N730K |
probably benign |
Het |
| Aoc2 |
A |
T |
11: 101,328,820 (GRCm38) |
|
probably null |
Het |
| Arhgef4 |
A |
G |
1: 34,723,274 (GRCm38) |
E537G |
unknown |
Het |
| Ccdc7b |
T |
C |
8: 129,178,235 (GRCm38) |
V118A |
probably benign |
Het |
| Ccdc88b |
T |
A |
19: 6,856,141 (GRCm38) |
R219W |
probably damaging |
Het |
| Ccdc97 |
T |
C |
7: 25,718,923 (GRCm38) |
|
probably null |
Het |
| Cnot1 |
T |
C |
8: 95,774,682 (GRCm38) |
N86S |
probably benign |
Het |
| Comp |
T |
C |
8: 70,376,702 (GRCm38) |
C310R |
probably damaging |
Het |
| Crtc2 |
A |
T |
3: 90,260,211 (GRCm38) |
N281Y |
probably damaging |
Het |
| Cryl1 |
T |
C |
14: 57,313,102 (GRCm38) |
K102E |
probably damaging |
Het |
| Csf2ra |
G |
A |
19: 61,226,053 (GRCm38) |
R225* |
probably null |
Het |
| Dao |
A |
T |
5: 114,012,632 (GRCm38) |
D99V |
probably benign |
Het |
| Dgkd |
A |
G |
1: 87,934,167 (GRCm38) |
T815A |
probably damaging |
Het |
| Dhrs7 |
T |
C |
12: 72,653,118 (GRCm38) |
T247A |
probably benign |
Het |
| Dnah7c |
G |
C |
1: 46,533,168 (GRCm38) |
D934H |
probably damaging |
Het |
| Dnajc15 |
T |
C |
14: 77,844,456 (GRCm38) |
Y82C |
probably benign |
Het |
| Dnajc4 |
T |
C |
19: 6,989,504 (GRCm38) |
Q152R |
probably damaging |
Het |
| Dsc1 |
T |
C |
18: 20,094,558 (GRCm38) |
K541R |
probably damaging |
Het |
| Elp4 |
G |
A |
2: 105,794,607 (GRCm38) |
R196C |
probably damaging |
Het |
| Epha8 |
GC |
G |
4: 136,938,695 (GRCm38) |
|
probably null |
Het |
| Ercc6 |
T |
C |
14: 32,569,907 (GRCm38) |
V1076A |
probably benign |
Het |
| Fgd4 |
T |
C |
16: 16,423,929 (GRCm38) |
Y677C |
probably damaging |
Het |
| Fndc3b |
C |
A |
3: 27,428,965 (GRCm38) |
C1028F |
probably damaging |
Het |
| Folr1 |
T |
A |
7: 101,863,977 (GRCm38) |
D37V |
probably damaging |
Het |
| Gabrr3 |
T |
A |
16: 59,447,914 (GRCm38) |
|
probably null |
Het |
| Garem1 |
C |
A |
18: 21,129,943 (GRCm38) |
V605L |
probably benign |
Het |
| Gbp7 |
A |
T |
3: 142,543,017 (GRCm38) |
D347V |
probably damaging |
Het |
| Gdpd4 |
A |
G |
7: 97,961,633 (GRCm38) |
T87A |
possibly damaging |
Het |
| Gm12258 |
C |
A |
11: 58,859,596 (GRCm38) |
H532Q |
probably damaging |
Het |
| Gm4788 |
A |
T |
1: 139,698,184 (GRCm38) |
C792S |
probably damaging |
Het |
| Herc2 |
A |
G |
7: 56,106,393 (GRCm38) |
E727G |
possibly damaging |
Het |
| Idua |
G |
T |
5: 108,681,036 (GRCm38) |
R335L |
probably damaging |
Het |
| Ifi207 |
A |
G |
1: 173,729,067 (GRCm38) |
S702P |
probably benign |
Het |
| Kif16b |
A |
T |
2: 142,857,426 (GRCm38) |
V78D |
probably damaging |
Het |
| Klra17 |
T |
A |
6: 129,872,269 (GRCm38) |
D114V |
probably damaging |
Het |
| Krt76 |
A |
G |
15: 101,885,745 (GRCm38) |
S481P |
probably damaging |
Het |
| Lhfpl5 |
A |
G |
17: 28,579,976 (GRCm38) |
D153G |
probably damaging |
Het |
| Med21 |
T |
A |
6: 146,649,202 (GRCm38) |
D70E |
possibly damaging |
Het |
| Mroh3 |
A |
T |
1: 136,185,499 (GRCm38) |
M739K |
probably benign |
Het |
| Myo1a |
A |
G |
10: 127,714,438 (GRCm38) |
E549G |
probably damaging |
Het |
| Narfl |
A |
T |
17: 25,780,353 (GRCm38) |
Y247F |
probably benign |
Het |
| Neu1 |
A |
G |
17: 34,934,383 (GRCm38) |
D294G |
possibly damaging |
Het |
| Nmur2 |
A |
T |
11: 56,040,279 (GRCm38) |
I202K |
probably benign |
Het |
| Nop2 |
T |
A |
6: 125,137,094 (GRCm38) |
D174E |
probably benign |
Het |
| Ogfr |
A |
T |
2: 180,594,423 (GRCm38) |
H267L |
probably damaging |
Het |
| Olfr1031 |
A |
G |
2: 85,991,927 (GRCm38) |
T37A |
probably damaging |
Het |
| Olfr796 |
G |
T |
10: 129,608,184 (GRCm38) |
A99E |
possibly damaging |
Het |
| P2ry13 |
T |
A |
3: 59,209,887 (GRCm38) |
I157F |
probably benign |
Het |
| Pank4 |
T |
C |
4: 154,979,532 (GRCm38) |
V660A |
probably damaging |
Het |
| Pax6 |
C |
A |
2: 105,696,502 (GRCm38) |
P251Q |
probably benign |
Het |
| Pcdhb13 |
T |
C |
18: 37,444,815 (GRCm38) |
Y749H |
probably damaging |
Het |
| Pcdhga3 |
C |
A |
18: 37,676,746 (GRCm38) |
Q751K |
probably benign |
Het |
| Pcnt |
C |
T |
10: 76,436,465 (GRCm38) |
E186K |
possibly damaging |
Het |
| Pecam1 |
A |
T |
11: 106,684,246 (GRCm38) |
F613I |
probably benign |
Het |
| Pias2 |
T |
C |
18: 77,152,792 (GRCm38) |
*615Q |
probably null |
Het |
| Plb1 |
A |
T |
5: 32,349,659 (GRCm38) |
M1193L |
probably benign |
Het |
| Pomgnt1 |
T |
C |
4: 116,156,199 (GRCm38) |
L506P |
probably damaging |
Het |
| Qrfp |
T |
C |
2: 31,808,840 (GRCm38) |
T27A |
probably damaging |
Het |
| Relb |
C |
A |
7: 19,627,922 (GRCm38) |
|
probably null |
Het |
| Rgl1 |
G |
T |
1: 152,524,699 (GRCm38) |
C685* |
probably null |
Het |
| Ric8b |
A |
G |
10: 84,917,764 (GRCm38) |
Y8C |
probably benign |
Het |
| Rrp36 |
G |
A |
17: 46,669,967 (GRCm38) |
A161V |
possibly damaging |
Het |
| Samd9l |
G |
A |
6: 3,375,504 (GRCm38) |
Q586* |
probably null |
Het |
| Sbf1 |
C |
T |
15: 89,302,713 (GRCm38) |
D821N |
probably damaging |
Het |
| Sept8 |
G |
C |
11: 53,536,718 (GRCm38) |
A255P |
probably damaging |
Het |
| Skp2 |
T |
C |
15: 9,113,839 (GRCm38) |
T329A |
possibly damaging |
Het |
| Slc15a2 |
C |
T |
16: 36,772,136 (GRCm38) |
V220M |
probably damaging |
Het |
| Slc25a11 |
T |
A |
11: 70,645,956 (GRCm38) |
T63S |
possibly damaging |
Het |
| Sowahc |
T |
C |
10: 59,223,161 (GRCm38) |
I373T |
probably benign |
Het |
| Sptbn2 |
T |
A |
19: 4,748,154 (GRCm38) |
M1969K |
probably benign |
Het |
| St14 |
G |
A |
9: 31,103,757 (GRCm38) |
T315M |
possibly damaging |
Het |
| Tagap |
G |
A |
17: 7,932,198 (GRCm38) |
R284H |
probably benign |
Het |
| Tdpoz3 |
T |
A |
3: 93,826,169 (GRCm38) |
S50R |
possibly damaging |
Het |
| Thoc5 |
A |
G |
11: 4,904,187 (GRCm38) |
D182G |
probably damaging |
Het |
| Tinag |
A |
G |
9: 76,996,956 (GRCm38) |
V395A |
probably benign |
Het |
| Tmc8 |
A |
G |
11: 117,792,724 (GRCm38) |
S702G |
probably benign |
Het |
| Tmem202 |
A |
G |
9: 59,519,194 (GRCm38) |
S230P |
possibly damaging |
Het |
| Tmem203 |
T |
C |
2: 25,255,752 (GRCm38) |
V28A |
probably benign |
Het |
| Traf3ip1 |
A |
T |
1: 91,527,757 (GRCm38) |
S647C |
probably damaging |
Het |
| Tram1 |
A |
T |
1: 13,589,646 (GRCm38) |
I26N |
probably damaging |
Het |
| Ttc6 |
A |
T |
12: 57,674,692 (GRCm38) |
D989V |
possibly damaging |
Het |
| Ttll6 |
A |
G |
11: 96,145,546 (GRCm38) |
T334A |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,919,742 (GRCm38) |
D3654E |
probably damaging |
Het |
| Ufd1 |
T |
G |
16: 18,821,082 (GRCm38) |
V112G |
probably damaging |
Het |
| Usp9y |
A |
T |
Y: 1,391,284 (GRCm38) |
Y629N |
possibly damaging |
Het |
| Vmn2r1 |
A |
G |
3: 64,081,846 (GRCm38) |
I69V |
probably benign |
Het |
| Zfp180 |
A |
T |
7: 24,105,821 (GRCm38) |
Y555F |
probably damaging |
Het |
| Zfp438 |
T |
C |
18: 5,214,403 (GRCm38) |
N185S |
probably benign |
Het |
| Zfp445 |
C |
T |
9: 122,857,150 (GRCm38) |
V15I |
possibly damaging |
Het |
| Zfp462 |
A |
G |
4: 55,013,476 (GRCm38) |
E1814G |
probably benign |
Het |
|
| Other mutations in Hfm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Hfm1
|
APN |
5 |
106,902,130 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
IGL01295:Hfm1
|
APN |
5 |
106,917,606 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
IGL01725:Hfm1
|
APN |
5 |
106,917,379 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01758:Hfm1
|
APN |
5 |
106,904,793 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01911:Hfm1
|
APN |
5 |
106,911,544 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02337:Hfm1
|
APN |
5 |
106,904,267 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
IGL02472:Hfm1
|
APN |
5 |
106,873,928 (GRCm38) |
splice site |
probably benign |
|
|
IGL02496:Hfm1
|
APN |
5 |
106,901,761 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02545:Hfm1
|
APN |
5 |
106,895,287 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02584:Hfm1
|
APN |
5 |
106,878,662 (GRCm38) |
splice site |
probably null |
|
|
IGL02728:Hfm1
|
APN |
5 |
106,878,823 (GRCm38) |
missense |
probably benign |
0.13 |
|
IGL02881:Hfm1
|
APN |
5 |
106,874,252 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03108:Hfm1
|
APN |
5 |
106,895,934 (GRCm38) |
unclassified |
probably benign |
|
|
IGL03351:Hfm1
|
APN |
5 |
106,911,575 (GRCm38) |
nonsense |
probably null |
|
|
IGL03353:Hfm1
|
APN |
5 |
106,856,929 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0024:Hfm1
|
UTSW |
5 |
106,856,924 (GRCm38) |
missense |
probably benign |
0.41 |
|
R0024:Hfm1
|
UTSW |
5 |
106,856,924 (GRCm38) |
missense |
probably benign |
0.41 |
|
R0094:Hfm1
|
UTSW |
5 |
106,917,478 (GRCm38) |
missense |
probably benign |
|
|
R0633:Hfm1
|
UTSW |
5 |
106,917,601 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R0644:Hfm1
|
UTSW |
5 |
106,898,256 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1078:Hfm1
|
UTSW |
5 |
106,878,830 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1120:Hfm1
|
UTSW |
5 |
106,904,218 (GRCm38) |
splice site |
probably benign |
|
|
R1166:Hfm1
|
UTSW |
5 |
106,911,411 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1242:Hfm1
|
UTSW |
5 |
106,874,901 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1414:Hfm1
|
UTSW |
5 |
106,872,353 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1450:Hfm1
|
UTSW |
5 |
106,918,458 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1529:Hfm1
|
UTSW |
5 |
106,853,123 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1622:Hfm1
|
UTSW |
5 |
106,893,523 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R1710:Hfm1
|
UTSW |
5 |
106,896,003 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1710:Hfm1
|
UTSW |
5 |
106,880,514 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1757:Hfm1
|
UTSW |
5 |
106,880,360 (GRCm38) |
splice site |
probably null |
|
|
R1856:Hfm1
|
UTSW |
5 |
106,847,676 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1984:Hfm1
|
UTSW |
5 |
106,898,576 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1985:Hfm1
|
UTSW |
5 |
106,898,576 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2040:Hfm1
|
UTSW |
5 |
106,901,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2122:Hfm1
|
UTSW |
5 |
106,896,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2426:Hfm1
|
UTSW |
5 |
106,847,653 (GRCm38) |
splice site |
probably null |
|
|
R2474:Hfm1
|
UTSW |
5 |
106,872,416 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R2926:Hfm1
|
UTSW |
5 |
106,874,282 (GRCm38) |
nonsense |
probably null |
|
|
R2944:Hfm1
|
UTSW |
5 |
106,872,330 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3705:Hfm1
|
UTSW |
5 |
106,892,839 (GRCm38) |
unclassified |
probably benign |
|
|
R4256:Hfm1
|
UTSW |
5 |
106,904,797 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R4455:Hfm1
|
UTSW |
5 |
106,886,508 (GRCm38) |
splice site |
probably null |
|
|
R4538:Hfm1
|
UTSW |
5 |
106,874,890 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4540:Hfm1
|
UTSW |
5 |
106,874,221 (GRCm38) |
nonsense |
probably null |
|
|
R4591:Hfm1
|
UTSW |
5 |
106,847,667 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4745:Hfm1
|
UTSW |
5 |
106,901,843 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R4765:Hfm1
|
UTSW |
5 |
106,842,539 (GRCm38) |
missense |
probably benign |
0.21 |
|
R4821:Hfm1
|
UTSW |
5 |
106,854,740 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4842:Hfm1
|
UTSW |
5 |
106,892,751 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4944:Hfm1
|
UTSW |
5 |
106,874,213 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R5093:Hfm1
|
UTSW |
5 |
106,901,731 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5399:Hfm1
|
UTSW |
5 |
106,917,562 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R5414:Hfm1
|
UTSW |
5 |
106,902,076 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5436:Hfm1
|
UTSW |
5 |
106,892,772 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R5459:Hfm1
|
UTSW |
5 |
106,904,763 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5485:Hfm1
|
UTSW |
5 |
106,847,662 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5585:Hfm1
|
UTSW |
5 |
106,911,439 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5631:Hfm1
|
UTSW |
5 |
106,904,763 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5705:Hfm1
|
UTSW |
5 |
106,911,453 (GRCm38) |
missense |
probably benign |
0.21 |
|
R5804:Hfm1
|
UTSW |
5 |
106,878,589 (GRCm38) |
splice site |
probably null |
|
|
R5959:Hfm1
|
UTSW |
5 |
106,874,917 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6046:Hfm1
|
UTSW |
5 |
106,898,643 (GRCm38) |
splice site |
probably null |
|
|
R6191:Hfm1
|
UTSW |
5 |
106,886,553 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6345:Hfm1
|
UTSW |
5 |
106,841,638 (GRCm38) |
missense |
probably benign |
|
|
R6580:Hfm1
|
UTSW |
5 |
106,847,709 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6651:Hfm1
|
UTSW |
5 |
106,847,687 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6761:Hfm1
|
UTSW |
5 |
106,895,279 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6835:Hfm1
|
UTSW |
5 |
106,878,815 (GRCm38) |
nonsense |
probably null |
|
|
R6891:Hfm1
|
UTSW |
5 |
106,917,374 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R6924:Hfm1
|
UTSW |
5 |
106,850,410 (GRCm38) |
splice site |
probably null |
|
|
R6980:Hfm1
|
UTSW |
5 |
106,880,477 (GRCm38) |
missense |
probably benign |
0.31 |
|
R7054:Hfm1
|
UTSW |
5 |
106,896,043 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7058:Hfm1
|
UTSW |
5 |
106,911,440 (GRCm38) |
missense |
probably benign |
0.04 |
|
R7189:Hfm1
|
UTSW |
5 |
106,901,703 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7250:Hfm1
|
UTSW |
5 |
106,904,331 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7376:Hfm1
|
UTSW |
5 |
106,895,218 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7577:Hfm1
|
UTSW |
5 |
106,896,043 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7636:Hfm1
|
UTSW |
5 |
106,917,466 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7639:Hfm1
|
UTSW |
5 |
106,898,475 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R7639:Hfm1
|
UTSW |
5 |
106,889,925 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7763:Hfm1
|
UTSW |
5 |
106,881,861 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7828:Hfm1
|
UTSW |
5 |
106,881,791 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7905:Hfm1
|
UTSW |
5 |
106,898,553 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8160:Hfm1
|
UTSW |
5 |
106,896,033 (GRCm38) |
missense |
probably null |
0.00 |
|
R8477:Hfm1
|
UTSW |
5 |
106,881,818 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8739:Hfm1
|
UTSW |
5 |
106,898,505 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8968:Hfm1
|
UTSW |
5 |
106,917,573 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9072:Hfm1
|
UTSW |
5 |
106,898,280 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9073:Hfm1
|
UTSW |
5 |
106,898,280 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9152:Hfm1
|
UTSW |
5 |
106,841,745 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9234:Hfm1
|
UTSW |
5 |
106,893,468 (GRCm38) |
missense |
probably benign |
|
|
R9244:Hfm1
|
UTSW |
5 |
106,874,900 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9576:Hfm1
|
UTSW |
5 |
106,874,072 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9649:Hfm1
|
UTSW |
5 |
106,918,463 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9743:Hfm1
|
UTSW |
5 |
106,874,259 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R9782:Hfm1
|
UTSW |
5 |
106,874,030 (GRCm38) |
missense |
probably benign |
0.38 |
|
R9789:Hfm1
|
UTSW |
5 |
106,917,480 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1177:Hfm1
|
UTSW |
5 |
106,871,820 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCTGATGTGCCCTGTCTG -3'
(R):5'- CAGTGCATGGTTCTTGTAATATTCG -3'
Sequencing Primer
(F):5'- GTCTTCTGCCACATCATGTAATTTTG -3'
(R):5'- CACTGTCTGTGTAGTCAGAGAAC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation