Incidental Mutation 'R4747:Cnot1'
| ID |
357195 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cnot1
|
| Ensembl Gene |
ENSMUSG00000036550 |
| Gene Name |
CCR4-NOT transcription complex, subunit 1 |
| Synonyms |
6030411K04Rik |
| MMRRC Submission |
042029-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4747 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
96446079-96534092 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 96501310 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 86
(N86S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148574
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068452]
[ENSMUST00000098473]
[ENSMUST00000211887]
[ENSMUST00000212323]
[ENSMUST00000213006]
[ENSMUST00000213046]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000068452
AA Change: N86S
PolyPhen 2
Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000063565
Gene: ENSMUSG00000036550
AA Change: N86S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
|
PDB:4J8S|A
|
798 |
999 |
1e-137 |
PDB |
|
low complexity region
|
1011 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1055 |
N/A |
INTRINSIC |
|
PDB:4CT4|C
|
1056 |
1295 |
1e-148 |
PDB |
|
low complexity region
|
1296 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1345 |
N/A |
INTRINSIC |
|
Pfam:DUF3819
|
1381 |
1530 |
2.5e-56 |
PFAM |
|
low complexity region
|
1634 |
1648 |
N/A |
INTRINSIC |
|
Pfam:Not1
|
1991 |
2305 |
2.4e-125 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098473
AA Change: N86S
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000096073
Gene: ENSMUSG00000036550
AA Change: N86S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_HEAT
|
500 |
656 |
2.4e-57 |
PFAM |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_TTP_bind
|
812 |
1004 |
1.4e-87 |
PFAM |
|
low complexity region
|
1016 |
1033 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1060 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_CAF1_bind
|
1087 |
1313 |
5.7e-99 |
PFAM |
|
low complexity region
|
1333 |
1350 |
N/A |
INTRINSIC |
|
Pfam:DUF3819
|
1387 |
1534 |
2.3e-57 |
PFAM |
|
low complexity region
|
1639 |
1653 |
N/A |
INTRINSIC |
|
Pfam:Not1
|
1998 |
2357 |
5.7e-157 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211887
AA Change: N84S
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212228
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212323
AA Change: N86S
PolyPhen 2
Score 0.272 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212863
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213006
AA Change: N86S
PolyPhen 2
Score 0.143 (Sensitivity: 0.92; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213046
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933402D24Rik |
A |
G |
1: 63,795,568 (GRCm39) |
|
probably benign |
Het |
| Acadvl |
G |
T |
11: 69,903,334 (GRCm39) |
N340K |
probably damaging |
Het |
| Adgrl4 |
T |
A |
3: 151,213,077 (GRCm39) |
N372K |
probably benign |
Het |
| Adh1 |
G |
A |
3: 137,994,642 (GRCm39) |
G321S |
probably damaging |
Het |
| Ankrd26 |
G |
T |
6: 118,504,718 (GRCm39) |
N730K |
probably benign |
Het |
| Aoc2 |
A |
T |
11: 101,219,646 (GRCm39) |
|
probably null |
Het |
| Arhgef4 |
A |
G |
1: 34,762,355 (GRCm39) |
E537G |
unknown |
Het |
| Ccdc7b |
T |
C |
8: 129,904,716 (GRCm39) |
V118A |
probably benign |
Het |
| Ccdc88b |
T |
A |
19: 6,833,509 (GRCm39) |
R219W |
probably damaging |
Het |
| Ccdc97 |
T |
C |
7: 25,418,348 (GRCm39) |
|
probably null |
Het |
| Cfhr4 |
A |
T |
1: 139,625,922 (GRCm39) |
C792S |
probably damaging |
Het |
| Ciao3 |
A |
T |
17: 25,999,327 (GRCm39) |
Y247F |
probably benign |
Het |
| Comp |
T |
C |
8: 70,829,352 (GRCm39) |
C310R |
probably damaging |
Het |
| Crtc2 |
A |
T |
3: 90,167,518 (GRCm39) |
N281Y |
probably damaging |
Het |
| Cryl1 |
T |
C |
14: 57,550,559 (GRCm39) |
K102E |
probably damaging |
Het |
| Csf2ra |
G |
A |
19: 61,214,491 (GRCm39) |
R225* |
probably null |
Het |
| Dao |
A |
T |
5: 114,150,693 (GRCm39) |
D99V |
probably benign |
Het |
| Dgkd |
A |
G |
1: 87,861,889 (GRCm39) |
T815A |
probably damaging |
Het |
| Dhrs7 |
T |
C |
12: 72,699,892 (GRCm39) |
T247A |
probably benign |
Het |
| Dnah7c |
G |
C |
1: 46,572,328 (GRCm39) |
D934H |
probably damaging |
Het |
| Dnajc15 |
T |
C |
14: 78,081,896 (GRCm39) |
Y82C |
probably benign |
Het |
| Dnajc4 |
T |
C |
19: 6,966,872 (GRCm39) |
Q152R |
probably damaging |
Het |
| Dsc1 |
T |
C |
18: 20,227,615 (GRCm39) |
K541R |
probably damaging |
Het |
| Elp4 |
G |
A |
2: 105,624,952 (GRCm39) |
R196C |
probably damaging |
Het |
| Epha8 |
GC |
G |
4: 136,666,006 (GRCm39) |
|
probably null |
Het |
| Ercc6 |
T |
C |
14: 32,291,864 (GRCm39) |
V1076A |
probably benign |
Het |
| Fgd4 |
T |
C |
16: 16,241,793 (GRCm39) |
Y677C |
probably damaging |
Het |
| Fndc3b |
C |
A |
3: 27,483,114 (GRCm39) |
C1028F |
probably damaging |
Het |
| Folr1 |
T |
A |
7: 101,513,184 (GRCm39) |
D37V |
probably damaging |
Het |
| Gabrr3 |
T |
A |
16: 59,268,277 (GRCm39) |
|
probably null |
Het |
| Garem1 |
C |
A |
18: 21,263,000 (GRCm39) |
V605L |
probably benign |
Het |
| Gbp7 |
A |
T |
3: 142,248,778 (GRCm39) |
D347V |
probably damaging |
Het |
| Gdpd4 |
A |
G |
7: 97,610,840 (GRCm39) |
T87A |
possibly damaging |
Het |
| Gm12258 |
C |
A |
11: 58,750,422 (GRCm39) |
H532Q |
probably damaging |
Het |
| Herc2 |
A |
G |
7: 55,756,141 (GRCm39) |
E727G |
possibly damaging |
Het |
| Hfm1 |
G |
A |
5: 107,065,389 (GRCm39) |
H97Y |
probably benign |
Het |
| Idua |
G |
T |
5: 108,828,902 (GRCm39) |
R335L |
probably damaging |
Het |
| Ifi207 |
A |
G |
1: 173,556,633 (GRCm39) |
S702P |
probably benign |
Het |
| Kif16b |
A |
T |
2: 142,699,346 (GRCm39) |
V78D |
probably damaging |
Het |
| Klra17 |
T |
A |
6: 129,849,232 (GRCm39) |
D114V |
probably damaging |
Het |
| Krt76 |
A |
G |
15: 101,794,180 (GRCm39) |
S481P |
probably damaging |
Het |
| Lhfpl5 |
A |
G |
17: 28,798,950 (GRCm39) |
D153G |
probably damaging |
Het |
| Med21 |
T |
A |
6: 146,550,700 (GRCm39) |
D70E |
possibly damaging |
Het |
| Mroh3 |
A |
T |
1: 136,113,237 (GRCm39) |
M739K |
probably benign |
Het |
| Myo1a |
A |
G |
10: 127,550,307 (GRCm39) |
E549G |
probably damaging |
Het |
| Neu1 |
A |
G |
17: 35,153,359 (GRCm39) |
D294G |
possibly damaging |
Het |
| Nmur2 |
A |
T |
11: 55,931,105 (GRCm39) |
I202K |
probably benign |
Het |
| Nop2 |
T |
A |
6: 125,114,057 (GRCm39) |
D174E |
probably benign |
Het |
| Ogfr |
A |
T |
2: 180,236,216 (GRCm39) |
H267L |
probably damaging |
Het |
| Or10p1 |
G |
T |
10: 129,444,053 (GRCm39) |
A99E |
possibly damaging |
Het |
| Or5m8 |
A |
G |
2: 85,822,271 (GRCm39) |
T37A |
probably damaging |
Het |
| P2ry13 |
T |
A |
3: 59,117,308 (GRCm39) |
I157F |
probably benign |
Het |
| Pank4 |
T |
C |
4: 155,063,989 (GRCm39) |
V660A |
probably damaging |
Het |
| Pax6 |
C |
A |
2: 105,526,847 (GRCm39) |
P251Q |
probably benign |
Het |
| Pcdhb13 |
T |
C |
18: 37,577,868 (GRCm39) |
Y749H |
probably damaging |
Het |
| Pcdhga3 |
C |
A |
18: 37,809,799 (GRCm39) |
Q751K |
probably benign |
Het |
| Pcnt |
C |
T |
10: 76,272,299 (GRCm39) |
E186K |
possibly damaging |
Het |
| Pecam1 |
A |
T |
11: 106,575,072 (GRCm39) |
F613I |
probably benign |
Het |
| Pias2 |
T |
C |
18: 77,240,488 (GRCm39) |
*615Q |
probably null |
Het |
| Plb1 |
A |
T |
5: 32,507,003 (GRCm39) |
M1193L |
probably benign |
Het |
| Pomgnt1 |
T |
C |
4: 116,013,396 (GRCm39) |
L506P |
probably damaging |
Het |
| Qrfp |
T |
C |
2: 31,698,852 (GRCm39) |
T27A |
probably damaging |
Het |
| Relb |
C |
A |
7: 19,361,847 (GRCm39) |
|
probably null |
Het |
| Resf1 |
A |
T |
6: 149,228,392 (GRCm39) |
E479D |
probably damaging |
Het |
| Rgl1 |
G |
T |
1: 152,400,450 (GRCm39) |
C685* |
probably null |
Het |
| Ric8b |
A |
G |
10: 84,753,628 (GRCm39) |
Y8C |
probably benign |
Het |
| Rrp36 |
G |
A |
17: 46,980,893 (GRCm39) |
A161V |
possibly damaging |
Het |
| Samd9l |
G |
A |
6: 3,375,504 (GRCm39) |
Q586* |
probably null |
Het |
| Sbf1 |
C |
T |
15: 89,186,916 (GRCm39) |
D821N |
probably damaging |
Het |
| Septin8 |
G |
C |
11: 53,427,545 (GRCm39) |
A255P |
probably damaging |
Het |
| Skp2 |
T |
C |
15: 9,113,927 (GRCm39) |
T329A |
possibly damaging |
Het |
| Slc15a2 |
C |
T |
16: 36,592,498 (GRCm39) |
V220M |
probably damaging |
Het |
| Slc25a11 |
T |
A |
11: 70,536,782 (GRCm39) |
T63S |
possibly damaging |
Het |
| Sowahc |
T |
C |
10: 59,058,983 (GRCm39) |
I373T |
probably benign |
Het |
| Sptbn2 |
T |
A |
19: 4,798,182 (GRCm39) |
M1969K |
probably benign |
Het |
| St14 |
G |
A |
9: 31,015,053 (GRCm39) |
T315M |
possibly damaging |
Het |
| Tagap |
G |
A |
17: 8,151,030 (GRCm39) |
R284H |
probably benign |
Het |
| Tdpoz3 |
T |
A |
3: 93,733,476 (GRCm39) |
S50R |
possibly damaging |
Het |
| Thoc5 |
A |
G |
11: 4,854,187 (GRCm39) |
D182G |
probably damaging |
Het |
| Tinag |
A |
G |
9: 76,904,238 (GRCm39) |
V395A |
probably benign |
Het |
| Tmc8 |
A |
G |
11: 117,683,550 (GRCm39) |
S702G |
probably benign |
Het |
| Tmem202 |
A |
G |
9: 59,426,477 (GRCm39) |
S230P |
possibly damaging |
Het |
| Tmem203 |
T |
C |
2: 25,145,764 (GRCm39) |
V28A |
probably benign |
Het |
| Traf3ip1 |
A |
T |
1: 91,455,479 (GRCm39) |
S647C |
probably damaging |
Het |
| Tram1 |
A |
T |
1: 13,659,870 (GRCm39) |
I26N |
probably damaging |
Het |
| Ttc6 |
A |
T |
12: 57,721,478 (GRCm39) |
D989V |
possibly damaging |
Het |
| Ttll6 |
A |
G |
11: 96,036,372 (GRCm39) |
T334A |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,750,086 (GRCm39) |
D3654E |
probably damaging |
Het |
| Ufd1 |
T |
G |
16: 18,639,832 (GRCm39) |
V112G |
probably damaging |
Het |
| Usp9y |
A |
T |
Y: 1,391,284 (GRCm39) |
Y629N |
possibly damaging |
Het |
| Vmn2r1 |
A |
G |
3: 63,989,267 (GRCm39) |
I69V |
probably benign |
Het |
| Zfp180 |
A |
T |
7: 23,805,246 (GRCm39) |
Y555F |
probably damaging |
Het |
| Zfp438 |
T |
C |
18: 5,214,403 (GRCm39) |
N185S |
probably benign |
Het |
| Zfp445 |
C |
T |
9: 122,686,215 (GRCm39) |
V15I |
possibly damaging |
Het |
| Zfp462 |
A |
G |
4: 55,013,476 (GRCm39) |
E1814G |
probably benign |
Het |
|
| Other mutations in Cnot1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Cnot1
|
APN |
8 |
96,452,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01340:Cnot1
|
APN |
8 |
96,487,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01457:Cnot1
|
APN |
8 |
96,467,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01505:Cnot1
|
APN |
8 |
96,455,346 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02401:Cnot1
|
APN |
8 |
96,482,761 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02693:Cnot1
|
APN |
8 |
96,500,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02696:Cnot1
|
APN |
8 |
96,471,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02754:Cnot1
|
APN |
8 |
96,481,706 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03092:Cnot1
|
APN |
8 |
96,496,243 (GRCm39) |
intron |
probably benign |
|
|
IGL03174:Cnot1
|
APN |
8 |
96,487,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03310:Cnot1
|
APN |
8 |
96,462,308 (GRCm39) |
splice site |
probably benign |
|
|
IGL03371:Cnot1
|
APN |
8 |
96,501,344 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Affiliate
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Barge
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
|
Byproduct
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
Chairman
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
cohort
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Director
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
|
kowloon
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Quorum
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
tugboat
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Xiao
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB001:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB003:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB011:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB013:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0091:Cnot1
|
UTSW |
8 |
96,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0335:Cnot1
|
UTSW |
8 |
96,498,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0409:Cnot1
|
UTSW |
8 |
96,475,483 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0445:Cnot1
|
UTSW |
8 |
96,486,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1505:Cnot1
|
UTSW |
8 |
96,455,295 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1517:Cnot1
|
UTSW |
8 |
96,469,841 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1640:Cnot1
|
UTSW |
8 |
96,496,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1737:Cnot1
|
UTSW |
8 |
96,474,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1755:Cnot1
|
UTSW |
8 |
96,451,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1901:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1902:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1903:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1988:Cnot1
|
UTSW |
8 |
96,468,572 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2051:Cnot1
|
UTSW |
8 |
96,451,221 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2054:Cnot1
|
UTSW |
8 |
96,466,469 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R2072:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2074:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2075:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2093:Cnot1
|
UTSW |
8 |
96,501,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2116:Cnot1
|
UTSW |
8 |
96,452,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2191:Cnot1
|
UTSW |
8 |
96,488,054 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2238:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2239:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2251:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2252:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2253:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2315:Cnot1
|
UTSW |
8 |
96,475,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2431:Cnot1
|
UTSW |
8 |
96,501,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2988:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2989:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3108:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3109:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3114:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3115:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3153:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3154:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4112:Cnot1
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Cnot1
|
UTSW |
8 |
96,466,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4382:Cnot1
|
UTSW |
8 |
96,496,407 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4910:Cnot1
|
UTSW |
8 |
96,459,859 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4913:Cnot1
|
UTSW |
8 |
96,489,695 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4971:Cnot1
|
UTSW |
8 |
96,448,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5056:Cnot1
|
UTSW |
8 |
96,467,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5092:Cnot1
|
UTSW |
8 |
96,479,396 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5101:Cnot1
|
UTSW |
8 |
96,486,815 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5498:Cnot1
|
UTSW |
8 |
96,483,983 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5719:Cnot1
|
UTSW |
8 |
96,470,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5850:Cnot1
|
UTSW |
8 |
96,460,775 (GRCm39) |
nonsense |
probably null |
|
|
R5956:Cnot1
|
UTSW |
8 |
96,481,606 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5981:Cnot1
|
UTSW |
8 |
96,515,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6093:Cnot1
|
UTSW |
8 |
96,475,522 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6108:Cnot1
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6261:Cnot1
|
UTSW |
8 |
96,468,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6632:Cnot1
|
UTSW |
8 |
96,499,895 (GRCm39) |
intron |
probably benign |
|
|
R6882:Cnot1
|
UTSW |
8 |
96,447,054 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6966:Cnot1
|
UTSW |
8 |
96,451,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6985:Cnot1
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7210:Cnot1
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7410:Cnot1
|
UTSW |
8 |
96,459,787 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7623:Cnot1
|
UTSW |
8 |
96,454,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7624:Cnot1
|
UTSW |
8 |
96,478,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7695:Cnot1
|
UTSW |
8 |
96,497,260 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7703:Cnot1
|
UTSW |
8 |
96,486,726 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7771:Cnot1
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7800:Cnot1
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7809:Cnot1
|
UTSW |
8 |
96,478,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7857:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7914:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7924:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7926:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7981:Cnot1
|
UTSW |
8 |
96,489,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8004:Cnot1
|
UTSW |
8 |
96,479,380 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8061:Cnot1
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8185:Cnot1
|
UTSW |
8 |
96,487,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8269:Cnot1
|
UTSW |
8 |
96,478,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8306:Cnot1
|
UTSW |
8 |
96,473,649 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8322:Cnot1
|
UTSW |
8 |
96,496,472 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8427:Cnot1
|
UTSW |
8 |
96,460,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8723:Cnot1
|
UTSW |
8 |
96,462,907 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8934:Cnot1
|
UTSW |
8 |
96,491,695 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9025:Cnot1
|
UTSW |
8 |
96,475,660 (GRCm39) |
missense |
probably benign |
|
|
R9179:Cnot1
|
UTSW |
8 |
96,500,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9280:Cnot1
|
UTSW |
8 |
96,497,227 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9285:Cnot1
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9299:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9337:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9480:Cnot1
|
UTSW |
8 |
96,497,338 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9548:Cnot1
|
UTSW |
8 |
96,482,854 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9601:Cnot1
|
UTSW |
8 |
96,482,835 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9629:Cnot1
|
UTSW |
8 |
96,455,874 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9752:Cnot1
|
UTSW |
8 |
96,488,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9764:Cnot1
|
UTSW |
8 |
96,496,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9789:Cnot1
|
UTSW |
8 |
96,455,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Cnot1
|
UTSW |
8 |
96,469,726 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Cnot1
|
UTSW |
8 |
96,474,905 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTACATATCTACAACAGCCCGG -3'
(R):5'- CTGAACGGAATCTCTTTGGCTTG -3'
Sequencing Primer
(F):5'- TATCTACAACAGCCCGGCACTG -3'
(R):5'- GGTGTTGCTGATAGGTTTTATATACC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation