Incidental Mutation 'R4752:Or5l14'
ID 357657
Institutional Source Beutler Lab
Gene Symbol Or5l14
Ensembl Gene ENSMUSG00000075143
Gene Name olfactory receptor family 5 subfamily L member 14
Synonyms MOR174-1, GA_x6K02T2Q125-49446395-49445457, Olfr1157
MMRRC Submission 042032-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # R4752 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87792296-87798601 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87792693 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 181 (L181P)
Ref Sequence ENSEMBL: ENSMUSP00000097429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099841]
AlphaFold A2AVC4
Predicted Effect probably damaging
Transcript: ENSMUST00000099841
AA Change: L181P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097429
Gene: ENSMUSG00000075143
AA Change: L181P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.7e-48 PFAM
Pfam:7tm_1 41 290 2.6e-20 PFAM
Meta Mutation Damage Score 0.3216 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 99% (68/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C A 3: 137,775,751 (GRCm39) Q1647K possibly damaging Het
Abcf3 A G 16: 20,369,326 (GRCm39) E236G probably damaging Het
Adamts17 A G 7: 66,654,218 (GRCm39) T483A probably damaging Het
Ankrd26 G T 6: 118,517,426 (GRCm39) P465Q probably null Het
Babam2 C T 5: 31,859,391 (GRCm39) probably benign Het
Bpifb1 T A 2: 154,058,200 (GRCm39) probably benign Het
Ccnb1ip1 T A 14: 51,031,122 (GRCm39) T64S possibly damaging Het
Cdhr3 A G 12: 33,136,102 (GRCm39) V46A probably damaging Het
Cep170 A T 1: 176,584,254 (GRCm39) D708E probably benign Het
Cpsf6 A T 10: 117,197,273 (GRCm39) probably benign Het
Cryzl2 C T 1: 157,286,219 (GRCm39) probably null Het
Dgka A T 10: 128,572,528 (GRCm39) F42I probably benign Het
Dip2a A T 10: 76,112,491 (GRCm39) V1059E probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dock4 T A 12: 40,496,364 (GRCm39) I3K probably benign Het
Dsc2 A T 18: 20,171,279 (GRCm39) N573K probably damaging Het
Eif2b4 G A 5: 31,348,575 (GRCm39) R213* probably null Het
Eif3b A G 5: 140,426,856 (GRCm39) D704G probably benign Het
Epn2 T C 11: 61,437,197 (GRCm39) E125G probably damaging Het
F830016B08Rik A G 18: 60,434,153 (GRCm39) N412S probably benign Het
Fbln2 A G 6: 91,233,225 (GRCm39) M570V probably benign Het
Gm16686 A T 4: 88,673,725 (GRCm39) probably benign Het
Hook2 C T 8: 85,729,349 (GRCm39) Q632* probably null Het
Ipcef1 A T 10: 6,929,573 (GRCm39) W56R probably damaging Het
Krt78 T C 15: 101,856,637 (GRCm39) I418M probably benign Het
Limk1 G A 5: 134,699,295 (GRCm39) T154I probably damaging Het
Lyl1 A T 8: 85,430,910 (GRCm39) T271S probably benign Het
Megf6 A G 4: 154,336,895 (GRCm39) I333V probably damaging Het
Meioc A G 11: 102,565,259 (GRCm39) T236A probably benign Het
Nbas A G 12: 13,532,538 (GRCm39) T1749A possibly damaging Het
Nfib T A 4: 82,215,016 (GRCm39) Q529L probably damaging Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Nisch A T 14: 30,914,545 (GRCm39) F42L probably damaging Het
Nomo1 T A 7: 45,706,626 (GRCm39) Y547N probably damaging Het
Or10g3 C T 14: 52,609,764 (GRCm39) V249I probably damaging Het
Or13a24 T C 7: 140,154,515 (GRCm39) S150P possibly damaging Het
Or8g51 T C 9: 38,609,266 (GRCm39) Y136C probably damaging Het
Pcdh18 T A 3: 49,709,563 (GRCm39) N117I probably damaging Het
Prkn T C 17: 12,223,010 (GRCm39) S387P probably benign Het
Prl3c1 A T 13: 27,387,508 (GRCm39) K164N probably benign Het
Prr23a3 T A 9: 98,747,700 (GRCm39) L218Q probably damaging Het
Prss43 A G 9: 110,656,836 (GRCm39) H114R possibly damaging Het
Ptcd3 A T 6: 71,878,296 (GRCm39) M142K probably damaging Het
Shisa7 G A 7: 4,837,249 (GRCm39) T89I possibly damaging Het
Slco1a1 C T 6: 141,892,340 (GRCm39) A9T possibly damaging Het
Srcap C T 7: 127,158,172 (GRCm39) probably benign Het
Tdg-ps G A 15: 82,400,572 (GRCm39) noncoding transcript Het
Tgm4 A G 9: 122,880,451 (GRCm39) D284G probably damaging Het
Tmc1 T A 19: 20,804,013 (GRCm39) I355F probably benign Het
Tmem121b A T 6: 120,469,995 (GRCm39) F241I possibly damaging Het
Tmem200c T A 17: 69,149,235 (GRCm39) V606E probably benign Het
Ttc39c A G 18: 12,861,782 (GRCm39) K370R probably benign Het
Vmn2r87 G A 10: 130,314,336 (GRCm39) Q417* probably null Het
Vps45 T C 3: 95,955,699 (GRCm39) Y97C possibly damaging Het
Zfp407 A G 18: 84,581,039 (GRCm39) S25P probably benign Het
Zfp566 A G 7: 29,777,306 (GRCm39) S292P probably damaging Het
Other mutations in Or5l14
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4453001:Or5l14 UTSW 2 87,792,802 (GRCm39) missense possibly damaging 0.90
R1502:Or5l14 UTSW 2 87,792,379 (GRCm39) missense probably damaging 1.00
R2127:Or5l14 UTSW 2 87,793,176 (GRCm39) missense probably benign 0.01
R2284:Or5l14 UTSW 2 87,793,137 (GRCm39) missense probably damaging 0.99
R2443:Or5l14 UTSW 2 87,793,209 (GRCm39) missense possibly damaging 0.47
R4021:Or5l14 UTSW 2 87,793,066 (GRCm39) missense possibly damaging 0.77
R4693:Or5l14 UTSW 2 87,793,053 (GRCm39) missense probably benign 0.39
R4879:Or5l14 UTSW 2 87,793,040 (GRCm39) missense possibly damaging 0.91
R4983:Or5l14 UTSW 2 87,793,042 (GRCm39) missense probably benign 0.26
R5592:Or5l14 UTSW 2 87,792,684 (GRCm39) missense probably damaging 1.00
R5945:Or5l14 UTSW 2 87,792,946 (GRCm39) missense probably damaging 1.00
R6412:Or5l14 UTSW 2 87,792,693 (GRCm39) missense probably damaging 1.00
R7470:Or5l14 UTSW 2 87,792,793 (GRCm39) missense possibly damaging 0.74
R9585:Or5l14 UTSW 2 87,792,919 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- AGGTGGAAAATGCTTTGCGC -3'
(R):5'- GTGGTCACTGAAGTCTTCCTAC -3'

Sequencing Primer
(F):5'- GAAAATGCTTTGCGCCTCCC -3'
(R):5'- ATGACCGTTTTGTAGCCATCTGTAAC -3'
Posted On 2015-11-11