Incidental Mutation 'R4753:Or1ad1'
ID 357743
Institutional Source Beutler Lab
Gene Symbol Or1ad1
Ensembl Gene ENSMUSG00000061952
Gene Name olfactory receptor family 1 subfamily AD member 1
Synonyms Olfr1377, MOR129-1, GA_x6K02T2QP88-4453480-4452557
MMRRC Submission 041971-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.094) question?
Stock # R4753 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 50875530-50876453 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50875978 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 150 (V150A)
Ref Sequence ENSEMBL: ENSMUSP00000151087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075177] [ENSMUST00000213291] [ENSMUST00000216101]
AlphaFold Q8VGH1
Predicted Effect probably benign
Transcript: ENSMUST00000075177
AA Change: V150A

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000074672
Gene: ENSMUSG00000061952
AA Change: V150A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2e-51 PFAM
Pfam:7tm_1 41 289 1.4e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204581
AA Change: V150A
SMART Domains Protein: ENSMUSP00000144855
Gene: ENSMUSG00000061952
AA Change: V150A

DomainStartEndE-ValueType
Pfam:7tm_4 31 237 5.9e-36 PFAM
Pfam:7TM_GPCR_Srsx 35 227 1.9e-4 PFAM
Pfam:7tm_1 41 235 1.3e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213291
AA Change: V150A

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000216101
AA Change: V150A

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd55 T A 13: 112,500,009 (GRCm39) D257E probably benign Het
Arhgef18 T C 8: 3,494,938 (GRCm39) V399A probably damaging Het
Atp8b5 C T 4: 43,372,710 (GRCm39) P1117S probably damaging Het
Cd48 A G 1: 171,527,156 (GRCm39) Q194R probably damaging Het
Cdk13 G A 13: 17,937,833 (GRCm39) R737C probably damaging Het
Clasrp A T 7: 19,328,865 (GRCm39) I89N probably damaging Het
Clrn1 G T 3: 58,792,318 (GRCm39) N48K probably damaging Het
Cntrl T A 2: 35,043,451 (GRCm39) V1313E possibly damaging Het
Cyld T A 8: 89,471,444 (GRCm39) probably null Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dtl T C 1: 191,301,815 (GRCm39) T81A probably damaging Het
Dus1l C T 11: 120,682,901 (GRCm39) E299K probably benign Het
E130114P18Rik A T 4: 97,463,129 (GRCm39) D14E possibly damaging Het
Fam83g C A 11: 61,586,095 (GRCm39) H228N probably damaging Het
Fhod3 A T 18: 25,223,382 (GRCm39) K909N possibly damaging Het
Fign T A 2: 63,809,363 (GRCm39) I636L probably benign Het
Foxm1 A G 6: 128,349,519 (GRCm39) E346G probably null Het
Gcc2 T C 10: 58,126,204 (GRCm39) Y1271H probably benign Het
Gcn1 T C 5: 115,754,537 (GRCm39) V2379A probably benign Het
Grin2d G T 7: 45,483,330 (GRCm39) P949Q probably damaging Het
Ighv1-43 C A 12: 114,909,762 (GRCm39) M53I probably benign Het
Itgad A G 7: 127,822,875 (GRCm39) *97W probably null Het
Jade1 C T 3: 41,551,106 (GRCm39) R2* probably null Het
Lama3 G T 18: 12,615,141 (GRCm39) C1355F probably damaging Het
Map3k13 T C 16: 21,710,752 (GRCm39) S12P probably benign Het
Masp2 A G 4: 148,696,608 (GRCm39) T402A probably benign Het
Mill1 A C 7: 17,996,472 (GRCm39) K96T probably benign Het
Muc19 T G 15: 91,761,955 (GRCm39) noncoding transcript Het
Muc5b C A 7: 141,410,590 (GRCm39) T1321N unknown Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Or1e35 T A 11: 73,797,677 (GRCm39) I214F probably damaging Het
Pdgfra C T 5: 75,342,185 (GRCm39) P669S probably damaging Het
Procr A G 2: 155,595,384 (GRCm39) N63D probably damaging Het
Prrc2c A G 1: 162,518,799 (GRCm39) S2136P probably damaging Het
Rab11fip1 T C 8: 27,642,769 (GRCm39) M677V probably benign Het
Rad52 T A 6: 119,889,946 (GRCm39) probably benign Het
Rasa1 A G 13: 85,436,509 (GRCm39) probably null Het
Rogdi T C 16: 4,828,363 (GRCm39) T189A probably damaging Het
Rph3al G A 11: 75,799,845 (GRCm39) T38M probably damaging Het
Rps6ka2 T A 17: 7,566,707 (GRCm39) V655E possibly damaging Het
Sik3 T C 9: 46,109,512 (GRCm39) F499L probably damaging Het
Skint4 A G 4: 112,003,728 (GRCm39) N387S probably benign Het
Slc6a12 C T 6: 121,333,862 (GRCm39) probably benign Het
Stk36 A G 1: 74,665,255 (GRCm39) T667A probably benign Het
Svep1 T C 4: 58,053,212 (GRCm39) I3378V probably benign Het
Thnsl1 C T 2: 21,218,175 (GRCm39) T122I probably damaging Het
Timeless G A 10: 128,075,889 (GRCm39) probably benign Het
Tnxb G A 17: 34,914,909 (GRCm39) V1966I possibly damaging Het
Tril A G 6: 53,796,698 (GRCm39) F175L probably damaging Het
Vav1 A G 17: 57,613,140 (GRCm39) Y604C probably damaging Het
Zfp423 T A 8: 88,508,074 (GRCm39) M736L probably benign Het
Zscan10 A C 17: 23,826,208 (GRCm39) E123D probably damaging Het
Other mutations in Or1ad1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Or1ad1 APN 11 50,875,830 (GRCm39) missense possibly damaging 0.94
R1386:Or1ad1 UTSW 11 50,876,194 (GRCm39) missense probably damaging 0.97
R1486:Or1ad1 UTSW 11 50,875,608 (GRCm39) missense probably benign 0.00
R1613:Or1ad1 UTSW 11 50,876,045 (GRCm39) missense probably damaging 1.00
R2224:Or1ad1 UTSW 11 50,876,059 (GRCm39) missense probably damaging 1.00
R2411:Or1ad1 UTSW 11 50,875,758 (GRCm39) missense probably damaging 0.98
R3014:Or1ad1 UTSW 11 50,875,534 (GRCm39) missense probably benign 0.00
R4080:Or1ad1 UTSW 11 50,875,683 (GRCm39) missense probably damaging 1.00
R4764:Or1ad1 UTSW 11 50,875,602 (GRCm39) missense probably benign 0.00
R4822:Or1ad1 UTSW 11 50,875,910 (GRCm39) nonsense probably null
R4865:Or1ad1 UTSW 11 50,876,370 (GRCm39) missense probably damaging 0.99
R5053:Or1ad1 UTSW 11 50,876,137 (GRCm39) missense probably damaging 1.00
R6054:Or1ad1 UTSW 11 50,875,631 (GRCm39) missense probably benign 0.00
R6368:Or1ad1 UTSW 11 50,875,613 (GRCm39) missense probably benign 0.00
R7589:Or1ad1 UTSW 11 50,875,857 (GRCm39) missense probably damaging 0.98
R7843:Or1ad1 UTSW 11 50,875,845 (GRCm39) missense probably benign 0.06
R8056:Or1ad1 UTSW 11 50,876,368 (GRCm39) missense probably damaging 0.98
R9189:Or1ad1 UTSW 11 50,876,166 (GRCm39) missense probably damaging 1.00
R9486:Or1ad1 UTSW 11 50,875,691 (GRCm39) missense possibly damaging 0.94
Predicted Primers
Posted On 2015-11-11