Mutagenetix > Incidental Mutation

Incidental Mutation 'R4755:Lrp1b'

357873

Institutional Source

Beutler Lab

Gene Symbol

Lrp1b

Ensembl Gene

ENSMUSG00000049252

Gene Name

low density lipoprotein-related protein 1B

Synonyms

9630004P12Rik

MMRRC Submission

042033-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4755 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

40485258-42543636 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 41361028 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 592 (T592S)

Ref Sequence

ENSEMBL: ENSMUSP00000129192 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052550] [ENSMUST00000167270] [ENSMUST00000203080]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000052550
AA Change: T706S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000054275
Gene: ENSMUSG00000049252
AA Change: T706S

Domain	Start	End	E-Value	Type
low complexity region	3	19	N/A	INTRINSIC
low complexity region	35	46	N/A	INTRINSIC
LDLa	62	102	2.97e-12	SMART
LDLa	107	146	1.31e-8	SMART
EGF	150	185	1.95e1	SMART
EGF_CA	186	225	8.37e-8	SMART
LY	256	300	4.06e1	SMART
LY	304	348	1.15e-5	SMART
LY	349	392	1.17e-11	SMART
LY	393	435	1.12e-8	SMART
LY	436	478	2.21e1	SMART
EGF	505	548	2.45e0	SMART
LY	579	621	1.32e-5	SMART
LY	622	665	1.88e-10	SMART
LY	668	717	1.47e-12	SMART
LY	718	760	5.78e-11	SMART
LY	761	802	1.45e0	SMART
EGF_like	828	865	4.55e1	SMART
LDLa	875	914	7.15e-15	SMART
LDLa	916	955	5.26e-13	SMART
LDLa	957	995	6.13e-14	SMART
LDLa	997	1035	6.47e-13	SMART
LDLa	1036	1075	1.76e-14	SMART
LDLa	1083	1121	2.29e-13	SMART
LDLa	1125	1164	3.36e-11	SMART
LDLa	1166	1206	2.57e-7	SMART
EGF	1206	1244	1.58e-3	SMART
EGF	1248	1284	4.56e0	SMART
LY	1311	1353	4.85e-4	SMART
LY	1358	1400	6.49e-14	SMART
LY	1401	1445	8.18e-11	SMART
LY	1446	1490	4.25e-9	SMART
LY	1492	1534	5.4e-2	SMART
EGF	1561	1601	9.41e-2	SMART
LY	1629	1671	3.03e-5	SMART
LY	1672	1716	1.22e-9	SMART
LY	1718	1756	1.02e-2	SMART
LY	1757	1798	8.25e-7	SMART
EGF	1868	1906	4.03e-1	SMART
LY	1933	1975	1.01e-1	SMART
LY	1976	2018	3.03e-14	SMART
LY	2019	2062	2.16e-10	SMART
LY	2063	2105	4.09e-11	SMART
LY	2107	2149	9.96e0	SMART
EGF	2177	2214	2.13e0	SMART
LY	2292	2334	6.96e-5	SMART
LY	2340	2385	1.07e-5	SMART
LY	2386	2428	1.1e-11	SMART
LY	2429	2470	4.78e-3	SMART
EGF	2498	2535	2.03e1	SMART
LDLa	2540	2580	1.1e-6	SMART
LDLa	2582	2619	1.72e-8	SMART
LDLa	2621	2658	2.45e-13	SMART
LDLa	2669	2707	6.53e-9	SMART
LDLa	2712	2749	7.97e-13	SMART
LDLa	2750	2789	1.22e-8	SMART
LDLa	2791	2832	3.07e-14	SMART
LDLa	2835	2873	7.32e-12	SMART
LDLa	2875	2917	1.85e-8	SMART
LDLa	2921	2958	4.76e-11	SMART
EGF_CA	2957	2998	1.79e-7	SMART
EGF_CA	2999	3039	1.85e-9	SMART
LY	3066	3111	2.58e-8	SMART
LY	3112	3152	1.22e-9	SMART
LY	3153	3196	8.84e-7	SMART
LY	3197	3237	3.22e-9	SMART
LY	3238	3279	1.04e-3	SMART
EGF	3307	3345	7.13e-2	SMART
LDLa	3347	3385	9.29e-14	SMART
LDLa	3387	3424	2.25e-12	SMART
LDLa	3426	3464	5.63e-13	SMART
LDLa	3466	3504	1.07e-13	SMART
LDLa	3506	3543	1.35e-15	SMART
EGF_like	3545	3581	2.8e1	SMART
LDLa	3545	3582	1.49e-12	SMART
LDLa	3583	3620	4.21e-12	SMART
LDLa	3624	3661	4.9e-13	SMART
LDLa	3662	3700	9.58e-16	SMART
LDLa	3704	3743	5.38e-10	SMART
LDLa	3745	3784	1.42e-9	SMART
LDLa	3792	3829	3.66e-12	SMART
EGF	3835	3874	3.71e0	SMART
EGF_CA	3875	3912	6.8e-8	SMART
LY	3987	4033	4.24e0	SMART
LY	4050	4093	4.46e-3	SMART
LY	4094	4136	1.73e-9	SMART
EGF	4206	4239	2.45e0	SMART
EGF	4247	4280	2.48e-1	SMART
EGF	4283	4316	1.49e-4	SMART
EGF	4319	4352	1.69e-3	SMART
EGF	4355	4388	1.18e1	SMART
EGF_like	4391	4423	6.67e1	SMART
EGF	4424	4458	1.61e0	SMART
transmembrane domain	4476	4498	N/A	INTRINSIC
low complexity region	4499	4509	N/A	INTRINSIC
low complexity region	4512	4523	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000167270
AA Change: T592S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129192
Gene: ENSMUSG00000049252
AA Change: T592S

Domain	Start	End	E-Value	Type
EGF	5	40	1.95e1	SMART
EGF_CA	41	80	8.37e-8	SMART
LY	111	155	4.06e1	SMART
LY	159	203	1.15e-5	SMART
LY	204	247	1.17e-11	SMART
LY	248	290	1.12e-8	SMART
LY	291	333	2.21e1	SMART
EGF	360	403	2.45e0	SMART
LY	434	476	1.32e-5	SMART
LY	477	520	1.88e-10	SMART
LY	523	572	1.47e-12	SMART
LY	573	615	5.78e-11	SMART
LY	616	657	1.45e0	SMART
EGF_like	683	720	4.55e1	SMART
LDLa	730	769	7.15e-15	SMART
LDLa	771	810	5.26e-13	SMART
LDLa	812	850	6.13e-14	SMART
LDLa	852	890	6.47e-13	SMART
LDLa	891	930	1.76e-14	SMART
LDLa	938	976	2.29e-13	SMART
LDLa	980	1019	3.36e-11	SMART
LDLa	1021	1061	2.57e-7	SMART
EGF	1061	1099	1.58e-3	SMART
EGF	1103	1139	4.56e0	SMART
LY	1166	1208	4.85e-4	SMART
LY	1213	1255	6.49e-14	SMART
LY	1256	1300	8.18e-11	SMART
LY	1301	1345	4.25e-9	SMART
LY	1347	1389	5.4e-2	SMART
EGF	1416	1456	9.41e-2	SMART
LY	1484	1526	3.03e-5	SMART
LY	1527	1571	1.22e-9	SMART
LY	1573	1611	1.02e-2	SMART
LY	1612	1653	8.25e-7	SMART
EGF	1723	1761	4.03e-1	SMART
LY	1788	1830	1.01e-1	SMART
LY	1831	1873	3.03e-14	SMART
LY	1874	1917	2.16e-10	SMART
LY	1918	1960	4.09e-11	SMART
LY	1962	2004	9.96e0	SMART
EGF	2032	2069	2.13e0	SMART
LY	2147	2189	6.96e-5	SMART
LY	2195	2240	1.07e-5	SMART
LY	2241	2283	1.1e-11	SMART
LY	2284	2325	4.78e-3	SMART
EGF	2353	2390	2.03e1	SMART
LDLa	2395	2435	1.1e-6	SMART
LDLa	2437	2474	1.72e-8	SMART
LDLa	2476	2513	2.45e-13	SMART
LDLa	2524	2562	6.53e-9	SMART
LDLa	2567	2604	7.97e-13	SMART
LDLa	2605	2644	1.22e-8	SMART
LDLa	2646	2687	3.07e-14	SMART
LDLa	2690	2728	7.32e-12	SMART
LDLa	2730	2772	1.85e-8	SMART
LDLa	2776	2813	4.76e-11	SMART
EGF_CA	2812	2853	1.79e-7	SMART
EGF_CA	2854	2894	1.85e-9	SMART
LY	2921	2966	2.58e-8	SMART
LY	2967	3007	1.22e-9	SMART
LY	3008	3051	8.84e-7	SMART
LY	3052	3092	3.22e-9	SMART
LY	3093	3134	1.04e-3	SMART
EGF	3162	3200	7.13e-2	SMART
LDLa	3202	3240	9.29e-14	SMART
LDLa	3242	3279	2.25e-12	SMART
LDLa	3281	3319	5.63e-13	SMART
LDLa	3321	3357	5.86e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000203080

SMART Domains

Protein: ENSMUSP00000145278
Gene: ENSMUSG00000049252

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
LDLa	31	70	1.4e-13	SMART
LDLa	71	109	3e-16	SMART
LDLa	111	149	3.3e-15	SMART
LDLa	150	189	8.4e-17	SMART
LDLa	197	235	1.1e-15	SMART
LDLa	239	278	1.6e-13	SMART
LDLa	280	320	1.2e-9	SMART
EGF	320	358	7.8e-6	SMART
EGF	362	398	2.3e-2	SMART
LY	425	467	2.4e-6	SMART
LY	472	514	3.3e-16	SMART
LY	515	559	4.1e-13	SMART
LY	560	604	2.1e-11	SMART
LY	606	648	2.7e-4	SMART
EGF	675	715	4.6e-4	SMART
LY	743	782	8.1e-3	SMART

Meta Mutation Damage Score

0.1390

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.3%
20x: 95.3%

Validation Efficiency

96% (112/117)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
PHENOTYPE: Homozygous null mice appear normal, are fertile, have normal brain histology and function, normal plasma cholesterol and fasting triglycerides, and do not develop tumors. [provided by MGI curators]

Allele List at MGI

All alleles(9) : Targeted, knock-out(3) Targeted, other(2) Gene trapped(4)

Other mutations in this stock

Total: 112 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930449A18Rik	T	A	3: 59,733,280 (GRCm39)		noncoding transcript	Het
Aadacl2fm1	C	T	3: 59,843,735 (GRCm39)	A143V	probably benign	Het
Accs	T	C	2: 93,671,682 (GRCm39)	E236G	probably damaging	Het
Agrn	C	T	4: 156,257,979 (GRCm39)		probably benign	Het
Ahi1	A	G	10: 20,930,946 (GRCm39)	I929V	possibly damaging	Het
Akap5	C	A	12: 76,374,581 (GRCm39)	C4*	probably null	Het
Amotl2	A	T	9: 102,597,679 (GRCm39)	H146L	probably damaging	Het
Ank1	A	G	8: 23,594,990 (GRCm39)	N666S	probably damaging	Het
Atp10d	A	T	5: 72,403,509 (GRCm39)	T373S	probably benign	Het
Bpifb9b	T	A	2: 154,161,614 (GRCm39)	M582K	probably benign	Het
Brca2	T	A	5: 150,483,452 (GRCm39)		probably null	Het
Ccdc149	A	G	5: 52,561,493 (GRCm39)	V229A	probably damaging	Het
Cd109	CATTTATTTATTTATTTATTTATTTATTTATTTAT	CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT	9: 78,619,782 (GRCm39)		probably benign	Het
Cdk5rap2	A	G	4: 70,156,662 (GRCm39)	S1617P	probably damaging	Het
Cenpk	A	T	13: 104,367,379 (GRCm39)	M37L	probably benign	Het
Cenpk	A	T	13: 104,386,020 (GRCm39)	H305L	probably benign	Het
Ces5a	C	A	8: 94,262,305 (GRCm39)	A11S	probably benign	Het
Cfap65	T	C	1: 74,967,520 (GRCm39)	E186G	probably damaging	Het
Cfh	T	A	1: 140,016,546 (GRCm39)	I593F	probably damaging	Het
Clstn2	C	T	9: 97,327,726 (GRCm39)	V961I	probably benign	Het
Cog5	T	A	12: 31,919,405 (GRCm39)		probably null	Het
Col4a4	T	C	1: 82,518,895 (GRCm39)	D100G	unknown	Het
Cyp3a41a	T	C	5: 145,652,316 (GRCm39)	D61G	probably damaging	Het
Dnah10	A	G	5: 124,824,809 (GRCm39)	N655S	probably benign	Het
Dnai1	C	G	4: 41,610,269 (GRCm39)	T295R	probably damaging	Het
Dnajc6	C	T	4: 101,407,996 (GRCm39)	A44V	probably damaging	Het
Eif4enif1	A	T	11: 3,194,016 (GRCm39)	D960V	probably damaging	Het
Fam167b	C	T	4: 129,472,135 (GRCm39)	G12R	probably damaging	Het
Fam20b	A	T	1: 156,515,066 (GRCm39)	Y266*	probably null	Het
Fer1l6	T	A	15: 58,512,060 (GRCm39)	V1509D	probably benign	Het
Fhad1	A	T	4: 141,655,794 (GRCm39)	I105N	probably damaging	Het
Fmo2	T	C	1: 162,716,374 (GRCm39)	D71G	probably damaging	Het
Folr2	T	C	7: 101,493,006 (GRCm39)	T6A	possibly damaging	Het
Fry	A	C	5: 150,321,719 (GRCm39)	E1018A	probably damaging	Het
Gas2l2	A	G	11: 83,320,193 (GRCm39)	I21T	probably damaging	Het
Gfra1	T	C	19: 58,441,676 (GRCm39)	Y85C	probably damaging	Het
Gpld1	A	T	13: 25,163,671 (GRCm39)	Y43F	probably benign	Het
Gpld1	T	A	13: 25,163,675 (GRCm39)	Y44*	probably null	Het
Grid2	A	G	6: 63,885,972 (GRCm39)	T123A	probably benign	Het
Grina	T	C	15: 76,133,442 (GRCm39)	L305P	probably damaging	Het
Gucy1a1	G	A	3: 82,002,102 (GRCm39)	A659V	probably benign	Het
H2-T10	T	A	17: 36,429,837 (GRCm39)	K319*	probably null	Het
Hey2	A	T	10: 30,710,300 (GRCm39)	V151E	probably benign	Het
Ighv1-69	G	A	12: 115,587,178 (GRCm39)	T13I	probably benign	Het
Il1rap	C	A	16: 26,541,532 (GRCm39)	A591E	probably benign	Het
Ildr1	T	C	16: 36,542,383 (GRCm39)	L261P	probably benign	Het
Jak1	A	G	4: 101,031,354 (GRCm39)	Y463H	probably damaging	Het
Lrrc36	A	G	8: 106,178,776 (GRCm39)	T445A	possibly damaging	Het
Ly9	G	A	1: 171,434,806 (GRCm39)	S29F	probably damaging	Het
Mapk7	A	C	11: 61,381,669 (GRCm39)	C32W	probably damaging	Het
Marchf10	C	T	11: 105,255,302 (GRCm39)		probably benign	Het
Mier2	A	T	10: 79,385,031 (GRCm39)	M119K	probably damaging	Het
Mpv17	A	T	5: 31,303,326 (GRCm39)	C59*	probably null	Het
Mrpl27	G	A	11: 94,544,659 (GRCm39)		probably benign	Het
Myo18b	G	A	5: 113,022,340 (GRCm39)	Q351*	probably null	Het
Myo1a	A	G	10: 127,551,557 (GRCm39)	I704M	probably damaging	Het
Nadsyn1	A	G	7: 143,360,650 (GRCm39)	C373R	probably damaging	Het
Nckipsd	C	A	9: 108,691,938 (GRCm39)	A513E	probably benign	Het
Neb	T	C	2: 52,110,221 (GRCm39)	D209G	probably damaging	Het
Nkapl	T	A	13: 21,652,457 (GRCm39)	Q52L	unknown	Het
Nptx2	G	A	5: 144,483,250 (GRCm39)	S126N	probably benign	Het
Or2a7	G	A	6: 43,150,977 (GRCm39)	S19N	probably benign	Het
Or52d3	T	A	7: 104,229,268 (GRCm39)	Y138*	probably null	Het
Or7g17	A	T	9: 18,768,476 (GRCm39)	H185L	probably benign	Het
Or8b52	A	G	9: 38,577,128 (GRCm39)	V4A	probably benign	Het
Pclo	A	T	5: 14,764,362 (GRCm39)	R4278S	unknown	Het
Pcnx1	T	G	12: 81,997,068 (GRCm39)	L988R	probably damaging	Het
Prl2c5	C	A	13: 13,363,970 (GRCm39)	N75K	probably benign	Het
Prpf19	T	G	19: 10,875,154 (GRCm39)		probably benign	Het
Ralgapa1	A	G	12: 55,759,533 (GRCm39)	S997P	probably damaging	Het
Rangap1	T	C	15: 81,597,118 (GRCm39)	T226A	probably benign	Het
Rimklb	G	A	6: 122,433,365 (GRCm39)	L262F	probably damaging	Het
Rnf169	A	G	7: 99,574,930 (GRCm39)	M555T	probably benign	Het
Rp1l1	A	T	14: 64,267,519 (GRCm39)	D1035V	probably benign	Het
Rps23rg1	A	T	8: 3,633,922 (GRCm39)	S8C	probably damaging	Het
Scd2	T	A	19: 44,289,791 (GRCm39)	L262Q	probably damaging	Het
Scgb2b12	T	A	7: 32,024,956 (GRCm39)	M84L	probably benign	Het
Shroom3	G	T	5: 93,090,945 (GRCm39)	V1151F	probably damaging	Het
Sipa1l1	G	A	12: 82,419,160 (GRCm39)	V613I	possibly damaging	Het
Slc25a23	T	A	17: 57,359,794 (GRCm39)	D67V	possibly damaging	Het
Slc25a39	C	T	11: 102,297,492 (GRCm39)		probably benign	Het
Slc4a10	T	A	2: 62,127,332 (GRCm39)	F895Y	probably damaging	Het
Slc5a4a	A	C	10: 76,022,398 (GRCm39)	K578Q	probably benign	Het
Slc6a13	G	A	6: 121,302,008 (GRCm39)	G197S	probably damaging	Het
Smarca2	A	T	19: 26,631,883 (GRCm39)	E566V	possibly damaging	Het
Sorbs3	A	T	14: 70,421,548 (GRCm39)	N594K	probably benign	Het
Spata22	A	T	11: 73,236,582 (GRCm39)	D296V	probably damaging	Het
Sphk2	G	A	7: 45,363,058 (GRCm39)	A11V	possibly damaging	Het
Spp1	A	T	5: 104,583,081 (GRCm39)		probably benign	Het
Strn3	T	A	12: 51,656,999 (GRCm39)	I760L	possibly damaging	Het
Syk	A	T	13: 52,796,022 (GRCm39)	Y539F	probably benign	Het
Tdpoz9-ps1	T	C	3: 93,846,093 (GRCm39)		probably null	Het
Thsd7b	T	A	1: 130,138,001 (GRCm39)	Y1560N	probably benign	Het
Tmod2	C	A	9: 75,504,494 (GRCm39)	E42*	probably null	Het
Tom1l1	T	C	11: 90,575,942 (GRCm39)	E30G	probably damaging	Het
Trav10	G	A	14: 53,743,518 (GRCm39)	A40T	probably benign	Het
Trav14-2	G	A	14: 53,878,237 (GRCm39)		probably benign	Het
Tril	T	A	6: 53,795,449 (GRCm39)	E591V	probably damaging	Het
Trp53bp1	T	A	2: 121,059,087 (GRCm39)	R179*	probably null	Het
Tspoap1	A	T	11: 87,662,489 (GRCm39)	D562V	possibly damaging	Het
Usp44	A	T	10: 93,682,768 (GRCm39)	H406L	probably damaging	Het
Vangl1	A	G	3: 102,065,608 (GRCm39)	I509T	probably benign	Het
Vax2	T	G	6: 83,688,379 (GRCm39)	L34W	probably damaging	Het
Vmn1r55	A	T	7: 5,150,025 (GRCm39)	C133S	probably damaging	Het
Vmn2r8	T	A	5: 108,949,566 (GRCm39)	D427V	probably benign	Het
Vwde	A	G	6: 13,205,851 (GRCm39)	I232T	possibly damaging	Het
Wnk1	C	A	6: 119,940,431 (GRCm39)	A769S	probably damaging	Het
Xpo4	A	C	14: 57,855,638 (GRCm39)	S264A	probably benign	Het
Zfp330	A	T	8: 83,496,015 (GRCm39)	C75*	probably null	Het
Zfp526	T	A	7: 24,925,064 (GRCm39)	L441Q	probably benign	Het
Zfp607b	T	G	7: 27,402,930 (GRCm39)	L462R	probably damaging	Het
Zfp719	T	A	7: 43,240,217 (GRCm39)	F602I	probably damaging	Het

Other mutations in Lrp1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00484:Lrp1b	APN	2	41,000,873 (GRCm39)	missense	probably damaging	1.00
IGL00543:Lrp1b	APN	2	41,358,960 (GRCm39)	missense	possibly damaging	0.69
IGL00578:Lrp1b	APN	2	40,569,185 (GRCm39)	missense	unknown
IGL01020:Lrp1b	APN	2	40,888,259 (GRCm39)	missense	probably damaging	1.00
IGL01092:Lrp1b	APN	2	40,640,959 (GRCm39)	missense	probably damaging	0.97
IGL01155:Lrp1b	APN	2	41,660,947 (GRCm39)	missense	probably benign	0.17
IGL01361:Lrp1b	APN	2	41,000,763 (GRCm39)	splice site	probably benign
IGL01377:Lrp1b	APN	2	40,491,550 (GRCm39)	missense	probably damaging	1.00
IGL01459:Lrp1b	APN	2	40,750,726 (GRCm39)	missense	probably damaging	0.97
IGL01473:Lrp1b	APN	2	40,501,498 (GRCm39)	missense	probably damaging	0.97
IGL01528:Lrp1b	APN	2	40,809,194 (GRCm39)	missense	probably damaging	0.99
IGL01536:Lrp1b	APN	2	41,000,895 (GRCm39)	missense	probably benign	0.01
IGL01564:Lrp1b	APN	2	40,567,498 (GRCm39)	splice site	probably benign
IGL01747:Lrp1b	APN	2	40,750,697 (GRCm39)	missense	probably damaging	1.00
IGL01764:Lrp1b	APN	2	40,587,454 (GRCm39)	missense	unknown
IGL01783:Lrp1b	APN	2	41,202,584 (GRCm39)	missense	probably damaging	1.00
IGL01802:Lrp1b	APN	2	41,401,494 (GRCm39)	missense	probably benign	0.07
IGL01826:Lrp1b	APN	2	41,339,246 (GRCm39)	missense	probably damaging	1.00
IGL01884:Lrp1b	APN	2	41,174,225 (GRCm39)	nonsense	probably null
IGL01908:Lrp1b	APN	2	40,592,816 (GRCm39)	missense	probably benign
IGL01935:Lrp1b	APN	2	41,158,367 (GRCm39)	missense	probably damaging	1.00
IGL01959:Lrp1b	APN	2	41,202,539 (GRCm39)	missense	probably damaging	0.99
IGL02010:Lrp1b	APN	2	41,358,954 (GRCm39)	missense	probably damaging	1.00
IGL02022:Lrp1b	APN	2	41,172,172 (GRCm39)	missense	probably damaging	1.00
IGL02028:Lrp1b	APN	2	41,401,464 (GRCm39)	missense	probably damaging	1.00
IGL02034:Lrp1b	APN	2	41,158,382 (GRCm39)	nonsense	probably null
IGL02043:Lrp1b	APN	2	40,587,537 (GRCm39)	missense	probably null	0.44
IGL02066:Lrp1b	APN	2	41,001,091 (GRCm39)	nonsense	probably null
IGL02085:Lrp1b	APN	2	40,779,321 (GRCm39)	missense	probably benign
IGL02137:Lrp1b	APN	2	40,620,700 (GRCm39)	splice site	probably benign
IGL02218:Lrp1b	APN	2	41,185,684 (GRCm39)	missense	probably benign	0.11
IGL02409:Lrp1b	APN	2	41,335,208 (GRCm39)	missense	possibly damaging	0.93
IGL02513:Lrp1b	APN	2	41,000,765 (GRCm39)	critical splice donor site	probably null
IGL02543:Lrp1b	APN	2	40,760,413 (GRCm39)	missense	possibly damaging	0.89
IGL02701:Lrp1b	APN	2	41,136,029 (GRCm39)	missense	possibly damaging	0.50
IGL02728:Lrp1b	APN	2	40,691,410 (GRCm39)	missense	probably benign	0.03
IGL02739:Lrp1b	APN	2	41,388,227 (GRCm39)	missense	probably damaging	1.00
IGL02748:Lrp1b	APN	2	40,592,761 (GRCm39)	missense	probably damaging	0.99
IGL02754:Lrp1b	APN	2	40,592,806 (GRCm39)	missense	probably benign	0.02
IGL02797:Lrp1b	APN	2	41,561,069 (GRCm39)	missense
IGL02813:Lrp1b	APN	2	40,569,229 (GRCm39)	critical splice acceptor site	probably null
IGL02831:Lrp1b	APN	2	41,083,603 (GRCm39)	missense	probably damaging	1.00
IGL02869:Lrp1b	APN	2	40,591,842 (GRCm39)	missense	unknown
IGL02946:Lrp1b	APN	2	41,202,571 (GRCm39)	missense	probably damaging	1.00
IGL02952:Lrp1b	APN	2	41,396,715 (GRCm39)	missense	probably benign	0.33
IGL02958:Lrp1b	APN	2	41,192,928 (GRCm39)	missense	probably damaging	1.00
IGL02977:Lrp1b	APN	2	40,620,747 (GRCm39)	missense	probably damaging	1.00
IGL03001:Lrp1b	APN	2	40,817,901 (GRCm39)	missense	probably damaging	1.00
IGL03010:Lrp1b	APN	2	42,213,618 (GRCm39)	missense	possibly damaging	0.94
IGL03060:Lrp1b	APN	2	40,527,765 (GRCm39)	missense	probably benign	0.04
IGL03129:Lrp1b	APN	2	41,202,478 (GRCm39)	splice site	probably benign
IGL03166:Lrp1b	APN	2	41,001,050 (GRCm39)	missense	probably damaging	1.00
IGL03170:Lrp1b	APN	2	40,587,456 (GRCm39)	missense	unknown
IGL03195:Lrp1b	APN	2	41,361,134 (GRCm39)	missense	possibly damaging	0.95
IGL03224:Lrp1b	APN	2	41,361,043 (GRCm39)	missense	possibly damaging	0.92
IGL03251:Lrp1b	APN	2	40,490,279 (GRCm39)	missense	probably benign	0.20
IGL03281:Lrp1b	APN	2	40,615,526 (GRCm39)	missense	probably benign	0.01
IGL03295:Lrp1b	APN	2	40,568,999 (GRCm39)	splice site	probably null
IGL03340:Lrp1b	APN	2	41,358,981 (GRCm39)	missense	probably damaging	0.97
IGL03391:Lrp1b	APN	2	41,185,653 (GRCm39)	missense	possibly damaging	0.95
IGL03401:Lrp1b	APN	2	41,000,790 (GRCm39)	missense	probably benign	0.18
IGL03403:Lrp1b	APN	2	40,592,836 (GRCm39)	missense	probably benign	0.16
IGL03408:Lrp1b	APN	2	40,748,594 (GRCm39)	missense	probably damaging	0.97
Fetching	UTSW	2	40,769,567 (GRCm39)	missense	probably benign	0.00
Heiden	UTSW	2	40,527,787 (GRCm39)	missense	probably benign	0.00
hither	UTSW	2	40,592,860 (GRCm39)	missense	probably benign	0.00
Roeslein	UTSW	2	40,615,919 (GRCm39)	missense	probably damaging	1.00
I2288:Lrp1b	UTSW	2	41,012,944 (GRCm39)	missense	probably damaging	0.99
I2289:Lrp1b	UTSW	2	41,012,944 (GRCm39)	missense	probably damaging	0.99
LCD18:Lrp1b	UTSW	2	42,127,574 (GRCm39)	intron	probably benign
PIT4431001:Lrp1b	UTSW	2	40,894,767 (GRCm39)	missense
PIT4585001:Lrp1b	UTSW	2	41,159,216 (GRCm39)	missense
R0022:Lrp1b	UTSW	2	40,888,050 (GRCm39)	splice site	probably benign
R0022:Lrp1b	UTSW	2	40,888,050 (GRCm39)	splice site	probably benign
R0054:Lrp1b	UTSW	2	40,632,829 (GRCm39)	missense	probably benign	0.11
R0054:Lrp1b	UTSW	2	40,632,829 (GRCm39)	missense	probably benign	0.11
R0094:Lrp1b	UTSW	2	41,172,042 (GRCm39)	unclassified	probably benign
R0102:Lrp1b	UTSW	2	41,298,997 (GRCm39)	splice site	probably benign
R0123:Lrp1b	UTSW	2	40,486,995 (GRCm39)	missense	probably damaging	1.00
R0128:Lrp1b	UTSW	2	41,401,520 (GRCm39)	missense	probably damaging	1.00
R0130:Lrp1b	UTSW	2	41,401,520 (GRCm39)	missense	probably damaging	1.00
R0134:Lrp1b	UTSW	2	40,486,995 (GRCm39)	missense	probably damaging	1.00
R0135:Lrp1b	UTSW	2	41,159,251 (GRCm39)	missense	probably damaging	0.99
R0153:Lrp1b	UTSW	2	41,013,031 (GRCm39)	missense	possibly damaging	0.92
R0178:Lrp1b	UTSW	2	40,615,919 (GRCm39)	missense	probably damaging	1.00
R0225:Lrp1b	UTSW	2	40,486,995 (GRCm39)	missense	probably damaging	1.00
R0242:Lrp1b	UTSW	2	40,888,195 (GRCm39)	missense	probably benign	0.01
R0242:Lrp1b	UTSW	2	40,888,195 (GRCm39)	missense	probably benign	0.01
R0312:Lrp1b	UTSW	2	41,172,183 (GRCm39)	missense	probably damaging	1.00
R0325:Lrp1b	UTSW	2	40,741,723 (GRCm39)	missense	probably damaging	1.00
R0330:Lrp1b	UTSW	2	40,591,773 (GRCm39)	nonsense	probably null
R0372:Lrp1b	UTSW	2	40,620,810 (GRCm39)	missense	probably benign	0.30
R0400:Lrp1b	UTSW	2	40,640,926 (GRCm39)	missense	probably benign	0.40
R0408:Lrp1b	UTSW	2	40,567,603 (GRCm39)	missense	probably damaging	1.00
R0498:Lrp1b	UTSW	2	41,348,417 (GRCm39)	missense	probably benign	0.19
R0563:Lrp1b	UTSW	2	40,640,926 (GRCm39)	missense	probably benign	0.40
R0569:Lrp1b	UTSW	2	40,779,251 (GRCm39)	missense	probably benign	0.11
R0622:Lrp1b	UTSW	2	41,618,563 (GRCm39)	critical splice donor site	probably null
R0682:Lrp1b	UTSW	2	41,185,653 (GRCm39)	missense	probably benign	0.01
R0727:Lrp1b	UTSW	2	40,640,956 (GRCm39)	missense	probably benign	0.40
R0747:Lrp1b	UTSW	2	40,760,353 (GRCm39)	missense	probably damaging	1.00
R0761:Lrp1b	UTSW	2	41,075,947 (GRCm39)	missense	probably damaging	0.99
R0905:Lrp1b	UTSW	2	41,174,197 (GRCm39)	missense	probably damaging	1.00
R0959:Lrp1b	UTSW	2	41,158,366 (GRCm39)	missense	possibly damaging	0.83
R1124:Lrp1b	UTSW	2	40,765,063 (GRCm39)	missense	probably damaging	1.00
R1158:Lrp1b	UTSW	2	40,567,506 (GRCm39)	missense	unknown
R1265:Lrp1b	UTSW	2	41,366,666 (GRCm39)	missense	probably damaging	1.00
R1276:Lrp1b	UTSW	2	41,618,588 (GRCm39)	missense	probably benign	0.35
R1277:Lrp1b	UTSW	2	40,615,957 (GRCm39)	missense	probably benign
R1282:Lrp1b	UTSW	2	40,750,773 (GRCm39)	missense	probably damaging	1.00
R1291:Lrp1b	UTSW	2	41,231,907 (GRCm39)	missense	probably benign	0.05
R1316:Lrp1b	UTSW	2	40,592,816 (GRCm39)	missense	probably benign
R1340:Lrp1b	UTSW	2	40,592,806 (GRCm39)	missense	probably benign	0.02
R1371:Lrp1b	UTSW	2	40,537,165 (GRCm39)	missense	probably damaging	1.00
R1415:Lrp1b	UTSW	2	40,519,676 (GRCm39)	missense	probably damaging	1.00
R1416:Lrp1b	UTSW	2	40,888,228 (GRCm39)	missense	probably damaging	1.00
R1417:Lrp1b	UTSW	2	40,894,653 (GRCm39)	missense	probably benign	0.14
R1465:Lrp1b	UTSW	2	41,001,071 (GRCm39)	missense	probably benign	0.00
R1465:Lrp1b	UTSW	2	41,001,071 (GRCm39)	missense	probably benign	0.00
R1467:Lrp1b	UTSW	2	40,547,368 (GRCm39)	splice site	probably benign
R1468:Lrp1b	UTSW	2	40,817,841 (GRCm39)	critical splice donor site	probably null
R1468:Lrp1b	UTSW	2	40,817,841 (GRCm39)	critical splice donor site	probably null
R1480:Lrp1b	UTSW	2	40,793,401 (GRCm39)	missense	probably damaging	1.00
R1488:Lrp1b	UTSW	2	41,392,036 (GRCm39)	missense	probably benign	0.01
R1496:Lrp1b	UTSW	2	42,213,674 (GRCm39)	missense	probably damaging	0.98
R1542:Lrp1b	UTSW	2	41,013,724 (GRCm39)	missense	probably damaging	1.00
R1571:Lrp1b	UTSW	2	41,366,658 (GRCm39)	missense	probably damaging	1.00
R1598:Lrp1b	UTSW	2	41,401,490 (GRCm39)	missense	probably damaging	1.00
R1619:Lrp1b	UTSW	2	40,587,601 (GRCm39)	missense	unknown
R1697:Lrp1b	UTSW	2	40,712,695 (GRCm39)	missense	probably damaging	0.99
R1698:Lrp1b	UTSW	2	40,741,818 (GRCm39)	nonsense	probably null
R1699:Lrp1b	UTSW	2	41,075,974 (GRCm39)	missense	possibly damaging	0.91
R1715:Lrp1b	UTSW	2	41,075,993 (GRCm39)	missense	probably damaging	1.00
R1748:Lrp1b	UTSW	2	41,618,718 (GRCm39)	missense	possibly damaging	0.56
R1756:Lrp1b	UTSW	2	41,000,837 (GRCm39)	missense	probably damaging	1.00
R1889:Lrp1b	UTSW	2	40,809,179 (GRCm39)	nonsense	probably null
R1895:Lrp1b	UTSW	2	40,555,159 (GRCm39)	missense	unknown
R1902:Lrp1b	UTSW	2	40,750,673 (GRCm39)	missense	probably damaging	1.00
R1919:Lrp1b	UTSW	2	41,618,741 (GRCm39)	missense	probably benign	0.00
R1939:Lrp1b	UTSW	2	40,587,601 (GRCm39)	missense	unknown
R1946:Lrp1b	UTSW	2	40,555,159 (GRCm39)	missense	unknown
R1954:Lrp1b	UTSW	2	40,748,453 (GRCm39)	missense	probably damaging	1.00
R1970:Lrp1b	UTSW	2	40,765,081 (GRCm39)	missense	probably damaging	1.00
R1983:Lrp1b	UTSW	2	41,401,416 (GRCm39)	critical splice donor site	probably null
R2029:Lrp1b	UTSW	2	41,231,861 (GRCm39)	missense	probably benign	0.02
R2054:Lrp1b	UTSW	2	40,587,494 (GRCm39)	missense	unknown
R2108:Lrp1b	UTSW	2	41,000,769 (GRCm39)	missense	probably damaging	1.00
R2158:Lrp1b	UTSW	2	40,769,567 (GRCm39)	missense	probably benign	0.00
R2168:Lrp1b	UTSW	2	41,265,858 (GRCm39)	missense	probably damaging	1.00
R2184:Lrp1b	UTSW	2	40,620,714 (GRCm39)	missense	probably benign
R2188:Lrp1b	UTSW	2	41,298,971 (GRCm39)	missense	probably benign	0.25
R2200:Lrp1b	UTSW	2	41,174,177 (GRCm39)	missense	probably benign	0.43
R2342:Lrp1b	UTSW	2	40,809,208 (GRCm39)	missense	possibly damaging	0.89
R2421:Lrp1b	UTSW	2	40,772,145 (GRCm39)	splice site	probably benign
R2656:Lrp1b	UTSW	2	41,401,593 (GRCm39)	missense	probably damaging	0.99
R2864:Lrp1b	UTSW	2	40,765,007 (GRCm39)	missense	possibly damaging	0.92
R2874:Lrp1b	UTSW	2	40,741,705 (GRCm39)	missense	probably damaging	1.00
R2911:Lrp1b	UTSW	2	41,396,704 (GRCm39)	missense	probably benign	0.00
R2919:Lrp1b	UTSW	2	41,660,911 (GRCm39)	missense	probably damaging	1.00
R3027:Lrp1b	UTSW	2	40,760,283 (GRCm39)	missense	probably benign	0.33
R3083:Lrp1b	UTSW	2	40,490,336 (GRCm39)	missense	probably damaging	0.99
R3545:Lrp1b	UTSW	2	40,490,300 (GRCm39)	missense	probably damaging	1.00
R3546:Lrp1b	UTSW	2	40,490,300 (GRCm39)	missense	probably damaging	1.00
R3547:Lrp1b	UTSW	2	40,490,300 (GRCm39)	missense	probably damaging	1.00
R3709:Lrp1b	UTSW	2	40,587,454 (GRCm39)	missense	unknown
R3817:Lrp1b	UTSW	2	40,766,670 (GRCm39)	missense	probably damaging	1.00
R3876:Lrp1b	UTSW	2	41,335,206 (GRCm39)	missense	probably damaging	1.00
R3877:Lrp1b	UTSW	2	41,335,206 (GRCm39)	missense	probably damaging	1.00
R3896:Lrp1b	UTSW	2	40,812,440 (GRCm39)	splice site	probably null
R3901:Lrp1b	UTSW	2	40,712,707 (GRCm39)	missense	probably damaging	1.00
R3915:Lrp1b	UTSW	2	41,339,248 (GRCm39)	missense	probably damaging	1.00
R3922:Lrp1b	UTSW	2	40,567,593 (GRCm39)	missense	unknown
R3964:Lrp1b	UTSW	2	41,202,482 (GRCm39)	splice site	probably benign
R4013:Lrp1b	UTSW	2	40,692,996 (GRCm39)	missense	possibly damaging	0.66
R4014:Lrp1b	UTSW	2	40,692,996 (GRCm39)	missense	possibly damaging	0.66
R4015:Lrp1b	UTSW	2	40,692,996 (GRCm39)	missense	possibly damaging	0.66
R4017:Lrp1b	UTSW	2	40,692,996 (GRCm39)	missense	possibly damaging	0.66
R4031:Lrp1b	UTSW	2	40,592,860 (GRCm39)	missense	probably benign	0.00
R4095:Lrp1b	UTSW	2	41,339,203 (GRCm39)	missense	probably benign	0.03
R4108:Lrp1b	UTSW	2	40,555,099 (GRCm39)	missense	unknown
R4176:Lrp1b	UTSW	2	41,298,405 (GRCm39)	missense	probably damaging	1.00
R4181:Lrp1b	UTSW	2	40,501,446 (GRCm39)	missense	probably damaging	1.00
R4359:Lrp1b	UTSW	2	40,793,077 (GRCm39)	missense	probably damaging	1.00
R4410:Lrp1b	UTSW	2	40,555,094 (GRCm39)	missense	possibly damaging	0.96
R4416:Lrp1b	UTSW	2	40,553,679 (GRCm39)	missense	unknown
R4489:Lrp1b	UTSW	2	40,551,501 (GRCm39)	unclassified	probably benign
R4577:Lrp1b	UTSW	2	40,711,731 (GRCm39)	missense	probably damaging	1.00
R4623:Lrp1b	UTSW	2	41,136,033 (GRCm39)	missense	probably damaging	1.00
R4677:Lrp1b	UTSW	2	40,691,496 (GRCm39)	missense	probably damaging	1.00
R4684:Lrp1b	UTSW	2	40,812,316 (GRCm39)	missense	probably benign	0.44
R4714:Lrp1b	UTSW	2	41,000,771 (GRCm39)	missense	possibly damaging	0.90
R4721:Lrp1b	UTSW	2	40,605,381 (GRCm39)	splice site	probably null
R4755:Lrp1b	UTSW	2	41,159,285 (GRCm39)	missense	probably benign	0.07
R4774:Lrp1b	UTSW	2	40,551,544 (GRCm39)	missense	probably null	1.00
R4854:Lrp1b	UTSW	2	41,001,089 (GRCm39)	missense	probably damaging	1.00
R4880:Lrp1b	UTSW	2	41,660,931 (GRCm39)	missense	probably benign	0.07
R4885:Lrp1b	UTSW	2	41,358,905 (GRCm39)	missense	probably benign
R4901:Lrp1b	UTSW	2	40,711,657 (GRCm39)	missense	probably damaging	1.00
R4919:Lrp1b	UTSW	2	40,537,246 (GRCm39)	missense	probably benign	0.25
R4935:Lrp1b	UTSW	2	41,388,405 (GRCm39)	missense	probably benign	0.01
R4937:Lrp1b	UTSW	2	40,692,897 (GRCm39)	splice site	probably null
R4967:Lrp1b	UTSW	2	41,678,986 (GRCm39)	missense	probably damaging	1.00
R4968:Lrp1b	UTSW	2	41,679,074 (GRCm39)	missense	probably damaging	1.00
R4968:Lrp1b	UTSW	2	40,592,719 (GRCm39)	splice site	probably null
R5155:Lrp1b	UTSW	2	41,618,634 (GRCm39)	splice site	probably null
R5221:Lrp1b	UTSW	2	41,002,994 (GRCm39)	missense	possibly damaging	0.79
R5224:Lrp1b	UTSW	2	41,000,852 (GRCm39)	missense	possibly damaging	0.61
R5227:Lrp1b	UTSW	2	40,741,805 (GRCm39)	missense	possibly damaging	0.95
R5246:Lrp1b	UTSW	2	41,360,952 (GRCm39)	critical splice donor site	probably null
R5263:Lrp1b	UTSW	2	41,850,691 (GRCm39)	missense	probably damaging	1.00
R5274:Lrp1b	UTSW	2	41,234,456 (GRCm39)	missense	probably null	1.00
R5291:Lrp1b	UTSW	2	40,793,015 (GRCm39)	missense	probably damaging	1.00
R5362:Lrp1b	UTSW	2	41,265,914 (GRCm39)	missense	probably damaging	1.00
R5365:Lrp1b	UTSW	2	40,537,137 (GRCm39)	missense	possibly damaging	0.55
R5369:Lrp1b	UTSW	2	40,894,625 (GRCm39)	nonsense	probably null
R5419:Lrp1b	UTSW	2	40,620,716 (GRCm39)	nonsense	probably null
R5434:Lrp1b	UTSW	2	41,660,880 (GRCm39)	missense	probably damaging	0.96
R5452:Lrp1b	UTSW	2	40,812,328 (GRCm39)	missense	probably damaging	1.00
R5453:Lrp1b	UTSW	2	41,172,249 (GRCm39)	missense	probably damaging	1.00
R5496:Lrp1b	UTSW	2	40,817,985 (GRCm39)	missense	probably benign	0.02
R5524:Lrp1b	UTSW	2	41,000,900 (GRCm39)	missense	probably damaging	1.00
R5538:Lrp1b	UTSW	2	40,587,486 (GRCm39)	missense	unknown
R5571:Lrp1b	UTSW	2	41,298,354 (GRCm39)	missense	probably damaging	0.97
R5577:Lrp1b	UTSW	2	40,765,135 (GRCm39)	missense	possibly damaging	0.70
R5609:Lrp1b	UTSW	2	41,231,807 (GRCm39)	missense	probably damaging	1.00
R5635:Lrp1b	UTSW	2	42,542,834 (GRCm39)	utr 5 prime	probably benign
R5669:Lrp1b	UTSW	2	41,001,050 (GRCm39)	missense	probably damaging	1.00
R5672:Lrp1b	UTSW	2	41,231,771 (GRCm39)	missense	probably benign	0.01
R5690:Lrp1b	UTSW	2	40,640,906 (GRCm39)	splice site	probably null
R5752:Lrp1b	UTSW	2	41,185,624 (GRCm39)	missense	probably damaging	1.00
R5853:Lrp1b	UTSW	2	40,553,738 (GRCm39)	missense	unknown
R5869:Lrp1b	UTSW	2	40,894,615 (GRCm39)	missense	probably damaging	0.98
R5880:Lrp1b	UTSW	2	41,231,826 (GRCm39)	missense	probably benign	0.23
R5887:Lrp1b	UTSW	2	40,711,719 (GRCm39)	missense	possibly damaging	0.91
R5893:Lrp1b	UTSW	2	40,491,599 (GRCm39)	missense	probably damaging	1.00
R5894:Lrp1b	UTSW	2	41,388,233 (GRCm39)	missense	probably benign	0.11
R6019:Lrp1b	UTSW	2	41,192,982 (GRCm39)	missense	probably damaging	1.00
R6019:Lrp1b	UTSW	2	41,366,821 (GRCm39)	missense	probably damaging	1.00
R6021:Lrp1b	UTSW	2	41,234,439 (GRCm39)	missense	probably benign	0.02
R6045:Lrp1b	UTSW	2	40,591,825 (GRCm39)	missense	unknown
R6047:Lrp1b	UTSW	2	40,527,787 (GRCm39)	missense	probably benign	0.00
R6060:Lrp1b	UTSW	2	40,640,946 (GRCm39)	missense
R6063:Lrp1b	UTSW	2	41,174,156 (GRCm39)	nonsense	probably null
R6090:Lrp1b	UTSW	2	41,075,880 (GRCm39)	critical splice donor site	probably null
R6112:Lrp1b	UTSW	2	41,231,894 (GRCm39)	missense	probably benign	0.14
R6128:Lrp1b	UTSW	2	40,750,667 (GRCm39)	missense	probably benign
R6149:Lrp1b	UTSW	2	40,765,165 (GRCm39)	splice site	probably null
R6174:Lrp1b	UTSW	2	41,339,275 (GRCm39)	missense	probably benign
R6177:Lrp1b	UTSW	2	41,013,748 (GRCm39)	splice site	probably null
R6257:Lrp1b	UTSW	2	40,486,981 (GRCm39)	splice site	probably null
R6267:Lrp1b	UTSW	2	40,547,537 (GRCm39)	missense	probably benign	0.00
R6268:Lrp1b	UTSW	2	40,711,729 (GRCm39)	missense	probably benign	0.01
R6331:Lrp1b	UTSW	2	40,693,221 (GRCm39)	missense	probably damaging	1.00
R6334:Lrp1b	UTSW	2	41,679,045 (GRCm39)	missense	probably benign
R6359:Lrp1b	UTSW	2	41,185,608 (GRCm39)	missense	probably damaging	1.00
R6371:Lrp1b	UTSW	2	40,741,666 (GRCm39)	missense	possibly damaging	0.61
R6421:Lrp1b	UTSW	2	40,779,282 (GRCm39)	missense	probably damaging	1.00
R6524:Lrp1b	UTSW	2	40,741,816 (GRCm39)	missense	possibly damaging	0.95
R6616:Lrp1b	UTSW	2	40,589,643 (GRCm39)	missense	unknown
R6632:Lrp1b	UTSW	2	40,615,454 (GRCm39)	missense	probably benign	0.23
R6656:Lrp1b	UTSW	2	40,527,876 (GRCm39)	nonsense	probably null
R6698:Lrp1b	UTSW	2	41,192,958 (GRCm39)	missense	probably damaging	1.00
R6741:Lrp1b	UTSW	2	41,136,001 (GRCm39)	missense	possibly damaging	0.82
R6742:Lrp1b	UTSW	2	41,361,132 (GRCm39)	missense	probably benign	0.31
R6811:Lrp1b	UTSW	2	41,339,206 (GRCm39)	missense	probably benign	0.01
R6811:Lrp1b	UTSW	2	40,605,512 (GRCm39)	splice site	probably null
R6855:Lrp1b	UTSW	2	40,518,708 (GRCm39)	missense	possibly damaging	0.66
R6888:Lrp1b	UTSW	2	41,361,138 (GRCm39)	missense	probably benign	0.18
R6946:Lrp1b	UTSW	2	40,587,451 (GRCm39)	missense	probably benign
R6984:Lrp1b	UTSW	2	40,712,640 (GRCm39)	missense	probably damaging	0.97
R7026:Lrp1b	UTSW	2	41,159,234 (GRCm39)	missense	probably damaging	1.00
R7028:Lrp1b	UTSW	2	41,136,023 (GRCm39)	missense	probably benign	0.45
R7036:Lrp1b	UTSW	2	41,002,354 (GRCm39)	missense	possibly damaging	0.89
R7043:Lrp1b	UTSW	2	40,812,426 (GRCm39)	missense	possibly damaging	0.84
R7071:Lrp1b	UTSW	2	41,298,276 (GRCm39)	missense
R7077:Lrp1b	UTSW	2	41,660,858 (GRCm39)	missense
R7115:Lrp1b	UTSW	2	40,888,247 (GRCm39)	missense
R7143:Lrp1b	UTSW	2	41,202,655 (GRCm39)	missense
R7146:Lrp1b	UTSW	2	41,266,006 (GRCm39)	nonsense	probably null
R7149:Lrp1b	UTSW	2	40,527,872 (GRCm39)	missense
R7185:Lrp1b	UTSW	2	40,691,524 (GRCm39)	critical splice acceptor site	probably null
R7239:Lrp1b	UTSW	2	40,894,725 (GRCm39)	missense
R7247:Lrp1b	UTSW	2	41,159,224 (GRCm39)	missense
R7331:Lrp1b	UTSW	2	40,553,622 (GRCm39)	splice site	probably null
R7369:Lrp1b	UTSW	2	41,172,051 (GRCm39)	missense
R7378:Lrp1b	UTSW	2	41,185,681 (GRCm39)	missense
R7381:Lrp1b	UTSW	2	40,692,929 (GRCm39)	missense
R7406:Lrp1b	UTSW	2	41,266,030 (GRCm39)	critical splice acceptor site	probably null
R7437:Lrp1b	UTSW	2	40,712,658 (GRCm39)	missense
R7437:Lrp1b	UTSW	2	40,712,657 (GRCm39)	missense
R7446:Lrp1b	UTSW	2	41,561,069 (GRCm39)	missense
R7460:Lrp1b	UTSW	2	40,488,478 (GRCm39)	missense
R7462:Lrp1b	UTSW	2	41,003,041 (GRCm39)	missense
R7475:Lrp1b	UTSW	2	41,234,588 (GRCm39)	missense
R7479:Lrp1b	UTSW	2	40,691,517 (GRCm39)	missense
R7523:Lrp1b	UTSW	2	41,401,473 (GRCm39)	missense
R7525:Lrp1b	UTSW	2	40,547,428 (GRCm39)	missense
R7549:Lrp1b	UTSW	2	40,765,134 (GRCm39)	missense
R7552:Lrp1b	UTSW	2	40,567,582 (GRCm39)	missense
R7558:Lrp1b	UTSW	2	41,231,948 (GRCm39)	missense
R7587:Lrp1b	UTSW	2	40,620,729 (GRCm39)	missense
R7599:Lrp1b	UTSW	2	40,551,561 (GRCm39)	missense
R7635:Lrp1b	UTSW	2	41,013,609 (GRCm39)	critical splice donor site	probably null
R7663:Lrp1b	UTSW	2	42,543,047 (GRCm39)	unclassified	probably benign
R7674:Lrp1b	UTSW	2	42,542,921 (GRCm39)	start gained	probably benign
R7681:Lrp1b	UTSW	2	40,765,011 (GRCm39)	nonsense	probably null
R7703:Lrp1b	UTSW	2	41,000,798 (GRCm39)	missense
R7742:Lrp1b	UTSW	2	40,712,641 (GRCm39)	missense
R7767:Lrp1b	UTSW	2	40,691,517 (GRCm39)	missense
R7829:Lrp1b	UTSW	2	40,793,460 (GRCm39)	nonsense	probably null
R7861:Lrp1b	UTSW	2	40,587,570 (GRCm39)	missense
R7868:Lrp1b	UTSW	2	41,339,246 (GRCm39)	missense
R7883:Lrp1b	UTSW	2	40,555,141 (GRCm39)	missense
R7956:Lrp1b	UTSW	2	41,172,161 (GRCm39)	splice site	probably null
R7963:Lrp1b	UTSW	2	40,817,947 (GRCm39)	missense
R7964:Lrp1b	UTSW	2	40,488,523 (GRCm39)	missense
R8035:Lrp1b	UTSW	2	40,750,667 (GRCm39)	missense
R8046:Lrp1b	UTSW	2	41,159,199 (GRCm39)	missense
R8128:Lrp1b	UTSW	2	41,159,248 (GRCm39)	missense	probably null
R8234:Lrp1b	UTSW	2	41,202,668 (GRCm39)	missense
R8237:Lrp1b	UTSW	2	40,741,786 (GRCm39)	missense
R8244:Lrp1b	UTSW	2	41,396,794 (GRCm39)	missense
R8370:Lrp1b	UTSW	2	40,888,117 (GRCm39)	missense
R8395:Lrp1b	UTSW	2	40,547,411 (GRCm39)	missense
R8398:Lrp1b	UTSW	2	40,591,819 (GRCm39)	missense
R8421:Lrp1b	UTSW	2	40,615,435 (GRCm39)	missense
R8426:Lrp1b	UTSW	2	41,388,318 (GRCm39)	missense
R8443:Lrp1b	UTSW	2	41,265,867 (GRCm39)	nonsense	probably null
R8444:Lrp1b	UTSW	2	40,760,272 (GRCm39)	missense
R8486:Lrp1b	UTSW	2	41,618,702 (GRCm39)	missense	probably damaging	1.00
R8500:Lrp1b	UTSW	2	41,396,791 (GRCm39)	missense	probably benign	0.12
R8507:Lrp1b	UTSW	2	41,298,387 (GRCm39)	missense
R8552:Lrp1b	UTSW	2	41,298,993 (GRCm39)	missense	probably benign	0.00
R8554:Lrp1b	UTSW	2	41,234,495 (GRCm39)	missense	probably benign	0.28
R8669:Lrp1b	UTSW	2	41,172,047 (GRCm39)	critical splice donor site	probably null
R8699:Lrp1b	UTSW	2	41,172,207 (GRCm39)	missense
R8796:Lrp1b	UTSW	2	40,793,426 (GRCm39)	missense
R8815:Lrp1b	UTSW	2	40,555,171 (GRCm39)	missense
R8842:Lrp1b	UTSW	2	41,158,417 (GRCm39)	missense
R8858:Lrp1b	UTSW	2	41,560,827 (GRCm39)	intron	probably benign
R8864:Lrp1b	UTSW	2	41,002,718 (GRCm39)	missense
R8918:Lrp1b	UTSW	2	40,615,893 (GRCm39)	missense
R8920:Lrp1b	UTSW	2	42,213,610 (GRCm39)	missense
R8963:Lrp1b	UTSW	2	40,888,196 (GRCm39)	missense	probably benign	0.28
R8971:Lrp1b	UTSW	2	41,325,640 (GRCm39)	missense
R9007:Lrp1b	UTSW	2	40,587,564 (GRCm39)	missense
R9042:Lrp1b	UTSW	2	41,392,029 (GRCm39)	missense
R9053:Lrp1b	UTSW	2	40,748,501 (GRCm39)	missense
R9063:Lrp1b	UTSW	2	41,231,838 (GRCm39)	missense
R9072:Lrp1b	UTSW	2	40,615,457 (GRCm39)	nonsense	probably null
R9105:Lrp1b	UTSW	2	41,396,803 (GRCm39)	missense
R9131:Lrp1b	UTSW	2	40,589,590 (GRCm39)	nonsense	probably null
R9226:Lrp1b	UTSW	2	41,401,460 (GRCm39)	missense
R9245:Lrp1b	UTSW	2	40,488,456 (GRCm39)	missense
R9275:Lrp1b	UTSW	2	40,487,076 (GRCm39)	missense
R9278:Lrp1b	UTSW	2	40,487,076 (GRCm39)	missense
R9303:Lrp1b	UTSW	2	41,618,574 (GRCm39)	missense
R9305:Lrp1b	UTSW	2	41,618,574 (GRCm39)	missense
R9306:Lrp1b	UTSW	2	40,518,762 (GRCm39)	missense	possibly damaging	0.66
R9320:Lrp1b	UTSW	2	41,335,111 (GRCm39)	critical splice donor site	probably null
R9330:Lrp1b	UTSW	2	41,012,993 (GRCm39)	missense
R9352:Lrp1b	UTSW	2	40,748,438 (GRCm39)	missense
R9386:Lrp1b	UTSW	2	41,013,640 (GRCm39)	missense
R9397:Lrp1b	UTSW	2	40,640,922 (GRCm39)	missense
R9444:Lrp1b	UTSW	2	41,013,730 (GRCm39)	missense
R9452:Lrp1b	UTSW	2	41,850,726 (GRCm39)	nonsense	probably null
R9474:Lrp1b	UTSW	2	40,491,599 (GRCm39)	missense	probably damaging	1.00
R9501:Lrp1b	UTSW	2	41,172,247 (GRCm39)	missense
R9523:Lrp1b	UTSW	2	41,660,978 (GRCm39)	missense
R9541:Lrp1b	UTSW	2	41,234,600 (GRCm39)	missense
R9555:Lrp1b	UTSW	2	40,748,438 (GRCm39)	missense
R9555:Lrp1b	UTSW	2	40,741,693 (GRCm39)	missense
R9563:Lrp1b	UTSW	2	41,185,711 (GRCm39)	missense
R9568:Lrp1b	UTSW	2	40,569,227 (GRCm39)	missense
R9622:Lrp1b	UTSW	2	40,779,354 (GRCm39)	nonsense	probably null
R9623:Lrp1b	UTSW	2	41,366,648 (GRCm39)	missense
R9634:Lrp1b	UTSW	2	41,135,951 (GRCm39)	critical splice donor site	probably null
R9640:Lrp1b	UTSW	2	41,078,929 (GRCm39)	missense
R9664:Lrp1b	UTSW	2	40,765,004 (GRCm39)	missense
R9668:Lrp1b	UTSW	2	41,075,982 (GRCm39)	missense
R9672:Lrp1b	UTSW	2	40,779,291 (GRCm39)	missense
R9717:Lrp1b	UTSW	2	41,158,395 (GRCm39)	missense
R9741:Lrp1b	UTSW	2	41,002,300 (GRCm39)	missense
RF018:Lrp1b	UTSW	2	41,000,919 (GRCm39)	missense
RF020:Lrp1b	UTSW	2	41,660,858 (GRCm39)	missense
V1662:Lrp1b	UTSW	2	41,012,944 (GRCm39)	missense	probably damaging	0.99
X0028:Lrp1b	UTSW	2	41,361,157 (GRCm39)	missense	probably damaging	1.00
X0064:Lrp1b	UTSW	2	41,392,055 (GRCm39)	missense	probably damaging	1.00
Z1176:Lrp1b	UTSW	2	40,812,395 (GRCm39)	missense
Z1176:Lrp1b	UTSW	2	40,587,594 (GRCm39)	missense
Z1176:Lrp1b	UTSW	2	40,567,518 (GRCm39)	missense
Z1176:Lrp1b	UTSW	2	41,618,722 (GRCm39)	missense
Z1177:Lrp1b	UTSW	2	41,078,860 (GRCm39)	missense
Z1177:Lrp1b	UTSW	2	40,527,761 (GRCm39)	missense
Z1187:Lrp1b	UTSW	2	40,640,946 (GRCm39)	missense
Z1188:Lrp1b	UTSW	2	40,640,946 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- ACTATTGGCAGCCACCTCAG -3'
(R):5'- AAATCCGAGGGTGCTTCTAGG -3'

Sequencing Primer
(F):5'- CCTCAGAGGGGTAAAAATAAACTTG -3'
(R):5'- CTAGGTGGCTACTGGAGATAATG -3'

Posted On

2015-11-11