Incidental Mutation 'R4755:Prl2c5'
ID 357952
Institutional Source Beutler Lab
Gene Symbol Prl2c5
Ensembl Gene ENSMUSG00000055360
Gene Name prolactin family 2, subfamily c, member 5
Synonyms MRP-4, Mrpplf4, PLF-4
MMRRC Submission 042033-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R4755 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 13357300-13366508 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 13363970 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 75 (N75K)
Ref Sequence ENSEMBL: ENSMUSP00000117522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021778] [ENSMUST00000126540] [ENSMUST00000151144]
AlphaFold Q9JLV9
Predicted Effect probably benign
Transcript: ENSMUST00000021778
AA Change: N75K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000021778
Gene: ENSMUSG00000055360
AA Change: N75K

DomainStartEndE-ValueType
Pfam:Hormone_1 16 222 2.7e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126540
AA Change: N78K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000115024
Gene: ENSMUSG00000055360
AA Change: N78K

DomainStartEndE-ValueType
Pfam:Hormone_1 19 225 1.5e-73 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143335
Predicted Effect probably benign
Transcript: ENSMUST00000151144
AA Change: N75K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000117522
Gene: ENSMUSG00000055360
AA Change: N75K

DomainStartEndE-ValueType
Pfam:Hormone_1 16 172 3.5e-51 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 96% (112/117)
Allele List at MGI
Other mutations in this stock
Total: 113 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930449A18Rik T A 3: 59,733,280 (GRCm39) noncoding transcript Het
Aadacl2fm1 C T 3: 59,843,735 (GRCm39) A143V probably benign Het
Accs T C 2: 93,671,682 (GRCm39) E236G probably damaging Het
Agrn C T 4: 156,257,979 (GRCm39) probably benign Het
Ahi1 A G 10: 20,930,946 (GRCm39) I929V possibly damaging Het
Akap5 C A 12: 76,374,581 (GRCm39) C4* probably null Het
Amotl2 A T 9: 102,597,679 (GRCm39) H146L probably damaging Het
Ank1 A G 8: 23,594,990 (GRCm39) N666S probably damaging Het
Atp10d A T 5: 72,403,509 (GRCm39) T373S probably benign Het
Bpifb9b T A 2: 154,161,614 (GRCm39) M582K probably benign Het
Brca2 T A 5: 150,483,452 (GRCm39) probably null Het
Ccdc149 A G 5: 52,561,493 (GRCm39) V229A probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cdk5rap2 A G 4: 70,156,662 (GRCm39) S1617P probably damaging Het
Cenpk A T 13: 104,367,379 (GRCm39) M37L probably benign Het
Cenpk A T 13: 104,386,020 (GRCm39) H305L probably benign Het
Ces5a C A 8: 94,262,305 (GRCm39) A11S probably benign Het
Cfap65 T C 1: 74,967,520 (GRCm39) E186G probably damaging Het
Cfh T A 1: 140,016,546 (GRCm39) I593F probably damaging Het
Clstn2 C T 9: 97,327,726 (GRCm39) V961I probably benign Het
Cog5 T A 12: 31,919,405 (GRCm39) probably null Het
Col4a4 T C 1: 82,518,895 (GRCm39) D100G unknown Het
Cyp3a41a T C 5: 145,652,316 (GRCm39) D61G probably damaging Het
Dnah10 A G 5: 124,824,809 (GRCm39) N655S probably benign Het
Dnai1 C G 4: 41,610,269 (GRCm39) T295R probably damaging Het
Dnajc6 C T 4: 101,407,996 (GRCm39) A44V probably damaging Het
Eif4enif1 A T 11: 3,194,016 (GRCm39) D960V probably damaging Het
Fam167b C T 4: 129,472,135 (GRCm39) G12R probably damaging Het
Fam20b A T 1: 156,515,066 (GRCm39) Y266* probably null Het
Fer1l6 T A 15: 58,512,060 (GRCm39) V1509D probably benign Het
Fhad1 A T 4: 141,655,794 (GRCm39) I105N probably damaging Het
Fmo2 T C 1: 162,716,374 (GRCm39) D71G probably damaging Het
Folr2 T C 7: 101,493,006 (GRCm39) T6A possibly damaging Het
Fry A C 5: 150,321,719 (GRCm39) E1018A probably damaging Het
Gas2l2 A G 11: 83,320,193 (GRCm39) I21T probably damaging Het
Gfra1 T C 19: 58,441,676 (GRCm39) Y85C probably damaging Het
Gpld1 A T 13: 25,163,671 (GRCm39) Y43F probably benign Het
Gpld1 T A 13: 25,163,675 (GRCm39) Y44* probably null Het
Grid2 A G 6: 63,885,972 (GRCm39) T123A probably benign Het
Grina T C 15: 76,133,442 (GRCm39) L305P probably damaging Het
Gucy1a1 G A 3: 82,002,102 (GRCm39) A659V probably benign Het
H2-T10 T A 17: 36,429,837 (GRCm39) K319* probably null Het
Hey2 A T 10: 30,710,300 (GRCm39) V151E probably benign Het
Ighv1-69 G A 12: 115,587,178 (GRCm39) T13I probably benign Het
Il1rap C A 16: 26,541,532 (GRCm39) A591E probably benign Het
Ildr1 T C 16: 36,542,383 (GRCm39) L261P probably benign Het
Jak1 A G 4: 101,031,354 (GRCm39) Y463H probably damaging Het
Lrp1b T C 2: 41,159,285 (GRCm39) I1666V probably benign Het
Lrp1b T A 2: 41,361,028 (GRCm39) T592S probably benign Het
Lrrc36 A G 8: 106,178,776 (GRCm39) T445A possibly damaging Het
Ly9 G A 1: 171,434,806 (GRCm39) S29F probably damaging Het
Mapk7 A C 11: 61,381,669 (GRCm39) C32W probably damaging Het
Marchf10 C T 11: 105,255,302 (GRCm39) probably benign Het
Mier2 A T 10: 79,385,031 (GRCm39) M119K probably damaging Het
Mpv17 A T 5: 31,303,326 (GRCm39) C59* probably null Het
Mrpl27 G A 11: 94,544,659 (GRCm39) probably benign Het
Myo18b G A 5: 113,022,340 (GRCm39) Q351* probably null Het
Myo1a A G 10: 127,551,557 (GRCm39) I704M probably damaging Het
Nadsyn1 A G 7: 143,360,650 (GRCm39) C373R probably damaging Het
Nckipsd C A 9: 108,691,938 (GRCm39) A513E probably benign Het
Neb T C 2: 52,110,221 (GRCm39) D209G probably damaging Het
Nkapl T A 13: 21,652,457 (GRCm39) Q52L unknown Het
Nptx2 G A 5: 144,483,250 (GRCm39) S126N probably benign Het
Or2a7 G A 6: 43,150,977 (GRCm39) S19N probably benign Het
Or52d3 T A 7: 104,229,268 (GRCm39) Y138* probably null Het
Or7g17 A T 9: 18,768,476 (GRCm39) H185L probably benign Het
Or8b52 A G 9: 38,577,128 (GRCm39) V4A probably benign Het
Pclo A T 5: 14,764,362 (GRCm39) R4278S unknown Het
Pcnx1 T G 12: 81,997,068 (GRCm39) L988R probably damaging Het
Prpf19 T G 19: 10,875,154 (GRCm39) probably benign Het
Ralgapa1 A G 12: 55,759,533 (GRCm39) S997P probably damaging Het
Rangap1 T C 15: 81,597,118 (GRCm39) T226A probably benign Het
Rimklb G A 6: 122,433,365 (GRCm39) L262F probably damaging Het
Rnf169 A G 7: 99,574,930 (GRCm39) M555T probably benign Het
Rp1l1 A T 14: 64,267,519 (GRCm39) D1035V probably benign Het
Rps23rg1 A T 8: 3,633,922 (GRCm39) S8C probably damaging Het
Scd2 T A 19: 44,289,791 (GRCm39) L262Q probably damaging Het
Scgb2b12 T A 7: 32,024,956 (GRCm39) M84L probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Sipa1l1 G A 12: 82,419,160 (GRCm39) V613I possibly damaging Het
Slc25a23 T A 17: 57,359,794 (GRCm39) D67V possibly damaging Het
Slc25a39 C T 11: 102,297,492 (GRCm39) probably benign Het
Slc4a10 T A 2: 62,127,332 (GRCm39) F895Y probably damaging Het
Slc5a4a A C 10: 76,022,398 (GRCm39) K578Q probably benign Het
Slc6a13 G A 6: 121,302,008 (GRCm39) G197S probably damaging Het
Smarca2 A T 19: 26,631,883 (GRCm39) E566V possibly damaging Het
Sorbs3 A T 14: 70,421,548 (GRCm39) N594K probably benign Het
Spata22 A T 11: 73,236,582 (GRCm39) D296V probably damaging Het
Sphk2 G A 7: 45,363,058 (GRCm39) A11V possibly damaging Het
Spp1 A T 5: 104,583,081 (GRCm39) probably benign Het
Strn3 T A 12: 51,656,999 (GRCm39) I760L possibly damaging Het
Syk A T 13: 52,796,022 (GRCm39) Y539F probably benign Het
Tdpoz9-ps1 T C 3: 93,846,093 (GRCm39) probably null Het
Thsd7b T A 1: 130,138,001 (GRCm39) Y1560N probably benign Het
Tmod2 C A 9: 75,504,494 (GRCm39) E42* probably null Het
Tom1l1 T C 11: 90,575,942 (GRCm39) E30G probably damaging Het
Trav10 G A 14: 53,743,518 (GRCm39) A40T probably benign Het
Trav14-2 G A 14: 53,878,237 (GRCm39) probably benign Het
Tril T A 6: 53,795,449 (GRCm39) E591V probably damaging Het
Trp53bp1 T A 2: 121,059,087 (GRCm39) R179* probably null Het
Tspoap1 A T 11: 87,662,489 (GRCm39) D562V possibly damaging Het
Usp44 A T 10: 93,682,768 (GRCm39) H406L probably damaging Het
Vangl1 A G 3: 102,065,608 (GRCm39) I509T probably benign Het
Vax2 T G 6: 83,688,379 (GRCm39) L34W probably damaging Het
Vmn1r55 A T 7: 5,150,025 (GRCm39) C133S probably damaging Het
Vmn2r8 T A 5: 108,949,566 (GRCm39) D427V probably benign Het
Vwde A G 6: 13,205,851 (GRCm39) I232T possibly damaging Het
Wnk1 C A 6: 119,940,431 (GRCm39) A769S probably damaging Het
Xpo4 A C 14: 57,855,638 (GRCm39) S264A probably benign Het
Zfp330 A T 8: 83,496,015 (GRCm39) C75* probably null Het
Zfp526 T A 7: 24,925,064 (GRCm39) L441Q probably benign Het
Zfp607b T G 7: 27,402,930 (GRCm39) L462R probably damaging Het
Zfp719 T A 7: 43,240,217 (GRCm39) F602I probably damaging Het
Other mutations in Prl2c5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00910:Prl2c5 APN 13 13,364,061 (GRCm39) critical splice donor site probably null
IGL01874:Prl2c5 APN 13 13,365,362 (GRCm39) missense probably benign
IGL01878:Prl2c5 APN 13 13,360,402 (GRCm39) missense probably benign 0.00
R0178:Prl2c5 UTSW 13 13,366,390 (GRCm39) missense probably damaging 0.98
R0276:Prl2c5 UTSW 13 13,357,634 (GRCm39) intron probably benign
R0373:Prl2c5 UTSW 13 13,357,609 (GRCm39) intron probably benign
R0539:Prl2c5 UTSW 13 13,363,906 (GRCm39) splice site probably null
R1037:Prl2c5 UTSW 13 13,360,492 (GRCm39) nonsense probably null
R1296:Prl2c5 UTSW 13 13,364,009 (GRCm39) missense probably damaging 1.00
R1458:Prl2c5 UTSW 13 13,365,310 (GRCm39) missense probably benign 0.40
R1557:Prl2c5 UTSW 13 13,365,265 (GRCm39) missense possibly damaging 0.52
R1850:Prl2c5 UTSW 13 13,360,377 (GRCm39) missense probably benign 0.40
R1866:Prl2c5 UTSW 13 13,365,358 (GRCm39) splice site probably null
R1894:Prl2c5 UTSW 13 13,366,263 (GRCm39) missense probably benign 0.04
R2060:Prl2c5 UTSW 13 13,365,238 (GRCm39) missense probably damaging 0.99
R2330:Prl2c5 UTSW 13 13,366,378 (GRCm39) missense possibly damaging 0.67
R5229:Prl2c5 UTSW 13 13,360,441 (GRCm39) missense probably damaging 1.00
R5364:Prl2c5 UTSW 13 13,357,627 (GRCm39) missense probably benign 0.01
R6307:Prl2c5 UTSW 13 13,365,175 (GRCm39) missense probably benign 0.01
R6350:Prl2c5 UTSW 13 13,357,631 (GRCm39) critical splice donor site probably null
R6927:Prl2c5 UTSW 13 13,357,503 (GRCm39) splice site probably null
R7397:Prl2c5 UTSW 13 13,366,327 (GRCm39) missense probably benign 0.01
R7965:Prl2c5 UTSW 13 13,360,469 (GRCm39) missense probably benign 0.01
R8084:Prl2c5 UTSW 13 13,360,539 (GRCm39) missense probably benign 0.20
R8959:Prl2c5 UTSW 13 13,365,392 (GRCm39) intron probably benign
R8980:Prl2c5 UTSW 13 13,360,470 (GRCm39) missense probably benign 0.12
R9258:Prl2c5 UTSW 13 13,365,297 (GRCm39) missense probably damaging 0.97
R9465:Prl2c5 UTSW 13 13,360,531 (GRCm39) missense probably benign 0.42
RF020:Prl2c5 UTSW 13 13,360,497 (GRCm39) missense probably benign 0.28
X0025:Prl2c5 UTSW 13 13,366,339 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TACCACAGAGAAAGGTTAAAGTTGT -3'
(R):5'- TGTCTCTATTTCCCCACATAAATGA -3'

Sequencing Primer
(F):5'- ATCTCCGAGTTTAAGGCCAG -3'
(R):5'- CAAACTCACGCGTATGTG -3'
Posted On 2015-11-11