Incidental Mutation 'R4756:Zfp608'
ID |
358053 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp608
|
Ensembl Gene |
ENSMUSG00000052713 |
Gene Name |
zinc finger protein 608 |
Synonyms |
4932417D18Rik |
MMRRC Submission |
041972-MU
|
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.899)
|
Stock # |
R4756 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
18 |
Chromosomal Location |
55021120-55125627 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 55027544 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamine to Histidine
at position 1424
(Q1424H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000068192
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064763]
|
AlphaFold |
Q56A10 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000064763
AA Change: Q1424H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000068192 Gene: ENSMUSG00000052713 AA Change: Q1424H
Domain | Start | End | E-Value | Type |
low complexity region
|
51 |
61 |
N/A |
INTRINSIC |
low complexity region
|
150 |
184 |
N/A |
INTRINSIC |
low complexity region
|
214 |
234 |
N/A |
INTRINSIC |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
309 |
326 |
N/A |
INTRINSIC |
low complexity region
|
428 |
445 |
N/A |
INTRINSIC |
low complexity region
|
459 |
471 |
N/A |
INTRINSIC |
ZnF_C2H2
|
552 |
577 |
1.86e0 |
SMART |
low complexity region
|
624 |
636 |
N/A |
INTRINSIC |
low complexity region
|
706 |
718 |
N/A |
INTRINSIC |
low complexity region
|
734 |
773 |
N/A |
INTRINSIC |
low complexity region
|
807 |
822 |
N/A |
INTRINSIC |
low complexity region
|
833 |
846 |
N/A |
INTRINSIC |
low complexity region
|
934 |
956 |
N/A |
INTRINSIC |
coiled coil region
|
1028 |
1054 |
N/A |
INTRINSIC |
low complexity region
|
1182 |
1193 |
N/A |
INTRINSIC |
low complexity region
|
1255 |
1268 |
N/A |
INTRINSIC |
low complexity region
|
1439 |
1450 |
N/A |
INTRINSIC |
low complexity region
|
1458 |
1466 |
N/A |
INTRINSIC |
low complexity region
|
1486 |
1502 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 77 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930550C14Rik |
A |
T |
9: 53,336,830 (GRCm39) |
M45L |
probably benign |
Het |
Acss2 |
T |
C |
2: 155,403,063 (GRCm39) |
F627L |
probably damaging |
Het |
Akap8 |
A |
G |
17: 32,535,184 (GRCm39) |
S277P |
probably damaging |
Het |
Akap9 |
T |
A |
5: 4,051,418 (GRCm39) |
M1395K |
probably damaging |
Het |
Ank1 |
A |
G |
8: 23,612,893 (GRCm39) |
D1468G |
probably benign |
Het |
Apoe |
A |
G |
7: 19,430,846 (GRCm39) |
V121A |
probably benign |
Het |
Aqp9 |
A |
T |
9: 71,070,331 (GRCm39) |
L12H |
probably damaging |
Het |
Atp2b4 |
G |
A |
1: 133,639,529 (GRCm39) |
A1115V |
probably benign |
Het |
Atp2b4 |
G |
A |
1: 133,667,134 (GRCm39) |
P139L |
probably benign |
Het |
B430218F22Rik |
T |
C |
13: 118,523,980 (GRCm39) |
|
probably benign |
Het |
Bltp2 |
T |
A |
11: 78,154,854 (GRCm39) |
L122H |
probably damaging |
Het |
Brsk1 |
A |
G |
7: 4,711,866 (GRCm39) |
E572G |
possibly damaging |
Het |
C6 |
T |
C |
15: 4,811,394 (GRCm39) |
I414T |
probably benign |
Het |
C8b |
T |
A |
4: 104,644,083 (GRCm39) |
M250K |
probably benign |
Het |
Camk1g |
T |
A |
1: 193,044,393 (GRCm39) |
E7V |
probably benign |
Het |
Clcc1 |
A |
G |
3: 108,580,236 (GRCm39) |
|
probably null |
Het |
Col4a3 |
G |
T |
1: 82,694,018 (GRCm39) |
|
probably null |
Het |
Cox5b |
T |
A |
1: 36,732,310 (GRCm39) |
W104R |
probably damaging |
Het |
Cyp2c55 |
A |
C |
19: 39,019,815 (GRCm39) |
H251P |
probably damaging |
Het |
Cyp2c67 |
G |
A |
19: 39,632,188 (GRCm39) |
T60I |
probably benign |
Het |
Defb42 |
T |
A |
14: 63,285,824 (GRCm39) |
V68E |
probably benign |
Het |
Ercc4 |
T |
A |
16: 12,941,287 (GRCm39) |
I225N |
probably damaging |
Het |
Fam120b |
G |
T |
17: 15,622,658 (GRCm39) |
C212F |
probably damaging |
Het |
Fgf10 |
T |
C |
13: 118,918,045 (GRCm39) |
V111A |
probably benign |
Het |
Fn1 |
G |
T |
1: 71,629,967 (GRCm39) |
T2186K |
probably damaging |
Het |
Fras1 |
T |
C |
5: 96,929,518 (GRCm39) |
V3974A |
probably benign |
Het |
Galnt4 |
T |
C |
10: 98,944,362 (GRCm39) |
V29A |
probably benign |
Het |
Gpr26 |
T |
C |
7: 131,569,230 (GRCm39) |
Y192H |
probably damaging |
Het |
Heatr9 |
A |
T |
11: 83,407,475 (GRCm39) |
L236Q |
probably damaging |
Het |
Hivep3 |
C |
A |
4: 119,955,020 (GRCm39) |
P1112H |
probably damaging |
Het |
Hnf4g |
A |
G |
3: 3,708,069 (GRCm39) |
Y106C |
possibly damaging |
Het |
Hnrnpdl |
A |
T |
5: 100,185,783 (GRCm39) |
Y69* |
probably null |
Het |
Itgb1 |
G |
A |
8: 129,443,703 (GRCm39) |
A320T |
probably damaging |
Het |
Kcna2 |
T |
C |
3: 107,012,733 (GRCm39) |
I438T |
probably benign |
Het |
Kif24 |
A |
G |
4: 41,397,545 (GRCm39) |
|
probably null |
Het |
Klhl1 |
G |
A |
14: 96,389,402 (GRCm39) |
T584I |
probably benign |
Het |
Ltbp1 |
A |
G |
17: 75,532,199 (GRCm39) |
D91G |
probably damaging |
Het |
Mdga2 |
T |
C |
12: 66,844,427 (GRCm39) |
I190M |
probably damaging |
Het |
Meis2 |
G |
A |
2: 115,830,686 (GRCm39) |
R276C |
probably damaging |
Het |
Mob4 |
C |
T |
1: 55,191,855 (GRCm39) |
R190W |
probably damaging |
Het |
Mrgpra2a |
A |
G |
7: 47,077,114 (GRCm39) |
I48T |
possibly damaging |
Het |
Mst1 |
T |
C |
9: 107,960,826 (GRCm39) |
V481A |
probably benign |
Het |
Mttp |
A |
T |
3: 137,821,832 (GRCm39) |
V245E |
possibly damaging |
Het |
Nbn |
T |
A |
4: 15,981,470 (GRCm39) |
S521T |
probably benign |
Het |
Neb |
G |
T |
2: 52,083,243 (GRCm39) |
T5654N |
probably damaging |
Het |
Nlrp9a |
A |
T |
7: 26,256,866 (GRCm39) |
K161N |
probably damaging |
Het |
Nod2 |
T |
G |
8: 89,390,902 (GRCm39) |
F388C |
possibly damaging |
Het |
Or3a1 |
G |
T |
11: 74,225,402 (GRCm39) |
F218L |
probably benign |
Het |
Or4a75 |
G |
T |
2: 89,447,814 (GRCm39) |
H241N |
possibly damaging |
Het |
Or4f58 |
A |
G |
2: 111,851,332 (GRCm39) |
F289S |
possibly damaging |
Het |
Or52e2 |
A |
T |
7: 102,804,332 (GRCm39) |
N207K |
probably benign |
Het |
Or7a38 |
T |
A |
10: 78,753,361 (GRCm39) |
I229N |
probably damaging |
Het |
Or7g25 |
G |
A |
9: 19,160,153 (GRCm39) |
L181F |
possibly damaging |
Het |
P2ry1 |
A |
G |
3: 60,911,898 (GRCm39) |
S346G |
probably benign |
Het |
Polr1f |
T |
A |
12: 33,487,679 (GRCm39) |
|
probably null |
Het |
Prkcd |
A |
G |
14: 30,321,623 (GRCm39) |
F524L |
probably benign |
Het |
Qrfprl |
T |
C |
6: 65,429,898 (GRCm39) |
I198T |
probably benign |
Het |
Ramp3 |
A |
T |
11: 6,624,843 (GRCm39) |
M46L |
probably benign |
Het |
Rint1 |
T |
C |
5: 24,014,791 (GRCm39) |
Y278H |
probably damaging |
Het |
Skint11 |
C |
T |
4: 114,051,874 (GRCm39) |
T74I |
probably benign |
Het |
Slc10a7 |
T |
C |
8: 79,433,579 (GRCm39) |
|
probably null |
Het |
Slc45a2 |
T |
A |
15: 11,028,016 (GRCm39) |
Y528* |
probably null |
Het |
Slit1 |
A |
G |
19: 41,637,452 (GRCm39) |
F329L |
probably damaging |
Het |
Sltm |
A |
T |
9: 70,498,892 (GRCm39) |
M989L |
possibly damaging |
Het |
Smad9 |
A |
T |
3: 54,701,874 (GRCm39) |
T372S |
possibly damaging |
Het |
Snrpc |
T |
A |
17: 28,061,306 (GRCm39) |
Y38* |
probably null |
Het |
Spag17 |
A |
G |
3: 100,010,701 (GRCm39) |
K2065R |
possibly damaging |
Het |
Stxbp4 |
T |
A |
11: 90,498,197 (GRCm39) |
K87N |
probably damaging |
Het |
Tbc1d23 |
AT |
ATT |
16: 57,019,258 (GRCm39) |
|
probably null |
Het |
Tgfb1i1 |
A |
T |
7: 127,848,571 (GRCm39) |
M96L |
probably damaging |
Het |
Tnc |
T |
A |
4: 63,885,580 (GRCm39) |
I1841F |
probably damaging |
Het |
Ubap2 |
G |
T |
4: 41,211,771 (GRCm39) |
H63Q |
probably damaging |
Het |
Vps13a |
T |
C |
19: 16,632,580 (GRCm39) |
N2592S |
probably benign |
Het |
Xdh |
G |
A |
17: 74,193,381 (GRCm39) |
P1305L |
probably benign |
Het |
Xrn1 |
G |
A |
9: 95,921,862 (GRCm39) |
R1425K |
probably benign |
Het |
Zfp418 |
G |
A |
7: 7,185,762 (GRCm39) |
R575Q |
possibly damaging |
Het |
Zfp839 |
C |
A |
12: 110,821,635 (GRCm39) |
L150I |
possibly damaging |
Het |
|
Other mutations in Zfp608 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00500:Zfp608
|
APN |
18 |
55,121,405 (GRCm39) |
missense |
probably benign |
|
IGL00920:Zfp608
|
APN |
18 |
55,022,903 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01088:Zfp608
|
APN |
18 |
55,031,159 (GRCm39) |
missense |
probably benign |
0.03 |
IGL01447:Zfp608
|
APN |
18 |
55,032,083 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL01534:Zfp608
|
APN |
18 |
55,032,004 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01547:Zfp608
|
APN |
18 |
55,027,521 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01933:Zfp608
|
APN |
18 |
55,120,871 (GRCm39) |
missense |
probably benign |
|
IGL01998:Zfp608
|
APN |
18 |
55,024,890 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02167:Zfp608
|
APN |
18 |
55,121,296 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02266:Zfp608
|
APN |
18 |
55,030,653 (GRCm39) |
missense |
probably benign |
0.08 |
IGL02335:Zfp608
|
APN |
18 |
55,030,509 (GRCm39) |
nonsense |
probably null |
|
IGL02455:Zfp608
|
APN |
18 |
55,032,405 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02612:Zfp608
|
APN |
18 |
55,031,273 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02900:Zfp608
|
APN |
18 |
55,079,865 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4243001:Zfp608
|
UTSW |
18 |
55,031,096 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4519001:Zfp608
|
UTSW |
18 |
55,079,783 (GRCm39) |
missense |
possibly damaging |
0.71 |
R0005:Zfp608
|
UTSW |
18 |
55,028,592 (GRCm39) |
missense |
possibly damaging |
0.88 |
R0010:Zfp608
|
UTSW |
18 |
55,028,286 (GRCm39) |
splice site |
probably benign |
|
R0010:Zfp608
|
UTSW |
18 |
55,028,286 (GRCm39) |
splice site |
probably benign |
|
R0064:Zfp608
|
UTSW |
18 |
55,031,888 (GRCm39) |
missense |
probably benign |
|
R0401:Zfp608
|
UTSW |
18 |
55,032,066 (GRCm39) |
missense |
probably benign |
|
R0722:Zfp608
|
UTSW |
18 |
55,033,306 (GRCm39) |
missense |
probably damaging |
1.00 |
R1351:Zfp608
|
UTSW |
18 |
55,031,463 (GRCm39) |
missense |
probably benign |
0.00 |
R1512:Zfp608
|
UTSW |
18 |
55,079,738 (GRCm39) |
missense |
probably damaging |
1.00 |
R1554:Zfp608
|
UTSW |
18 |
55,031,126 (GRCm39) |
missense |
probably damaging |
1.00 |
R1622:Zfp608
|
UTSW |
18 |
55,121,366 (GRCm39) |
missense |
probably benign |
0.07 |
R1669:Zfp608
|
UTSW |
18 |
55,120,811 (GRCm39) |
missense |
probably benign |
0.09 |
R1690:Zfp608
|
UTSW |
18 |
55,120,706 (GRCm39) |
missense |
possibly damaging |
0.62 |
R1721:Zfp608
|
UTSW |
18 |
55,032,321 (GRCm39) |
missense |
probably benign |
|
R1826:Zfp608
|
UTSW |
18 |
55,031,648 (GRCm39) |
missense |
probably benign |
0.03 |
R1864:Zfp608
|
UTSW |
18 |
55,030,983 (GRCm39) |
missense |
probably benign |
0.00 |
R1952:Zfp608
|
UTSW |
18 |
55,030,851 (GRCm39) |
nonsense |
probably null |
|
R2049:Zfp608
|
UTSW |
18 |
55,028,637 (GRCm39) |
missense |
probably damaging |
1.00 |
R2051:Zfp608
|
UTSW |
18 |
55,121,386 (GRCm39) |
missense |
probably benign |
|
R2168:Zfp608
|
UTSW |
18 |
55,031,125 (GRCm39) |
nonsense |
probably null |
|
R2218:Zfp608
|
UTSW |
18 |
55,120,756 (GRCm39) |
missense |
probably benign |
0.14 |
R2283:Zfp608
|
UTSW |
18 |
55,121,446 (GRCm39) |
missense |
probably damaging |
1.00 |
R2399:Zfp608
|
UTSW |
18 |
55,030,974 (GRCm39) |
missense |
probably damaging |
1.00 |
R2520:Zfp608
|
UTSW |
18 |
55,121,578 (GRCm39) |
missense |
possibly damaging |
0.92 |
R2961:Zfp608
|
UTSW |
18 |
55,031,544 (GRCm39) |
missense |
possibly damaging |
0.60 |
R4074:Zfp608
|
UTSW |
18 |
55,031,180 (GRCm39) |
missense |
probably damaging |
1.00 |
R4076:Zfp608
|
UTSW |
18 |
55,031,180 (GRCm39) |
missense |
probably damaging |
1.00 |
R4206:Zfp608
|
UTSW |
18 |
55,121,267 (GRCm39) |
missense |
probably damaging |
1.00 |
R4771:Zfp608
|
UTSW |
18 |
55,121,372 (GRCm39) |
missense |
probably benign |
|
R4820:Zfp608
|
UTSW |
18 |
55,120,756 (GRCm39) |
missense |
probably benign |
0.14 |
R4825:Zfp608
|
UTSW |
18 |
55,031,041 (GRCm39) |
missense |
probably benign |
0.01 |
R4912:Zfp608
|
UTSW |
18 |
55,079,663 (GRCm39) |
missense |
probably damaging |
1.00 |
R4975:Zfp608
|
UTSW |
18 |
55,022,962 (GRCm39) |
missense |
probably damaging |
1.00 |
R5138:Zfp608
|
UTSW |
18 |
55,024,871 (GRCm39) |
missense |
probably damaging |
1.00 |
R5192:Zfp608
|
UTSW |
18 |
55,031,569 (GRCm39) |
missense |
probably damaging |
1.00 |
R5557:Zfp608
|
UTSW |
18 |
55,120,942 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5624:Zfp608
|
UTSW |
18 |
55,031,344 (GRCm39) |
missense |
probably damaging |
1.00 |
R5818:Zfp608
|
UTSW |
18 |
55,028,468 (GRCm39) |
missense |
probably benign |
0.02 |
R5840:Zfp608
|
UTSW |
18 |
55,031,978 (GRCm39) |
missense |
probably damaging |
1.00 |
R5992:Zfp608
|
UTSW |
18 |
55,032,320 (GRCm39) |
missense |
probably benign |
0.15 |
R6106:Zfp608
|
UTSW |
18 |
55,120,944 (GRCm39) |
missense |
possibly damaging |
0.54 |
R6174:Zfp608
|
UTSW |
18 |
55,121,616 (GRCm39) |
start gained |
probably benign |
|
R6181:Zfp608
|
UTSW |
18 |
55,028,700 (GRCm39) |
missense |
possibly damaging |
0.56 |
R6517:Zfp608
|
UTSW |
18 |
55,032,150 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6567:Zfp608
|
UTSW |
18 |
55,030,628 (GRCm39) |
missense |
probably damaging |
1.00 |
R6668:Zfp608
|
UTSW |
18 |
55,031,091 (GRCm39) |
missense |
probably damaging |
1.00 |
R6920:Zfp608
|
UTSW |
18 |
55,121,337 (GRCm39) |
missense |
probably damaging |
1.00 |
R7061:Zfp608
|
UTSW |
18 |
55,121,069 (GRCm39) |
missense |
probably benign |
|
R7074:Zfp608
|
UTSW |
18 |
55,030,454 (GRCm39) |
missense |
possibly damaging |
0.69 |
R7087:Zfp608
|
UTSW |
18 |
55,032,469 (GRCm39) |
missense |
probably damaging |
1.00 |
R7391:Zfp608
|
UTSW |
18 |
55,030,619 (GRCm39) |
missense |
possibly damaging |
0.49 |
R7600:Zfp608
|
UTSW |
18 |
55,121,092 (GRCm39) |
missense |
probably damaging |
1.00 |
R7723:Zfp608
|
UTSW |
18 |
55,030,673 (GRCm39) |
missense |
probably damaging |
1.00 |
R8054:Zfp608
|
UTSW |
18 |
55,032,618 (GRCm39) |
missense |
probably benign |
0.28 |
R8236:Zfp608
|
UTSW |
18 |
55,032,281 (GRCm39) |
missense |
probably damaging |
1.00 |
R8260:Zfp608
|
UTSW |
18 |
55,030,821 (GRCm39) |
missense |
possibly damaging |
0.60 |
R8732:Zfp608
|
UTSW |
18 |
55,121,072 (GRCm39) |
missense |
probably benign |
0.06 |
R8781:Zfp608
|
UTSW |
18 |
55,031,801 (GRCm39) |
missense |
probably damaging |
1.00 |
R8851:Zfp608
|
UTSW |
18 |
55,032,194 (GRCm39) |
missense |
possibly damaging |
0.94 |
R8940:Zfp608
|
UTSW |
18 |
55,033,301 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9051:Zfp608
|
UTSW |
18 |
55,032,266 (GRCm39) |
missense |
probably damaging |
1.00 |
R9091:Zfp608
|
UTSW |
18 |
55,032,190 (GRCm39) |
missense |
probably damaging |
1.00 |
R9092:Zfp608
|
UTSW |
18 |
55,031,648 (GRCm39) |
missense |
probably benign |
0.03 |
R9236:Zfp608
|
UTSW |
18 |
55,032,354 (GRCm39) |
missense |
probably benign |
0.39 |
R9270:Zfp608
|
UTSW |
18 |
55,032,190 (GRCm39) |
missense |
probably damaging |
1.00 |
R9283:Zfp608
|
UTSW |
18 |
55,030,913 (GRCm39) |
missense |
possibly damaging |
0.50 |
R9288:Zfp608
|
UTSW |
18 |
55,033,341 (GRCm39) |
missense |
probably benign |
0.39 |
R9463:Zfp608
|
UTSW |
18 |
55,030,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CGTTCCCACAAAGGCTTCAATG -3'
(R):5'- GATGTATCCTGTAACATGATGTGAC -3'
Sequencing Primer
(F):5'- TGTGTGACCACATCTTATATTTCAAG -3'
(R):5'- CCTGTAACATGATGTGACATTTGTTG -3'
|
Posted On |
2015-11-11 |