Mutagenetix > Incidental Mutation

Incidental Mutation 'R4741:Oog2'

358068

Institutional Source

Beutler Lab

Gene Symbol

Oog2

Ensembl Gene

ENSMUSG00000066030

Gene Name

oogenesin 2

Synonyms

MMRRC Submission

042026-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4741 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

144190719-144196934 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 144195145 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 208 (E208D)

Ref Sequence

ENSEMBL: ENSMUSP00000079267 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080405] [ENSMUST00000143978]

AlphaFold

Q7TPX8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000080405
AA Change: E208D

PolyPhen 2 Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000079267
Gene: ENSMUSG00000066030
AA Change: E208D

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	204	391	2e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129781

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141847

Predicted Effect

probably benign
Transcript: ENSMUST00000143978

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	A	G	3: 36,942,375	T1079A	probably damaging	Het
Angptl2	T	C	2: 33,246,188	Y462H	probably benign	Het
Arhgef12	A	G	9: 42,972,153	I1360T	possibly damaging	Het
Armc10	T	G	5: 21,651,836	L111R	probably damaging	Het
Atm	T	C	9: 53,453,607	K2628E	probably benign	Het
Best3	A	T	10: 117,023,996	N387I	probably benign	Het
Brpf3	T	C	17: 28,817,784	F721S	possibly damaging	Het
Cacna1c	A	G	6: 118,613,310	S1411P	probably damaging	Het
Cldn8	G	A	16: 88,562,408	H210Y	probably benign	Het
Clip2	T	A	5: 134,516,269	T344S	probably benign	Het
Csmd1	A	C	8: 15,910,447	W3323G	probably damaging	Het
Doc2a	A	T	7: 126,851,445	T298S	possibly damaging	Het
Dpp9	T	C	17: 56,205,286	N234S	probably benign	Het
Dtx2	C	T	5: 136,026,517	R353C	probably benign	Het
Epm2aip1	A	G	9: 111,272,613	H218R	probably benign	Het
F2rl1	G	A	13: 95,514,143	T77M	probably damaging	Het
Fsd2	A	G	7: 81,551,895		probably null	Het
Grin2a	T	C	16: 9,663,512	Y475C	probably damaging	Het
H2-Ob	T	A	17: 34,242,571	S95T	possibly damaging	Het
Hddc3	A	G	7: 80,345,716	T160A	probably benign	Het
Hp	A	T	8: 109,575,472	C281*	probably null	Het
Ighg1	T	C	12: 113,326,558		probably benign	Het
Ints7	A	G	1: 191,619,635	I819V	probably benign	Het
Jam2	G	A	16: 84,812,952	V151M	probably damaging	Het
Jmjd1c	A	G	10: 67,224,939	I737V	possibly damaging	Het
Krt74	C	T	15: 101,761,441		noncoding transcript	Het
Lnpep	T	C	17: 17,571,658	Y407C	probably damaging	Het
Lrp4	T	G	2: 91,511,567	C1842G	probably damaging	Het
Mug2	T	A	6: 122,079,613	N1172K	probably benign	Het
Npy6r	A	T	18: 44,275,724	T71S	probably damaging	Het
Nsd3	A	T	8: 25,673,366	I591F	probably damaging	Het
Otogl	A	G	10: 107,779,260	I1928T	probably benign	Het
Papss1	T	C	3: 131,619,099	L418P	probably damaging	Het
Pcdhb13	T	A	18: 37,443,518	D316E	probably benign	Het
Pcdhgb2	T	A	18: 37,691,684		probably null	Het
Ptcd3	T	A	6: 71,902,949	L108F	probably damaging	Het
Ralgps1	T	C	2: 33,336,587	S31G	probably benign	Het
Rnf225	A	T	7: 12,927,930	H12L	probably benign	Het
Ryr3	T	A	2: 112,803,268	M2047L	probably damaging	Het
Secisbp2l	C	T	2: 125,740,737	G933D	possibly damaging	Het
Serpinb3b	G	T	1: 107,154,470	Q355K	probably benign	Het
Slc8a2	T	A	7: 16,134,308	F155Y	probably damaging	Het
Taf1c	A	G	8: 119,603,395		probably benign	Het
Tln2	A	G	9: 67,386,555		probably null	Het
Tmpo	A	G	10: 91,162,644	V427A	probably benign	Het
Vmn1r17	A	T	6: 57,361,352	Y9*	probably null	Het
Vmn2r63	C	T	7: 42,928,120	M331I	probably benign	Het
Zdhhc1	CGGGGG	CGGGGGG	8: 105,483,744		probably null	Het
Zfand5	C	T	19: 21,276,481	T16I	probably damaging	Het
Zfp352	A	T	4: 90,224,940	K439M	possibly damaging	Het
Zfp786	G	A	6: 47,820,691	H438Y	probably damaging	Het
Zfp808	T	A	13: 62,171,949	C331S	probably damaging	Het

Other mutations in Oog2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00843:Oog2	APN	4	144195172	missense	probably damaging	1.00
IGL01317:Oog2	APN	4	144195267	missense	probably benign	0.16
IGL01697:Oog2	APN	4	144195184	missense	possibly damaging	0.90
IGL02237:Oog2	APN	4	144196446	missense	possibly damaging	0.95
IGL02411:Oog2	APN	4	144195048	missense	probably damaging	0.99
IGL02476:Oog2	APN	4	144195229	missense	probably benign	0.02
IGL03284:Oog2	APN	4	144196607	unclassified	probably benign
IGL03394:Oog2	APN	4	144194006	missense	probably benign	0.17
R0538:Oog2	UTSW	4	144196084	nonsense	probably null
R0892:Oog2	UTSW	4	144196499	missense	probably benign	0.00
R1024:Oog2	UTSW	4	144196286	missense	probably damaging	1.00
R4156:Oog2	UTSW	4	144193953	intron	probably benign
R4157:Oog2	UTSW	4	144193953	intron	probably benign
R4166:Oog2	UTSW	4	144194841	missense	probably damaging	1.00
R4167:Oog2	UTSW	4	144196212	missense	probably benign	0.18
R4732:Oog2	UTSW	4	144193941	intron	probably benign
R4734:Oog2	UTSW	4	144196451	missense	probably benign	0.00
R4909:Oog2	UTSW	4	144195099	missense	possibly damaging	0.78
R4954:Oog2	UTSW	4	144190732	start gained	probably benign
R6437:Oog2	UTSW	4	144195108	splice site	probably null
R6487:Oog2	UTSW	4	144196485	missense	possibly damaging	0.48
R6946:Oog2	UTSW	4	144196464	missense	possibly damaging	0.95
R7000:Oog2	UTSW	4	144195327	missense	probably damaging	1.00
R7167:Oog2	UTSW	4	144195175	missense	probably benign	0.04
R7303:Oog2	UTSW	4	144195342	missense	probably benign	0.04
R7399:Oog2	UTSW	4	144195281	missense	probably benign	0.01
R8004:Oog2	UTSW	4	144194251	missense	probably benign	0.00
R8141:Oog2	UTSW	4	144194207	missense	probably damaging	0.97
R8411:Oog2	UTSW	4	144194173	missense	probably damaging	1.00
R8932:Oog2	UTSW	4	144194115	missense	probably benign	0.00
R9290:Oog2	UTSW	4	144196445	missense	probably benign	0.02
R9348:Oog2	UTSW	4	144195219	missense	probably damaging	1.00
R9614:Oog2	UTSW	4	144196137	missense	probably damaging	1.00
RF009:Oog2	UTSW	4	144195285	missense	probably benign	0.36
Z1177:Oog2	UTSW	4	144194015	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- AGCCAGTTGAGAATAGTCCTGG -3'
(R):5'- CATAGAGTTCCTGGAGATGGTG -3'

Sequencing Primer
(F):5'- CCAGTTGAGAATAGTCCTGGCTATG -3'
(R):5'- ATAGAGTTCCTGGAGATGGTGGAATG -3'

Posted On

2015-11-11