Mutagenetix > Incidental Mutation

Incidental Mutation 'R4741:Zdhhc1'

358085

Institutional Source

Beutler Lab

Gene Symbol

Zdhhc1

Ensembl Gene

ENSMUSG00000039199

Gene Name

zinc finger, DHHC domain containing 1

Synonyms

4432412D04Rik

MMRRC Submission

042026-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4741 (G1)

Quality Score

111

Status

Not validated

Chromosome

Chromosomal Location

106199055-106223534 bp(-) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

CGGGGG to CGGGGGG at 106210376 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000148381 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044286] [ENSMUST00000212303]

AlphaFold

Q8R0N9

Predicted Effect

probably null
Transcript: ENSMUST00000044286
AA Change: 13

SMART Domains

Protein: ENSMUSP00000036471
Gene: ENSMUSG00000039199
AA Change: 13

Domain	Start	End	E-Value	Type
transmembrane domain	49	71	N/A	INTRINSIC
transmembrane domain	78	100	N/A	INTRINSIC
Pfam:zf-DHHC	126	282	2.5e-38	PFAM
low complexity region	359	371	N/A	INTRINSIC
low complexity region	383	392	N/A	INTRINSIC
low complexity region	395	411	N/A	INTRINSIC
low complexity region	414	426	N/A	INTRINSIC
low complexity region	468	482	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212109

Predicted Effect

probably null
Transcript: ENSMUST00000212303

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212538

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Angptl2	T	C	2: 33,136,200 (GRCm39)	Y462H	probably benign	Het
Arhgef12	A	G	9: 42,883,449 (GRCm39)	I1360T	possibly damaging	Het
Armc10	T	G	5: 21,856,834 (GRCm39)	L111R	probably damaging	Het
Atm	T	C	9: 53,364,907 (GRCm39)	K2628E	probably benign	Het
Best3	A	T	10: 116,859,901 (GRCm39)	N387I	probably benign	Het
Bltp1	A	G	3: 36,996,524 (GRCm39)	T1079A	probably damaging	Het
Brpf3	T	C	17: 29,036,758 (GRCm39)	F721S	possibly damaging	Het
Cacna1c	A	G	6: 118,590,271 (GRCm39)	S1411P	probably damaging	Het
Cldn8	G	A	16: 88,359,296 (GRCm39)	H210Y	probably benign	Het
Clip2	T	A	5: 134,545,123 (GRCm39)	T344S	probably benign	Het
Csmd1	A	C	8: 15,960,447 (GRCm39)	W3323G	probably damaging	Het
Doc2a	A	T	7: 126,450,617 (GRCm39)	T298S	possibly damaging	Het
Dpp9	T	C	17: 56,512,286 (GRCm39)	N234S	probably benign	Het
Dtx2	C	T	5: 136,055,371 (GRCm39)	R353C	probably benign	Het
Epm2aip1	A	G	9: 111,101,681 (GRCm39)	H218R	probably benign	Het
F2rl1	G	A	13: 95,650,651 (GRCm39)	T77M	probably damaging	Het
Fsd2	A	G	7: 81,201,643 (GRCm39)		probably null	Het
Grin2a	T	C	16: 9,481,376 (GRCm39)	Y475C	probably damaging	Het
H2-Ob	T	A	17: 34,461,545 (GRCm39)	S95T	possibly damaging	Het
Hddc3	A	G	7: 79,995,464 (GRCm39)	T160A	probably benign	Het
Hp	A	T	8: 110,302,104 (GRCm39)	C281*	probably null	Het
Ighg1	T	C	12: 113,290,178 (GRCm39)		probably benign	Het
Ints7	A	G	1: 191,351,747 (GRCm39)	I819V	probably benign	Het
Jam2	G	A	16: 84,609,840 (GRCm39)	V151M	probably damaging	Het
Jmjd1c	A	G	10: 67,060,718 (GRCm39)	I737V	possibly damaging	Het
Krt74	C	T	15: 101,669,876 (GRCm39)		noncoding transcript	Het
Lnpep	T	C	17: 17,791,920 (GRCm39)	Y407C	probably damaging	Het
Lrp4	T	G	2: 91,341,912 (GRCm39)	C1842G	probably damaging	Het
Mug2	T	A	6: 122,056,572 (GRCm39)	N1172K	probably benign	Het
Npy6r	A	T	18: 44,408,791 (GRCm39)	T71S	probably damaging	Het
Nsd3	A	T	8: 26,163,382 (GRCm39)	I591F	probably damaging	Het
Oog2	A	C	4: 143,921,715 (GRCm39)	E208D	possibly damaging	Het
Otogl	A	G	10: 107,615,121 (GRCm39)	I1928T	probably benign	Het
Papss1	T	C	3: 131,324,860 (GRCm39)	L418P	probably damaging	Het
Pcdhb13	T	A	18: 37,576,571 (GRCm39)	D316E	probably benign	Het
Pcdhgb2	T	A	18: 37,824,737 (GRCm39)		probably null	Het
Ptcd3	T	A	6: 71,879,933 (GRCm39)	L108F	probably damaging	Het
Ralgps1	T	C	2: 33,226,599 (GRCm39)	S31G	probably benign	Het
Rnf225	A	T	7: 12,661,857 (GRCm39)	H12L	probably benign	Het
Ryr3	T	A	2: 112,633,613 (GRCm39)	M2047L	probably damaging	Het
Secisbp2l	C	T	2: 125,582,657 (GRCm39)	G933D	possibly damaging	Het
Serpinb3b	G	T	1: 107,082,200 (GRCm39)	Q355K	probably benign	Het
Slc8a2	T	A	7: 15,868,233 (GRCm39)	F155Y	probably damaging	Het
Taf1c	A	G	8: 120,330,134 (GRCm39)		probably benign	Het
Tln2	A	G	9: 67,293,837 (GRCm39)		probably null	Het
Tmpo	A	G	10: 90,998,506 (GRCm39)	V427A	probably benign	Het
Vmn1r17	A	T	6: 57,338,337 (GRCm39)	Y9*	probably null	Het
Vmn2r63	C	T	7: 42,577,544 (GRCm39)	M331I	probably benign	Het
Zfand5	C	T	19: 21,253,845 (GRCm39)	T16I	probably damaging	Het
Zfp352	A	T	4: 90,113,177 (GRCm39)	K439M	possibly damaging	Het
Zfp786	G	A	6: 47,797,625 (GRCm39)	H438Y	probably damaging	Het
Zfp808	T	A	13: 62,319,763 (GRCm39)	C331S	probably damaging	Het

Other mutations in Zdhhc1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01315:Zdhhc1	APN	8	106,199,630 (GRCm39)	missense	probably benign
hacked	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
middleman	UTSW	8	106,210,279 (GRCm39)	missense	probably damaging	1.00
R0329:Zdhhc1	UTSW	8	106,210,175 (GRCm39)	missense	probably benign	0.04
R1898:Zdhhc1	UTSW	8	106,205,378 (GRCm39)	splice site	probably null
R2511:Zdhhc1	UTSW	8	106,210,190 (GRCm39)	missense	probably benign	0.16
R4734:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R4795:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R4818:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R4819:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R4822:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R4871:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R4891:Zdhhc1	UTSW	8	106,199,649 (GRCm39)	missense	probably benign	0.00
R4901:Zdhhc1	UTSW	8	106,199,484 (GRCm39)	missense	probably benign
R4905:Zdhhc1	UTSW	8	106,210,326 (GRCm39)	missense	probably damaging	0.98
R4953:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R5128:Zdhhc1	UTSW	8	106,210,268 (GRCm39)	missense	probably benign	0.02
R5274:Zdhhc1	UTSW	8	106,210,402 (GRCm39)	missense	probably benign	0.30
R5380:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R5381:Zdhhc1	UTSW	8	106,210,376 (GRCm39)	frame shift	probably null
R6852:Zdhhc1	UTSW	8	106,203,704 (GRCm39)	missense	possibly damaging	0.70
R6962:Zdhhc1	UTSW	8	106,210,279 (GRCm39)	missense	probably damaging	1.00
R7990:Zdhhc1	UTSW	8	106,203,001 (GRCm39)	critical splice donor site	probably null
R8836:Zdhhc1	UTSW	8	106,200,173 (GRCm39)	missense	probably benign	0.43
R9047:Zdhhc1	UTSW	8	106,205,533 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AAGGATACAGCATAGCCAGC -3'
(R):5'- TTTAATTAGGCTAAGACCCCAGG -3'

Sequencing Primer
(F):5'- CCCAGTGGTGAGGCAAG -3'
(R):5'- ATTAGGCTAAGACCCCAGGTTTCC -3'

Posted On

2015-11-11