Mutagenetix > Incidental Mutation

Incidental Mutation 'R4743:Gm9755'

358181

Institutional Source

Beutler Lab

Gene Symbol

Gm9755

Ensembl Gene

ENSMUSG00000030735

Gene Name

predicted pseudogene 9755

Synonyms

MMRRC Submission

041967-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.923) question?

Stock #

R4743 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

67966887-67968242 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

A to T at 67966929 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000032981

SMART Domains

Protein: ENSMUSP00000091180
Gene: ENSMUSG00000030735

Domain	Start	End	E-Value	Type
Pfam:GTP_EFTU	55	249	1.4e-55	PFAM
Pfam:GTP_EFTU_D2	272	341	4.8e-17	PFAM
Pfam:GTP_EFTU_D3	345	440	1.5e-25	PFAM

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.3%

Validation Efficiency

98% (44/45)

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933407L21Rik	A	G	1: 85,858,972 (GRCm39)		probably benign	Het
Ahcy	T	C	2: 154,910,888 (GRCm39)	N27D	probably damaging	Het
Akap9	T	G	5: 4,011,013 (GRCm39)	L572R	probably damaging	Het
Akna	A	G	4: 63,296,850 (GRCm39)	S909P	probably damaging	Het
Atr	A	G	9: 95,744,845 (GRCm39)	E54G	probably benign	Het
Baz2b	A	G	2: 59,744,255 (GRCm39)	S1417P	probably benign	Het
Colgalt2	A	G	1: 152,276,094 (GRCm39)	Y69C	probably damaging	Het
Comp	A	G	8: 70,828,711 (GRCm39)	E181G	probably damaging	Het
Dcaf10	T	A	4: 45,370,409 (GRCm39)	S326T	probably damaging	Het
Dscam	T	C	16: 96,631,256 (GRCm39)	E253G	probably benign	Het
Dysf	C	A	6: 84,074,697 (GRCm39)	D499E	probably damaging	Het
Epha1	G	T	6: 42,349,155 (GRCm39)	T36K	probably benign	Het
Ewsr1	A	T	11: 5,033,541 (GRCm39)	D210E	unknown	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Fndc1	T	A	17: 7,991,111 (GRCm39)	R862*	probably null	Het
Gbp8	T	C	5: 105,178,707 (GRCm39)	K203E	possibly damaging	Het
Gigyf2	T	A	1: 87,292,970 (GRCm39)	L79*	probably null	Het
Gm8220	T	A	14: 44,523,152 (GRCm39)		probably benign	Het
Il6	T	C	5: 30,223,042 (GRCm39)	Y120H	probably damaging	Het
Kcnma1	T	C	14: 23,853,270 (GRCm39)	T2A	probably damaging	Het
Mroh9	T	C	1: 162,852,061 (GRCm39)	Y876C	probably benign	Het
Plekhh2	A	G	17: 84,878,548 (GRCm39)	Y601C	probably damaging	Het
Rabgap1l	G	T	1: 160,281,353 (GRCm39)	Q623K	probably damaging	Het
Rad9a	G	A	19: 4,250,560 (GRCm39)	R85C	probably damaging	Het
Rapgef2	T	C	3: 79,080,375 (GRCm39)	Y109C	probably damaging	Het
Rhox2c	A	C	X: 36,635,351 (GRCm39)	Q4H	probably benign	Het
Rlig1	T	C	10: 100,414,243 (GRCm39)	I139V	probably benign	Het
Slain2	T	A	5: 73,114,927 (GRCm39)	L386*	probably null	Het
Slc4a7	A	G	14: 14,796,073 (GRCm38)		probably null	Het
Slco1c1	T	C	6: 141,510,242 (GRCm39)	C582R	probably damaging	Het
Sulf1	A	G	1: 12,906,517 (GRCm39)	N520D	probably benign	Het
Tbc1d7	A	G	13: 43,323,325 (GRCm39)	V22A	probably damaging	Het
Tmprss6	A	G	15: 78,327,910 (GRCm39)	V612A	probably damaging	Het
Trpv2	A	G	11: 62,483,627 (GRCm39)	E488G	probably benign	Het
Ttn	T	A	2: 76,585,168 (GRCm39)	I22042F	probably damaging	Het
Uspl1	A	G	5: 149,146,566 (GRCm39)	Y439C	probably damaging	Het
Vwf	A	G	6: 125,661,054 (GRCm39)		probably null	Het

Other mutations in Gm9755

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01655:Gm9755	APN	8	67,967,885 (GRCm39)	exon	noncoding transcript
IGL03217:Gm9755	APN	8	67,967,035 (GRCm39)	exon	noncoding transcript
IGL03229:Gm9755	APN	8	67,967,324 (GRCm39)	exon	noncoding transcript
R1110:Gm9755	UTSW	8	67,967,710 (GRCm39)	exon	noncoding transcript
R1630:Gm9755	UTSW	8	67,967,312 (GRCm39)	exon	noncoding transcript
R4257:Gm9755	UTSW	8	67,967,129 (GRCm39)	exon	noncoding transcript
R5960:Gm9755	UTSW	8	67,967,840 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- TGTCCACAGTGGGAATGCTG -3'
(R):5'- GCCCAGGTTTATATCCTCAGCAAG -3'

Sequencing Primer
(F):5'- AATGCTGACCAGGGCAGC -3'
(R):5'- GTCATGTTCTCCCTGACCTGG -3'

Posted On

2015-11-11