Incidental Mutation 'R0306:Vmn2r118'
ID 35825
Institutional Source Beutler Lab
Gene Symbol Vmn2r118
Ensembl Gene ENSMUSG00000091504
Gene Name vomeronasal 2, receptor 118
Synonyms Vmn2r119, EG668547, EG383258
MMRRC Submission 038517-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R0306 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 55899341-55931672 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 55915616 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 445 (F445V)
Ref Sequence ENSEMBL: ENSMUSP00000131128 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168440]
AlphaFold E9Q1C1
Predicted Effect possibly damaging
Transcript: ENSMUST00000168440
AA Change: F445V

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: F445V

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 142 470 4.6e-27 PFAM
Pfam:NCD3G 513 566 2.6e-20 PFAM
Pfam:7tm_3 599 834 5.9e-55 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.2%
Validation Efficiency 94% (61/65)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aoc1l1 T C 6: 48,953,020 (GRCm39) V315A probably damaging Het
BC028528 C T 3: 95,797,132 (GRCm39) probably benign Het
Bspry T C 4: 62,414,394 (GRCm39) F329S probably damaging Het
Cd209a A G 8: 3,795,535 (GRCm39) Y120H probably benign Het
Ces1f T C 8: 94,003,172 (GRCm39) probably benign Het
Cfap52 T C 11: 67,844,896 (GRCm39) N58D probably benign Het
Cfap74 G A 4: 155,549,896 (GRCm39) probably benign Het
Chst8 T C 7: 34,374,723 (GRCm39) E372G probably benign Het
Cplane1 T C 15: 8,209,373 (GRCm39) V270A probably damaging Het
Ddx49 A G 8: 70,747,322 (GRCm39) probably benign Het
Ddx52 G T 11: 83,835,474 (GRCm39) L133F probably benign Het
Defb26 T A 2: 152,349,888 (GRCm39) I131F unknown Het
Dip2c T A 13: 9,654,635 (GRCm39) S719T probably benign Het
Dnmt3a A G 12: 3,916,096 (GRCm39) S94G possibly damaging Het
Dytn G A 1: 63,724,272 (GRCm39) P3S possibly damaging Het
Fmn2 T C 1: 174,437,050 (GRCm39) probably benign Het
Gal3st1 T A 11: 3,948,546 (GRCm39) L251Q probably damaging Het
Gm19684 A T 17: 36,438,300 (GRCm39) probably benign Het
Il15 T A 8: 83,061,083 (GRCm39) probably benign Het
Jag1 C T 2: 136,927,855 (GRCm39) G852D probably damaging Het
Kbtbd4 A G 2: 90,744,530 (GRCm39) probably benign Het
Kdm3b C A 18: 34,937,070 (GRCm39) Q451K probably benign Het
Lrfn2 A T 17: 49,403,283 (GRCm39) I469F probably damaging Het
Mep1a A T 17: 43,813,534 (GRCm39) probably benign Het
Morn5 T C 2: 35,944,986 (GRCm39) F70S probably damaging Het
Nav2 C A 7: 49,195,651 (GRCm39) P1009Q probably benign Het
Noc3l T C 19: 38,796,094 (GRCm39) Y334C probably damaging Het
Nsun4 A T 4: 115,910,019 (GRCm39) Y180* probably null Het
Nup210l T C 3: 90,114,675 (GRCm39) I1750T probably benign Het
Or51s1 A T 7: 102,559,010 (GRCm39) I12N probably benign Het
Or5p53 A T 7: 107,532,907 (GRCm39) Y60F probably damaging Het
Or8u9 T A 2: 86,002,060 (GRCm39) I34F possibly damaging Het
Parp14 A G 16: 35,676,944 (GRCm39) L1008P probably benign Het
Paxbp1 A G 16: 90,819,003 (GRCm39) V759A possibly damaging Het
Prdm10 C A 9: 31,227,520 (GRCm39) Q42K probably damaging Het
Prkcsh T C 9: 21,917,822 (GRCm39) probably benign Het
Psmg1 A G 16: 95,788,540 (GRCm39) C138R probably damaging Het
Ptprb T C 10: 116,179,893 (GRCm39) M1437T probably benign Het
Ryr3 A G 2: 112,606,000 (GRCm39) probably null Het
Serpinf1 T C 11: 75,304,761 (GRCm39) Y200C probably damaging Het
Shox2 T C 3: 66,881,167 (GRCm39) H130R probably damaging Het
Slc22a1 A G 17: 12,881,485 (GRCm39) F335L probably benign Het
Slc44a5 A G 3: 153,975,638 (GRCm39) N683S probably damaging Het
Slc9a9 A T 9: 95,019,987 (GRCm39) T519S probably benign Het
Smarca2 T A 19: 26,618,013 (GRCm39) L348Q probably damaging Het
Sorbs1 T C 19: 40,332,855 (GRCm39) D521G possibly damaging Het
Sorbs2 A T 8: 46,248,767 (GRCm39) T593S probably benign Het
Srp19 T C 18: 34,467,629 (GRCm39) probably benign Het
Stk35 T A 2: 129,643,683 (GRCm39) Y222* probably null Het
Syt10 T G 15: 89,711,191 (GRCm39) K114T probably benign Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Trpc4ap A G 2: 155,478,180 (GRCm39) V662A probably benign Het
Ttll4 G A 1: 74,735,916 (GRCm39) R1066Q probably benign Het
Tulp2 C T 7: 45,168,000 (GRCm39) probably benign Het
Unc5b C A 10: 60,615,437 (GRCm39) probably benign Het
Vmn1r230 T A 17: 21,066,895 (GRCm39) I28K possibly damaging Het
Zfp142 C T 1: 74,609,341 (GRCm39) E1485K probably damaging Het
Zfp819 C A 7: 43,266,621 (GRCm39) A292E possibly damaging Het
Other mutations in Vmn2r118
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Vmn2r118 APN 17 55,899,708 (GRCm39) missense probably damaging 1.00
IGL00976:Vmn2r118 APN 17 55,900,204 (GRCm39) missense probably damaging 1.00
IGL01419:Vmn2r118 APN 17 55,900,000 (GRCm39) missense probably benign 0.01
IGL01796:Vmn2r118 APN 17 55,915,585 (GRCm39) missense probably benign 0.30
IGL01799:Vmn2r118 APN 17 55,899,990 (GRCm39) missense probably damaging 1.00
IGL02002:Vmn2r118 APN 17 55,899,619 (GRCm39) missense probably damaging 1.00
IGL02075:Vmn2r118 APN 17 55,917,517 (GRCm39) missense probably benign 0.18
IGL02172:Vmn2r118 APN 17 55,931,598 (GRCm39) missense probably benign 0.00
IGL02529:Vmn2r118 APN 17 55,917,870 (GRCm39) missense possibly damaging 0.58
IGL02712:Vmn2r118 APN 17 55,899,655 (GRCm39) missense probably benign 0.21
IGL03096:Vmn2r118 APN 17 55,914,996 (GRCm39) missense probably damaging 1.00
R0329:Vmn2r118 UTSW 17 55,917,717 (GRCm39) missense probably damaging 1.00
R0330:Vmn2r118 UTSW 17 55,917,717 (GRCm39) missense probably damaging 1.00
R0396:Vmn2r118 UTSW 17 55,915,643 (GRCm39) missense probably benign 0.00
R0411:Vmn2r118 UTSW 17 55,918,021 (GRCm39) splice site probably benign
R0513:Vmn2r118 UTSW 17 55,917,970 (GRCm39) nonsense probably null
R0627:Vmn2r118 UTSW 17 55,917,772 (GRCm39) missense probably benign 0.01
R0638:Vmn2r118 UTSW 17 55,915,466 (GRCm39) missense probably benign 0.03
R1328:Vmn2r118 UTSW 17 55,915,620 (GRCm39) missense probably benign 0.01
R1366:Vmn2r118 UTSW 17 55,900,237 (GRCm39) nonsense probably null
R1465:Vmn2r118 UTSW 17 55,917,935 (GRCm39) missense probably benign 0.33
R1465:Vmn2r118 UTSW 17 55,917,935 (GRCm39) missense probably benign 0.33
R1511:Vmn2r118 UTSW 17 55,915,496 (GRCm39) nonsense probably null
R1515:Vmn2r118 UTSW 17 55,917,643 (GRCm39) missense probably benign 0.25
R1550:Vmn2r118 UTSW 17 55,915,083 (GRCm39) missense probably damaging 1.00
R1779:Vmn2r118 UTSW 17 55,918,530 (GRCm39) missense probably benign 0.03
R1834:Vmn2r118 UTSW 17 55,899,456 (GRCm39) missense probably damaging 1.00
R1840:Vmn2r118 UTSW 17 55,917,406 (GRCm39) nonsense probably null
R1854:Vmn2r118 UTSW 17 55,918,556 (GRCm39) missense possibly damaging 0.57
R1967:Vmn2r118 UTSW 17 55,899,882 (GRCm39) missense probably damaging 1.00
R1976:Vmn2r118 UTSW 17 55,899,925 (GRCm39) missense probably damaging 1.00
R2308:Vmn2r118 UTSW 17 55,931,650 (GRCm39) missense probably benign 0.33
R3700:Vmn2r118 UTSW 17 55,915,421 (GRCm39) missense possibly damaging 0.68
R4334:Vmn2r118 UTSW 17 55,917,347 (GRCm39) missense possibly damaging 0.58
R4647:Vmn2r118 UTSW 17 55,917,665 (GRCm39) missense probably damaging 1.00
R4709:Vmn2r118 UTSW 17 55,917,860 (GRCm39) missense probably damaging 1.00
R4805:Vmn2r118 UTSW 17 55,899,581 (GRCm39) missense probably damaging 1.00
R4858:Vmn2r118 UTSW 17 55,899,894 (GRCm39) missense probably damaging 0.98
R5384:Vmn2r118 UTSW 17 55,918,565 (GRCm39) missense probably benign 0.00
R5385:Vmn2r118 UTSW 17 55,918,565 (GRCm39) missense probably benign 0.00
R5664:Vmn2r118 UTSW 17 55,899,765 (GRCm39) missense possibly damaging 0.46
R5740:Vmn2r118 UTSW 17 55,900,103 (GRCm39) missense probably benign 0.00
R5927:Vmn2r118 UTSW 17 55,931,494 (GRCm39) missense probably benign 0.04
R6143:Vmn2r118 UTSW 17 55,899,871 (GRCm39) missense possibly damaging 0.92
R6513:Vmn2r118 UTSW 17 55,915,093 (GRCm39) missense probably damaging 1.00
R6573:Vmn2r118 UTSW 17 55,899,996 (GRCm39) missense probably damaging 1.00
R6760:Vmn2r118 UTSW 17 55,899,714 (GRCm39) missense possibly damaging 0.92
R6794:Vmn2r118 UTSW 17 55,899,348 (GRCm39) missense possibly damaging 0.48
R6929:Vmn2r118 UTSW 17 55,917,440 (GRCm39) missense probably benign 0.01
R7201:Vmn2r118 UTSW 17 55,915,496 (GRCm39) nonsense probably null
R7539:Vmn2r118 UTSW 17 55,899,853 (GRCm39) missense probably damaging 0.98
R7836:Vmn2r118 UTSW 17 55,900,242 (GRCm39) missense probably damaging 0.99
R8179:Vmn2r118 UTSW 17 55,915,484 (GRCm39) missense probably benign 0.36
R8248:Vmn2r118 UTSW 17 55,917,936 (GRCm39) missense probably benign 0.18
R8347:Vmn2r118 UTSW 17 55,917,423 (GRCm39) missense possibly damaging 0.94
R8415:Vmn2r118 UTSW 17 55,915,057 (GRCm39) missense probably benign 0.08
R8428:Vmn2r118 UTSW 17 55,915,642 (GRCm39) missense probably benign 0.33
R8917:Vmn2r118 UTSW 17 55,917,216 (GRCm39) missense possibly damaging 0.82
R8993:Vmn2r118 UTSW 17 55,917,835 (GRCm39) missense possibly damaging 0.72
R9038:Vmn2r118 UTSW 17 55,918,649 (GRCm39) missense probably damaging 1.00
R9155:Vmn2r118 UTSW 17 55,917,207 (GRCm39) missense probably null 0.83
R9603:Vmn2r118 UTSW 17 55,899,837 (GRCm39) missense probably damaging 1.00
R9742:Vmn2r118 UTSW 17 55,918,009 (GRCm39) missense probably damaging 0.98
R9749:Vmn2r118 UTSW 17 55,915,415 (GRCm39) critical splice donor site probably null
R9792:Vmn2r118 UTSW 17 55,899,496 (GRCm39) missense probably damaging 0.99
R9793:Vmn2r118 UTSW 17 55,899,496 (GRCm39) missense probably damaging 0.99
R9795:Vmn2r118 UTSW 17 55,899,496 (GRCm39) missense probably damaging 0.99
X0022:Vmn2r118 UTSW 17 55,900,218 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r118 UTSW 17 55,917,655 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CACAGCTCACACTGCATACAGAAGG -3'
(R):5'- cacagctcAGCATGTAAAAGAAGGCTAA -3'

Sequencing Primer
(F):5'- AGGCCCATTGGATCATGTC -3'
(R):5'- GGCTAATTTGATCTACTCTTATCTCC -3'
Posted On 2013-05-09