Incidental Mutation 'R4758:Adgrb2'
| ID |
358300 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb2
|
| Ensembl Gene |
ENSMUSG00000028782 |
| Gene Name |
adhesion G protein-coupled receptor B2 |
| Synonyms |
Bai2 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4758 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
129878663-129916426 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 129903143 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 581
(N581S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101639
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030571]
[ENSMUST00000097868]
[ENSMUST00000106015]
[ENSMUST00000106017]
[ENSMUST00000106018]
[ENSMUST00000120204]
[ENSMUST00000121049]
|
| AlphaFold |
Q8CGM1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030571
AA Change: N636S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000030571
Gene: ENSMUSG00000028782
AA Change: N636S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:GAIN
|
600 |
842 |
1.6e-41 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
1.7e-67 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097868
AA Change: N636S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000095480
Gene: ENSMUSG00000028782
AA Change: N636S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
1.2e-54 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1159 |
2.6e-69 |
PFAM |
|
low complexity region
|
1324 |
1338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000106012
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106015
AA Change: N636S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000101636
Gene: ENSMUSG00000028782
AA Change: N636S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.4e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
4.1e-68 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106017
AA Change: N636S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000101638
Gene: ENSMUSG00000028782
AA Change: N636S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.3e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1180 |
4.6e-68 |
PFAM |
|
low complexity region
|
1345 |
1359 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106018
AA Change: N581S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000101639
Gene: ENSMUSG00000028782
AA Change: N581S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
1.1e-54 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
2.4e-69 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120204
AA Change: N581S
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000112524
Gene: ENSMUSG00000028782
AA Change: N581S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
8.2e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
9.6e-70 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121049
AA Change: N581S
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000112869
Gene: ENSMUSG00000028782
AA Change: N581S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
6.1e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1137 |
3.8e-68 |
PFAM |
|
low complexity region
|
1302 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000166118
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149282
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136416
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene show a lessening of depression like behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad9 |
T |
A |
3: 36,127,754 (GRCm39) |
Y119N |
probably damaging |
Het |
| Actn2 |
T |
A |
13: 12,303,472 (GRCm39) |
K443* |
probably null |
Het |
| Afg2a |
T |
A |
3: 37,487,385 (GRCm39) |
S416T |
probably benign |
Het |
| Alb |
A |
T |
5: 90,616,452 (GRCm39) |
H319L |
probably benign |
Het |
| Aox1 |
A |
G |
1: 58,371,741 (GRCm39) |
I802V |
probably benign |
Het |
| Arhgap45 |
G |
A |
10: 79,866,127 (GRCm39) |
G995E |
probably benign |
Het |
| Capn12 |
A |
C |
7: 28,592,148 (GRCm39) |
T689P |
possibly damaging |
Het |
| Cars1 |
T |
C |
7: 143,125,304 (GRCm39) |
S312G |
probably benign |
Het |
| Cast |
T |
A |
13: 74,887,999 (GRCm39) |
D216V |
possibly damaging |
Het |
| Ccdc13 |
C |
T |
9: 121,662,800 (GRCm39) |
E72K |
possibly damaging |
Het |
| Cd300lg |
G |
T |
11: 101,944,417 (GRCm39) |
|
probably null |
Het |
| Cep41 |
A |
G |
6: 30,671,368 (GRCm39) |
|
probably benign |
Het |
| Chrna3 |
A |
G |
9: 54,929,560 (GRCm39) |
Y93H |
probably damaging |
Het |
| Cic |
A |
G |
7: 24,991,636 (GRCm39) |
R1309G |
possibly damaging |
Het |
| Clcnkb |
A |
G |
4: 141,135,160 (GRCm39) |
V526A |
probably benign |
Het |
| Clec4a1 |
G |
T |
6: 122,910,825 (GRCm39) |
V227F |
probably damaging |
Het |
| Cpa5 |
C |
A |
6: 30,615,159 (GRCm39) |
H99N |
possibly damaging |
Het |
| Crem |
C |
A |
18: 3,327,527 (GRCm39) |
C4F |
probably damaging |
Het |
| Cybb |
C |
G |
X: 9,316,989 (GRCm39) |
D246H |
probably benign |
Het |
| Decr2 |
C |
A |
17: 26,307,914 (GRCm39) |
E46D |
probably damaging |
Het |
| Dlg1 |
G |
A |
16: 31,610,570 (GRCm39) |
V284I |
possibly damaging |
Het |
| Dnah3 |
T |
C |
7: 119,678,629 (GRCm39) |
E360G |
probably benign |
Het |
| Dnajc1 |
A |
T |
2: 18,313,757 (GRCm39) |
Y121* |
probably null |
Het |
| Dnajc13 |
A |
G |
9: 104,049,773 (GRCm39) |
F1783L |
probably damaging |
Het |
| Eps8l2 |
T |
A |
7: 140,940,286 (GRCm39) |
D505E |
probably damaging |
Het |
| Eral1 |
G |
A |
11: 77,966,425 (GRCm39) |
T251I |
probably benign |
Het |
| Eya3 |
T |
C |
4: 132,422,196 (GRCm39) |
|
probably null |
Het |
| Fam120a |
G |
A |
13: 49,034,333 (GRCm39) |
T1093I |
probably benign |
Het |
| Fbn2 |
C |
T |
18: 58,159,458 (GRCm39) |
A2424T |
probably benign |
Het |
| Git2 |
G |
A |
5: 114,868,412 (GRCm39) |
T256M |
probably damaging |
Het |
| Gm9805 |
A |
T |
17: 22,689,871 (GRCm38) |
Y34F |
probably benign |
Het |
| Itgb7 |
T |
G |
15: 102,124,642 (GRCm39) |
T792P |
probably benign |
Het |
| Jakmip1 |
T |
A |
5: 37,285,966 (GRCm39) |
I665N |
probably damaging |
Het |
| Kcnt2 |
T |
C |
1: 140,446,635 (GRCm39) |
Y677H |
probably damaging |
Het |
| Klhdc4 |
G |
A |
8: 122,524,783 (GRCm39) |
P382S |
probably benign |
Het |
| Knl1 |
TCC |
TC |
2: 118,902,213 (GRCm39) |
|
probably null |
Het |
| Lamb3 |
T |
A |
1: 193,022,269 (GRCm39) |
M1039K |
possibly damaging |
Het |
| Lipm |
A |
T |
19: 34,078,570 (GRCm39) |
M1L |
possibly damaging |
Het |
| Lrrc37 |
A |
G |
11: 103,505,290 (GRCm39) |
V2226A |
possibly damaging |
Het |
| Magi3 |
T |
A |
3: 103,922,637 (GRCm39) |
D1360V |
probably benign |
Het |
| Mier2 |
C |
A |
10: 79,386,182 (GRCm39) |
C23F |
probably damaging |
Het |
| Myo1h |
C |
T |
5: 114,487,643 (GRCm39) |
R616C |
probably damaging |
Het |
| Nars2 |
A |
G |
7: 96,622,735 (GRCm39) |
D187G |
probably damaging |
Het |
| Nbea |
T |
C |
3: 55,912,824 (GRCm39) |
M988V |
probably benign |
Het |
| Nlrc5 |
C |
A |
8: 95,238,956 (GRCm39) |
Q1465K |
possibly damaging |
Het |
| Nlrp4e |
T |
C |
7: 23,020,043 (GRCm39) |
F177L |
probably benign |
Het |
| Oas1a |
A |
G |
5: 121,045,401 (GRCm39) |
F47L |
probably damaging |
Het |
| Oas1f |
A |
G |
5: 120,985,545 (GRCm39) |
E30G |
probably damaging |
Het |
| Obscn |
A |
T |
11: 58,894,189 (GRCm39) |
M6689K |
unknown |
Het |
| Obscn |
A |
T |
11: 59,026,743 (GRCm39) |
D153E |
probably damaging |
Het |
| Or52s6 |
A |
C |
7: 103,092,076 (GRCm39) |
C85G |
probably damaging |
Het |
| Osmr |
A |
T |
15: 6,882,036 (GRCm39) |
I36K |
probably benign |
Het |
| Pcf11 |
A |
T |
7: 92,310,383 (GRCm39) |
F535Y |
probably damaging |
Het |
| Pde2a |
C |
T |
7: 101,160,706 (GRCm39) |
R886C |
probably damaging |
Het |
| Pik3ca |
T |
A |
3: 32,492,127 (GRCm39) |
C242S |
probably benign |
Het |
| Pikfyve |
T |
A |
1: 65,311,674 (GRCm39) |
D1925E |
possibly damaging |
Het |
| Plekhm2 |
A |
T |
4: 141,369,316 (GRCm39) |
Y123N |
possibly damaging |
Het |
| Pomt2 |
A |
T |
12: 87,169,652 (GRCm39) |
V406D |
probably damaging |
Het |
| Ppfia2 |
G |
C |
10: 106,597,978 (GRCm39) |
L180F |
probably damaging |
Het |
| Prdm10 |
A |
T |
9: 31,273,708 (GRCm39) |
T985S |
probably benign |
Het |
| Proc |
T |
A |
18: 32,256,863 (GRCm39) |
Y268F |
probably damaging |
Het |
| Prrc1 |
C |
T |
18: 57,517,320 (GRCm39) |
T365M |
probably damaging |
Het |
| Rasa1 |
A |
T |
13: 85,382,567 (GRCm39) |
D446E |
probably benign |
Het |
| Ribc2 |
T |
A |
15: 85,025,867 (GRCm39) |
L281Q |
probably damaging |
Het |
| Runx1t1 |
A |
G |
4: 13,865,907 (GRCm39) |
D385G |
probably damaging |
Het |
| Sdk2 |
A |
G |
11: 113,717,880 (GRCm39) |
S1495P |
possibly damaging |
Het |
| Slc15a3 |
G |
T |
19: 10,831,726 (GRCm39) |
|
probably null |
Het |
| Slc43a3 |
A |
G |
2: 84,774,869 (GRCm39) |
N149S |
probably damaging |
Het |
| Specc1l |
A |
G |
10: 75,082,182 (GRCm39) |
Q543R |
probably damaging |
Het |
| Spef1 |
T |
C |
2: 131,014,661 (GRCm39) |
|
probably null |
Het |
| Spns1 |
A |
T |
7: 125,969,966 (GRCm39) |
F478Y |
probably damaging |
Het |
| Srebf2 |
T |
C |
15: 82,080,370 (GRCm39) |
V821A |
probably benign |
Het |
| Stac3 |
A |
G |
10: 127,339,214 (GRCm39) |
M108V |
possibly damaging |
Het |
| Stradb |
A |
G |
1: 59,027,730 (GRCm39) |
T87A |
probably benign |
Het |
| Stxbp5l |
A |
T |
16: 36,954,592 (GRCm39) |
M906K |
probably benign |
Het |
| Tex14 |
T |
C |
11: 87,405,311 (GRCm39) |
V741A |
probably benign |
Het |
| Thoc2l |
A |
C |
5: 104,668,265 (GRCm39) |
E929A |
possibly damaging |
Het |
| Tpo |
C |
A |
12: 30,125,870 (GRCm39) |
G830C |
probably damaging |
Het |
| Unc79 |
T |
A |
12: 103,128,080 (GRCm39) |
C2308* |
probably null |
Het |
| Vmn1r205 |
T |
C |
13: 22,777,016 (GRCm39) |
T29A |
possibly damaging |
Het |
| Vmn1r69 |
G |
A |
7: 10,314,473 (GRCm39) |
T7I |
probably benign |
Het |
| Vmn2r27 |
T |
G |
6: 124,208,596 (GRCm39) |
T50P |
possibly damaging |
Het |
| Wdr83 |
A |
G |
8: 85,801,867 (GRCm39) |
Y302H |
probably benign |
Het |
| Xirp2 |
A |
T |
2: 67,346,879 (GRCm39) |
E3040V |
probably damaging |
Het |
| Zfp629 |
C |
A |
7: 127,209,758 (GRCm39) |
G684W |
probably damaging |
Het |
|
| Other mutations in Adgrb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Adgrb2
|
APN |
4 |
129,912,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00425:Adgrb2
|
APN |
4 |
129,912,865 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00490:Adgrb2
|
APN |
4 |
129,905,665 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00928:Adgrb2
|
APN |
4 |
129,886,096 (GRCm39) |
missense |
probably benign |
|
|
IGL01353:Adgrb2
|
APN |
4 |
129,906,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Adgrb2
|
APN |
4 |
129,886,085 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01590:Adgrb2
|
APN |
4 |
129,907,606 (GRCm39) |
splice site |
probably benign |
|
|
IGL01813:Adgrb2
|
APN |
4 |
129,906,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01831:Adgrb2
|
APN |
4 |
129,903,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Adgrb2
|
APN |
4 |
129,885,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01960:Adgrb2
|
APN |
4 |
129,906,177 (GRCm39) |
splice site |
probably benign |
|
|
IGL01993:Adgrb2
|
APN |
4 |
129,912,635 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02646:Adgrb2
|
APN |
4 |
129,913,075 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02655:Adgrb2
|
APN |
4 |
129,885,972 (GRCm39) |
nonsense |
probably null |
|
|
IGL02695:Adgrb2
|
APN |
4 |
129,912,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02998:Adgrb2
|
APN |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03372:Adgrb2
|
APN |
4 |
129,911,362 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0098:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0206:Adgrb2
|
UTSW |
4 |
129,886,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Adgrb2
|
UTSW |
4 |
129,910,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0382:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0492:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0544:Adgrb2
|
UTSW |
4 |
129,911,335 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0965:Adgrb2
|
UTSW |
4 |
129,886,209 (GRCm39) |
small deletion |
probably benign |
|
|
R1458:Adgrb2
|
UTSW |
4 |
129,908,384 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1601:Adgrb2
|
UTSW |
4 |
129,886,630 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1711:Adgrb2
|
UTSW |
4 |
129,886,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Adgrb2
|
UTSW |
4 |
129,905,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Adgrb2
|
UTSW |
4 |
129,903,098 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1827:Adgrb2
|
UTSW |
4 |
129,906,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Adgrb2
|
UTSW |
4 |
129,904,024 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1881:Adgrb2
|
UTSW |
4 |
129,904,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Adgrb2
|
UTSW |
4 |
129,900,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Adgrb2
|
UTSW |
4 |
129,902,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Adgrb2
|
UTSW |
4 |
129,902,146 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4490:Adgrb2
|
UTSW |
4 |
129,906,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4499:Adgrb2
|
UTSW |
4 |
129,886,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4900:Adgrb2
|
UTSW |
4 |
129,907,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Adgrb2
|
UTSW |
4 |
129,906,332 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4922:Adgrb2
|
UTSW |
4 |
129,901,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5331:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5550:Adgrb2
|
UTSW |
4 |
129,908,727 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5995:Adgrb2
|
UTSW |
4 |
129,910,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6047:Adgrb2
|
UTSW |
4 |
129,912,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6534:Adgrb2
|
UTSW |
4 |
129,916,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6565:Adgrb2
|
UTSW |
4 |
129,913,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Adgrb2
|
UTSW |
4 |
129,903,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R6966:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R7197:Adgrb2
|
UTSW |
4 |
129,903,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Adgrb2
|
UTSW |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7451:Adgrb2
|
UTSW |
4 |
129,908,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Adgrb2
|
UTSW |
4 |
129,908,430 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7461:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7511:Adgrb2
|
UTSW |
4 |
129,915,904 (GRCm39) |
missense |
probably benign |
|
|
R7613:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7729:Adgrb2
|
UTSW |
4 |
129,885,917 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,762 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8033:Adgrb2
|
UTSW |
4 |
129,912,805 (GRCm39) |
missense |
probably benign |
|
|
R8039:Adgrb2
|
UTSW |
4 |
129,916,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8097:Adgrb2
|
UTSW |
4 |
129,901,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8256:Adgrb2
|
UTSW |
4 |
129,901,921 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8425:Adgrb2
|
UTSW |
4 |
129,898,850 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8804:Adgrb2
|
UTSW |
4 |
129,899,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9011:Adgrb2
|
UTSW |
4 |
129,916,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9018:Adgrb2
|
UTSW |
4 |
129,907,659 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9102:Adgrb2
|
UTSW |
4 |
129,912,802 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9113:Adgrb2
|
UTSW |
4 |
129,910,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Adgrb2
|
UTSW |
4 |
129,906,302 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9211:Adgrb2
|
UTSW |
4 |
129,886,199 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9267:Adgrb2
|
UTSW |
4 |
129,885,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9328:Adgrb2
|
UTSW |
4 |
129,915,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9470:Adgrb2
|
UTSW |
4 |
129,903,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9608:Adgrb2
|
UTSW |
4 |
129,907,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF020:Adgrb2
|
UTSW |
4 |
129,903,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb2
|
UTSW |
4 |
129,911,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,912,912 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,905,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTCCTGGATGCACGTAGC -3'
(R):5'- TCTGAATCCACCATGAAGCTC -3'
Sequencing Primer
(F):5'- CAGTTTCTGATGCTACAATGACAGGG -3'
(R):5'- TGAAGCTCACCACCTGGAAG -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation