Incidental Mutation 'R4726:Or8k28'
ID 358441
Institutional Source Beutler Lab
Gene Symbol Or8k28
Ensembl Gene ENSMUSG00000075181
Gene Name olfactory receptor family 8 subfamily K member 28
Synonyms Olfr1066, MOR188-8, MOR256-52P, GA_x6K02T2Q125-47925557-47924616
MMRRC Submission 041989-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R4726 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 86285672-86286613 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86286580 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 12 (F12L)
Ref Sequence ENSEMBL: ENSMUSP00000097470 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099885]
AlphaFold A2AK62
Predicted Effect possibly damaging
Transcript: ENSMUST00000099885
AA Change: F12L

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097470
Gene: ENSMUSG00000075181
AA Change: F12L

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.1e-50 PFAM
Pfam:7TM_GPCR_Srsx 35 172 1.9e-6 PFAM
Pfam:7tm_1 41 290 1.3e-15 PFAM
Meta Mutation Damage Score 0.2045 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 99% (74/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930583I09Rik T C 17: 65,141,448 (GRCm39) S52G probably null Het
Abcc2 T C 19: 43,820,553 (GRCm39) S1351P probably benign Het
Acp2 T A 2: 91,034,622 (GRCm39) L87Q probably damaging Het
Adgrl3 C A 5: 81,794,425 (GRCm39) T550K possibly damaging Het
Amotl2 A G 9: 102,601,018 (GRCm39) R329G probably benign Het
Angel1 T C 12: 86,768,649 (GRCm39) N278S probably damaging Het
Ankrd12 A C 17: 66,277,319 (GRCm39) M1985R probably damaging Het
Apob T A 12: 8,040,267 (GRCm39) F535I probably damaging Het
Art3 A G 5: 92,559,002 (GRCm39) K313R probably benign Het
Asxl2 C T 12: 3,551,872 (GRCm39) H1205Y possibly damaging Het
Bsph1 A T 7: 13,206,920 (GRCm39) M99L probably benign Het
Ccdc153 T C 9: 44,154,963 (GRCm39) probably null Het
Cdh16 A T 8: 105,342,664 (GRCm39) M28K probably damaging Het
Cdhr2 T C 13: 54,866,352 (GRCm39) F353L probably damaging Het
Chrna2 G T 14: 66,386,345 (GRCm39) V164L possibly damaging Het
Cip2a A G 16: 48,834,433 (GRCm39) T672A probably benign Het
Ckmt1 T C 2: 121,191,712 (GRCm39) probably null Het
Col25a1 A T 3: 130,313,430 (GRCm39) E280V possibly damaging Het
Dnajc12 A G 10: 63,233,087 (GRCm39) D76G probably damaging Het
Drd3 G T 16: 43,643,164 (GRCm39) E467* probably null Het
Ecpas A G 4: 58,844,191 (GRCm39) V525A probably damaging Het
Ehbp1l1 C A 19: 5,769,204 (GRCm39) A700S possibly damaging Het
Gab1 T C 8: 81,515,682 (GRCm39) D212G possibly damaging Het
Gm26996 A G 6: 130,557,134 (GRCm39) noncoding transcript Het
Gm28113 A G 15: 75,198,577 (GRCm39) noncoding transcript Het
Has3 T C 8: 107,604,718 (GRCm39) F308S probably damaging Het
Ifit3b T A 19: 34,588,860 (GRCm39) I12N probably benign Het
Ifna4 C A 4: 88,760,519 (GRCm39) T141K probably benign Het
Ints3 A G 3: 90,301,084 (GRCm39) S840P probably damaging Het
Itih4 T C 14: 30,611,792 (GRCm39) V132A probably damaging Het
Itprid2 T A 2: 79,493,101 (GRCm39) I1216N probably damaging Het
Kcnj10 A G 1: 172,196,639 (GRCm39) Y51C probably damaging Het
Klk1b24 G A 7: 43,839,820 (GRCm39) V60I probably damaging Het
Klra14-ps C A 6: 130,134,626 (GRCm39) noncoding transcript Het
Krt6b A G 15: 101,586,520 (GRCm39) I323T probably damaging Het
Lilra5 A C 7: 4,240,957 (GRCm39) Q17P probably benign Het
Lrrc7 GAAGTTGTTTGGAGATTCTTATCTTA GA 3: 158,024,045 (GRCm39) probably benign Het
Map3k4 T C 17: 12,451,851 (GRCm39) N1479S possibly damaging Het
Mbd3l2 A T 9: 18,356,256 (GRCm39) I194F probably damaging Het
Megf10 T C 18: 57,420,864 (GRCm39) I834T probably benign Het
Mterf4 G A 1: 93,229,471 (GRCm39) T251M probably damaging Het
Mtmr3 A T 11: 4,457,634 (GRCm39) D170E probably damaging Het
Myom3 C T 4: 135,534,586 (GRCm39) probably null Het
Nemp1 G A 10: 127,530,462 (GRCm39) V305I probably benign Het
Nlrp1b G T 11: 71,072,232 (GRCm39) T537K probably benign Het
Npdc1 G A 2: 25,298,957 (GRCm39) D284N probably damaging Het
Or5b3 T A 19: 13,388,469 (GRCm39) C179S probably damaging Het
Or6c206 A G 10: 129,097,045 (GRCm39) T72A possibly damaging Het
Pias1 A G 9: 62,827,771 (GRCm39) V212A probably damaging Het
Plscr1 T A 9: 92,145,221 (GRCm39) V77D probably damaging Het
Plxna1 T C 6: 89,299,798 (GRCm39) N1657S probably damaging Het
Ptprf A G 4: 118,069,414 (GRCm39) V1551A possibly damaging Het
Ptprn2 C A 12: 117,211,393 (GRCm39) Y857* probably null Het
Puf60 A T 15: 75,944,183 (GRCm39) probably null Het
Rnf20 C T 4: 49,654,579 (GRCm39) R879* probably null Het
Robo1 G A 16: 72,768,931 (GRCm39) A499T probably damaging Het
Slc39a14 A G 14: 70,551,048 (GRCm39) probably null Het
Smarcad1 A T 6: 65,052,025 (GRCm39) H6L probably damaging Het
Smg5 A G 3: 88,243,758 (GRCm39) S10G possibly damaging Het
Stk39 T A 2: 68,093,647 (GRCm39) D488V probably damaging Het
Stx19 A G 16: 62,642,495 (GRCm39) N104D probably benign Het
Tcstv1b A T 13: 120,635,173 (GRCm39) S152C possibly damaging Het
Tmem222 T C 4: 133,004,975 (GRCm39) M21V probably benign Het
Trim43b T A 9: 88,971,538 (GRCm39) N205I possibly damaging Het
Ubr4 C A 4: 139,209,890 (GRCm39) H5017N possibly damaging Het
Vmn2r93 A G 17: 18,536,960 (GRCm39) T548A probably damaging Het
Vps8 G A 16: 21,267,154 (GRCm39) probably null Het
Wasl A G 6: 24,633,110 (GRCm39) V176A probably benign Het
Wbp2nl T A 15: 82,190,255 (GRCm39) V61E probably damaging Het
Zfp959 T A 17: 56,205,260 (GRCm39) probably null Het
Zmiz1 T C 14: 25,644,098 (GRCm39) probably null Het
Other mutations in Or8k28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01661:Or8k28 APN 2 86,285,846 (GRCm39) missense possibly damaging 0.92
IGL01668:Or8k28 APN 2 86,285,746 (GRCm39) missense probably damaging 1.00
IGL02016:Or8k28 APN 2 86,285,841 (GRCm39) missense probably damaging 0.99
R0396:Or8k28 UTSW 2 86,286,363 (GRCm39) missense possibly damaging 0.54
R0980:Or8k28 UTSW 2 86,285,704 (GRCm39) missense probably benign 0.01
R0987:Or8k28 UTSW 2 86,285,891 (GRCm39) nonsense probably null
R1169:Or8k28 UTSW 2 86,285,931 (GRCm39) missense possibly damaging 0.85
R2001:Or8k28 UTSW 2 86,285,817 (GRCm39) missense probably benign 0.45
R2002:Or8k28 UTSW 2 86,285,817 (GRCm39) missense probably benign 0.45
R2265:Or8k28 UTSW 2 86,286,558 (GRCm39) missense possibly damaging 0.77
R3811:Or8k28 UTSW 2 86,285,691 (GRCm39) missense probably benign 0.21
R4579:Or8k28 UTSW 2 86,285,859 (GRCm39) missense probably damaging 0.99
R4768:Or8k28 UTSW 2 86,285,994 (GRCm39) nonsense probably null
R4871:Or8k28 UTSW 2 86,286,153 (GRCm39) missense possibly damaging 0.95
R5304:Or8k28 UTSW 2 86,285,779 (GRCm39) missense probably damaging 1.00
R6037:Or8k28 UTSW 2 86,286,133 (GRCm39) missense probably benign 0.14
R6037:Or8k28 UTSW 2 86,286,133 (GRCm39) missense probably benign 0.14
R7080:Or8k28 UTSW 2 86,285,835 (GRCm39) nonsense probably null
R7223:Or8k28 UTSW 2 86,286,211 (GRCm39) missense possibly damaging 0.78
R7378:Or8k28 UTSW 2 86,286,412 (GRCm39) missense probably benign 0.10
R7465:Or8k28 UTSW 2 86,286,150 (GRCm39) missense probably benign 0.07
R7598:Or8k28 UTSW 2 86,286,234 (GRCm39) missense probably damaging 0.98
R8524:Or8k28 UTSW 2 86,285,961 (GRCm39) missense probably damaging 1.00
R8703:Or8k28 UTSW 2 86,286,244 (GRCm39) missense possibly damaging 0.95
R8818:Or8k28 UTSW 2 86,286,078 (GRCm39) missense probably damaging 1.00
R8954:Or8k28 UTSW 2 86,285,892 (GRCm39) missense probably damaging 1.00
R9396:Or8k28 UTSW 2 86,285,845 (GRCm39) missense probably benign 0.00
X0025:Or8k28 UTSW 2 86,286,213 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- GTCCCACAGCTGTTGAATAAC -3'
(R):5'- CTTGATGCAATTTTGTACGTATGCC -3'

Sequencing Primer
(F):5'- CAGCTGTTGAATAACCAAGATCAG -3'
(R):5'- GCCATTTTTGTGCAGATGAATTC -3'
Posted On 2015-11-11