Incidental Mutation 'R4731:Zfhx3'
| ID |
358839 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfhx3
|
| Ensembl Gene |
ENSMUSG00000038872 |
| Gene Name |
zinc finger homeobox 3 |
| Synonyms |
Sci, A230102L03Rik, WBP9, Atbf1 |
| MMRRC Submission |
042021-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.923)
|
| Stock # |
R4731 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
109005975-109688268 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 109682716 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 3385
(Q3385R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152353
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043896]
[ENSMUST00000220518]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
unknown
Transcript: ENSMUST00000043896
AA Change: Q3385R
|
| SMART Domains |
Protein: ENSMUSP00000044612
Gene: ENSMUSG00000038872
AA Change: Q3385R
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
79 |
103 |
7.89e0 |
SMART |
|
low complexity region
|
110 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
148 |
165 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
282 |
305 |
1.36e1 |
SMART |
|
low complexity region
|
393 |
411 |
N/A |
INTRINSIC |
|
coiled coil region
|
453 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
500 |
523 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
641 |
664 |
3.47e0 |
SMART |
|
ZnF_C2H2
|
672 |
695 |
6.78e-3 |
SMART |
|
ZnF_U1
|
724 |
758 |
5.71e-1 |
SMART |
|
ZnF_C2H2
|
727 |
751 |
4.87e-4 |
SMART |
|
low complexity region
|
771 |
785 |
N/A |
INTRINSIC |
|
low complexity region
|
796 |
804 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
805 |
829 |
6.67e-2 |
SMART |
|
ZnF_U1
|
982 |
1016 |
2.35e0 |
SMART |
|
ZnF_C2H2
|
985 |
1009 |
4.57e0 |
SMART |
|
ZnF_C2H2
|
1041 |
1065 |
3.99e0 |
SMART |
|
ZnF_U1
|
1086 |
1120 |
1.36e0 |
SMART |
|
ZnF_C2H2
|
1089 |
1113 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
1233 |
1256 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
1262 |
1285 |
4.34e-1 |
SMART |
|
ZnF_C2H2
|
1370 |
1395 |
1.08e-1 |
SMART |
|
ZnF_C2H2
|
1411 |
1433 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
1439 |
1462 |
8.09e-1 |
SMART |
|
low complexity region
|
1500 |
1512 |
N/A |
INTRINSIC |
|
ZnF_U1
|
1552 |
1586 |
1.05e0 |
SMART |
|
ZnF_C2H2
|
1555 |
1579 |
8.22e-2 |
SMART |
|
ZnF_U1
|
1603 |
1637 |
4.19e0 |
SMART |
|
ZnF_C2H2
|
1606 |
1630 |
1.16e-1 |
SMART |
|
low complexity region
|
1643 |
1669 |
N/A |
INTRINSIC |
|
low complexity region
|
1734 |
1776 |
N/A |
INTRINSIC |
|
low complexity region
|
1792 |
1802 |
N/A |
INTRINSIC |
|
low complexity region
|
1842 |
1878 |
N/A |
INTRINSIC |
|
low complexity region
|
1881 |
1894 |
N/A |
INTRINSIC |
|
low complexity region
|
1967 |
1985 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1990 |
2013 |
1.62e0 |
SMART |
|
low complexity region
|
2041 |
2088 |
N/A |
INTRINSIC |
|
low complexity region
|
2110 |
2125 |
N/A |
INTRINSIC |
|
HOX
|
2152 |
2214 |
1.13e-16 |
SMART |
|
HOX
|
2249 |
2311 |
2.41e-20 |
SMART |
|
ZnF_C2H2
|
2335 |
2355 |
1.72e1 |
SMART |
|
low complexity region
|
2383 |
2414 |
N/A |
INTRINSIC |
|
low complexity region
|
2458 |
2473 |
N/A |
INTRINSIC |
|
low complexity region
|
2476 |
2521 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
2539 |
2561 |
1.79e-2 |
SMART |
|
low complexity region
|
2606 |
2619 |
N/A |
INTRINSIC |
|
HOX
|
2650 |
2712 |
2.97e-20 |
SMART |
|
ZnF_C2H2
|
2720 |
2743 |
7.67e-2 |
SMART |
|
low complexity region
|
2929 |
2950 |
N/A |
INTRINSIC |
|
HOX
|
2954 |
3016 |
1.07e-17 |
SMART |
|
ZnF_U1
|
3029 |
3063 |
1.8e-1 |
SMART |
|
ZnF_C2H2
|
3032 |
3056 |
8.31e0 |
SMART |
|
low complexity region
|
3130 |
3144 |
N/A |
INTRINSIC |
|
low complexity region
|
3181 |
3235 |
N/A |
INTRINSIC |
|
low complexity region
|
3237 |
3256 |
N/A |
INTRINSIC |
|
low complexity region
|
3268 |
3282 |
N/A |
INTRINSIC |
|
low complexity region
|
3290 |
3299 |
N/A |
INTRINSIC |
|
coiled coil region
|
3362 |
3417 |
N/A |
INTRINSIC |
|
low complexity region
|
3452 |
3476 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
3489 |
3509 |
1.45e2 |
SMART |
|
ZnF_U1
|
3546 |
3580 |
1.36e0 |
SMART |
|
ZnF_C2H2
|
3549 |
3573 |
1.77e1 |
SMART |
|
low complexity region
|
3602 |
3633 |
N/A |
INTRINSIC |
|
low complexity region
|
3642 |
3674 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000220518
AA Change: Q3385R
|
| Meta Mutation Damage Score |
0.0869 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.9%
|
| Validation Efficiency |
99% (117/118) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit normal initial pituitary development but reduced GH and TSH-beta staining within the pituitary by E17.5. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(18) : Gene trapped(18) |
| Other mutations in this stock |
Total: 115 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actmap |
T |
A |
7: 26,900,468 (GRCm39) |
M149K |
probably damaging |
Het |
| Adamts12 |
A |
T |
15: 11,270,748 (GRCm39) |
S668C |
probably damaging |
Het |
| Adcy8 |
A |
G |
15: 64,626,711 (GRCm39) |
V709A |
possibly damaging |
Het |
| Aim2 |
T |
A |
1: 173,291,442 (GRCm39) |
D282E |
possibly damaging |
Het |
| Akap9 |
T |
A |
5: 4,012,266 (GRCm39) |
S990T |
possibly damaging |
Het |
| Aloxe3 |
A |
T |
11: 69,019,480 (GRCm39) |
D131V |
probably null |
Het |
| Ankrd28 |
A |
C |
14: 31,477,698 (GRCm39) |
C115G |
probably benign |
Het |
| Anxa2 |
A |
T |
9: 69,393,812 (GRCm39) |
M217L |
probably benign |
Het |
| Asah2 |
T |
C |
19: 31,972,758 (GRCm39) |
N659S |
probably benign |
Het |
| Btaf1 |
A |
G |
19: 36,958,478 (GRCm39) |
D665G |
probably benign |
Het |
| Cdc42bpg |
T |
A |
19: 6,361,221 (GRCm39) |
V282E |
probably damaging |
Het |
| Cdh15 |
G |
A |
8: 123,588,763 (GRCm39) |
R279Q |
probably damaging |
Het |
| Cdipt |
T |
A |
7: 126,577,530 (GRCm39) |
L92H |
probably damaging |
Het |
| Cep104 |
T |
A |
4: 154,072,883 (GRCm39) |
D380E |
probably damaging |
Het |
| Cfap74 |
T |
A |
4: 155,548,059 (GRCm39) |
|
probably benign |
Het |
| Chd1 |
A |
T |
17: 17,598,079 (GRCm39) |
E55D |
probably benign |
Het |
| Cldnd2 |
T |
A |
7: 43,091,613 (GRCm39) |
C65S |
possibly damaging |
Het |
| Clec9a |
G |
T |
6: 129,393,299 (GRCm39) |
A108S |
probably benign |
Het |
| Cog7 |
T |
C |
7: 121,563,467 (GRCm39) |
D215G |
probably benign |
Het |
| Col9a3 |
G |
A |
2: 180,252,474 (GRCm39) |
E373K |
probably damaging |
Het |
| Deptor |
C |
A |
15: 55,044,406 (GRCm39) |
H191N |
probably benign |
Het |
| Dgkz |
A |
T |
2: 91,768,684 (GRCm39) |
I699N |
probably damaging |
Het |
| Dnah7c |
T |
A |
1: 46,809,333 (GRCm39) |
N3550K |
probably damaging |
Het |
| Dnah8 |
A |
G |
17: 30,994,035 (GRCm39) |
K3384R |
probably null |
Het |
| Dnajc13 |
CT |
C |
9: 104,064,004 (GRCm39) |
|
probably benign |
Het |
| Dnhd1 |
C |
A |
7: 105,323,056 (GRCm39) |
N521K |
probably benign |
Het |
| Efhb |
G |
A |
17: 53,733,272 (GRCm39) |
T533I |
probably damaging |
Het |
| Ercc4 |
A |
T |
16: 12,965,471 (GRCm39) |
H701L |
probably damaging |
Het |
| Ern1 |
A |
T |
11: 106,325,676 (GRCm39) |
|
probably benign |
Het |
| Etfb |
T |
C |
7: 43,093,624 (GRCm39) |
V17A |
probably damaging |
Het |
| Evc |
T |
A |
5: 37,481,141 (GRCm39) |
M235L |
probably benign |
Het |
| Fbxw22 |
T |
C |
9: 109,207,937 (GRCm39) |
I445V |
probably benign |
Het |
| Fmnl2 |
A |
G |
2: 53,007,081 (GRCm39) |
T764A |
possibly damaging |
Het |
| Fto |
T |
A |
8: 92,136,342 (GRCm39) |
D205E |
probably damaging |
Het |
| Galntl6 |
G |
A |
8: 58,880,847 (GRCm39) |
P147L |
probably damaging |
Het |
| Gm6871 |
T |
C |
7: 41,196,173 (GRCm39) |
I39V |
probably benign |
Het |
| Gpr83 |
A |
G |
9: 14,777,470 (GRCm39) |
|
probably benign |
Het |
| Gucy1a2 |
A |
T |
9: 3,759,424 (GRCm39) |
H410L |
probably benign |
Het |
| Helb |
T |
C |
10: 119,930,193 (GRCm39) |
|
probably null |
Het |
| Ifi214 |
T |
C |
1: 173,354,157 (GRCm39) |
Q171R |
probably benign |
Het |
| Ifit1bl1 |
T |
C |
19: 34,571,721 (GRCm39) |
I245M |
probably benign |
Het |
| Igdcc3 |
A |
G |
9: 65,089,279 (GRCm39) |
T492A |
probably damaging |
Het |
| Ighv13-1 |
T |
C |
12: 114,231,252 (GRCm39) |
|
probably benign |
Het |
| Igkv4-50 |
T |
C |
6: 69,677,984 (GRCm39) |
K40R |
probably benign |
Het |
| Igkv8-18 |
T |
A |
6: 70,333,280 (GRCm39) |
I74N |
probably damaging |
Het |
| Iho1 |
A |
G |
9: 108,282,584 (GRCm39) |
V368A |
probably benign |
Het |
| Kbtbd7 |
T |
C |
14: 79,666,240 (GRCm39) |
*691Q |
probably null |
Het |
| Khnyn |
T |
A |
14: 56,123,946 (GRCm39) |
|
probably null |
Het |
| Kif26a |
G |
A |
12: 112,142,007 (GRCm39) |
A754T |
probably benign |
Het |
| Llgl1 |
T |
A |
11: 60,597,051 (GRCm39) |
L194* |
probably null |
Het |
| Map3k12 |
G |
T |
15: 102,409,717 (GRCm39) |
T686N |
probably benign |
Het |
| Myo18a |
C |
A |
11: 77,720,585 (GRCm39) |
P741Q |
probably benign |
Het |
| Ncaph2 |
G |
A |
15: 89,240,030 (GRCm39) |
|
probably benign |
Het |
| Nfkb2 |
A |
G |
19: 46,297,403 (GRCm39) |
Q406R |
possibly damaging |
Het |
| Or10g9b |
A |
T |
9: 39,917,564 (GRCm39) |
I227N |
probably damaging |
Het |
| Or11g2 |
T |
A |
14: 50,856,026 (GRCm39) |
C116S |
probably benign |
Het |
| Or1ad6 |
G |
A |
11: 50,860,093 (GRCm39) |
V83M |
possibly damaging |
Het |
| Or2i1 |
T |
C |
17: 37,507,915 (GRCm39) |
T315A |
probably damaging |
Het |
| Or2n1e |
T |
A |
17: 38,586,438 (GRCm39) |
Y259N |
probably damaging |
Het |
| Or8b12 |
A |
T |
9: 37,657,831 (GRCm39) |
T134S |
probably benign |
Het |
| Ostm1 |
C |
T |
10: 42,554,975 (GRCm39) |
|
probably benign |
Het |
| Pabpc1 |
A |
T |
15: 36,599,528 (GRCm39) |
V389E |
probably benign |
Het |
| Pank4 |
A |
T |
4: 155,055,847 (GRCm39) |
M291L |
probably benign |
Het |
| Pex6 |
A |
G |
17: 47,033,214 (GRCm39) |
D579G |
probably benign |
Het |
| Pex6 |
A |
G |
17: 47,035,633 (GRCm39) |
|
probably null |
Het |
| Phc2 |
C |
T |
4: 128,601,764 (GRCm39) |
T73M |
probably damaging |
Het |
| Pkp4 |
G |
A |
2: 59,165,276 (GRCm39) |
|
probably null |
Het |
| Plekhg1 |
T |
A |
10: 3,907,506 (GRCm39) |
S808T |
probably benign |
Het |
| Plk5 |
A |
T |
10: 80,194,631 (GRCm39) |
H118L |
probably damaging |
Het |
| Pnlip |
T |
C |
19: 58,664,919 (GRCm39) |
I249T |
probably benign |
Het |
| Ptov1 |
T |
C |
7: 44,516,533 (GRCm39) |
D134G |
probably benign |
Het |
| Ptprb |
T |
C |
10: 116,155,238 (GRCm39) |
V664A |
probably benign |
Het |
| Ptprz1 |
T |
A |
6: 23,002,609 (GRCm39) |
S1566R |
probably benign |
Het |
| Pum1 |
T |
C |
4: 130,445,504 (GRCm39) |
S158P |
probably benign |
Het |
| Rae1 |
G |
T |
2: 172,857,185 (GRCm39) |
|
probably benign |
Het |
| Ros1 |
A |
C |
10: 52,018,325 (GRCm39) |
W778G |
probably damaging |
Het |
| Ryr2 |
A |
T |
13: 11,592,795 (GRCm39) |
M4653K |
possibly damaging |
Het |
| Sacm1l |
G |
A |
9: 123,419,895 (GRCm39) |
V553I |
probably benign |
Het |
| Samd4b |
G |
A |
7: 28,106,088 (GRCm39) |
R377W |
probably benign |
Het |
| Selenoo |
A |
G |
15: 88,983,531 (GRCm39) |
Q524R |
probably benign |
Het |
| Slc30a3 |
T |
C |
5: 31,250,638 (GRCm39) |
S22G |
probably benign |
Het |
| Slc35g2 |
A |
C |
9: 100,434,555 (GRCm39) |
V372G |
probably benign |
Het |
| Slc5a8 |
T |
C |
10: 88,761,649 (GRCm39) |
|
probably null |
Het |
| Slc7a7 |
T |
C |
14: 54,646,190 (GRCm39) |
Y91C |
probably damaging |
Het |
| Slc7a9 |
T |
A |
7: 35,152,988 (GRCm39) |
Y135* |
probably null |
Het |
| Slfn1 |
A |
T |
11: 83,012,661 (GRCm39) |
E259V |
probably damaging |
Het |
| Slmap |
T |
C |
14: 26,189,690 (GRCm39) |
N156S |
probably damaging |
Het |
| Smim29 |
A |
G |
17: 27,784,244 (GRCm39) |
|
probably benign |
Het |
| Sorbs1 |
T |
A |
19: 40,303,133 (GRCm39) |
R485S |
probably benign |
Het |
| Sptbn2 |
T |
A |
19: 4,792,508 (GRCm39) |
F1388I |
probably damaging |
Het |
| Stac2 |
C |
T |
11: 97,930,521 (GRCm39) |
G349E |
probably damaging |
Het |
| Tigd2 |
T |
A |
6: 59,188,400 (GRCm39) |
H422Q |
probably benign |
Het |
| Tle1 |
T |
C |
4: 72,043,256 (GRCm39) |
N538D |
possibly damaging |
Het |
| Tmtc1 |
A |
C |
6: 148,186,478 (GRCm39) |
|
probably null |
Het |
| Tns3 |
C |
T |
11: 8,400,986 (GRCm39) |
R1104H |
probably benign |
Het |
| Tom1l2 |
C |
G |
11: 60,161,259 (GRCm39) |
R84P |
probably damaging |
Het |
| Trank1 |
T |
C |
9: 111,219,478 (GRCm39) |
F2072L |
probably damaging |
Het |
| Trim6 |
T |
C |
7: 103,881,855 (GRCm39) |
Y369H |
probably damaging |
Het |
| Trpc7 |
A |
G |
13: 56,952,366 (GRCm39) |
S541P |
probably damaging |
Het |
| Trpv4 |
T |
C |
5: 114,760,814 (GRCm39) |
D732G |
possibly damaging |
Het |
| Tsc2 |
C |
A |
17: 24,822,249 (GRCm39) |
V1141F |
possibly damaging |
Het |
| Tspoap1 |
T |
A |
11: 87,656,473 (GRCm39) |
V257E |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,773,355 (GRCm39) |
M2395K |
unknown |
Het |
| Ubd |
A |
C |
17: 37,506,593 (GRCm39) |
T160P |
probably benign |
Het |
| Ubr7 |
A |
G |
12: 102,735,485 (GRCm39) |
T315A |
probably benign |
Het |
| Ugt2b36 |
G |
T |
5: 87,229,397 (GRCm39) |
Y156* |
probably null |
Het |
| Ulk4 |
G |
A |
9: 121,092,704 (GRCm39) |
R178* |
probably null |
Het |
| Urod |
G |
A |
4: 116,848,870 (GRCm39) |
A92V |
possibly damaging |
Het |
| Utp20 |
T |
C |
10: 88,590,382 (GRCm39) |
D2364G |
possibly damaging |
Het |
| Vmn1r87 |
A |
T |
7: 12,866,254 (GRCm39) |
M11K |
possibly damaging |
Het |
| Vstm4 |
A |
G |
14: 32,639,859 (GRCm39) |
K96E |
possibly damaging |
Het |
| Wwp1 |
T |
C |
4: 19,661,990 (GRCm39) |
D172G |
probably benign |
Het |
| Zfp229 |
C |
T |
17: 21,964,267 (GRCm39) |
H166Y |
possibly damaging |
Het |
| Zfp738 |
A |
T |
13: 67,818,033 (GRCm39) |
C653S |
probably damaging |
Het |
| Zp2 |
C |
A |
7: 119,737,343 (GRCm39) |
V282L |
probably damaging |
Het |
|
| Other mutations in Zfhx3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Zfhx3
|
APN |
8 |
109,520,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01946:Zfhx3
|
APN |
8 |
109,660,561 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01973:Zfhx3
|
APN |
8 |
109,673,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01983:Zfhx3
|
APN |
8 |
109,673,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Zfhx3
|
APN |
8 |
109,520,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02405:Zfhx3
|
APN |
8 |
109,682,374 (GRCm39) |
missense |
unknown |
|
|
IGL02406:Zfhx3
|
APN |
8 |
109,682,374 (GRCm39) |
missense |
unknown |
|
|
IGL02408:Zfhx3
|
APN |
8 |
109,682,004 (GRCm39) |
splice site |
probably benign |
|
|
IGL02549:Zfhx3
|
APN |
8 |
109,527,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02601:Zfhx3
|
APN |
8 |
109,583,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02649:Zfhx3
|
APN |
8 |
109,520,167 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03027:Zfhx3
|
APN |
8 |
109,519,820 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03053:Zfhx3
|
APN |
8 |
109,673,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03168:Zfhx3
|
APN |
8 |
109,673,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03194:Zfhx3
|
APN |
8 |
109,521,359 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03248:Zfhx3
|
APN |
8 |
109,673,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4449:Zfhx3
|
UTSW |
8 |
109,682,726 (GRCm39) |
small insertion |
probably benign |
|
|
FR4589:Zfhx3
|
UTSW |
8 |
109,682,733 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfhx3
|
UTSW |
8 |
109,682,735 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfhx3
|
UTSW |
8 |
109,682,734 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfhx3
|
UTSW |
8 |
109,682,720 (GRCm39) |
small insertion |
probably benign |
|
|
G5030:Zfhx3
|
UTSW |
8 |
109,678,091 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0016:Zfhx3
|
UTSW |
8 |
109,676,810 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0090:Zfhx3
|
UTSW |
8 |
109,676,689 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0330:Zfhx3
|
UTSW |
8 |
109,675,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0332:Zfhx3
|
UTSW |
8 |
109,673,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0398:Zfhx3
|
UTSW |
8 |
109,677,878 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0539:Zfhx3
|
UTSW |
8 |
109,527,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0546:Zfhx3
|
UTSW |
8 |
109,520,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Zfhx3
|
UTSW |
8 |
109,675,599 (GRCm39) |
nonsense |
probably null |
|
|
R0614:Zfhx3
|
UTSW |
8 |
109,675,171 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0653:Zfhx3
|
UTSW |
8 |
109,673,440 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0718:Zfhx3
|
UTSW |
8 |
109,682,282 (GRCm39) |
missense |
unknown |
|
|
R0825:Zfhx3
|
UTSW |
8 |
109,675,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1143:Zfhx3
|
UTSW |
8 |
109,521,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1319:Zfhx3
|
UTSW |
8 |
109,660,465 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1347:Zfhx3
|
UTSW |
8 |
109,527,330 (GRCm39) |
splice site |
probably benign |
|
|
R1412:Zfhx3
|
UTSW |
8 |
109,641,199 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1447:Zfhx3
|
UTSW |
8 |
109,675,076 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1530:Zfhx3
|
UTSW |
8 |
109,675,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1745:Zfhx3
|
UTSW |
8 |
109,682,494 (GRCm39) |
missense |
unknown |
|
|
R1764:Zfhx3
|
UTSW |
8 |
109,678,276 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1781:Zfhx3
|
UTSW |
8 |
109,520,167 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1917:Zfhx3
|
UTSW |
8 |
109,682,880 (GRCm39) |
missense |
unknown |
|
|
R1956:Zfhx3
|
UTSW |
8 |
109,520,774 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2049:Zfhx3
|
UTSW |
8 |
109,671,809 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2196:Zfhx3
|
UTSW |
8 |
109,526,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3085:Zfhx3
|
UTSW |
8 |
109,682,664 (GRCm39) |
missense |
unknown |
|
|
R3765:Zfhx3
|
UTSW |
8 |
109,519,394 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4162:Zfhx3
|
UTSW |
8 |
109,683,619 (GRCm39) |
missense |
unknown |
|
|
R4243:Zfhx3
|
UTSW |
8 |
109,518,952 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4380:Zfhx3
|
UTSW |
8 |
109,683,022 (GRCm39) |
missense |
unknown |
|
|
R4433:Zfhx3
|
UTSW |
8 |
109,682,269 (GRCm39) |
missense |
unknown |
|
|
R4509:Zfhx3
|
UTSW |
8 |
109,520,411 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4788:Zfhx3
|
UTSW |
8 |
109,520,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4812:Zfhx3
|
UTSW |
8 |
109,674,593 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4893:Zfhx3
|
UTSW |
8 |
109,683,639 (GRCm39) |
missense |
unknown |
|
|
R4907:Zfhx3
|
UTSW |
8 |
109,519,986 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4935:Zfhx3
|
UTSW |
8 |
109,674,482 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4943:Zfhx3
|
UTSW |
8 |
109,674,949 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5154:Zfhx3
|
UTSW |
8 |
109,527,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Zfhx3
|
UTSW |
8 |
109,677,817 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5388:Zfhx3
|
UTSW |
8 |
109,673,446 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5434:Zfhx3
|
UTSW |
8 |
109,519,031 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5445:Zfhx3
|
UTSW |
8 |
109,682,842 (GRCm39) |
missense |
unknown |
|
|
R5541:Zfhx3
|
UTSW |
8 |
109,675,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5571:Zfhx3
|
UTSW |
8 |
109,682,623 (GRCm39) |
missense |
unknown |
|
|
R5700:Zfhx3
|
UTSW |
8 |
109,660,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5754:Zfhx3
|
UTSW |
8 |
109,526,964 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5867:Zfhx3
|
UTSW |
8 |
109,520,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5905:Zfhx3
|
UTSW |
8 |
109,520,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5922:Zfhx3
|
UTSW |
8 |
109,673,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5972:Zfhx3
|
UTSW |
8 |
109,677,483 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6020:Zfhx3
|
UTSW |
8 |
109,519,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6028:Zfhx3
|
UTSW |
8 |
109,520,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6113:Zfhx3
|
UTSW |
8 |
109,674,053 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6253:Zfhx3
|
UTSW |
8 |
109,682,020 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6356:Zfhx3
|
UTSW |
8 |
109,673,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6800:Zfhx3
|
UTSW |
8 |
109,676,149 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6829:Zfhx3
|
UTSW |
8 |
109,676,915 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6872:Zfhx3
|
UTSW |
8 |
109,527,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6873:Zfhx3
|
UTSW |
8 |
109,527,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6919:Zfhx3
|
UTSW |
8 |
109,527,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6921:Zfhx3
|
UTSW |
8 |
109,678,024 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6925:Zfhx3
|
UTSW |
8 |
109,683,453 (GRCm39) |
missense |
unknown |
|
|
R6927:Zfhx3
|
UTSW |
8 |
109,683,453 (GRCm39) |
missense |
unknown |
|
|
R7152:Zfhx3
|
UTSW |
8 |
109,674,839 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7169:Zfhx3
|
UTSW |
8 |
109,678,030 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7214:Zfhx3
|
UTSW |
8 |
109,675,493 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7378:Zfhx3
|
UTSW |
8 |
109,519,880 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7391:Zfhx3
|
UTSW |
8 |
109,674,475 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7442:Zfhx3
|
UTSW |
8 |
109,519,468 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7636:Zfhx3
|
UTSW |
8 |
109,673,441 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7649:Zfhx3
|
UTSW |
8 |
109,678,276 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7699:Zfhx3
|
UTSW |
8 |
109,677,754 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7728:Zfhx3
|
UTSW |
8 |
109,678,201 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7780:Zfhx3
|
UTSW |
8 |
109,678,283 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7904:Zfhx3
|
UTSW |
8 |
109,677,695 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8032:Zfhx3
|
UTSW |
8 |
109,677,854 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8158:Zfhx3
|
UTSW |
8 |
109,675,353 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8163:Zfhx3
|
UTSW |
8 |
109,675,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8215:Zfhx3
|
UTSW |
8 |
109,677,349 (GRCm39) |
missense |
probably benign |
|
|
R8217:Zfhx3
|
UTSW |
8 |
109,677,349 (GRCm39) |
missense |
probably benign |
|
|
R8218:Zfhx3
|
UTSW |
8 |
109,677,349 (GRCm39) |
missense |
probably benign |
|
|
R8369:Zfhx3
|
UTSW |
8 |
109,583,448 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8424:Zfhx3
|
UTSW |
8 |
109,583,385 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8482:Zfhx3
|
UTSW |
8 |
109,674,511 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8504:Zfhx3
|
UTSW |
8 |
109,583,549 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8871:Zfhx3
|
UTSW |
8 |
109,676,867 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9144:Zfhx3
|
UTSW |
8 |
109,676,794 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9202:Zfhx3
|
UTSW |
8 |
109,677,920 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9213:Zfhx3
|
UTSW |
8 |
109,676,756 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9218:Zfhx3
|
UTSW |
8 |
109,520,501 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9370:Zfhx3
|
UTSW |
8 |
109,521,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Zfhx3
|
UTSW |
8 |
109,430,850 (GRCm39) |
start gained |
probably benign |
|
|
R9530:Zfhx3
|
UTSW |
8 |
109,527,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF027:Zfhx3
|
UTSW |
8 |
109,682,730 (GRCm39) |
small insertion |
probably benign |
|
|
RF028:Zfhx3
|
UTSW |
8 |
109,682,728 (GRCm39) |
small insertion |
probably benign |
|
|
RF029:Zfhx3
|
UTSW |
8 |
109,682,724 (GRCm39) |
small insertion |
probably benign |
|
|
RF031:Zfhx3
|
UTSW |
8 |
109,682,730 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Zfhx3
|
UTSW |
8 |
109,682,724 (GRCm39) |
small insertion |
probably benign |
|
|
RF037:Zfhx3
|
UTSW |
8 |
109,682,730 (GRCm39) |
nonsense |
probably null |
|
|
RF038:Zfhx3
|
UTSW |
8 |
109,682,733 (GRCm39) |
small insertion |
probably benign |
|
|
RF040:Zfhx3
|
UTSW |
8 |
109,682,733 (GRCm39) |
small insertion |
probably benign |
|
|
RF042:Zfhx3
|
UTSW |
8 |
109,682,730 (GRCm39) |
small insertion |
probably benign |
|
|
RF042:Zfhx3
|
UTSW |
8 |
109,682,720 (GRCm39) |
small insertion |
probably benign |
|
|
RF054:Zfhx3
|
UTSW |
8 |
109,682,728 (GRCm39) |
small insertion |
probably benign |
|
|
RF060:Zfhx3
|
UTSW |
8 |
109,682,720 (GRCm39) |
small insertion |
probably benign |
|
|
X0019:Zfhx3
|
UTSW |
8 |
109,678,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0026:Zfhx3
|
UTSW |
8 |
109,675,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Zfhx3
|
UTSW |
8 |
109,677,989 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1176:Zfhx3
|
UTSW |
8 |
109,527,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Zfhx3
|
UTSW |
8 |
109,520,555 (GRCm39) |
missense |
probably benign |
0.09 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCAGACCCCACAGCTTTGC -3'
(R):5'- AGTCCGCACTTGCACTTTTG -3'
Sequencing Primer
(F):5'- CCACAGCTTTGCTCACGAG -3'
(R):5'- CTGCTTCTGGCTCTTCGGG -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation