Incidental Mutation 'R4734:Mef2c'
ID |
359192 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Mef2c
|
Ensembl Gene |
ENSMUSG00000005583 |
Gene Name |
myocyte enhancer factor 2C |
Synonyms |
5430401D19Rik, 9930028G15Rik |
MMRRC Submission |
041961-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R4734 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
13 |
Chromosomal Location |
83652153-83815199 bp(+) (GRCm39) |
Type of Mutation |
makesense |
DNA Base Change (assembly) |
T to A
at 83810748 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Stop codon to Arginine
at position 467
(*467R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000143315
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005722]
[ENSMUST00000163888]
[ENSMUST00000185052]
[ENSMUST00000197145]
[ENSMUST00000197146]
[ENSMUST00000197681]
[ENSMUST00000197722]
[ENSMUST00000199210]
[ENSMUST00000198199]
[ENSMUST00000198217]
[ENSMUST00000199019]
[ENSMUST00000199105]
[ENSMUST00000199432]
[ENSMUST00000199450]
|
AlphaFold |
Q8CFN5 |
Predicted Effect |
probably null
Transcript: ENSMUST00000005722
AA Change: *465R
|
SMART Domains |
Protein: ENSMUSP00000005722 Gene: ENSMUSG00000005583 AA Change: *465R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
154 |
5.3e-27 |
PFAM |
low complexity region
|
314 |
324 |
N/A |
INTRINSIC |
low complexity region
|
378 |
394 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000163888
AA Change: *485R
|
SMART Domains |
Protein: ENSMUSP00000132547 Gene: ENSMUSG00000005583 AA Change: *485R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
155 |
1.4e-17 |
PFAM |
low complexity region
|
316 |
326 |
N/A |
INTRINSIC |
low complexity region
|
412 |
428 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000185052
AA Change: *473R
|
SMART Domains |
Protein: ENSMUSP00000138826 Gene: ENSMUSG00000005583 AA Change: *473R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
154 |
6e-27 |
PFAM |
low complexity region
|
322 |
332 |
N/A |
INTRINSIC |
low complexity region
|
418 |
434 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000197145
|
SMART Domains |
Protein: ENSMUSP00000142619 Gene: ENSMUSG00000005583
Domain | Start | End | E-Value | Type |
low complexity region
|
87 |
97 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000197146
AA Change: *443R
|
SMART Domains |
Protein: ENSMUSP00000143227 Gene: ENSMUSG00000005583 AA Change: *443R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
156 |
9.5e-15 |
PFAM |
low complexity region
|
324 |
334 |
N/A |
INTRINSIC |
low complexity region
|
388 |
404 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000197681
AA Change: *443R
|
SMART Domains |
Protein: ENSMUSP00000143420 Gene: ENSMUSG00000005583 AA Change: *443R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
156 |
9.5e-15 |
PFAM |
low complexity region
|
324 |
334 |
N/A |
INTRINSIC |
low complexity region
|
388 |
404 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000197722
|
SMART Domains |
Protein: ENSMUSP00000142456 Gene: ENSMUSG00000005583
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
1.1e-39 |
SMART |
Pfam:HJURP_C
|
90 |
156 |
2.8e-12 |
PFAM |
low complexity region
|
324 |
334 |
N/A |
INTRINSIC |
low complexity region
|
363 |
374 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000199210
AA Change: *395R
|
SMART Domains |
Protein: ENSMUSP00000142595 Gene: ENSMUSG00000005583 AA Change: *395R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
1.1e-39 |
SMART |
low complexity region
|
276 |
286 |
N/A |
INTRINSIC |
low complexity region
|
340 |
356 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000198199
AA Change: *433R
|
SMART Domains |
Protein: ENSMUSP00000143742 Gene: ENSMUSG00000005583 AA Change: *433R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
153 |
2e-23 |
PFAM |
low complexity region
|
314 |
324 |
N/A |
INTRINSIC |
low complexity region
|
378 |
394 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000198217
AA Change: *419R
|
SMART Domains |
Protein: ENSMUSP00000142487 Gene: ENSMUSG00000005583 AA Change: *419R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
1.1e-39 |
SMART |
low complexity region
|
268 |
278 |
N/A |
INTRINSIC |
low complexity region
|
364 |
380 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000199019
AA Change: *475R
|
SMART Domains |
Protein: ENSMUSP00000143401 Gene: ENSMUSG00000005583 AA Change: *475R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
156 |
1.1e-14 |
PFAM |
low complexity region
|
324 |
334 |
N/A |
INTRINSIC |
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000199105
AA Change: *475R
|
SMART Domains |
Protein: ENSMUSP00000143212 Gene: ENSMUSG00000005583 AA Change: *475R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
156 |
1.1e-14 |
PFAM |
low complexity region
|
324 |
334 |
N/A |
INTRINSIC |
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000199432
AA Change: *435R
|
SMART Domains |
Protein: ENSMUSP00000142714 Gene: ENSMUSG00000005583 AA Change: *435R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
1.1e-39 |
SMART |
Pfam:HJURP_C
|
90 |
156 |
3.1e-12 |
PFAM |
low complexity region
|
316 |
326 |
N/A |
INTRINSIC |
low complexity region
|
380 |
396 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000199450
AA Change: *467R
|
SMART Domains |
Protein: ENSMUSP00000143315 Gene: ENSMUSG00000005583 AA Change: *467R
Domain | Start | End | E-Value | Type |
MADS
|
1 |
60 |
3.29e-37 |
SMART |
Pfam:HJURP_C
|
90 |
156 |
5.1e-15 |
PFAM |
low complexity region
|
316 |
326 |
N/A |
INTRINSIC |
low complexity region
|
412 |
428 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000200138
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] PHENOTYPE: Mice homozygous for disruptions in this gene have cardiovascular abnormalities and die as embryos. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 75 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2700062C07Rik |
A |
G |
18: 24,603,961 (GRCm39) |
M1V |
probably null |
Het |
Abcb11 |
T |
A |
2: 69,154,306 (GRCm39) |
T87S |
possibly damaging |
Het |
Arap3 |
A |
G |
18: 38,129,328 (GRCm39) |
V210A |
probably benign |
Het |
Avl9 |
T |
C |
6: 56,713,479 (GRCm39) |
S246P |
probably damaging |
Het |
Ccdc88a |
A |
G |
11: 29,432,720 (GRCm39) |
K222R |
probably benign |
Het |
Cdhr18 |
T |
C |
14: 13,845,292 (GRCm38) |
N540S |
probably benign |
Het |
Cfap96 |
A |
T |
8: 46,423,454 (GRCm39) |
M86K |
possibly damaging |
Het |
Chsy3 |
C |
A |
18: 59,312,485 (GRCm39) |
F319L |
probably benign |
Het |
Coro2b |
T |
C |
9: 62,333,860 (GRCm39) |
T345A |
probably benign |
Het |
Cpb1 |
A |
G |
3: 20,317,876 (GRCm39) |
V216A |
probably benign |
Het |
Cyp2c65 |
A |
G |
19: 39,060,778 (GRCm39) |
I213V |
probably benign |
Het |
Dcaf15 |
A |
G |
8: 84,824,357 (GRCm39) |
C586R |
probably benign |
Het |
Ddr2 |
T |
A |
1: 169,825,657 (GRCm39) |
E314D |
probably benign |
Het |
Dennd5a |
C |
T |
7: 109,495,543 (GRCm39) |
R1196H |
probably damaging |
Het |
Dnah9 |
G |
A |
11: 65,724,941 (GRCm39) |
A4404V |
probably damaging |
Het |
Dpf2 |
A |
G |
19: 5,957,027 (GRCm39) |
|
probably null |
Het |
Eif2ak4 |
A |
T |
2: 118,252,568 (GRCm39) |
H302L |
probably damaging |
Het |
Eif2d |
G |
T |
1: 131,092,889 (GRCm39) |
R399L |
probably damaging |
Het |
Fat2 |
A |
G |
11: 55,202,294 (GRCm39) |
V260A |
probably benign |
Het |
Fhod3 |
T |
A |
18: 25,161,192 (GRCm39) |
Y575N |
probably benign |
Het |
Fscb |
T |
C |
12: 64,521,244 (GRCm39) |
E74G |
possibly damaging |
Het |
Gdpd2 |
G |
A |
X: 99,777,799 (GRCm39) |
M243I |
possibly damaging |
Het |
Glra1 |
C |
A |
11: 55,427,210 (GRCm39) |
D42Y |
probably damaging |
Het |
Gnl2 |
T |
C |
4: 124,934,811 (GRCm39) |
F156L |
probably benign |
Het |
Gpr37 |
C |
A |
6: 25,689,085 (GRCm39) |
R4L |
possibly damaging |
Het |
Hectd4 |
A |
T |
5: 121,480,040 (GRCm39) |
H2892L |
possibly damaging |
Het |
Helb |
T |
C |
10: 119,920,754 (GRCm39) |
D1063G |
probably benign |
Het |
Htr2c |
A |
G |
X: 145,976,793 (GRCm39) |
T163A |
probably benign |
Het |
Impact |
T |
A |
18: 13,118,346 (GRCm39) |
H188Q |
probably damaging |
Het |
Kirrel1 |
C |
T |
3: 86,996,458 (GRCm39) |
M380I |
probably null |
Het |
Lnx2 |
C |
T |
5: 146,965,947 (GRCm39) |
G391R |
probably damaging |
Het |
Lrrc19 |
T |
C |
4: 94,526,586 (GRCm39) |
I324V |
probably benign |
Het |
Lrrcc1 |
G |
T |
3: 14,627,345 (GRCm39) |
Q458H |
probably damaging |
Het |
Maml3 |
A |
T |
3: 51,597,296 (GRCm39) |
D483E |
probably damaging |
Het |
Mms19 |
T |
A |
19: 41,932,997 (GRCm39) |
S1031C |
probably damaging |
Het |
Myt1l |
T |
C |
12: 29,969,925 (GRCm39) |
I143T |
possibly damaging |
Het |
Nuggc |
T |
C |
14: 65,860,679 (GRCm39) |
Y426H |
probably damaging |
Het |
Oit3 |
A |
T |
10: 59,259,904 (GRCm39) |
C500S |
probably damaging |
Het |
Oog2 |
T |
C |
4: 143,923,021 (GRCm39) |
S429P |
probably benign |
Het |
Or4d1 |
T |
A |
11: 87,805,016 (GRCm39) |
T239S |
probably damaging |
Het |
Or51f1 |
A |
G |
7: 102,506,186 (GRCm39) |
I101T |
probably damaging |
Het |
Or5p1 |
A |
T |
7: 107,916,959 (GRCm39) |
N286I |
probably damaging |
Het |
Or5p51 |
T |
C |
7: 107,444,635 (GRCm39) |
I102V |
probably benign |
Het |
Pcnt |
T |
C |
10: 76,273,040 (GRCm39) |
D93G |
probably benign |
Het |
Pdia5 |
A |
T |
16: 35,276,883 (GRCm39) |
M95K |
probably benign |
Het |
Pdzrn4 |
A |
T |
15: 92,668,133 (GRCm39) |
R762* |
probably null |
Het |
Piezo1 |
G |
T |
8: 123,224,945 (GRCm39) |
Q654K |
probably damaging |
Het |
Ppil3 |
A |
G |
1: 58,470,428 (GRCm39) |
Y141H |
probably benign |
Het |
Prb1c |
T |
A |
6: 132,338,891 (GRCm39) |
N109I |
unknown |
Het |
Rassf8 |
G |
T |
6: 145,761,266 (GRCm39) |
K197N |
probably benign |
Het |
Ryr2 |
T |
C |
13: 11,752,639 (GRCm39) |
Q1894R |
probably damaging |
Het |
Ryr3 |
T |
A |
2: 112,740,847 (GRCm39) |
N487Y |
probably damaging |
Het |
Scn5a |
T |
C |
9: 119,368,604 (GRCm39) |
Y307C |
probably damaging |
Het |
Sdad1 |
C |
T |
5: 92,452,836 (GRCm39) |
R134Q |
possibly damaging |
Het |
Shroom1 |
C |
T |
11: 53,356,060 (GRCm39) |
S370F |
probably damaging |
Het |
Slc29a3 |
A |
G |
10: 60,552,105 (GRCm39) |
V313A |
probably benign |
Het |
Slc2a9 |
C |
A |
5: 38,539,442 (GRCm39) |
G353C |
probably damaging |
Het |
Snx33 |
T |
A |
9: 56,833,185 (GRCm39) |
T295S |
possibly damaging |
Het |
Spata31d1b |
G |
A |
13: 59,866,172 (GRCm39) |
V1107M |
probably damaging |
Het |
Supt6 |
T |
C |
11: 78,115,509 (GRCm39) |
D761G |
probably benign |
Het |
Tfeb |
T |
C |
17: 48,096,787 (GRCm39) |
V18A |
probably benign |
Het |
Thap12 |
G |
T |
7: 98,365,161 (GRCm39) |
C443F |
probably damaging |
Het |
Thap12 |
T |
A |
7: 98,365,162 (GRCm39) |
C443* |
probably null |
Het |
Tmem67 |
T |
C |
4: 12,063,158 (GRCm39) |
D496G |
probably benign |
Het |
Trappc8 |
G |
A |
18: 20,974,629 (GRCm39) |
R900* |
probably null |
Het |
Trim9 |
T |
C |
12: 70,295,047 (GRCm39) |
N688D |
probably damaging |
Het |
Trmt1l |
A |
T |
1: 151,318,388 (GRCm39) |
I80L |
probably benign |
Het |
Trpm5 |
C |
A |
7: 142,636,522 (GRCm39) |
V472L |
probably benign |
Het |
Tspear |
C |
T |
10: 77,700,529 (GRCm39) |
L120F |
probably damaging |
Het |
Ttc9b |
G |
A |
7: 27,355,443 (GRCm39) |
V238M |
probably benign |
Het |
Usp20 |
A |
G |
2: 30,909,836 (GRCm39) |
I819V |
probably benign |
Het |
Vmn2r102 |
T |
A |
17: 19,897,795 (GRCm39) |
V270E |
probably damaging |
Het |
Vmn2r63 |
C |
T |
7: 42,577,544 (GRCm39) |
M331I |
probably benign |
Het |
Zc3h18 |
A |
T |
8: 123,110,382 (GRCm39) |
D77V |
probably damaging |
Het |
Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Mef2c |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00819:Mef2c
|
APN |
13 |
83,773,499 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01012:Mef2c
|
APN |
13 |
83,803,714 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03131:Mef2c
|
APN |
13 |
83,810,494 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03186:Mef2c
|
APN |
13 |
83,800,987 (GRCm39) |
missense |
probably benign |
0.03 |
LCD18:Mef2c
|
UTSW |
13 |
83,753,942 (GRCm39) |
intron |
probably benign |
|
R0021:Mef2c
|
UTSW |
13 |
83,804,359 (GRCm39) |
missense |
probably damaging |
1.00 |
R0062:Mef2c
|
UTSW |
13 |
83,800,992 (GRCm39) |
missense |
possibly damaging |
0.65 |
R0480:Mef2c
|
UTSW |
13 |
83,741,020 (GRCm39) |
missense |
probably damaging |
1.00 |
R0755:Mef2c
|
UTSW |
13 |
83,804,472 (GRCm39) |
critical splice donor site |
probably null |
|
R1290:Mef2c
|
UTSW |
13 |
83,810,478 (GRCm39) |
missense |
probably benign |
0.19 |
R4085:Mef2c
|
UTSW |
13 |
83,723,821 (GRCm39) |
missense |
probably damaging |
0.98 |
R5230:Mef2c
|
UTSW |
13 |
83,801,026 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5385:Mef2c
|
UTSW |
13 |
83,810,532 (GRCm39) |
missense |
probably benign |
0.19 |
R6032:Mef2c
|
UTSW |
13 |
83,810,478 (GRCm39) |
missense |
probably benign |
0.19 |
R6032:Mef2c
|
UTSW |
13 |
83,810,478 (GRCm39) |
missense |
probably benign |
0.19 |
R6258:Mef2c
|
UTSW |
13 |
83,801,057 (GRCm39) |
missense |
probably damaging |
1.00 |
R6670:Mef2c
|
UTSW |
13 |
83,810,716 (GRCm39) |
missense |
probably damaging |
1.00 |
R6672:Mef2c
|
UTSW |
13 |
83,800,975 (GRCm39) |
missense |
probably damaging |
1.00 |
R6702:Mef2c
|
UTSW |
13 |
83,773,525 (GRCm39) |
missense |
possibly damaging |
0.70 |
R6703:Mef2c
|
UTSW |
13 |
83,773,525 (GRCm39) |
missense |
possibly damaging |
0.70 |
R6881:Mef2c
|
UTSW |
13 |
83,741,061 (GRCm39) |
missense |
probably damaging |
1.00 |
R6907:Mef2c
|
UTSW |
13 |
83,802,730 (GRCm39) |
missense |
probably benign |
0.32 |
R7503:Mef2c
|
UTSW |
13 |
83,810,623 (GRCm39) |
missense |
possibly damaging |
0.80 |
R8168:Mef2c
|
UTSW |
13 |
83,804,469 (GRCm39) |
missense |
probably damaging |
0.99 |
R8438:Mef2c
|
UTSW |
13 |
83,804,336 (GRCm39) |
missense |
probably damaging |
0.99 |
R9374:Mef2c
|
UTSW |
13 |
83,810,461 (GRCm39) |
missense |
probably benign |
0.43 |
R9552:Mef2c
|
UTSW |
13 |
83,810,461 (GRCm39) |
missense |
probably benign |
0.43 |
Z1177:Mef2c
|
UTSW |
13 |
83,773,385 (GRCm39) |
missense |
probably benign |
0.11 |
|
Predicted Primers |
PCR Primer
(F):5'- GGTCTCCTGTTGACAGCTTG -3'
(R):5'- CAAGTGTTCTGTTGTACAACTCAAG -3'
Sequencing Primer
(F):5'- TGAGCAGCTGTAGCAGTTCCTAC -3'
(R):5'- TAATGCATATCGACCCCC -3'
|
Posted On |
2015-11-11 |