Incidental Mutation 'R4737:Pappa2'
| ID |
359304 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa2
|
| Ensembl Gene |
ENSMUSG00000073530 |
| Gene Name |
pappalysin 2 |
| Synonyms |
pregnancy-associated plasma preproprotein-A2, placenta-specific 3, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe |
| MMRRC Submission |
042024-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4737 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
158711727-158980490 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 158957012 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 143
(R143G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124022
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159861]
|
| AlphaFold |
E9PZ87 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159861
AA Change: R143G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000124022
Gene: ENSMUSG00000073530
AA Change: R143G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Laminin_G_3
|
271 |
440 |
1.2e-25 |
PFAM |
|
NL
|
572 |
614 |
2.81e-5 |
SMART |
|
Pfam:Peptidase_M43
|
669 |
832 |
1.5e-12 |
PFAM |
|
Blast:FN3
|
844 |
1103 |
1e-169 |
BLAST |
|
low complexity region
|
1130 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1361 |
1370 |
N/A |
INTRINSIC |
|
CCP
|
1394 |
1457 |
4.97e0 |
SMART |
|
CCP
|
1462 |
1519 |
4.81e-1 |
SMART |
|
CCP
|
1523 |
1588 |
2.58e-4 |
SMART |
|
CCP
|
1593 |
1644 |
1.13e0 |
SMART |
|
NL
|
1720 |
1757 |
2.66e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159892
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177789
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
100% (94/94) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A430110L20Rik |
A |
G |
1: 181,227,819 (GRCm38) |
|
noncoding transcript |
Het |
| Acp2 |
A |
T |
2: 91,210,723 (GRCm38) |
R419W |
probably benign |
Het |
| Actr5 |
A |
G |
2: 158,628,071 (GRCm38) |
N207S |
probably damaging |
Het |
| Afap1 |
G |
A |
5: 35,961,782 (GRCm38) |
V254M |
probably benign |
Het |
| Arfgef1 |
A |
T |
1: 10,189,611 (GRCm38) |
M544K |
possibly damaging |
Het |
| Arhgap5 |
A |
T |
12: 52,519,077 (GRCm38) |
M944L |
probably benign |
Het |
| Bnip3l-ps |
G |
A |
12: 18,216,772 (GRCm38) |
|
noncoding transcript |
Het |
| Carf |
A |
G |
1: 60,109,318 (GRCm38) |
T58A |
probably benign |
Het |
| Carns1 |
A |
G |
19: 4,170,928 (GRCm38) |
|
probably benign |
Het |
| Ccp110 |
T |
A |
7: 118,724,548 (GRCm38) |
I670K |
possibly damaging |
Het |
| Cftr |
T |
A |
6: 18,299,883 (GRCm38) |
D1218E |
probably benign |
Het |
| Chrna9 |
A |
T |
5: 65,967,871 (GRCm38) |
T52S |
probably damaging |
Het |
| Chst9 |
T |
C |
18: 15,452,777 (GRCm38) |
Y243C |
probably damaging |
Het |
| Clk2 |
A |
T |
3: 89,168,709 (GRCm38) |
H62L |
probably benign |
Het |
| Cntnap2 |
A |
T |
6: 45,060,317 (GRCm38) |
R10W |
possibly damaging |
Het |
| Cpt1b |
C |
T |
15: 89,421,406 (GRCm38) |
D369N |
probably benign |
Het |
| Crhr2 |
G |
T |
6: 55,091,305 (GRCm38) |
H423Q |
probably damaging |
Het |
| D8Ertd738e |
T |
A |
8: 84,249,521 (GRCm38) |
I33F |
probably damaging |
Het |
| Dbt |
T |
C |
3: 116,539,132 (GRCm38) |
I200T |
probably damaging |
Het |
| Ddhd1 |
A |
T |
14: 45,628,821 (GRCm38) |
|
probably benign |
Het |
| Ddx27 |
A |
G |
2: 167,029,299 (GRCm38) |
I480V |
probably benign |
Het |
| Dpp9 |
A |
C |
17: 56,198,970 (GRCm38) |
|
probably null |
Het |
| Dpy19l3 |
A |
T |
7: 35,703,501 (GRCm38) |
M562K |
probably damaging |
Het |
| Dus3l |
T |
C |
17: 56,767,868 (GRCm38) |
L330P |
probably damaging |
Het |
| Efcab7 |
C |
T |
4: 99,831,568 (GRCm38) |
Q96* |
probably null |
Het |
| Egfr |
T |
C |
11: 16,869,231 (GRCm38) |
F254L |
probably damaging |
Het |
| Eml5 |
C |
T |
12: 98,798,852 (GRCm38) |
V1566M |
probably damaging |
Het |
| Entpd7 |
T |
A |
19: 43,691,195 (GRCm38) |
Y62* |
probably null |
Het |
| Erbb4 |
T |
C |
1: 68,343,900 (GRCm38) |
M313V |
probably damaging |
Het |
| Gm5528 |
A |
G |
1: 72,004,552 (GRCm38) |
|
noncoding transcript |
Het |
| H2-M9 |
G |
T |
17: 36,640,739 (GRCm38) |
Y281* |
probably null |
Het |
| Hmcn1 |
T |
G |
1: 150,689,595 (GRCm38) |
K2260N |
possibly damaging |
Het |
| Hnf4a |
A |
G |
2: 163,564,219 (GRCm38) |
I259V |
probably benign |
Het |
| Ick |
A |
G |
9: 78,150,654 (GRCm38) |
T162A |
probably damaging |
Het |
| Insm1 |
A |
T |
2: 146,222,902 (GRCm38) |
T213S |
probably benign |
Het |
| Iqca |
T |
C |
1: 90,077,822 (GRCm38) |
D488G |
probably damaging |
Het |
| Kdm5a |
T |
A |
6: 120,406,015 (GRCm38) |
|
probably benign |
Het |
| Kdm7a |
G |
C |
6: 39,152,839 (GRCm38) |
L468V |
possibly damaging |
Het |
| Lck |
G |
A |
4: 129,555,984 (GRCm38) |
T229I |
possibly damaging |
Het |
| Lig3 |
T |
C |
11: 82,787,727 (GRCm38) |
L265P |
probably damaging |
Het |
| Lipa |
T |
A |
19: 34,501,634 (GRCm38) |
K229* |
probably null |
Het |
| Lrrk1 |
C |
T |
7: 66,306,873 (GRCm38) |
S418N |
probably benign |
Het |
| Mark2 |
A |
G |
19: 7,281,232 (GRCm38) |
V126A |
probably damaging |
Het |
| Met |
T |
C |
6: 17,491,541 (GRCm38) |
C101R |
probably damaging |
Het |
| Mkln1 |
A |
T |
6: 31,426,799 (GRCm38) |
K85M |
probably damaging |
Het |
| Mst1 |
A |
G |
9: 108,080,521 (GRCm38) |
R15G |
probably benign |
Het |
| Muc6 |
T |
G |
7: 141,640,159 (GRCm38) |
|
probably benign |
Het |
| Muc6 |
G |
T |
7: 141,638,772 (GRCm38) |
T1996N |
possibly damaging |
Het |
| Myo7b |
T |
C |
18: 31,998,602 (GRCm38) |
S514G |
probably damaging |
Het |
| Narfl |
A |
T |
17: 25,781,309 (GRCm38) |
H322L |
probably damaging |
Het |
| Nars |
T |
C |
18: 64,516,427 (GRCm38) |
E11G |
probably benign |
Het |
| Ogdh |
T |
A |
11: 6,297,044 (GRCm38) |
F23I |
probably benign |
Het |
| Olfr1121 |
T |
C |
2: 87,372,321 (GRCm38) |
I263T |
probably damaging |
Het |
| Olfr1186 |
C |
T |
2: 88,526,225 (GRCm38) |
S214F |
probably damaging |
Het |
| Olfr1238 |
C |
T |
2: 89,406,486 (GRCm38) |
V198I |
probably benign |
Het |
| Olfr1272 |
A |
G |
2: 90,282,381 (GRCm38) |
S65P |
probably damaging |
Het |
| Olfr584 |
C |
T |
7: 103,085,914 (GRCm38) |
A127V |
probably damaging |
Het |
| Olfr825 |
T |
A |
10: 130,162,838 (GRCm38) |
T163S |
probably benign |
Het |
| Olfr979 |
A |
T |
9: 40,000,422 (GRCm38) |
D268E |
probably damaging |
Het |
| Otub2 |
T |
A |
12: 103,392,844 (GRCm38) |
L64Q |
probably benign |
Het |
| Patl2 |
T |
A |
2: 122,125,306 (GRCm38) |
T250S |
probably damaging |
Het |
| Pcdhac2 |
C |
T |
18: 37,145,899 (GRCm38) |
T644I |
possibly damaging |
Het |
| Pi4kb |
C |
T |
3: 95,004,338 (GRCm38) |
T690I |
probably damaging |
Het |
| Pla2g4d |
T |
C |
2: 120,266,790 (GRCm38) |
Y776C |
probably benign |
Het |
| Plekhh2 |
C |
T |
17: 84,563,959 (GRCm38) |
S215L |
probably benign |
Het |
| Psmd2 |
T |
G |
16: 20,659,815 (GRCm38) |
|
probably benign |
Het |
| Ptpn21 |
T |
C |
12: 98,708,844 (GRCm38) |
E183G |
probably benign |
Het |
| Ptprg |
T |
A |
14: 12,226,314 (GRCm38) |
D527E |
probably damaging |
Het |
| Rhobtb1 |
T |
A |
10: 69,279,497 (GRCm38) |
|
probably null |
Het |
| Scel |
T |
A |
14: 103,572,037 (GRCm38) |
M271K |
possibly damaging |
Het |
| Senp3 |
A |
T |
11: 69,678,829 (GRCm38) |
C310* |
probably null |
Het |
| Slc25a3 |
T |
C |
10: 91,122,188 (GRCm38) |
T97A |
possibly damaging |
Het |
| Srsf11 |
A |
T |
3: 158,026,732 (GRCm38) |
Y82* |
probably null |
Het |
| Tbc1d8 |
G |
A |
1: 39,402,878 (GRCm38) |
T211I |
possibly damaging |
Het |
| Tbkbp1 |
T |
C |
11: 97,148,648 (GRCm38) |
E145G |
probably damaging |
Het |
| Tln1 |
T |
C |
4: 43,540,588 (GRCm38) |
N1471S |
probably benign |
Het |
| Tnn |
T |
G |
1: 160,146,089 (GRCm38) |
D236A |
probably damaging |
Het |
| Trmt2a |
C |
T |
16: 18,251,286 (GRCm38) |
|
probably benign |
Het |
| Ttn |
A |
T |
2: 76,811,243 (GRCm38) |
L5176Q |
possibly damaging |
Het |
| Ubxn10 |
G |
A |
4: 138,735,948 (GRCm38) |
|
probably benign |
Het |
| Ulk4 |
G |
A |
9: 121,073,872 (GRCm38) |
Q1180* |
probably null |
Het |
| Usp43 |
T |
A |
11: 67,855,505 (GRCm38) |
K1120N |
probably damaging |
Het |
| Uspl1 |
T |
A |
5: 149,194,339 (GRCm38) |
L244Q |
possibly damaging |
Het |
| Vmn1r32 |
T |
C |
6: 66,553,645 (GRCm38) |
H49R |
probably damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,409,963 (GRCm38) |
D118G |
probably damaging |
Het |
| Vwce |
A |
G |
19: 10,650,579 (GRCm38) |
I468V |
probably benign |
Het |
| Zbtb7c |
G |
T |
18: 76,146,154 (GRCm38) |
R561L |
probably benign |
Het |
| Zfp956 |
T |
C |
6: 47,962,542 (GRCm38) |
S175P |
probably damaging |
Het |
|
| Other mutations in Pappa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Pappa2
|
APN |
1 |
158,857,148 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01394:Pappa2
|
APN |
1 |
158,765,104 (GRCm38) |
splice site |
probably benign |
|
|
IGL01570:Pappa2
|
APN |
1 |
158,814,540 (GRCm38) |
nonsense |
probably null |
|
|
IGL01618:Pappa2
|
APN |
1 |
158,857,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01717:Pappa2
|
APN |
1 |
158,857,132 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01804:Pappa2
|
APN |
1 |
158,936,519 (GRCm38) |
missense |
probably benign |
|
|
IGL01904:Pappa2
|
APN |
1 |
158,783,941 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02116:Pappa2
|
APN |
1 |
158,845,125 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02174:Pappa2
|
APN |
1 |
158,761,618 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02302:Pappa2
|
APN |
1 |
158,715,001 (GRCm38) |
missense |
probably benign |
0.38 |
|
IGL02422:Pappa2
|
APN |
1 |
158,936,933 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02572:Pappa2
|
APN |
1 |
158,851,216 (GRCm38) |
missense |
probably benign |
|
|
IGL02659:Pappa2
|
APN |
1 |
158,936,794 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02887:Pappa2
|
APN |
1 |
158,782,259 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02981:Pappa2
|
APN |
1 |
158,851,144 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03128:Pappa2
|
APN |
1 |
158,936,484 (GRCm38) |
missense |
probably benign |
0.16 |
|
IGL03142:Pappa2
|
APN |
1 |
158,854,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03270:Pappa2
|
APN |
1 |
158,765,067 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
Fritas
|
UTSW |
1 |
158,847,963 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
Gulliver
|
UTSW |
1 |
158,857,136 (GRCm38) |
missense |
probably null |
1.00 |
|
Lilliputian
|
UTSW |
1 |
158,716,990 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Lilliputian2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
lilliputian3
|
UTSW |
1 |
158,782,403 (GRCm38) |
splice site |
probably null |
|
|
Pitzel
|
UTSW |
1 |
158,956,645 (GRCm38) |
missense |
probably damaging |
1.00 |
|
shrink
|
UTSW |
1 |
158,763,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,714,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,714,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0172:Pappa2
|
UTSW |
1 |
158,854,849 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0194:Pappa2
|
UTSW |
1 |
158,765,101 (GRCm38) |
splice site |
probably benign |
|
|
R0418:Pappa2
|
UTSW |
1 |
158,716,990 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0421:Pappa2
|
UTSW |
1 |
158,848,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0441:Pappa2
|
UTSW |
1 |
158,763,058 (GRCm38) |
unclassified |
probably benign |
|
|
R0602:Pappa2
|
UTSW |
1 |
158,763,055 (GRCm38) |
unclassified |
probably benign |
|
|
R0630:Pappa2
|
UTSW |
1 |
158,832,773 (GRCm38) |
missense |
probably benign |
|
|
R0760:Pappa2
|
UTSW |
1 |
158,716,961 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1146:Pappa2
|
UTSW |
1 |
158,854,982 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1146:Pappa2
|
UTSW |
1 |
158,854,982 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1243:Pappa2
|
UTSW |
1 |
158,845,100 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1413:Pappa2
|
UTSW |
1 |
158,936,554 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1502:Pappa2
|
UTSW |
1 |
158,957,288 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1599:Pappa2
|
UTSW |
1 |
158,857,172 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1689:Pappa2
|
UTSW |
1 |
158,957,398 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1750:Pappa2
|
UTSW |
1 |
158,763,150 (GRCm38) |
nonsense |
probably null |
|
|
R1772:Pappa2
|
UTSW |
1 |
158,814,368 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1832:Pappa2
|
UTSW |
1 |
158,857,316 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1905:Pappa2
|
UTSW |
1 |
158,803,503 (GRCm38) |
splice site |
probably null |
|
|
R1914:Pappa2
|
UTSW |
1 |
158,750,563 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2013:Pappa2
|
UTSW |
1 |
158,834,928 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2037:Pappa2
|
UTSW |
1 |
158,956,644 (GRCm38) |
nonsense |
probably null |
|
|
R2118:Pappa2
|
UTSW |
1 |
158,857,266 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2268:Pappa2
|
UTSW |
1 |
158,857,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2269:Pappa2
|
UTSW |
1 |
158,857,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2347:Pappa2
|
UTSW |
1 |
158,765,043 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3024:Pappa2
|
UTSW |
1 |
158,936,225 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3706:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R3707:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R3708:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R4600:Pappa2
|
UTSW |
1 |
158,814,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4738:Pappa2
|
UTSW |
1 |
158,957,012 (GRCm38) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,957,002 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4739:Pappa2
|
UTSW |
1 |
158,957,012 (GRCm38) |
missense |
probably benign |
|
|
R4788:Pappa2
|
UTSW |
1 |
158,783,917 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4798:Pappa2
|
UTSW |
1 |
158,857,379 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4952:Pappa2
|
UTSW |
1 |
158,857,136 (GRCm38) |
missense |
probably null |
1.00 |
|
R5121:Pappa2
|
UTSW |
1 |
158,838,627 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5144:Pappa2
|
UTSW |
1 |
158,957,133 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5159:Pappa2
|
UTSW |
1 |
158,761,619 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5278:Pappa2
|
UTSW |
1 |
158,782,403 (GRCm38) |
splice site |
probably null |
|
|
R5428:Pappa2
|
UTSW |
1 |
158,814,785 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R5452:Pappa2
|
UTSW |
1 |
158,838,602 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5477:Pappa2
|
UTSW |
1 |
158,956,738 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5504:Pappa2
|
UTSW |
1 |
158,848,045 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5852:Pappa2
|
UTSW |
1 |
158,717,014 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6003:Pappa2
|
UTSW |
1 |
158,936,250 (GRCm38) |
missense |
probably benign |
0.23 |
|
R6129:Pappa2
|
UTSW |
1 |
158,714,997 (GRCm38) |
nonsense |
probably null |
|
|
R6137:Pappa2
|
UTSW |
1 |
158,871,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6374:Pappa2
|
UTSW |
1 |
158,956,645 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6472:Pappa2
|
UTSW |
1 |
158,834,799 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6804:Pappa2
|
UTSW |
1 |
158,936,868 (GRCm38) |
missense |
probably benign |
0.24 |
|
R7020:Pappa2
|
UTSW |
1 |
158,848,009 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7051:Pappa2
|
UTSW |
1 |
158,957,183 (GRCm38) |
missense |
unknown |
|
|
R7082:Pappa2
|
UTSW |
1 |
158,763,119 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R7111:Pappa2
|
UTSW |
1 |
158,956,526 (GRCm38) |
missense |
probably benign |
0.38 |
|
R7213:Pappa2
|
UTSW |
1 |
158,936,886 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7575:Pappa2
|
UTSW |
1 |
158,814,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7587:Pappa2
|
UTSW |
1 |
158,851,131 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7826:Pappa2
|
UTSW |
1 |
158,936,440 (GRCm38) |
nonsense |
probably null |
|
|
R7957:Pappa2
|
UTSW |
1 |
158,761,561 (GRCm38) |
nonsense |
probably null |
|
|
R8007:Pappa2
|
UTSW |
1 |
158,782,304 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8050:Pappa2
|
UTSW |
1 |
158,848,400 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8063:Pappa2
|
UTSW |
1 |
158,936,556 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R8068:Pappa2
|
UTSW |
1 |
158,935,985 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R8128:Pappa2
|
UTSW |
1 |
158,936,664 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R8264:Pappa2
|
UTSW |
1 |
158,854,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8317:Pappa2
|
UTSW |
1 |
158,764,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8499:Pappa2
|
UTSW |
1 |
158,936,522 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8744:Pappa2
|
UTSW |
1 |
158,783,917 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R8793:Pappa2
|
UTSW |
1 |
158,851,161 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Pappa2
|
UTSW |
1 |
158,763,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9004:Pappa2
|
UTSW |
1 |
158,936,948 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R9004:Pappa2
|
UTSW |
1 |
158,936,409 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9088:Pappa2
|
UTSW |
1 |
158,936,357 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9191:Pappa2
|
UTSW |
1 |
158,857,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9243:Pappa2
|
UTSW |
1 |
158,936,193 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9280:Pappa2
|
UTSW |
1 |
158,847,963 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R9301:Pappa2
|
UTSW |
1 |
158,845,044 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9306:Pappa2
|
UTSW |
1 |
158,936,922 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9367:Pappa2
|
UTSW |
1 |
158,956,972 (GRCm38) |
missense |
probably benign |
0.40 |
|
R9471:Pappa2
|
UTSW |
1 |
158,814,459 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9544:Pappa2
|
UTSW |
1 |
158,957,247 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9680:Pappa2
|
UTSW |
1 |
158,782,248 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9762:Pappa2
|
UTSW |
1 |
158,857,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9774:Pappa2
|
UTSW |
1 |
158,848,350 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9776:Pappa2
|
UTSW |
1 |
158,783,911 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0058:Pappa2
|
UTSW |
1 |
158,814,397 (GRCm38) |
missense |
probably null |
|
|
X0061:Pappa2
|
UTSW |
1 |
158,936,618 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,956,933 (GRCm38) |
missense |
probably benign |
|
|
Z1176:Pappa2
|
UTSW |
1 |
158,814,816 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,814,814 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGAAACCTTGAGGGGTATTC -3'
(R):5'- GCAGCAAACCCTGTATGCAG -3'
Sequencing Primer
(F):5'- GGGGTCTCCAGTCATGTCTTC -3'
(R):5'- CCCTGTATGCAGAATGGAGTC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation