Incidental Mutation 'R4739:Nek1'
| ID |
359528 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nek1
|
| Ensembl Gene |
ENSMUSG00000031644 |
| Gene Name |
NIMA (never in mitosis gene a)-related expressed kinase 1 |
| Synonyms |
kat, D8Ertd790e, kidney, anemia and testis |
| MMRRC Submission |
042025-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4739 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
61446229-61584380 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 61551545 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 853
(N853I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147809
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034065]
[ENSMUST00000120689]
[ENSMUST00000211256]
[ENSMUST00000211672]
|
| AlphaFold |
P51954 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000034065
AA Change: N781I
PolyPhen 2
Score 0.322 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000034065
Gene: ENSMUSG00000031644
AA Change: N781I
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
4 |
258 |
4.23e-95 |
SMART |
|
Blast:S_TKc
|
266 |
303 |
3e-7 |
BLAST |
|
low complexity region
|
321 |
337 |
N/A |
INTRINSIC |
|
coiled coil region
|
372 |
402 |
N/A |
INTRINSIC |
|
coiled coil region
|
556 |
592 |
N/A |
INTRINSIC |
|
coiled coil region
|
647 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
1130 |
1141 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120689
AA Change: N809I
PolyPhen 2
Score 0.322 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000113932
Gene: ENSMUSG00000031644
AA Change: N809I
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
4 |
258 |
4.23e-95 |
SMART |
|
Blast:S_TKc
|
266 |
303 |
3e-7 |
BLAST |
|
low complexity region
|
321 |
337 |
N/A |
INTRINSIC |
|
coiled coil region
|
372 |
402 |
N/A |
INTRINSIC |
|
coiled coil region
|
487 |
510 |
N/A |
INTRINSIC |
|
low complexity region
|
521 |
533 |
N/A |
INTRINSIC |
|
coiled coil region
|
584 |
620 |
N/A |
INTRINSIC |
|
coiled coil region
|
675 |
713 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1169 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155664
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211256
AA Change: N756I
PolyPhen 2
Score 0.322 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211672
AA Change: N853I
PolyPhen 2
Score 0.322 (Sensitivity: 0.90; Specificity: 0.89)
|
| Meta Mutation Damage Score |
0.0771 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.5%
|
| Validation Efficiency |
96% (102/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
PHENOTYPE: Spontaneous mutations of this gene result in pleiotropic effects that include facial dysmorphism, dwarfism, male sterility, anemia, cystic choroid plexus, a late-onset slowly progressive polycystic kidney disease, and premature death. Postnatal survival is sensitive to genetic background. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted(1) Gene trapped(1) Spontaneous(2)
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600012P17Rik |
C |
T |
1: 158,796,904 (GRCm39) |
|
noncoding transcript |
Het |
| 2300002M23Rik |
A |
G |
17: 35,878,403 (GRCm39) |
|
probably benign |
Het |
| Aadat |
T |
C |
8: 60,993,140 (GRCm39) |
V360A |
probably benign |
Het |
| Abcc5 |
T |
A |
16: 20,218,376 (GRCm39) |
D283V |
probably damaging |
Het |
| Abraxas1 |
T |
A |
5: 100,959,886 (GRCm39) |
K155N |
probably damaging |
Het |
| Acot3 |
T |
C |
12: 84,105,364 (GRCm39) |
I277T |
probably benign |
Het |
| Ankrd45 |
G |
A |
1: 160,982,960 (GRCm39) |
C157Y |
probably damaging |
Het |
| Apol10a |
C |
T |
15: 77,372,841 (GRCm39) |
T159I |
possibly damaging |
Het |
| Arhgef11 |
G |
A |
3: 87,605,306 (GRCm39) |
V214M |
possibly damaging |
Het |
| Ash1l |
A |
C |
3: 88,890,152 (GRCm39) |
N677T |
probably benign |
Het |
| Atg13 |
A |
G |
2: 91,515,040 (GRCm39) |
S254P |
probably damaging |
Het |
| Atg16l2 |
A |
G |
7: 100,946,385 (GRCm39) |
L129P |
probably damaging |
Het |
| Avl9 |
T |
A |
6: 56,703,294 (GRCm39) |
V120D |
probably damaging |
Het |
| Castor1 |
A |
G |
11: 4,169,004 (GRCm39) |
E57G |
possibly damaging |
Het |
| Cc2d1b |
T |
C |
4: 108,485,239 (GRCm39) |
V527A |
probably benign |
Het |
| Ccnl1 |
A |
G |
3: 65,854,092 (GRCm39) |
|
probably benign |
Het |
| Cenpl |
T |
A |
1: 160,910,837 (GRCm39) |
D261E |
probably damaging |
Het |
| Cep192 |
T |
G |
18: 67,984,803 (GRCm39) |
I1604M |
probably benign |
Het |
| Cep95 |
A |
G |
11: 106,706,560 (GRCm39) |
I573V |
probably benign |
Het |
| Cfap100 |
A |
G |
6: 90,389,825 (GRCm39) |
|
probably null |
Het |
| Ciao3 |
A |
T |
17: 26,000,283 (GRCm39) |
H322L |
probably damaging |
Het |
| Cmc1 |
T |
A |
9: 117,904,245 (GRCm39) |
M49L |
probably benign |
Het |
| Cyfip2 |
G |
T |
11: 46,170,820 (GRCm39) |
N176K |
probably damaging |
Het |
| Cyp2w1 |
T |
C |
5: 139,342,430 (GRCm39) |
F408L |
probably damaging |
Het |
| D630045J12Rik |
G |
A |
6: 38,172,971 (GRCm39) |
S399F |
possibly damaging |
Het |
| Dcbld2 |
T |
A |
16: 58,281,339 (GRCm39) |
L528Q |
probably damaging |
Het |
| Dip2b |
T |
C |
15: 100,105,658 (GRCm39) |
V1138A |
probably damaging |
Het |
| Dip2c |
T |
A |
13: 9,583,375 (GRCm39) |
L119Q |
probably damaging |
Het |
| Dnah3 |
T |
C |
7: 119,677,169 (GRCm39) |
D444G |
possibly damaging |
Het |
| Dsg1c |
A |
T |
18: 20,408,246 (GRCm39) |
N432Y |
possibly damaging |
Het |
| Dst |
T |
A |
1: 34,230,228 (GRCm39) |
I2785N |
probably benign |
Het |
| Dynap |
A |
T |
18: 70,374,296 (GRCm39) |
Y77N |
possibly damaging |
Het |
| Eif4g3 |
T |
C |
4: 137,910,510 (GRCm39) |
L1330P |
possibly damaging |
Het |
| Eif4g3 |
T |
A |
4: 137,925,408 (GRCm39) |
S1584T |
probably benign |
Het |
| Enpp1 |
A |
T |
10: 24,555,146 (GRCm39) |
C67S |
probably null |
Het |
| Enpp5 |
C |
T |
17: 44,392,027 (GRCm39) |
T152I |
probably damaging |
Het |
| Erbb4 |
T |
C |
1: 68,383,059 (GRCm39) |
M313V |
probably damaging |
Het |
| Erc2 |
T |
G |
14: 27,498,838 (GRCm39) |
L238R |
probably damaging |
Het |
| Eya3 |
T |
A |
4: 132,448,698 (GRCm39) |
|
probably benign |
Het |
| Farp1 |
T |
C |
14: 121,476,199 (GRCm39) |
F339L |
probably damaging |
Het |
| Fsip2 |
A |
C |
2: 82,805,697 (GRCm39) |
D672A |
possibly damaging |
Het |
| Gap43 |
G |
T |
16: 42,112,581 (GRCm39) |
P60Q |
probably benign |
Het |
| Gpr37l1 |
T |
A |
1: 135,094,783 (GRCm39) |
I154F |
probably damaging |
Het |
| Greb1 |
A |
G |
12: 16,746,329 (GRCm39) |
S1314P |
probably damaging |
Het |
| Hectd4 |
A |
T |
5: 121,486,505 (GRCm39) |
M3167L |
probably benign |
Het |
| Hps3 |
C |
T |
3: 20,084,574 (GRCm39) |
|
probably null |
Het |
| Hps5 |
A |
G |
7: 46,436,013 (GRCm39) |
C178R |
probably benign |
Het |
| Hspg2 |
T |
A |
4: 137,297,384 (GRCm39) |
|
probably benign |
Het |
| Impdh2-ps |
A |
G |
8: 100,757,839 (GRCm39) |
|
noncoding transcript |
Het |
| Josd2 |
T |
A |
7: 44,120,678 (GRCm39) |
N138K |
probably damaging |
Het |
| Mtmr6 |
T |
G |
14: 60,529,546 (GRCm39) |
M315R |
probably damaging |
Het |
| Mtrf1 |
G |
A |
14: 79,650,520 (GRCm39) |
V323M |
probably damaging |
Het |
| Myo16 |
G |
T |
8: 10,423,527 (GRCm39) |
G288W |
probably damaging |
Het |
| Myo18a |
T |
C |
11: 77,714,149 (GRCm39) |
Y748H |
probably damaging |
Het |
| Npnt |
T |
G |
3: 132,610,452 (GRCm39) |
T272P |
possibly damaging |
Het |
| Obi1 |
C |
T |
14: 104,747,819 (GRCm39) |
D43N |
probably damaging |
Het |
| Or2ag1b |
C |
A |
7: 106,288,351 (GRCm39) |
E196* |
probably null |
Het |
| Or2b6 |
T |
A |
13: 21,823,340 (GRCm39) |
M118L |
possibly damaging |
Het |
| Or2y17 |
G |
A |
11: 49,232,148 (GRCm39) |
G263D |
probably benign |
Het |
| Or51e1 |
T |
A |
7: 102,359,378 (GRCm39) |
I304N |
probably damaging |
Het |
| Or52n2c |
G |
A |
7: 104,574,017 (GRCm39) |
T318I |
possibly damaging |
Het |
| Or5a1 |
A |
G |
19: 12,097,234 (GRCm39) |
Y269H |
possibly damaging |
Het |
| Pappa2 |
T |
C |
1: 158,784,582 (GRCm39) |
R143G |
probably benign |
Het |
| Pappa2 |
T |
G |
1: 158,784,572 (GRCm39) |
D146A |
probably damaging |
Het |
| Pcsk9 |
C |
T |
4: 106,304,353 (GRCm39) |
G496R |
probably damaging |
Het |
| Pes1 |
A |
G |
11: 3,914,058 (GRCm39) |
K8E |
probably damaging |
Het |
| Phlpp2 |
G |
A |
8: 110,667,052 (GRCm39) |
G1194S |
probably damaging |
Het |
| Pkn1 |
A |
C |
8: 84,398,378 (GRCm39) |
V763G |
probably damaging |
Het |
| Pkp2 |
C |
A |
16: 16,048,588 (GRCm39) |
A331E |
probably damaging |
Het |
| Plb1 |
T |
A |
5: 32,507,023 (GRCm39) |
|
probably null |
Het |
| Plxna1 |
A |
T |
6: 89,309,657 (GRCm39) |
|
probably null |
Het |
| Polq |
C |
T |
16: 36,862,109 (GRCm39) |
T264M |
probably damaging |
Het |
| Prkag3 |
T |
C |
1: 74,779,864 (GRCm39) |
*490W |
probably null |
Het |
| Prl2c1 |
T |
C |
13: 28,041,661 (GRCm39) |
C228R |
probably damaging |
Het |
| Pus7l |
T |
C |
15: 94,438,591 (GRCm39) |
S85G |
probably benign |
Het |
| Rfc3 |
A |
C |
5: 151,568,241 (GRCm39) |
|
probably benign |
Het |
| Riox2 |
A |
G |
16: 59,309,732 (GRCm39) |
N362S |
probably benign |
Het |
| Scaper |
A |
T |
9: 55,650,932 (GRCm39) |
D904E |
probably damaging |
Het |
| Scn11a |
T |
C |
9: 119,583,627 (GRCm39) |
M1663V |
probably benign |
Het |
| Slc13a3 |
A |
T |
2: 165,272,209 (GRCm39) |
I278N |
possibly damaging |
Het |
| Slc22a7 |
T |
C |
17: 46,745,923 (GRCm39) |
E278G |
probably damaging |
Het |
| Snrnp48 |
T |
A |
13: 38,393,893 (GRCm39) |
M66K |
probably damaging |
Het |
| Styk1 |
T |
G |
6: 131,277,429 (GRCm39) |
E404A |
probably damaging |
Het |
| Synj1 |
T |
A |
16: 90,752,307 (GRCm39) |
H1016L |
probably benign |
Het |
| Tbc1d8 |
G |
A |
1: 39,441,959 (GRCm39) |
T211I |
possibly damaging |
Het |
| Tjp2 |
T |
C |
19: 24,097,475 (GRCm39) |
|
probably null |
Het |
| Tmem87a |
A |
G |
2: 120,190,518 (GRCm39) |
|
probably null |
Het |
| Trappc9 |
T |
G |
15: 72,808,909 (GRCm39) |
Y718S |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Ubqlnl |
C |
T |
7: 103,798,925 (GRCm39) |
V191M |
probably benign |
Het |
| Ugt2a3 |
C |
T |
5: 87,475,054 (GRCm39) |
G397R |
probably damaging |
Het |
| Wdr33 |
T |
A |
18: 32,019,139 (GRCm39) |
M454K |
probably benign |
Het |
| Wdtc1 |
G |
T |
4: 133,029,110 (GRCm39) |
N325K |
possibly damaging |
Het |
| Whrn |
T |
C |
4: 63,336,402 (GRCm39) |
H720R |
probably damaging |
Het |
| Xirp2 |
A |
T |
2: 67,349,609 (GRCm39) |
D3268V |
probably damaging |
Het |
| Zc3h7a |
A |
T |
16: 10,959,573 (GRCm39) |
H793Q |
probably damaging |
Het |
| Zfp518b |
C |
T |
5: 38,831,841 (GRCm39) |
A55T |
possibly damaging |
Het |
| Zmynd8 |
G |
A |
2: 165,647,249 (GRCm39) |
T901M |
probably damaging |
Het |
|
| Other mutations in Nek1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00471:Nek1
|
APN |
8 |
61,496,318 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01075:Nek1
|
APN |
8 |
61,577,166 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01122:Nek1
|
APN |
8 |
61,574,000 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01151:Nek1
|
APN |
8 |
61,473,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01286:Nek1
|
APN |
8 |
61,577,250 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01377:Nek1
|
APN |
8 |
61,542,490 (GRCm39) |
missense |
probably benign |
|
|
IGL01485:Nek1
|
APN |
8 |
61,502,860 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01688:Nek1
|
APN |
8 |
61,558,631 (GRCm39) |
nonsense |
probably null |
|
|
IGL01806:Nek1
|
APN |
8 |
61,577,246 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02006:Nek1
|
APN |
8 |
61,557,226 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL02304:Nek1
|
APN |
8 |
61,465,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02659:Nek1
|
APN |
8 |
61,542,514 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02662:Nek1
|
APN |
8 |
61,557,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02801:Nek1
|
APN |
8 |
61,574,095 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02806:Nek1
|
APN |
8 |
61,497,120 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03037:Nek1
|
APN |
8 |
61,487,086 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03252:Nek1
|
APN |
8 |
61,525,364 (GRCm39) |
nonsense |
probably null |
|
|
P0014:Nek1
|
UTSW |
8 |
61,524,781 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Nek1
|
UTSW |
8 |
61,542,768 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0403:Nek1
|
UTSW |
8 |
61,559,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0464:Nek1
|
UTSW |
8 |
61,525,307 (GRCm39) |
splice site |
probably benign |
|
|
R0726:Nek1
|
UTSW |
8 |
61,542,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0761:Nek1
|
UTSW |
8 |
61,542,489 (GRCm39) |
missense |
probably benign |
|
|
R0827:Nek1
|
UTSW |
8 |
61,558,682 (GRCm39) |
splice site |
probably benign |
|
|
R0972:Nek1
|
UTSW |
8 |
61,542,465 (GRCm39) |
splice site |
probably null |
|
|
R1268:Nek1
|
UTSW |
8 |
61,475,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1343:Nek1
|
UTSW |
8 |
61,481,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1415:Nek1
|
UTSW |
8 |
61,542,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1466:Nek1
|
UTSW |
8 |
61,578,170 (GRCm39) |
splice site |
probably benign |
|
|
R1480:Nek1
|
UTSW |
8 |
61,577,360 (GRCm39) |
splice site |
probably null |
|
|
R1526:Nek1
|
UTSW |
8 |
61,502,975 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1552:Nek1
|
UTSW |
8 |
61,459,771 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1606:Nek1
|
UTSW |
8 |
61,577,310 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1650:Nek1
|
UTSW |
8 |
61,489,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1757:Nek1
|
UTSW |
8 |
61,542,847 (GRCm39) |
splice site |
probably null |
|
|
R1808:Nek1
|
UTSW |
8 |
61,469,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1966:Nek1
|
UTSW |
8 |
61,469,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2067:Nek1
|
UTSW |
8 |
61,460,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nek1
|
UTSW |
8 |
61,577,360 (GRCm39) |
splice site |
probably null |
|
|
R2113:Nek1
|
UTSW |
8 |
61,469,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Nek1
|
UTSW |
8 |
61,481,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2255:Nek1
|
UTSW |
8 |
61,542,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2422:Nek1
|
UTSW |
8 |
61,472,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3848:Nek1
|
UTSW |
8 |
61,525,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3849:Nek1
|
UTSW |
8 |
61,525,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3850:Nek1
|
UTSW |
8 |
61,525,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4418:Nek1
|
UTSW |
8 |
61,559,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4526:Nek1
|
UTSW |
8 |
61,559,978 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4533:Nek1
|
UTSW |
8 |
61,460,247 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4544:Nek1
|
UTSW |
8 |
61,469,338 (GRCm39) |
nonsense |
probably null |
|
|
R4677:Nek1
|
UTSW |
8 |
61,481,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5068:Nek1
|
UTSW |
8 |
61,469,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5421:Nek1
|
UTSW |
8 |
61,459,711 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5516:Nek1
|
UTSW |
8 |
61,542,523 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5855:Nek1
|
UTSW |
8 |
61,469,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6125:Nek1
|
UTSW |
8 |
61,481,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6267:Nek1
|
UTSW |
8 |
61,525,343 (GRCm39) |
nonsense |
probably null |
|
|
R6292:Nek1
|
UTSW |
8 |
61,507,770 (GRCm39) |
splice site |
probably null |
|
|
R6296:Nek1
|
UTSW |
8 |
61,525,343 (GRCm39) |
nonsense |
probably null |
|
|
R6458:Nek1
|
UTSW |
8 |
61,553,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6568:Nek1
|
UTSW |
8 |
61,559,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6629:Nek1
|
UTSW |
8 |
61,507,367 (GRCm39) |
splice site |
probably null |
|
|
R6867:Nek1
|
UTSW |
8 |
61,525,364 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7122:Nek1
|
UTSW |
8 |
61,559,829 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7193:Nek1
|
UTSW |
8 |
61,526,612 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7272:Nek1
|
UTSW |
8 |
61,578,120 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7356:Nek1
|
UTSW |
8 |
61,573,994 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7368:Nek1
|
UTSW |
8 |
61,542,741 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7478:Nek1
|
UTSW |
8 |
61,583,179 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7479:Nek1
|
UTSW |
8 |
61,583,179 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7512:Nek1
|
UTSW |
8 |
61,583,179 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7715:Nek1
|
UTSW |
8 |
61,459,794 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7984:Nek1
|
UTSW |
8 |
61,574,087 (GRCm39) |
nonsense |
probably null |
|
|
R8271:Nek1
|
UTSW |
8 |
61,558,646 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8431:Nek1
|
UTSW |
8 |
61,487,066 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9076:Nek1
|
UTSW |
8 |
61,481,768 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9149:Nek1
|
UTSW |
8 |
61,574,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9250:Nek1
|
UTSW |
8 |
61,465,151 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9429:Nek1
|
UTSW |
8 |
61,559,892 (GRCm39) |
missense |
probably benign |
|
|
R9563:Nek1
|
UTSW |
8 |
61,577,157 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9616:Nek1
|
UTSW |
8 |
61,473,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF023:Nek1
|
UTSW |
8 |
61,525,779 (GRCm39) |
splice site |
probably null |
|
|
X0028:Nek1
|
UTSW |
8 |
61,496,292 (GRCm39) |
missense |
probably benign |
0.19 |
|
X0066:Nek1
|
UTSW |
8 |
61,578,162 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCTTTTAGCCTGAAGCACTTG -3'
(R):5'- CTTCCCAGTCCAAGAATAATGATAC -3'
Sequencing Primer
(F):5'- ACATACTGTGGGAGAGGT -3'
(R):5'- GAAGACATGCGTGCATTTTTCCAG -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation