Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02792:Pla2g4f'

359799

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Pla2g4f

Ensembl Gene

ENSMUSG00000046971

Gene Name

phospholipase A2, group IVF

Synonyms

4732472I07Rik, Pla2zeta

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL02792

Quality Score

Status

Chromosome

Chromosomal Location

120130438-120144646 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 120133850 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 517 (Y517C)

Ref Sequence

ENSEMBL: ENSMUSP00000062607 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054651]

AlphaFold

Q50L41

Predicted Effect

probably damaging
Transcript: ENSMUST00000054651
AA Change: Y517C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000062607
Gene: ENSMUSG00000046971
AA Change: Y517C

Domain	Start	End	E-Value	Type
C2	45	144	7.51e-11	SMART
PLAc	285	797	1.6e-13	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142183

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700067P10Rik	G	A	17: 48,401,107 (GRCm39)	V131M	probably benign	Het
Abca6	A	T	11: 110,079,507 (GRCm39)	C1216S	probably damaging	Het
Acly	T	C	11: 100,369,236 (GRCm39)	K1018E	probably damaging	Het
Acsl5	G	A	19: 55,282,163 (GRCm39)		probably null	Het
Adgrb1	C	A	15: 74,419,471 (GRCm39)	L771I	probably damaging	Het
Adh7	A	T	3: 137,929,498 (GRCm39)	K89I	probably damaging	Het
Adora2b	A	T	11: 62,156,309 (GRCm39)	I253F	possibly damaging	Het
Akna	G	A	4: 63,295,943 (GRCm39)	P975S	possibly damaging	Het
Alg9	T	C	9: 50,754,048 (GRCm39)	L576P	possibly damaging	Het
Arhgap20	A	G	9: 51,761,218 (GRCm39)	E1023G	possibly damaging	Het
Astn2	A	T	4: 65,563,058 (GRCm39)	S908T	probably benign	Het
Atp1a4	C	T	1: 172,054,866 (GRCm39)		probably null	Het
Cabin1	T	C	10: 75,582,573 (GRCm39)	Y281C	probably damaging	Het
Cdc42bpb	G	T	12: 111,265,995 (GRCm39)	F1312L	probably benign	Het
Cfap65	A	C	1: 74,966,337 (GRCm39)	F330C	probably damaging	Het
Col27a1	C	T	4: 63,233,820 (GRCm39)	P689S	unknown	Het
Col4a3	A	T	1: 82,696,524 (GRCm39)	K1643N	probably damaging	Het
Dop1b	T	A	16: 93,598,460 (GRCm39)	V1875D	possibly damaging	Het
Eftud2	A	G	11: 102,761,082 (GRCm39)		probably benign	Het
Ergic3	C	A	2: 155,859,770 (GRCm39)	T357K	probably damaging	Het
Glra1	A	T	11: 55,427,226 (GRCm39)	D36E	probably damaging	Het
Gpatch1	A	G	7: 35,001,018 (GRCm39)	Y330H	probably damaging	Het
Hmcn2	T	C	2: 31,236,602 (GRCm39)	S382P	probably damaging	Het
Kat6a	G	A	8: 23,428,316 (GRCm39)	E1224K	probably damaging	Het
Klk13	A	G	7: 43,370,838 (GRCm39)	E29G	possibly damaging	Het
Klra9	T	C	6: 130,165,643 (GRCm39)	D124G	probably benign	Het
Lrmda	T	C	14: 22,069,978 (GRCm39)		probably null	Het
Ltbp1	G	A	17: 75,589,989 (GRCm39)	V539M	probably damaging	Het
Ngfr	A	C	11: 95,462,687 (GRCm39)	L317R	probably damaging	Het
Nlrp6	C	A	7: 140,502,348 (GRCm39)	H151Q	probably damaging	Het
Nnt	A	G	13: 119,494,182 (GRCm39)	L633P	probably damaging	Het
Nxpe3	C	T	16: 55,686,535 (GRCm39)	V158M	probably damaging	Het
Or11i1	T	C	3: 106,729,456 (GRCm39)	T140A	probably damaging	Het
Or2d36	T	C	7: 106,747,425 (GRCm39)	F301L	probably benign	Het
Or7g16	C	T	9: 18,727,254 (GRCm39)	S112N	probably benign	Het
Poc1a	A	T	9: 106,172,393 (GRCm39)	I207F	possibly damaging	Het
Polr2a	A	G	11: 69,636,938 (GRCm39)	S338P	probably damaging	Het
Ptprz1	T	C	6: 22,959,722 (GRCm39)	V73A	probably damaging	Het
Relb	A	T	7: 19,347,789 (GRCm39)	L281Q	probably damaging	Het
Rrp8	A	T	7: 105,383,018 (GRCm39)	L382*	probably null	Het
Setd1a	C	T	7: 127,390,522 (GRCm39)	S523F	unknown	Het
Slamf8	A	G	1: 172,415,697 (GRCm39)	I47T	probably damaging	Het
Slc16a4	G	A	3: 107,206,193 (GRCm39)	A88T	probably benign	Het
Sox6	C	T	7: 115,140,884 (GRCm39)	M532I	probably benign	Het
Tcp11l1	T	A	2: 104,512,165 (GRCm39)	Y489F	probably benign	Het
Tdrd6	T	G	17: 43,935,918 (GRCm39)	D1710A	probably benign	Het
Trim58	C	T	11: 58,531,292 (GRCm39)		probably benign	Het
Vangl1	A	T	3: 102,070,739 (GRCm39)	I399N	probably damaging	Het
Vmn1r201	T	C	13: 22,659,014 (GRCm39)	L76P	probably damaging	Het
Vmn1r58	T	C	7: 5,414,228 (GRCm39)	M1V	probably null	Het
Wdfy4	T	C	14: 32,817,262 (GRCm39)	I1561V	probably benign	Het
Xkr9	A	G	1: 13,771,027 (GRCm39)	D181G	probably damaging	Het
Zfp318	T	C	17: 46,720,104 (GRCm39)	F1101L	probably damaging	Het
Zfpm2	C	A	15: 40,966,409 (GRCm39)	Q833K	probably benign	Het

Other mutations in Pla2g4f

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00539:Pla2g4f	APN	2	120,133,219 (GRCm39)	missense	possibly damaging	0.53
IGL01652:Pla2g4f	APN	2	120,132,716 (GRCm39)	missense	possibly damaging	0.86
R0625:Pla2g4f	UTSW	2	120,135,522 (GRCm39)	missense	probably damaging	1.00
R1760:Pla2g4f	UTSW	2	120,144,547 (GRCm39)	unclassified	probably benign
R1799:Pla2g4f	UTSW	2	120,141,549 (GRCm39)	missense	possibly damaging	0.49
R2212:Pla2g4f	UTSW	2	120,133,587 (GRCm39)	missense	probably benign
R2351:Pla2g4f	UTSW	2	120,130,923 (GRCm39)	missense	probably benign	0.01
R3412:Pla2g4f	UTSW	2	120,133,587 (GRCm39)	missense	probably benign
R3414:Pla2g4f	UTSW	2	120,133,587 (GRCm39)	missense	probably benign
R3906:Pla2g4f	UTSW	2	120,130,980 (GRCm39)	missense	probably benign	0.28
R4084:Pla2g4f	UTSW	2	120,142,806 (GRCm39)	missense	probably benign	0.36
R4477:Pla2g4f	UTSW	2	120,134,153 (GRCm39)	missense	probably damaging	1.00
R4529:Pla2g4f	UTSW	2	120,131,100 (GRCm39)	missense	probably damaging	0.99
R4606:Pla2g4f	UTSW	2	120,144,467 (GRCm39)	missense	probably benign	0.00
R4685:Pla2g4f	UTSW	2	120,135,496 (GRCm39)	missense	probably damaging	1.00
R4728:Pla2g4f	UTSW	2	120,131,402 (GRCm39)	missense	probably benign	0.19
R4782:Pla2g4f	UTSW	2	120,133,757 (GRCm39)	missense	probably damaging	1.00
R4957:Pla2g4f	UTSW	2	120,130,980 (GRCm39)	missense	probably benign	0.28
R5781:Pla2g4f	UTSW	2	120,135,504 (GRCm39)	missense	probably damaging	0.97
R6158:Pla2g4f	UTSW	2	120,131,552 (GRCm39)	missense	probably benign	0.21
R6232:Pla2g4f	UTSW	2	120,132,702 (GRCm39)	missense	possibly damaging	0.63
R6629:Pla2g4f	UTSW	2	120,138,723 (GRCm39)	missense	probably damaging	1.00
R6894:Pla2g4f	UTSW	2	120,134,077 (GRCm39)	missense	probably benign	0.44
R6939:Pla2g4f	UTSW	2	120,137,782 (GRCm39)	missense	probably damaging	1.00
R7131:Pla2g4f	UTSW	2	120,135,035 (GRCm39)	missense	probably null	0.01
R7221:Pla2g4f	UTSW	2	120,131,476 (GRCm39)	missense	probably benign	0.06
R7421:Pla2g4f	UTSW	2	120,137,737 (GRCm39)	missense	probably benign	0.07
R7767:Pla2g4f	UTSW	2	120,135,490 (GRCm39)	missense	possibly damaging	0.87
R8466:Pla2g4f	UTSW	2	120,130,963 (GRCm39)	missense	probably damaging	1.00
R9389:Pla2g4f	UTSW	2	120,132,781 (GRCm39)	missense	probably damaging	1.00
R9425:Pla2g4f	UTSW	2	120,133,264 (GRCm39)	missense	possibly damaging	0.75
R9500:Pla2g4f	UTSW	2	120,142,713 (GRCm39)	critical splice acceptor site	probably null
R9657:Pla2g4f	UTSW	2	120,135,138 (GRCm39)	missense	probably benign
R9714:Pla2g4f	UTSW	2	120,142,900 (GRCm39)	missense	probably benign	0.00

Posted On

2015-12-18