Incidental Mutation 'IGL02795:Fbxw19'
ID359916
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw19
Ensembl Gene ENSMUSG00000074061
Gene NameF-box and WD-40 domain protein 19
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL02795
Quality Score
Status
Chromosome9
Chromosomal Location109476654-109495875 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 109495818 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 10 (M10I)
Ref Sequence ENSEMBL: ENSMUSP00000075918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076617]
Predicted Effect possibly damaging
Transcript: ENSMUST00000076617
AA Change: M10I

PolyPhen 2 Score 0.525 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000075918
Gene: ENSMUSG00000074061
AA Change: M10I

DomainStartEndE-ValueType
FBOX 5 45 1.8e-6 SMART
SCOP:d1gxra_ 87 284 3e-5 SMART
Blast:WD40 137 176 8e-8 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A G 1: 71,288,748 L1391P probably damaging Het
Abcc3 G A 11: 94,361,642 probably benign Het
Acvr1 A G 2: 58,462,952 I332T probably damaging Het
Atp8a2 C T 14: 60,033,742 V247M probably damaging Het
Btn1a1 T C 13: 23,460,616 probably null Het
Btnl9 A T 11: 49,174,867 probably benign Het
Dbx1 T A 7: 49,636,577 I47F probably benign Het
Dnaja3 A G 16: 4,690,073 probably benign Het
Dnmt1 T C 9: 20,927,111 S220G probably benign Het
Dock9 A T 14: 121,639,978 M451K probably benign Het
Eml3 A G 19: 8,933,778 Y257C probably benign Het
Flg2 C T 3: 93,203,613 R983W unknown Het
Galnt5 C A 2: 58,027,871 P707H probably damaging Het
Gba2 G T 4: 43,578,331 P6Q probably damaging Het
Gm13199 A G 2: 5,862,673 probably benign Het
Gpr45 C T 1: 43,032,493 R99C possibly damaging Het
Hecw1 G A 13: 14,322,517 S302L probably damaging Het
Hrg T C 16: 22,957,553 probably benign Het
Kdelc2 A G 9: 53,392,105 D99G probably damaging Het
Lama1 A G 17: 67,738,894 probably null Het
Lgr4 T C 2: 110,008,210 probably benign Het
Lrrc9 C T 12: 72,478,768 T830M probably damaging Het
Mdga2 T C 12: 66,689,432 T341A probably benign Het
Mms19 C T 19: 41,952,406 probably null Het
Nectin1 A G 9: 43,803,552 S362G probably benign Het
Nlrc3 G T 16: 3,965,285 H87N probably damaging Het
Oit1 T A 14: 8,355,497 M113L probably benign Het
Olfr1018 T A 2: 85,823,512 C180* probably null Het
Olfr142 A G 2: 90,252,562 L142P probably damaging Het
Olfr183 G T 16: 59,000,277 L197F possibly damaging Het
Olfr23 G A 11: 73,940,929 V228I probably benign Het
Olfr243 T A 7: 103,716,883 F96L probably benign Het
Pcsk1 G T 13: 75,112,620 G321C probably damaging Het
Prrc2c G T 1: 162,714,299 P374T probably benign Het
Rusc1 A T 3: 89,091,950 L175Q probably damaging Het
Ryr2 T C 13: 11,595,190 N4250S probably benign Het
Scara5 A C 14: 65,730,680 N134T possibly damaging Het
Sema4d T C 13: 51,703,411 K595R probably benign Het
Serpinb6a A C 13: 33,931,593 L15R probably damaging Het
Setdb1 A T 3: 95,327,373 N1006K probably damaging Het
Slc18a2 G A 19: 59,274,490 probably benign Het
Slc22a30 C T 19: 8,400,895 C139Y probably damaging Het
Slc25a27 T A 17: 43,647,112 Y269F probably damaging Het
Slc9c1 A T 16: 45,575,419 D611V probably benign Het
Spag6 G T 2: 18,733,083 V255F probably benign Het
St5 T C 7: 109,556,364 Y393C probably damaging Het
Svep1 C A 4: 58,123,223 G698W probably damaging Het
Syne2 T C 12: 75,966,549 L2839P probably damaging Het
Tfb2m T C 1: 179,545,959 E58G possibly damaging Het
Trim24 A T 6: 37,919,389 E260D probably damaging Het
Ugt2b1 T A 5: 86,917,701 D493V probably damaging Het
Vmn1r27 A G 6: 58,215,302 V189A possibly damaging Het
Vmn2r91 A G 17: 18,085,277 Q74R probably benign Het
Vps25 A G 11: 101,256,090 Y64C probably damaging Het
Xirp2 G A 2: 67,509,136 G574S probably damaging Het
Ythdc2 A G 18: 44,837,438 E273G possibly damaging Het
Other mutations in Fbxw19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01094:Fbxw19 APN 9 109493546 missense probably benign 0.03
IGL01878:Fbxw19 APN 9 109483279 splice site probably benign
IGL02622:Fbxw19 APN 9 109493534 missense probably benign 0.22
IGL02752:Fbxw19 APN 9 109494641 missense probably benign 0.07
IGL03401:Fbxw19 APN 9 109494970 critical splice donor site probably null
R0402:Fbxw19 UTSW 9 109484425 missense probably benign 0.00
R0423:Fbxw19 UTSW 9 109486066 missense probably benign 0.22
R0466:Fbxw19 UTSW 9 109478649 missense probably benign 0.32
R0513:Fbxw19 UTSW 9 109481553 splice site probably null
R1538:Fbxw19 UTSW 9 109494988 missense probably damaging 1.00
R1768:Fbxw19 UTSW 9 109494772 nonsense probably null
R1869:Fbxw19 UTSW 9 109482032 missense probably benign 0.11
R1933:Fbxw19 UTSW 9 109481650 missense probably benign 0.20
R1960:Fbxw19 UTSW 9 109485936 missense probably benign
R2288:Fbxw19 UTSW 9 109493568 missense probably damaging 0.99
R2877:Fbxw19 UTSW 9 109485970 missense probably damaging 1.00
R2878:Fbxw19 UTSW 9 109485970 missense probably damaging 1.00
R4778:Fbxw19 UTSW 9 109494646 missense probably damaging 1.00
R5192:Fbxw19 UTSW 9 109484428 missense probably benign 0.01
R5196:Fbxw19 UTSW 9 109484428 missense probably benign 0.01
R5533:Fbxw19 UTSW 9 109486065 missense probably benign 0.00
R6107:Fbxw19 UTSW 9 109495766 missense probably damaging 1.00
R6333:Fbxw19 UTSW 9 109494683 missense probably benign 0.01
R6820:Fbxw19 UTSW 9 109482011 missense probably benign 0.07
R7631:Fbxw19 UTSW 9 109482001 missense probably damaging 1.00
R7651:Fbxw19 UTSW 9 109494646 missense probably damaging 1.00
Z1176:Fbxw19 UTSW 9 109481582 missense probably benign 0.00
Posted On2015-12-18