Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02795:Vmn1r27'

359917

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r27

Ensembl Gene

ENSMUSG00000071428

Gene Name

vomeronasal 1 receptor 27

Synonyms

V1rc33

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.159) question?

Stock #

IGL02795

Quality Score

Status

Chromosome

Chromosomal Location

58213091-58218821 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 58215302 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 189 (V189A)

Ref Sequence

ENSEMBL: ENSMUSP00000154455 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095862] [ENSMUST00000226666] [ENSMUST00000228530]

AlphaFold

K7N688

Predicted Effect

possibly damaging
Transcript: ENSMUST00000095862
AA Change: V239A

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000093547
Gene: ENSMUSG00000071428
AA Change: V239A

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	4.2e-51	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226666
AA Change: V189A

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228530
AA Change: V239A

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	G	1: 71,288,748 (GRCm38)	L1391P	probably damaging	Het
Abcc3	G	A	11: 94,361,642 (GRCm38)		probably benign	Het
Acvr1	A	G	2: 58,462,952 (GRCm38)	I332T	probably damaging	Het
Atp8a2	C	T	14: 60,033,742 (GRCm38)	V247M	probably damaging	Het
Btn1a1	T	C	13: 23,460,616 (GRCm38)		probably null	Het
Btnl9	A	T	11: 49,174,867 (GRCm38)		probably benign	Het
Dbx1	T	A	7: 49,636,577 (GRCm38)	I47F	probably benign	Het
Dnaja3	A	G	16: 4,690,073 (GRCm38)		probably benign	Het
Dnmt1	T	C	9: 20,927,111 (GRCm38)	S220G	probably benign	Het
Dock9	A	T	14: 121,639,978 (GRCm38)	M451K	probably benign	Het
Eml3	A	G	19: 8,933,778 (GRCm38)	Y257C	probably benign	Het
Fam3d	T	A	14: 8,355,497 (GRCm38)	M113L	probably benign	Het
Fbxw19	C	A	9: 109,495,818 (GRCm38)	M10I	possibly damaging	Het
Flg2	C	T	3: 93,203,613 (GRCm38)	R983W	unknown	Het
Galnt5	C	A	2: 58,027,871 (GRCm38)	P707H	probably damaging	Het
Gba2	G	T	4: 43,578,331 (GRCm38)	P6Q	probably damaging	Het
Gm13199	A	G	2: 5,862,673 (GRCm38)		probably benign	Het
Gpr45	C	T	1: 43,032,493 (GRCm38)	R99C	possibly damaging	Het
Hecw1	G	A	13: 14,322,517 (GRCm38)	S302L	probably damaging	Het
Hrg	T	C	16: 22,957,553 (GRCm38)		probably benign	Het
Lama1	A	G	17: 67,738,894 (GRCm38)		probably null	Het
Lgr4	T	C	2: 110,008,210 (GRCm38)		probably benign	Het
Lrrc9	C	T	12: 72,478,768 (GRCm38)	T830M	probably damaging	Het
Mdga2	T	C	12: 66,689,432 (GRCm38)	T341A	probably benign	Het
Mms19	C	T	19: 41,952,406 (GRCm38)		probably null	Het
Nectin1	A	G	9: 43,803,552 (GRCm38)	S362G	probably benign	Het
Nlrc3	G	T	16: 3,965,285 (GRCm38)	H87N	probably damaging	Het
Or1e17	G	A	11: 73,940,929 (GRCm38)	V228I	probably benign	Het
Or2ah1	T	A	2: 85,823,512 (GRCm38)	C180*	probably null	Het
Or4b13	A	G	2: 90,252,562 (GRCm38)	L142P	probably damaging	Het
Or52a20	T	A	7: 103,716,883 (GRCm38)	F96L	probably benign	Het
Or5h17	G	T	16: 59,000,277 (GRCm38)	L197F	possibly damaging	Het
Pcsk1	G	T	13: 75,112,620 (GRCm38)	G321C	probably damaging	Het
Poglut3	A	G	9: 53,392,105 (GRCm38)	D99G	probably damaging	Het
Prrc2c	G	T	1: 162,714,299 (GRCm38)	P374T	probably benign	Het
Rusc1	A	T	3: 89,091,950 (GRCm38)	L175Q	probably damaging	Het
Ryr2	T	C	13: 11,595,190 (GRCm38)	N4250S	probably benign	Het
Scara5	A	C	14: 65,730,680 (GRCm38)	N134T	possibly damaging	Het
Sema4d	T	C	13: 51,703,411 (GRCm38)	K595R	probably benign	Het
Serpinb6a	A	C	13: 33,931,593 (GRCm38)	L15R	probably damaging	Het
Setdb1	A	T	3: 95,327,373 (GRCm38)	N1006K	probably damaging	Het
Slc18a2	G	A	19: 59,274,490 (GRCm38)		probably benign	Het
Slc22a30	C	T	19: 8,400,895 (GRCm38)	C139Y	probably damaging	Het
Slc25a27	T	A	17: 43,647,112 (GRCm38)	Y269F	probably damaging	Het
Slc9c1	A	T	16: 45,575,419 (GRCm38)	D611V	probably benign	Het
Spag6	G	T	2: 18,733,083 (GRCm38)	V255F	probably benign	Het
St5	T	C	7: 109,556,364 (GRCm38)	Y393C	probably damaging	Het
Svep1	C	A	4: 58,123,223 (GRCm38)	G698W	probably damaging	Het
Syne2	T	C	12: 75,966,549 (GRCm38)	L2839P	probably damaging	Het
Tfb2m	T	C	1: 179,545,959 (GRCm38)	E58G	possibly damaging	Het
Trim24	A	T	6: 37,919,389 (GRCm38)	E260D	probably damaging	Het
Ugt2b1	T	A	5: 86,917,701 (GRCm38)	D493V	probably damaging	Het
Vmn2r91	A	G	17: 18,085,277 (GRCm38)	Q74R	probably benign	Het
Vps25	A	G	11: 101,256,090 (GRCm38)	Y64C	probably damaging	Het
Xirp2	G	A	2: 67,509,136 (GRCm38)	G574S	probably damaging	Het
Ythdc2	A	G	18: 44,837,438 (GRCm38)	E273G	possibly damaging	Het

Other mutations in Vmn1r27

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00160:Vmn1r27	APN	6	58,215,134 (GRCm38)	missense	probably benign	0.00
IGL01548:Vmn1r27	APN	6	58,215,553 (GRCm38)	missense	probably benign	0.01
IGL02662:Vmn1r27	APN	6	58,215,287 (GRCm38)	missense	probably damaging	1.00
IGL02726:Vmn1r27	APN	6	58,215,869 (GRCm38)	missense	possibly damaging	0.95
IGL03241:Vmn1r27	APN	6	58,215,141 (GRCm38)	missense	probably benign	0.04
IGL03373:Vmn1r27	APN	6	58,215,704 (GRCm38)	missense	probably damaging	1.00
R0119:Vmn1r27	UTSW	6	58,215,719 (GRCm38)	missense	possibly damaging	0.56
R0124:Vmn1r27	UTSW	6	58,215,248 (GRCm38)	missense	probably damaging	1.00
R0136:Vmn1r27	UTSW	6	58,215,719 (GRCm38)	missense	possibly damaging	0.56
R3613:Vmn1r27	UTSW	6	58,215,802 (GRCm38)	missense	probably damaging	1.00
R4192:Vmn1r27	UTSW	6	58,215,827 (GRCm38)	missense	probably damaging	0.99
R4556:Vmn1r27	UTSW	6	58,215,819 (GRCm38)	missense	possibly damaging	0.94
R4831:Vmn1r27	UTSW	6	58,215,842 (GRCm38)	missense	possibly damaging	0.85
R5354:Vmn1r27	UTSW	6	58,215,596 (GRCm38)	missense	probably benign	0.00
R5813:Vmn1r27	UTSW	6	58,216,000 (GRCm38)	missense	possibly damaging	0.76
R6856:Vmn1r27	UTSW	6	58,215,447 (GRCm38)	missense	possibly damaging	0.65
R7653:Vmn1r27	UTSW	6	58,215,894 (GRCm38)	missense	probably benign	0.21
R7653:Vmn1r27	UTSW	6	58,215,800 (GRCm38)	missense	possibly damaging	0.88
R8089:Vmn1r27	UTSW	6	58,215,209 (GRCm38)	missense	possibly damaging	0.82
R8177:Vmn1r27	UTSW	6	58,215,774 (GRCm38)	missense	probably benign	0.00
R9123:Vmn1r27	UTSW	6	58,215,431 (GRCm38)	missense	probably benign	0.00
R9125:Vmn1r27	UTSW	6	58,215,431 (GRCm38)	missense	probably benign	0.00
R9372:Vmn1r27	UTSW	6	58,215,761 (GRCm38)	missense	possibly damaging	0.95
R9422:Vmn1r27	UTSW	6	58,215,882 (GRCm38)	missense	probably benign	0.23

Posted On

2015-12-18