Incidental Mutation 'IGL02798:Olfr1341'
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ID360027
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1341
Ensembl Gene ENSMUSG00000046790
Gene Nameolfactory receptor 1341
SynonymsMOR258-1, GA_x6K02T2QD9B-18838170-18837232
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock #IGL02798
Quality Score
Status
Chromosome4
Chromosomal Location118703523-118713438 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 118709499 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 31 (F31L)
Ref Sequence ENSEMBL: ENSMUSP00000149466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061215] [ENSMUST00000214131] [ENSMUST00000215117]
Predicted Effect probably damaging
Transcript: ENSMUST00000061215
AA Change: F31L

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000095523
Gene: ENSMUSG00000046790
AA Change: F31L

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 8.4e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 304 1.5e-7 PFAM
Pfam:7tm_1 41 290 1.7e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214131
AA Change: F31L

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000215117
AA Change: F31L

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam2 A T 14: 66,040,275 C514S probably damaging Het
Alcam A G 16: 52,305,639 I105T probably damaging Het
Arhgef10l A T 4: 140,565,130 probably null Het
Arhgef17 A G 7: 100,929,626 V705A probably benign Het
C87436 T A 6: 86,446,202 C253S probably benign Het
Cbx7 T C 15: 79,918,399 T226A probably damaging Het
Cdh20 T C 1: 104,947,465 I324T probably damaging Het
Celsr3 A T 9: 108,843,575 H2608L probably damaging Het
Cramp1l A G 17: 24,968,920 probably benign Het
Ddx25 A G 9: 35,551,397 C231R probably damaging Het
Emilin2 A G 17: 71,256,695 probably benign Het
Fam46a A T 9: 85,324,884 V287E probably damaging Het
Hip1r T C 5: 123,994,712 probably benign Het
Insrr C T 3: 87,810,517 P842S probably damaging Het
Lama1 G T 17: 67,795,191 probably benign Het
Lig3 T C 11: 82,795,705 probably benign Het
Lrp4 C A 2: 91,476,710 T392K probably benign Het
Msl2 G T 9: 101,075,377 R33S probably benign Het
Nrde2 T A 12: 100,143,822 K317* probably null Het
Nub1 C A 5: 24,692,814 A42D probably damaging Het
Obox2 T C 7: 15,396,882 V13A possibly damaging Het
Olfr202 A T 16: 59,284,115 C127* probably null Het
Olfr729 T A 14: 50,148,378 K165N probably benign Het
Phkb T C 8: 86,043,777 Y892H probably benign Het
Ptdss1 A G 13: 66,976,760 Y341C probably damaging Het
Ripor2 A T 13: 24,674,666 D147V probably damaging Het
Scn7a T C 2: 66,713,875 D424G probably benign Het
Scn9a C T 2: 66,540,559 R559Q possibly damaging Het
Sctr G A 1: 120,022,180 C33Y probably damaging Het
Sh2b2 G T 5: 136,221,963 A419E probably damaging Het
Slc22a30 A T 19: 8,370,085 M317K probably damaging Het
Slc39a4 T C 15: 76,615,182 S178G probably benign Het
Slc7a12 T A 3: 14,481,157 C121S probably damaging Het
Slmap T C 14: 26,470,378 S148G possibly damaging Het
Tktl2 A G 8: 66,513,311 K507R probably benign Het
Ttn T G 2: 76,755,863 K21841N probably damaging Het
Ugcg T C 4: 59,220,346 Y380H probably damaging Het
Zfp106 T C 2: 120,510,510 T1840A probably damaging Het
Zmynd8 T C 2: 165,852,150 probably null Het
Other mutations in Olfr1341
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00983:Olfr1341 APN 4 118709922 missense probably damaging 1.00
IGL02699:Olfr1341 APN 4 118710198 missense probably benign 0.36
IGL03271:Olfr1341 APN 4 118709785 missense probably damaging 0.99
R0085:Olfr1341 UTSW 4 118709881 missense probably benign 0.18
R0355:Olfr1341 UTSW 4 118709611 missense probably benign 0.06
R1134:Olfr1341 UTSW 4 118710279 missense probably damaging 0.97
R1561:Olfr1341 UTSW 4 118709554 missense probably damaging 0.99
R1574:Olfr1341 UTSW 4 118709554 missense probably damaging 0.99
R2167:Olfr1341 UTSW 4 118710055 missense probably benign 0.18
R2182:Olfr1341 UTSW 4 118710345 makesense probably null
R2237:Olfr1341 UTSW 4 118709995 missense probably damaging 1.00
R3775:Olfr1341 UTSW 4 118710154 missense probably damaging 1.00
R6000:Olfr1341 UTSW 4 118710244 missense probably damaging 1.00
R6249:Olfr1341 UTSW 4 118709713 missense probably damaging 1.00
R6331:Olfr1341 UTSW 4 118709947 missense probably benign 0.34
R6527:Olfr1341 UTSW 4 118709848 missense possibly damaging 0.56
R7795:Olfr1341 UTSW 4 118709658 missense possibly damaging 0.94
X0063:Olfr1341 UTSW 4 118709755 missense probably damaging 1.00
Z1088:Olfr1341 UTSW 4 118710226 missense probably benign 0.00
Z1177:Olfr1341 UTSW 4 118710158 missense not run
Posted On2015-12-18