Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02798:Cramp1'

360065

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cramp1

Ensembl Gene

ENSMUSG00000038002

Gene Name

cramped chromatin regulator 1

Synonyms

5830477H08Rik, Tce4, Cramp1l

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02798

Quality Score

Status

Chromosome

Chromosomal Location

25180200-25234762 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 25187894 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000073060 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073337]

AlphaFold

Q6PG95

Predicted Effect

probably benign
Transcript: ENSMUST00000073337

SMART Domains

Protein: ENSMUSP00000073060
Gene: ENSMUSG00000038002

Domain	Start	End	E-Value	Type
low complexity region	11	20	N/A	INTRINSIC
low complexity region	29	43	N/A	INTRINSIC
low complexity region	51	64	N/A	INTRINSIC
low complexity region	100	126	N/A	INTRINSIC
low complexity region	134	147	N/A	INTRINSIC
SANT	159	219	3.68e-3	SMART
low complexity region	479	503	N/A	INTRINSIC
low complexity region	548	562	N/A	INTRINSIC
low complexity region	792	803	N/A	INTRINSIC
low complexity region	833	845	N/A	INTRINSIC
low complexity region	889	903	N/A	INTRINSIC
low complexity region	1069	1086	N/A	INTRINSIC
low complexity region	1113	1124	N/A	INTRINSIC
low complexity region	1141	1156	N/A	INTRINSIC
low complexity region	1171	1185	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit cleft palate. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam2	A	T	14: 66,277,724 (GRCm39)	C514S	probably damaging	Het
Alcam	A	G	16: 52,126,002 (GRCm39)	I105T	probably damaging	Het
Arhgef10l	A	T	4: 140,292,441 (GRCm39)		probably null	Het
Arhgef17	A	G	7: 100,578,833 (GRCm39)	V705A	probably benign	Het
C87436	T	A	6: 86,423,184 (GRCm39)	C253S	probably benign	Het
Cbx7	T	C	15: 79,802,600 (GRCm39)	T226A	probably damaging	Het
Cdh20	T	C	1: 104,875,190 (GRCm39)	I324T	probably damaging	Het
Celsr3	A	T	9: 108,720,774 (GRCm39)	H2608L	probably damaging	Het
Ddx25	A	G	9: 35,462,693 (GRCm39)	C231R	probably damaging	Het
Emilin2	A	G	17: 71,563,690 (GRCm39)		probably benign	Het
Hip1r	T	C	5: 124,132,775 (GRCm39)		probably benign	Het
Insrr	C	T	3: 87,717,824 (GRCm39)	P842S	probably damaging	Het
Lama1	G	T	17: 68,102,186 (GRCm39)		probably benign	Het
Lig3	T	C	11: 82,686,531 (GRCm39)		probably benign	Het
Lrp4	C	A	2: 91,307,055 (GRCm39)	T392K	probably benign	Het
Msl2	G	T	9: 100,957,430 (GRCm39)	R33S	probably benign	Het
Nrde2	T	A	12: 100,110,081 (GRCm39)	K317*	probably null	Het
Nub1	C	A	5: 24,897,812 (GRCm39)	A42D	probably damaging	Het
Obox2	T	C	7: 15,130,807 (GRCm39)	V13A	possibly damaging	Het
Or13p3	T	C	4: 118,566,696 (GRCm39)	F31L	probably damaging	Het
Or4k5	T	A	14: 50,385,835 (GRCm39)	K165N	probably benign	Het
Or5ac20	A	T	16: 59,104,478 (GRCm39)	C127*	probably null	Het
Phkb	T	C	8: 86,770,406 (GRCm39)	Y892H	probably benign	Het
Ptdss1	A	G	13: 67,124,824 (GRCm39)	Y341C	probably damaging	Het
Ripor2	A	T	13: 24,858,649 (GRCm39)	D147V	probably damaging	Het
Scn7a	T	C	2: 66,544,219 (GRCm39)	D424G	probably benign	Het
Scn9a	C	T	2: 66,370,903 (GRCm39)	R559Q	possibly damaging	Het
Sctr	G	A	1: 119,949,910 (GRCm39)	C33Y	probably damaging	Het
Sh2b2	G	T	5: 136,250,817 (GRCm39)	A419E	probably damaging	Het
Slc22a30	A	T	19: 8,347,449 (GRCm39)	M317K	probably damaging	Het
Slc39a4	T	C	15: 76,499,382 (GRCm39)	S178G	probably benign	Het
Slc7a12	T	A	3: 14,546,217 (GRCm39)	C121S	probably damaging	Het
Slmap	T	C	14: 26,191,533 (GRCm39)	S148G	possibly damaging	Het
Tent5a	A	T	9: 85,206,937 (GRCm39)	V287E	probably damaging	Het
Tktl2	A	G	8: 66,965,963 (GRCm39)	K507R	probably benign	Het
Ttn	T	G	2: 76,586,207 (GRCm39)	K21841N	probably damaging	Het
Ugcg	T	C	4: 59,220,346 (GRCm39)	Y380H	probably damaging	Het
Zfp106	T	C	2: 120,340,991 (GRCm39)	T1840A	probably damaging	Het
Zmynd8	T	C	2: 165,694,070 (GRCm39)		probably null	Het

Other mutations in Cramp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00566:Cramp1	APN	17	25,202,925 (GRCm39)	missense	probably benign	0.11
IGL01360:Cramp1	APN	17	25,216,547 (GRCm39)	missense	probably damaging	1.00
IGL01966:Cramp1	APN	17	25,201,917 (GRCm39)	missense	probably benign	0.01
IGL02211:Cramp1	APN	17	25,196,610 (GRCm39)	missense	possibly damaging	0.94
IGL02474:Cramp1	APN	17	25,204,024 (GRCm39)	missense	probably damaging	0.98
IGL03340:Cramp1	APN	17	25,192,516 (GRCm39)	missense	probably damaging	1.00
Interred	UTSW	17	25,202,956 (GRCm39)	missense	probably damaging	0.99
R0106:Cramp1	UTSW	17	25,191,350 (GRCm39)	missense	probably benign	0.30
R1054:Cramp1	UTSW	17	25,202,151 (GRCm39)	missense	probably damaging	1.00
R1220:Cramp1	UTSW	17	25,201,211 (GRCm39)	missense	probably damaging	1.00
R1341:Cramp1	UTSW	17	25,196,514 (GRCm39)	missense	probably damaging	1.00
R1491:Cramp1	UTSW	17	25,191,323 (GRCm39)	missense	probably benign	0.17
R1610:Cramp1	UTSW	17	25,202,925 (GRCm39)	missense	probably benign	0.11
R1649:Cramp1	UTSW	17	25,202,217 (GRCm39)	missense	probably damaging	1.00
R1795:Cramp1	UTSW	17	25,183,884 (GRCm39)	missense	probably damaging	1.00
R1856:Cramp1	UTSW	17	25,187,952 (GRCm39)	missense	probably damaging	1.00
R1881:Cramp1	UTSW	17	25,196,656 (GRCm39)	splice site	probably benign
R1968:Cramp1	UTSW	17	25,183,913 (GRCm39)	missense	probably damaging	1.00
R2047:Cramp1	UTSW	17	25,222,189 (GRCm39)	nonsense	probably null
R2099:Cramp1	UTSW	17	25,192,059 (GRCm39)	missense	probably benign	0.01
R2298:Cramp1	UTSW	17	25,216,454 (GRCm39)	missense	probably damaging	0.96
R3752:Cramp1	UTSW	17	25,190,532 (GRCm39)	missense	probably damaging	1.00
R3821:Cramp1	UTSW	17	25,193,756 (GRCm39)	missense	probably damaging	1.00
R3861:Cramp1	UTSW	17	25,216,588 (GRCm39)	splice site	probably benign
R4399:Cramp1	UTSW	17	25,198,559 (GRCm39)	missense	probably damaging	1.00
R4847:Cramp1	UTSW	17	25,204,063 (GRCm39)	missense	probably damaging	1.00
R4883:Cramp1	UTSW	17	25,201,293 (GRCm39)	missense	probably benign
R5579:Cramp1	UTSW	17	25,192,087 (GRCm39)	missense	possibly damaging	0.89
R5631:Cramp1	UTSW	17	25,204,577 (GRCm39)	missense	possibly damaging	0.93
R5716:Cramp1	UTSW	17	25,193,709 (GRCm39)	missense	probably damaging	0.99
R6589:Cramp1	UTSW	17	25,196,466 (GRCm39)	splice site	probably null
R6631:Cramp1	UTSW	17	25,202,931 (GRCm39)	missense	probably benign	0.40
R7307:Cramp1	UTSW	17	25,193,719 (GRCm39)	missense	possibly damaging	0.94
R7323:Cramp1	UTSW	17	25,201,379 (GRCm39)	missense	possibly damaging	0.90
R7672:Cramp1	UTSW	17	25,201,440 (GRCm39)	missense	probably damaging	0.96
R7832:Cramp1	UTSW	17	25,202,196 (GRCm39)	missense	probably damaging	0.96
R8071:Cramp1	UTSW	17	25,201,674 (GRCm39)	missense	probably damaging	0.99
R8244:Cramp1	UTSW	17	25,190,384 (GRCm39)	missense	probably damaging	1.00
R8430:Cramp1	UTSW	17	25,196,536 (GRCm39)	missense	probably damaging	1.00
R8783:Cramp1	UTSW	17	25,193,732 (GRCm39)	missense	probably damaging	0.99
R8890:Cramp1	UTSW	17	25,202,114 (GRCm39)	missense	probably damaging	1.00
R8892:Cramp1	UTSW	17	25,202,114 (GRCm39)	missense	probably damaging	1.00
R8894:Cramp1	UTSW	17	25,202,114 (GRCm39)	missense	probably damaging	1.00
R8937:Cramp1	UTSW	17	25,202,956 (GRCm39)	missense	probably damaging	0.99
R8941:Cramp1	UTSW	17	25,202,114 (GRCm39)	missense	probably damaging	1.00
R9029:Cramp1	UTSW	17	25,232,884 (GRCm39)	missense	probably damaging	1.00
R9047:Cramp1	UTSW	17	25,198,603 (GRCm39)	missense	possibly damaging	0.90
R9149:Cramp1	UTSW	17	25,187,920 (GRCm39)	missense	probably damaging	0.99
R9262:Cramp1	UTSW	17	25,232,920 (GRCm39)	missense	probably damaging	0.99
R9460:Cramp1	UTSW	17	25,222,281 (GRCm39)	missense	probably damaging	1.00
R9614:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9615:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9651:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9652:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9653:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9665:Cramp1	UTSW	17	25,196,545 (GRCm39)	missense	probably damaging	1.00
R9753:Cramp1	UTSW	17	25,191,320 (GRCm39)	missense	possibly damaging	0.81

Posted On

2015-12-18