Incidental Mutation 'IGL02799:Myh8'
ID 360124
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Myh8
Ensembl Gene ENSMUSG00000055775
Gene Name myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms Myhsp, 4832426G23Rik, MyHC-pn, Myhs-p
Accession Numbers
Essential gene? Probably essential (E-score: 0.826) question?
Stock # IGL02799 (G1)
Quality Score
Status
Chromosome 11
Chromosomal Location 67277124-67308634 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 67301592 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000019625 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019625]
AlphaFold P13542
Predicted Effect probably benign
Transcript: ENSMUST00000019625
SMART Domains Protein: ENSMUSP00000019625
Gene: ENSMUSG00000055775

DomainStartEndE-ValueType
Pfam:Myosin_N 37 76 2.1e-13 PFAM
MYSc 82 782 N/A SMART
IQ 783 805 5.44e-3 SMART
Pfam:Myosin_tail_1 846 1927 2.4e-164 PFAM
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 99% (67/68)
MGI Phenotype FUNCTION: This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add2 A G 6: 86,106,252 (GRCm38) N444S possibly damaging Het
Atp2b2 A T 6: 113,762,852 (GRCm38) Y823* probably null Het
Atp2c1 A C 9: 105,413,043 (GRCm38) probably benign Het
Capns1 A T 7: 30,192,219 (GRCm38) D133E probably benign Het
Cast A G 13: 74,736,752 (GRCm38) V361A probably damaging Het
Cd69 G A 6: 129,268,260 (GRCm38) probably benign Het
Celsr2 T A 3: 108,414,062 (GRCm38) D478V probably damaging Het
Cenpf T C 1: 189,659,652 (GRCm38) E661G probably damaging Het
Chrna1 A G 2: 73,574,641 (GRCm38) probably benign Het
Clec5a C A 6: 40,578,049 (GRCm38) V138F probably damaging Het
Ctsj T A 13: 61,003,820 (GRCm38) I95F probably benign Het
Dcaf1 T A 9: 106,857,940 (GRCm38) S696T probably benign Het
Dcp1a T C 14: 30,519,679 (GRCm38) probably null Het
Dnajc14 C T 10: 128,806,856 (GRCm38) P216S possibly damaging Het
Dst T C 1: 34,179,849 (GRCm38) I1790T possibly damaging Het
Ehmt1 A T 2: 24,815,806 (GRCm38) H789Q probably damaging Het
Exoc7 A T 11: 116,301,181 (GRCm38) L188Q probably damaging Het
Faap100 A G 11: 120,370,735 (GRCm38) L823P probably damaging Het
Fdxacb1 T A 9: 50,772,596 (GRCm38) S620T probably benign Het
Fhl2 C T 1: 43,128,402 (GRCm38) R177Q probably benign Het
Gars1 C A 6: 55,063,099 (GRCm38) T337K probably damaging Het
Ggta1 A T 2: 35,422,199 (GRCm38) F56I probably damaging Het
Gm10715 A C 9: 3,038,062 (GRCm38) probably benign Het
Gpr108 T A 17: 57,237,482 (GRCm38) I343F probably damaging Het
Gpr12 T A 5: 146,583,819 (GRCm38) I98F possibly damaging Het
Hk2 A G 6: 82,760,238 (GRCm38) L3P probably damaging Het
Imp4 C A 1: 34,440,177 (GRCm38) probably benign Het
Insrr G A 3: 87,813,581 (GRCm38) V1049M probably damaging Het
Klhl24 T C 16: 20,114,581 (GRCm38) V314A probably damaging Het
Krt32 A T 11: 100,087,907 (GRCm38) V107D possibly damaging Het
Krtap5-1 G A 7: 142,296,505 (GRCm38) Q189* probably null Het
Lrrc9 A G 12: 72,506,404 (GRCm38) E1360G probably damaging Het
Mdc1 G T 17: 35,846,191 (GRCm38) L163F possibly damaging Het
Mroh1 T G 15: 76,392,461 (GRCm38) probably null Het
Ndufab1 A T 7: 122,093,726 (GRCm38) probably benign Het
Nek3 A G 8: 22,158,719 (GRCm38) probably benign Het
Ngly1 A T 14: 16,260,636 (GRCm38) I107L probably benign Het
Nkain4 A T 2: 180,935,935 (GRCm38) probably null Het
Nsd2 T A 5: 33,864,788 (GRCm38) probably benign Het
Or4n4 A G 14: 50,281,344 (GRCm38) I303T probably benign Het
Or5e1 A T 7: 108,755,623 (GRCm38) M256L probably benign Het
Or5t9 A T 2: 86,828,956 (GRCm38) H68L probably damaging Het
Or7e166 T A 9: 19,713,018 (GRCm38) Y64N probably damaging Het
Or8b12 T A 9: 37,746,509 (GRCm38) I125N probably damaging Het
Pcnt G A 10: 76,412,583 (GRCm38) Q901* probably null Het
Pctp C A 11: 89,991,087 (GRCm38) W81C probably damaging Het
Pik3r5 A T 11: 68,495,947 (GRCm38) I801F probably damaging Het
Ptprj A T 2: 90,469,598 (GRCm38) N193K probably benign Het
Rab11fip1 A T 8: 27,152,760 (GRCm38) D670E probably benign Het
Racgap1 T C 15: 99,632,747 (GRCm38) K201E probably benign Het
Ranbp2 T C 10: 58,480,264 (GRCm38) F2269L probably damaging Het
Rint1 C A 5: 23,819,480 (GRCm38) A760D possibly damaging Het
Ryr2 G A 13: 11,665,962 (GRCm38) P3166S probably damaging Het
Snap29 A G 16: 17,422,503 (GRCm38) N158D probably benign Het
Speer4c1 A C 5: 15,714,216 (GRCm38) probably benign Het
St6galnac1 G T 11: 116,766,647 (GRCm38) probably benign Het
Strc G A 2: 121,379,236 (GRCm38) T202I probably damaging Het
Stxbp4 A G 11: 90,494,600 (GRCm38) probably null Het
Syne1 A T 10: 5,359,059 (GRCm38) M650K probably damaging Het
Tbc1d2b C T 9: 90,223,434 (GRCm38) probably benign Het
Tcfl5 A T 2: 180,638,626 (GRCm38) I328N possibly damaging Het
Tenm2 A G 11: 36,273,408 (GRCm38) Y337H probably damaging Het
Tgfbr2 T C 9: 116,110,136 (GRCm38) K233E possibly damaging Het
Tnk2 T C 16: 32,665,881 (GRCm38) probably benign Het
Trbv13-2 A G 6: 41,121,537 (GRCm38) probably benign Het
Tut4 T C 4: 108,513,528 (GRCm38) Y875H probably benign Het
Usp6nl T A 2: 6,427,549 (GRCm38) probably benign Het
Vmn2r62 A G 7: 42,787,972 (GRCm38) S363P possibly damaging Het
Vnn3 T C 10: 23,851,971 (GRCm38) I93T possibly damaging Het
Ylpm1 A G 12: 85,044,484 (GRCm38) D1108G probably damaging Het
Zbtb17 G A 4: 141,463,380 (GRCm38) G170S probably benign Het
Zfyve26 T C 12: 79,273,310 (GRCm38) E1087G probably benign Het
Other mutations in Myh8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Myh8 APN 11 67,283,818 (GRCm38) missense probably damaging 0.97
IGL01020:Myh8 APN 11 67,283,403 (GRCm38) missense probably damaging 0.99
IGL01348:Myh8 APN 11 67,297,780 (GRCm38) missense probably damaging 1.00
IGL01382:Myh8 APN 11 67,301,973 (GRCm38) missense probably damaging 1.00
IGL01454:Myh8 APN 11 67,283,596 (GRCm38) missense probably damaging 1.00
IGL01457:Myh8 APN 11 67,292,679 (GRCm38) missense probably benign 0.00
IGL01472:Myh8 APN 11 67,288,379 (GRCm38) splice site probably benign
IGL01473:Myh8 APN 11 67,301,825 (GRCm38) critical splice donor site probably null
IGL01613:Myh8 APN 11 67,301,710 (GRCm38) missense probably benign 0.11
IGL01763:Myh8 APN 11 67,286,419 (GRCm38) missense probably benign 0.01
IGL01828:Myh8 APN 11 67,303,826 (GRCm38) missense possibly damaging 0.82
IGL01862:Myh8 APN 11 67,289,694 (GRCm38) nonsense probably null
IGL01905:Myh8 APN 11 67,284,651 (GRCm38) missense possibly damaging 0.90
IGL02280:Myh8 APN 11 67,283,372 (GRCm38) unclassified probably benign
IGL02386:Myh8 APN 11 67,294,440 (GRCm38) missense probably damaging 0.99
IGL02449:Myh8 APN 11 67,294,614 (GRCm38) critical splice donor site probably null
IGL02500:Myh8 APN 11 67,305,710 (GRCm38) missense probably benign 0.00
IGL02745:Myh8 APN 11 67,297,501 (GRCm38) missense possibly damaging 0.88
IGL03063:Myh8 APN 11 67,288,205 (GRCm38) missense probably benign 0.00
IGL03223:Myh8 APN 11 67,283,818 (GRCm38) missense probably damaging 0.97
IGL03336:Myh8 APN 11 67,284,702 (GRCm38) missense probably damaging 1.00
IGL03338:Myh8 APN 11 67,298,346 (GRCm38) missense probably damaging 1.00
IGL03351:Myh8 APN 11 67,303,913 (GRCm38) missense possibly damaging 0.94
IGL03392:Myh8 APN 11 67,294,418 (GRCm38) missense probably damaging 1.00
BB003:Myh8 UTSW 11 67,278,906 (GRCm38) missense possibly damaging 0.94
BB009:Myh8 UTSW 11 67,294,604 (GRCm38) missense probably benign 0.00
BB013:Myh8 UTSW 11 67,278,906 (GRCm38) missense possibly damaging 0.94
BB019:Myh8 UTSW 11 67,294,604 (GRCm38) missense probably benign 0.00
PIT4354001:Myh8 UTSW 11 67,289,630 (GRCm38) missense probably benign 0.01
R0012:Myh8 UTSW 11 67,300,021 (GRCm38) missense probably benign 0.02
R0016:Myh8 UTSW 11 67,298,525 (GRCm38) missense probably damaging 1.00
R0016:Myh8 UTSW 11 67,298,525 (GRCm38) missense probably damaging 1.00
R0115:Myh8 UTSW 11 67,306,264 (GRCm38) splice site probably benign
R0131:Myh8 UTSW 11 67,292,188 (GRCm38) missense probably damaging 0.96
R0131:Myh8 UTSW 11 67,292,188 (GRCm38) missense probably damaging 0.96
R0132:Myh8 UTSW 11 67,292,188 (GRCm38) missense probably damaging 0.96
R0238:Myh8 UTSW 11 67,301,692 (GRCm38) missense probably benign 0.00
R0238:Myh8 UTSW 11 67,301,692 (GRCm38) missense probably benign 0.00
R0239:Myh8 UTSW 11 67,301,692 (GRCm38) missense probably benign 0.00
R0239:Myh8 UTSW 11 67,301,692 (GRCm38) missense probably benign 0.00
R0393:Myh8 UTSW 11 67,306,017 (GRCm38) splice site probably benign
R0453:Myh8 UTSW 11 67,292,905 (GRCm38) missense probably benign 0.03
R0454:Myh8 UTSW 11 67,303,765 (GRCm38) nonsense probably null
R0466:Myh8 UTSW 11 67,298,579 (GRCm38) missense probably benign 0.01
R0487:Myh8 UTSW 11 67,302,011 (GRCm38) missense probably benign
R0511:Myh8 UTSW 11 67,284,507 (GRCm38) missense probably benign 0.01
R0557:Myh8 UTSW 11 67,301,798 (GRCm38) missense possibly damaging 0.88
R0589:Myh8 UTSW 11 67,298,627 (GRCm38) missense probably benign 0.00
R0658:Myh8 UTSW 11 67,284,532 (GRCm38) critical splice donor site probably null
R0782:Myh8 UTSW 11 67,289,754 (GRCm38) missense probably benign 0.16
R0829:Myh8 UTSW 11 67,283,500 (GRCm38) unclassified probably benign
R0845:Myh8 UTSW 11 67,286,264 (GRCm38) missense probably damaging 1.00
R0930:Myh8 UTSW 11 67,305,998 (GRCm38) missense possibly damaging 0.93
R0972:Myh8 UTSW 11 67,297,759 (GRCm38) missense probably damaging 1.00
R1132:Myh8 UTSW 11 67,297,131 (GRCm38) nonsense probably null
R1417:Myh8 UTSW 11 67,306,185 (GRCm38) missense probably damaging 1.00
R1478:Myh8 UTSW 11 67,292,725 (GRCm38) missense probably benign 0.23
R1497:Myh8 UTSW 11 67,289,812 (GRCm38) missense probably benign 0.00
R1605:Myh8 UTSW 11 67,301,671 (GRCm38) missense probably damaging 0.99
R1701:Myh8 UTSW 11 67,280,138 (GRCm38) missense probably damaging 1.00
R1950:Myh8 UTSW 11 67,279,004 (GRCm38) missense possibly damaging 0.75
R1989:Myh8 UTSW 11 67,292,724 (GRCm38) missense probably benign 0.00
R2010:Myh8 UTSW 11 67,297,164 (GRCm38) nonsense probably null
R2095:Myh8 UTSW 11 67,286,224 (GRCm38) missense probably benign 0.00
R2132:Myh8 UTSW 11 67,292,876 (GRCm38) missense probably damaging 1.00
R2152:Myh8 UTSW 11 67,294,469 (GRCm38) missense probably damaging 0.97
R2229:Myh8 UTSW 11 67,308,348 (GRCm38) missense probably damaging 0.98
R2302:Myh8 UTSW 11 67,286,239 (GRCm38) missense probably damaging 1.00
R2364:Myh8 UTSW 11 67,294,518 (GRCm38) missense probably benign 0.03
R2429:Myh8 UTSW 11 67,303,897 (GRCm38) missense probably benign 0.21
R2880:Myh8 UTSW 11 67,297,264 (GRCm38) missense probably damaging 0.97
R3692:Myh8 UTSW 11 67,301,918 (GRCm38) missense probably damaging 0.98
R3756:Myh8 UTSW 11 67,284,617 (GRCm38) unclassified probably benign
R3924:Myh8 UTSW 11 67,297,137 (GRCm38) missense probably damaging 0.99
R4172:Myh8 UTSW 11 67,292,421 (GRCm38) missense probably damaging 1.00
R4255:Myh8 UTSW 11 67,299,734 (GRCm38) missense probably benign
R4621:Myh8 UTSW 11 67,286,258 (GRCm38) missense probably damaging 1.00
R4623:Myh8 UTSW 11 67,286,258 (GRCm38) missense probably damaging 1.00
R4790:Myh8 UTSW 11 67,279,963 (GRCm38) missense probably damaging 0.99
R4914:Myh8 UTSW 11 67,292,684 (GRCm38) missense probably damaging 1.00
R5074:Myh8 UTSW 11 67,305,916 (GRCm38) missense possibly damaging 0.79
R5119:Myh8 UTSW 11 67,298,358 (GRCm38) missense probably damaging 1.00
R5159:Myh8 UTSW 11 67,288,353 (GRCm38) missense probably damaging 0.99
R5229:Myh8 UTSW 11 67,284,484 (GRCm38) missense probably damaging 0.96
R5320:Myh8 UTSW 11 67,286,263 (GRCm38) missense probably damaging 1.00
R5455:Myh8 UTSW 11 67,301,418 (GRCm38) missense possibly damaging 0.59
R5523:Myh8 UTSW 11 67,305,962 (GRCm38) missense possibly damaging 0.95
R5540:Myh8 UTSW 11 67,286,440 (GRCm38) missense probably benign 0.00
R5726:Myh8 UTSW 11 67,294,566 (GRCm38) missense possibly damaging 0.79
R5770:Myh8 UTSW 11 67,297,200 (GRCm38) missense probably damaging 1.00
R6135:Myh8 UTSW 11 67,297,500 (GRCm38) missense possibly damaging 0.51
R6253:Myh8 UTSW 11 67,301,967 (GRCm38) missense probably benign 0.06
R6318:Myh8 UTSW 11 67,299,341 (GRCm38) missense probably benign 0.00
R6432:Myh8 UTSW 11 67,298,579 (GRCm38) missense probably benign 0.01
R6452:Myh8 UTSW 11 67,305,739 (GRCm38) missense possibly damaging 0.88
R6452:Myh8 UTSW 11 67,292,449 (GRCm38) missense probably benign 0.27
R6512:Myh8 UTSW 11 67,289,662 (GRCm38) nonsense probably null
R6714:Myh8 UTSW 11 67,306,949 (GRCm38) missense probably damaging 1.00
R6842:Myh8 UTSW 11 67,284,655 (GRCm38) missense probably damaging 1.00
R7007:Myh8 UTSW 11 67,288,316 (GRCm38) missense probably benign 0.03
R7025:Myh8 UTSW 11 67,297,539 (GRCm38) missense probably benign 0.02
R7086:Myh8 UTSW 11 67,292,627 (GRCm38) splice site probably null
R7098:Myh8 UTSW 11 67,279,053 (GRCm38) missense probably benign 0.03
R7498:Myh8 UTSW 11 67,283,437 (GRCm38) missense possibly damaging 0.80
R7716:Myh8 UTSW 11 67,298,652 (GRCm38) missense possibly damaging 0.51
R7765:Myh8 UTSW 11 67,303,655 (GRCm38) missense probably benign 0.44
R7825:Myh8 UTSW 11 67,303,712 (GRCm38) missense possibly damaging 0.94
R7921:Myh8 UTSW 11 67,283,818 (GRCm38) missense probably damaging 0.97
R7926:Myh8 UTSW 11 67,278,906 (GRCm38) missense possibly damaging 0.94
R7932:Myh8 UTSW 11 67,294,604 (GRCm38) missense probably benign 0.00
R8003:Myh8 UTSW 11 67,299,760 (GRCm38) missense probably damaging 1.00
R8028:Myh8 UTSW 11 67,303,676 (GRCm38) missense possibly damaging 0.65
R8121:Myh8 UTSW 11 67,289,821 (GRCm38) missense probably benign 0.00
R8125:Myh8 UTSW 11 67,299,772 (GRCm38) missense possibly damaging 0.94
R8170:Myh8 UTSW 11 67,288,266 (GRCm38) missense probably benign 0.30
R8277:Myh8 UTSW 11 67,292,909 (GRCm38) missense probably benign 0.10
R8304:Myh8 UTSW 11 67,304,336 (GRCm38) missense possibly damaging 0.72
R8431:Myh8 UTSW 11 67,283,614 (GRCm38) missense possibly damaging 0.94
R8535:Myh8 UTSW 11 67,278,915 (GRCm38) missense probably damaging 1.00
R8795:Myh8 UTSW 11 67,283,377 (GRCm38) critical splice acceptor site probably benign
R8858:Myh8 UTSW 11 67,301,994 (GRCm38) missense possibly damaging 0.67
R8927:Myh8 UTSW 11 67,283,255 (GRCm38) missense probably benign 0.10
R8928:Myh8 UTSW 11 67,283,255 (GRCm38) missense probably benign 0.10
R9031:Myh8 UTSW 11 67,299,315 (GRCm38) missense possibly damaging 0.49
R9172:Myh8 UTSW 11 67,292,434 (GRCm38) missense possibly damaging 0.82
R9252:Myh8 UTSW 11 67,286,476 (GRCm38) missense probably damaging 1.00
R9365:Myh8 UTSW 11 67,283,806 (GRCm38) missense probably benign 0.42
R9468:Myh8 UTSW 11 67,306,904 (GRCm38) missense probably damaging 1.00
R9564:Myh8 UTSW 11 67,286,389 (GRCm38) missense probably benign 0.40
R9565:Myh8 UTSW 11 67,286,389 (GRCm38) missense probably benign 0.40
T0722:Myh8 UTSW 11 67,304,436 (GRCm38) missense probably benign 0.41
Z1088:Myh8 UTSW 11 67,298,592 (GRCm38) missense probably damaging 1.00
Z1176:Myh8 UTSW 11 67,303,674 (GRCm38) missense probably damaging 1.00
Z1177:Myh8 UTSW 11 67,308,355 (GRCm38) missense possibly damaging 0.64
Z1177:Myh8 UTSW 11 67,301,424 (GRCm38) missense probably damaging 0.99
Z1187:Myh8 UTSW 11 67,297,486 (GRCm38) missense probably benign
Z1188:Myh8 UTSW 11 67,297,486 (GRCm38) missense probably benign
Z1190:Myh8 UTSW 11 67,297,486 (GRCm38) missense probably benign
Z1191:Myh8 UTSW 11 67,297,486 (GRCm38) missense probably benign
Posted On 2015-12-18