Incidental Mutation 'IGL02800:Wdr70'
ID360158
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr70
Ensembl Gene ENSMUSG00000039828
Gene NameWD repeat domain 70
Synonyms4833422F06Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.962) question?
Stock #IGL02800
Quality Score
Status
Chromosome15
Chromosomal Location7873055-8099209 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 8082496 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 88 (S88G)
Ref Sequence ENSEMBL: ENSMUSP00000037340 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045766]
Predicted Effect probably benign
Transcript: ENSMUST00000045766
AA Change: S88G

PolyPhen 2 Score 0.254 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000037340
Gene: ENSMUSG00000039828
AA Change: S88G

DomainStartEndE-ValueType
coiled coil region 51 81 N/A INTRINSIC
low complexity region 137 167 N/A INTRINSIC
WD40 174 213 1.61e-3 SMART
WD40 220 260 3.2e0 SMART
WD40 272 315 1.03e0 SMART
WD40 324 363 1.7e-2 SMART
WD40 367 409 1.38e-2 SMART
Blast:WD40 413 460 5e-16 BLAST
WD40 463 502 3.44e0 SMART
low complexity region 570 586 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg6 A G 10: 14,420,605 I1045T probably damaging Het
Ankrd22 T C 19: 34,165,781 probably benign Het
Bahcc1 A G 11: 120,272,934 D686G probably damaging Het
Carns1 A G 19: 4,166,570 probably benign Het
Cc2d1b C T 4: 108,626,136 L306F probably benign Het
Ccdc153 A G 9: 44,245,832 E135G probably damaging Het
Ccne1 T C 7: 38,102,799 D148G probably damaging Het
Cfap57 A T 4: 118,614,750 M144K probably damaging Het
Chd6 A G 2: 160,984,632 V1049A probably damaging Het
Cpne9 A G 6: 113,302,073 D476G probably benign Het
Dna2 T C 10: 62,961,725 probably null Het
Eif4h T C 5: 134,627,605 D77G probably benign Het
Fam208b T C 13: 3,585,154 N551S probably benign Het
Fhl2 C T 1: 43,128,402 R177Q probably benign Het
Fxyd5 C T 7: 31,032,979 R176H possibly damaging Het
G6pd2 A G 5: 61,809,392 E170G probably damaging Het
Haus3 A G 5: 34,166,324 I314T possibly damaging Het
Igkv4-54 A G 6: 69,631,878 V41A probably damaging Het
Kidins220 T A 12: 25,003,093 C461S probably damaging Het
Lsr T C 7: 30,958,413 D442G probably damaging Het
Mecom T C 3: 29,961,034 I847V probably damaging Het
Mia2 C T 12: 59,188,491 R1326* probably null Het
Myo15 C A 11: 60,502,369 H2240N probably damaging Het
Olfr1318 A T 2: 112,156,244 I98F possibly damaging Het
Olfr23 A G 11: 73,941,116 Y290C probably damaging Het
Osgep T A 14: 50,915,857 probably benign Het
Pcnt G A 10: 76,412,583 Q901* probably null Het
Pgm3 T C 9: 86,555,378 E481G possibly damaging Het
Plch1 T A 3: 63,698,478 D1326V probably benign Het
Rabgap1l T C 1: 160,472,053 D590G possibly damaging Het
Rapsn A G 2: 91,043,239 M244V probably benign Het
Rcbtb2 T A 14: 73,168,103 Y299* probably null Het
Slc8a1 A T 17: 81,408,323 D760E probably benign Het
Smim23 C A 11: 32,824,424 probably null Het
Sva A G 6: 42,040,135 T59A unknown Het
Tacc2 T A 7: 130,624,079 D831E probably benign Het
Tg G T 15: 66,757,886 W472L probably damaging Het
Tmem231 A G 8: 111,914,032 V283A probably benign Het
Traf4 A T 11: 78,160,235 I365N possibly damaging Het
Usf3 G A 16: 44,219,096 S1313N probably benign Het
Vangl1 G A 3: 102,163,295 probably benign Het
Other mutations in Wdr70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:Wdr70 APN 15 8019607 missense probably benign 0.07
IGL01121:Wdr70 APN 15 7873174 missense possibly damaging 0.53
IGL01508:Wdr70 APN 15 8079263 missense probably benign 0.33
IGL01801:Wdr70 APN 15 7887324 splice site probably null
IGL01815:Wdr70 APN 15 7887324 splice site probably null
IGL01929:Wdr70 APN 15 7920634 splice site probably null
IGL02150:Wdr70 APN 15 8082546 missense possibly damaging 0.72
IGL02245:Wdr70 APN 15 8046482 missense possibly damaging 0.86
IGL02541:Wdr70 APN 15 7884302 nonsense probably null
IGL02829:Wdr70 APN 15 7976982 missense possibly damaging 0.92
IGL02831:Wdr70 APN 15 7884306 missense possibly damaging 0.86
IGL03169:Wdr70 APN 15 7884340 missense possibly damaging 0.73
IGL03405:Wdr70 APN 15 8035871 missense possibly damaging 0.73
R0106:Wdr70 UTSW 15 8019587 critical splice donor site probably null
R0106:Wdr70 UTSW 15 8019587 critical splice donor site probably null
R0462:Wdr70 UTSW 15 8079161 missense probably benign 0.00
R0539:Wdr70 UTSW 15 7885637 missense possibly damaging 0.96
R1398:Wdr70 UTSW 15 8035844 missense probably benign 0.01
R1812:Wdr70 UTSW 15 8079179 missense probably benign 0.00
R1863:Wdr70 UTSW 15 7920573 missense probably benign 0.25
R1913:Wdr70 UTSW 15 7884410 missense possibly damaging 0.72
R2425:Wdr70 UTSW 15 7887359 nonsense probably null
R4013:Wdr70 UTSW 15 8079214 nonsense probably null
R4015:Wdr70 UTSW 15 8079214 nonsense probably null
R4017:Wdr70 UTSW 15 8079214 nonsense probably null
R4111:Wdr70 UTSW 15 7976991 missense probably benign 0.32
R5241:Wdr70 UTSW 15 8079216 missense probably benign
R5277:Wdr70 UTSW 15 7976984 nonsense probably null
R5306:Wdr70 UTSW 15 7924273 missense probably benign 0.04
R5426:Wdr70 UTSW 15 7922105 missense possibly damaging 0.59
R5586:Wdr70 UTSW 15 7884288 missense possibly damaging 0.86
R6010:Wdr70 UTSW 15 7887419 splice site probably null
R6035:Wdr70 UTSW 15 7887349 missense possibly damaging 0.86
R6035:Wdr70 UTSW 15 7887349 missense possibly damaging 0.86
R6109:Wdr70 UTSW 15 8079154 splice site probably null
R6139:Wdr70 UTSW 15 8079251 missense probably benign 0.04
R6400:Wdr70 UTSW 15 8042841 missense probably benign 0.32
R6456:Wdr70 UTSW 15 7885637 missense possibly damaging 0.96
R6518:Wdr70 UTSW 15 8079337 missense unknown
R7036:Wdr70 UTSW 15 7884374 missense possibly damaging 0.85
R7056:Wdr70 UTSW 15 7884396 missense possibly damaging 0.53
R7341:Wdr70 UTSW 15 7924244 missense possibly damaging 0.71
R7484:Wdr70 UTSW 15 7922081 missense probably benign 0.23
R7572:Wdr70 UTSW 15 8035846 missense possibly damaging 0.85
R7652:Wdr70 UTSW 15 8079216 missense probably benign
R7886:Wdr70 UTSW 15 8079249 missense probably benign 0.02
R8103:Wdr70 UTSW 15 7977131 missense possibly damaging 0.70
R8214:Wdr70 UTSW 15 7887370 missense probably benign 0.03
R8252:Wdr70 UTSW 15 8042856 splice site probably benign
Posted On2015-12-18