Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02801:Fbxw16'

360178

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw16

Ensembl Gene

ENSMUSG00000074062

Gene Name

F-box and WD-40 domain protein 16

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL02801

Quality Score

Status

Chromosome

Chromosomal Location

109432316-109449140 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 109441076 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 199 (F199S)

Ref Sequence

ENSEMBL: ENSMUSP00000082051 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084984]

AlphaFold

Q497Z0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000084984
AA Change: F199S

PolyPhen 2 Score 0.730 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000082051
Gene: ENSMUSG00000074062
AA Change: F199S

Domain	Start	End	E-Value	Type
FBOX	5	45	2.72e-6	SMART
SCOP:d1e1aa_	128	249	3e-5	SMART
Blast:WD40	137	176	1e-7	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196410

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196515

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap5	A	T	12: 76,328,995	K400N	probably benign	Het
Aox2	A	T	1: 58,354,177	I1193F	probably damaging	Het
Arhgef16	A	T	4: 154,291,507	L10Q	probably damaging	Het
Arl10	T	C	13: 54,575,883	V106A	probably benign	Het
Bmi1	T	C	2: 18,681,881	Y24H	probably damaging	Het
Cd163	T	A	6: 124,320,529	I878K	probably benign	Het
Col12a1	A	G	9: 79,608,414		probably null	Het
Csmd2	T	C	4: 128,552,075		probably null	Het
Dcp2	G	T	18: 44,417,711	M417I	probably damaging	Het
Ddx11	T	A	17: 66,148,033	C662S	probably benign	Het
Dhx29	G	A	13: 112,964,646	C1241Y	probably damaging	Het
Dnajc6	C	T	4: 101,597,813	P37L	probably benign	Het
Dqx1	A	G	6: 83,060,495		probably null	Het
Dzip1	T	A	14: 118,885,655	K643*	probably null	Het
Ecel1	A	G	1: 87,152,003	S463P	probably damaging	Het
Eml5	A	G	12: 98,817,845	V1361A	possibly damaging	Het
Fads2	C	A	19: 10,082,645	A222S	possibly damaging	Het
Fancd2	A	G	6: 113,593,317	N1410D	probably benign	Het
Frem2	A	G	3: 53,652,175	V1637A	possibly damaging	Het
Gabrg2	A	G	11: 41,912,393	S442P	probably damaging	Het
Gprin3	T	C	6: 59,354,981	T114A	possibly damaging	Het
Hoxd8	A	G	2: 74,706,568	E27G	probably damaging	Het
Isl2	A	G	9: 55,545,532		probably null	Het
Lamc2	T	A	1: 153,136,783	H715L	probably benign	Het
Lrif1	T	C	3: 106,734,614	V102A	possibly damaging	Het
Lrrc39	A	G	3: 116,578,346	N254S	possibly damaging	Het
Med13l	T	C	5: 118,745,113	W1346R	probably damaging	Het
Melk	T	C	4: 44,360,930	I570T	probably damaging	Het
Mlkl	G	A	8: 111,316,432	T361M	probably benign	Het
Myo1f	T	A	17: 33,578,137	M94K	probably damaging	Het
Naip1	A	G	13: 100,444,368	C124R	probably damaging	Het
Nek1	G	A	8: 61,121,061		probably null	Het
Nrn1	C	A	13: 36,730,106		probably null	Het
Pde1c	G	T	6: 56,173,666	N289K	probably damaging	Het
Pfas	G	A	11: 68,988,277		probably benign	Het
Pms2	A	T	5: 143,925,835	I587F	probably benign	Het
Ppargc1b	T	C	18: 61,307,684	E721G	possibly damaging	Het
Ppp2r1b	A	G	9: 50,878,827	I435V	probably benign	Het
Psip1	C	T	4: 83,458,120	S494N	probably benign	Het
Ranbp3	T	C	17: 56,710,766	V474A	probably benign	Het
Rnf220	C	T	4: 117,273,251	C259Y	probably damaging	Het
Sdr16c6	T	C	4: 4,076,603	I99V	probably benign	Het
Slc36a1	A	T	11: 55,226,053	I303F	probably benign	Het
Slc4a1	C	T	11: 102,359,146		probably null	Het
Syncrip	A	T	9: 88,479,809	D84E	probably damaging	Het
Tbc1d9b	T	C	11: 50,152,830	Y593H	probably damaging	Het
Tenm2	G	T	11: 36,047,030	Y1605*	probably null	Het
Tmem135	T	A	7: 89,154,125	H280L	probably benign	Het
Tmem229a	T	A	6: 24,955,122	Q211L	probably benign	Het
Txlna	T	C	4: 129,640,408	D5G	probably damaging	Het
Vmn2r57	T	C	7: 41,448,632	I4V	probably benign	Het
Wdfy3	A	G	5: 101,907,587	L1539S	probably damaging	Het
Zdhhc14	T	G	17: 5,726,819		probably null	Het

Other mutations in Fbxw16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02139:Fbxw16	APN	9	109436686	missense	probably benign	0.34
milky_way	UTSW	9	109441250	missense	probably damaging	1.00
R0041:Fbxw16	UTSW	9	109448164	missense	probably damaging	1.00
R0245:Fbxw16	UTSW	9	109436168	missense	possibly damaging	0.93
R0389:Fbxw16	UTSW	9	109432482	missense	probably benign	0.03
R0652:Fbxw16	UTSW	9	109436168	missense	possibly damaging	0.93
R1693:Fbxw16	UTSW	9	109436259	missense	possibly damaging	0.74
R1772:Fbxw16	UTSW	9	109439582	missense	possibly damaging	0.91
R1965:Fbxw16	UTSW	9	109441221	missense	probably damaging	1.00
R2190:Fbxw16	UTSW	9	109436671	missense	probably damaging	1.00
R2334:Fbxw16	UTSW	9	109438361	missense	probably benign	0.16
R3800:Fbxw16	UTSW	9	109436597	missense	probably damaging	0.99
R3976:Fbxw16	UTSW	9	109439629	missense	probably benign	0.42
R4298:Fbxw16	UTSW	9	109446557	missense	probably benign	0.00
R4914:Fbxw16	UTSW	9	109438177	missense	probably benign	0.01
R4948:Fbxw16	UTSW	9	109438347	missense	probably damaging	1.00
R4995:Fbxw16	UTSW	9	109441250	missense	probably damaging	1.00
R5057:Fbxw16	UTSW	9	109441164	missense	probably damaging	1.00
R5077:Fbxw16	UTSW	9	109441049	critical splice donor site	probably null
R5111:Fbxw16	UTSW	9	109436728	missense	probably benign	0.11
R5294:Fbxw16	UTSW	9	109436644	missense	probably benign	0.34
R5901:Fbxw16	UTSW	9	109441217	missense	probably benign	0.06
R6295:Fbxw16	UTSW	9	109448769	intron	probably benign
R6303:Fbxw16	UTSW	9	109449101	missense	probably benign	0.00
R6664:Fbxw16	UTSW	9	109438258	missense	probably benign	0.27
R6670:Fbxw16	UTSW	9	109438212	missense	probably damaging	1.00
R6890:Fbxw16	UTSW	9	109436742	missense	probably benign	0.14
R7056:Fbxw16	UTSW	9	109436284	missense	possibly damaging	0.50
R7073:Fbxw16	UTSW	9	109441055	missense	probably damaging	1.00
R7344:Fbxw16	UTSW	9	109449035	missense	probably benign	0.00
R7396:Fbxw16	UTSW	9	109449023	missense	probably damaging	1.00
R7464:Fbxw16	UTSW	9	109439551	missense	possibly damaging	0.50
R7568:Fbxw16	UTSW	9	109439589	missense	possibly damaging	0.49
R7735:Fbxw16	UTSW	9	109441067	missense	probably damaging	1.00
R7808:Fbxw16	UTSW	9	109448154	missense	probably damaging	0.96
R7998:Fbxw16	UTSW	9	109436698	missense	probably damaging	1.00
R9019:Fbxw16	UTSW	9	109441067	missense	probably damaging	1.00
R9111:Fbxw16	UTSW	9	109436611	missense	probably damaging	1.00
R9216:Fbxw16	UTSW	9	109447819	missense	probably damaging	1.00
R9758:Fbxw16	UTSW	9	109449101	missense	probably benign	0.00

Posted On

2015-12-18