Incidental Mutation 'IGL02801:Arl10'
ID360206
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arl10
Ensembl Gene ENSMUSG00000025870
Gene NameADP-ribosylation factor-like 10
SynonymsArl10a, ARL10, Arm1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02801
Quality Score
Status
Chromosome13
Chromosomal Location54575015-54581128 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 54575883 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 106 (V106A)
Ref Sequence ENSEMBL: ENSMUSP00000116506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026988] [ENSMUST00000156024]
Predicted Effect probably benign
Transcript: ENSMUST00000026988
AA Change: V106A

PolyPhen 2 Score 0.093 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000026988
Gene: ENSMUSG00000025870
AA Change: V106A

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
low complexity region 33 49 N/A INTRINSIC
Pfam:Arf 70 231 6.6e-38 PFAM
Pfam:SRPRB 74 203 9e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000116804
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135354
Predicted Effect probably benign
Transcript: ENSMUST00000142246
SMART Domains Protein: ENSMUSP00000114680
Gene: ENSMUSG00000025870

DomainStartEndE-ValueType
Pfam:Arf 1 54 4.3e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000156024
AA Change: V106A

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000116506
Gene: ENSMUSG00000025870
AA Change: V106A

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
low complexity region 33 49 N/A INTRINSIC
Pfam:Arf 70 191 7.7e-32 PFAM
Pfam:SRPRB 74 194 6e-7 PFAM
Pfam:Miro 78 186 3e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap5 A T 12: 76,328,995 K400N probably benign Het
Aox2 A T 1: 58,354,177 I1193F probably damaging Het
Arhgef16 A T 4: 154,291,507 L10Q probably damaging Het
Bmi1 T C 2: 18,681,881 Y24H probably damaging Het
Cd163 T A 6: 124,320,529 I878K probably benign Het
Col12a1 A G 9: 79,608,414 probably null Het
Csmd2 T C 4: 128,552,075 probably null Het
Dcp2 G T 18: 44,417,711 M417I probably damaging Het
Ddx11 T A 17: 66,148,033 C662S probably benign Het
Dhx29 G A 13: 112,964,646 C1241Y probably damaging Het
Dnajc6 C T 4: 101,597,813 P37L probably benign Het
Dqx1 A G 6: 83,060,495 probably null Het
Dzip1 T A 14: 118,885,655 K643* probably null Het
Ecel1 A G 1: 87,152,003 S463P probably damaging Het
Eml5 A G 12: 98,817,845 V1361A possibly damaging Het
Fads2 C A 19: 10,082,645 A222S possibly damaging Het
Fancd2 A G 6: 113,593,317 N1410D probably benign Het
Fbxw16 A G 9: 109,441,076 F199S possibly damaging Het
Frem2 A G 3: 53,652,175 V1637A possibly damaging Het
Gabrg2 A G 11: 41,912,393 S442P probably damaging Het
Gprin3 T C 6: 59,354,981 T114A possibly damaging Het
Hoxd8 A G 2: 74,706,568 E27G probably damaging Het
Isl2 A G 9: 55,545,532 probably null Het
Lamc2 T A 1: 153,136,783 H715L probably benign Het
Lrif1 T C 3: 106,734,614 V102A possibly damaging Het
Lrrc39 A G 3: 116,578,346 N254S possibly damaging Het
Med13l T C 5: 118,745,113 W1346R probably damaging Het
Melk T C 4: 44,360,930 I570T probably damaging Het
Mlkl G A 8: 111,316,432 T361M probably benign Het
Myo1f T A 17: 33,578,137 M94K probably damaging Het
Naip1 A G 13: 100,444,368 C124R probably damaging Het
Nek1 G A 8: 61,121,061 probably null Het
Nrn1 C A 13: 36,730,106 probably null Het
Pde1c G T 6: 56,173,666 N289K probably damaging Het
Pfas G A 11: 68,988,277 probably benign Het
Pms2 A T 5: 143,925,835 I587F probably benign Het
Ppargc1b T C 18: 61,307,684 E721G possibly damaging Het
Ppp2r1b A G 9: 50,878,827 I435V probably benign Het
Psip1 C T 4: 83,458,120 S494N probably benign Het
Ranbp3 T C 17: 56,710,766 V474A probably benign Het
Rnf220 C T 4: 117,273,251 C259Y probably damaging Het
Sdr16c6 T C 4: 4,076,603 I99V probably benign Het
Slc36a1 A T 11: 55,226,053 I303F probably benign Het
Slc4a1 C T 11: 102,359,146 probably null Het
Syncrip A T 9: 88,479,809 D84E probably damaging Het
Tbc1d9b T C 11: 50,152,830 Y593H probably damaging Het
Tenm2 G T 11: 36,047,030 Y1605* probably null Het
Tmem135 T A 7: 89,154,125 H280L probably benign Het
Tmem229a T A 6: 24,955,122 Q211L probably benign Het
Txlna T C 4: 129,640,408 D5G probably damaging Het
Vmn2r57 T C 7: 41,448,632 I4V probably benign Het
Wdfy3 A G 5: 101,907,587 L1539S probably damaging Het
Zdhhc14 T G 17: 5,726,819 probably null Het
Other mutations in Arl10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02150:Arl10 APN 13 54578849 missense probably damaging 1.00
IGL03114:Arl10 APN 13 54575766 unclassified probably benign
R0015:Arl10 UTSW 13 54575957 splice site probably benign
R0976:Arl10 UTSW 13 54575808 unclassified probably benign
R1223:Arl10 UTSW 13 54578931 missense probably damaging 1.00
R2125:Arl10 UTSW 13 54579124 splice site probably null
R2239:Arl10 UTSW 13 54575149 missense probably benign 0.23
R2380:Arl10 UTSW 13 54575149 missense probably benign 0.23
R5828:Arl10 UTSW 13 54578955 missense probably damaging 1.00
R6222:Arl10 UTSW 13 54578831 missense probably damaging 0.99
R6602:Arl10 UTSW 13 54578937 missense probably damaging 1.00
Z1176:Arl10 UTSW 13 54580724 missense probably benign 0.10
Posted On2015-12-18