Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02801:Gprin3'

360207

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gprin3

Ensembl Gene

ENSMUSG00000045441

Gene Name

GPRIN family member 3

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL02801

Quality Score

Status

Chromosome

Chromosomal Location

59347226-59426294 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 59354981 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 114 (T114A)

Ref Sequence

ENSEMBL: ENSMUSP00000051805 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051065]

AlphaFold

Q8BWS5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000051065
AA Change: T114A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000051805
Gene: ENSMUSG00000045441
AA Change: T114A

Domain	Start	End	E-Value	Type
low complexity region	52	63	N/A	INTRINSIC
low complexity region	311	329	N/A	INTRINSIC
low complexity region	593	609	N/A	INTRINSIC
Pfam:GRIN_C	627	758	2.7e-49	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap5	A	T	12: 76,328,995 (GRCm38)	K400N	probably benign	Het
Aox2	A	T	1: 58,354,177 (GRCm38)	I1193F	probably damaging	Het
Arhgef16	A	T	4: 154,291,507 (GRCm38)	L10Q	probably damaging	Het
Arl10	T	C	13: 54,575,883 (GRCm38)	V106A	probably benign	Het
Bmi1	T	C	2: 18,681,881 (GRCm38)	Y24H	probably damaging	Het
Cd163	T	A	6: 124,320,529 (GRCm38)	I878K	probably benign	Het
Col12a1	A	G	9: 79,608,414 (GRCm38)		probably null	Het
Csmd2	T	C	4: 128,552,075 (GRCm38)		probably null	Het
Dcp2	G	T	18: 44,417,711 (GRCm38)	M417I	probably damaging	Het
Ddx11	T	A	17: 66,148,033 (GRCm38)	C662S	probably benign	Het
Dhx29	G	A	13: 112,964,646 (GRCm38)	C1241Y	probably damaging	Het
Dnajc6	C	T	4: 101,597,813 (GRCm38)	P37L	probably benign	Het
Dqx1	A	G	6: 83,060,495 (GRCm38)		probably null	Het
Dzip1	T	A	14: 118,885,655 (GRCm38)	K643*	probably null	Het
Ecel1	A	G	1: 87,152,003 (GRCm38)	S463P	probably damaging	Het
Eml5	A	G	12: 98,817,845 (GRCm38)	V1361A	possibly damaging	Het
Fads2	C	A	19: 10,082,645 (GRCm38)	A222S	possibly damaging	Het
Fancd2	A	G	6: 113,593,317 (GRCm38)	N1410D	probably benign	Het
Fbxw16	A	G	9: 109,441,076 (GRCm38)	F199S	possibly damaging	Het
Frem2	A	G	3: 53,652,175 (GRCm38)	V1637A	possibly damaging	Het
Gabrg2	A	G	11: 41,912,393 (GRCm38)	S442P	probably damaging	Het
Hoxd8	A	G	2: 74,706,568 (GRCm38)	E27G	probably damaging	Het
Isl2	A	G	9: 55,545,532 (GRCm38)		probably null	Het
Lamc2	T	A	1: 153,136,783 (GRCm38)	H715L	probably benign	Het
Lrif1	T	C	3: 106,734,614 (GRCm38)	V102A	possibly damaging	Het
Lrrc39	A	G	3: 116,578,346 (GRCm38)	N254S	possibly damaging	Het
Med13l	T	C	5: 118,745,113 (GRCm38)	W1346R	probably damaging	Het
Melk	T	C	4: 44,360,930 (GRCm38)	I570T	probably damaging	Het
Mlkl	G	A	8: 111,316,432 (GRCm38)	T361M	probably benign	Het
Myo1f	T	A	17: 33,578,137 (GRCm38)	M94K	probably damaging	Het
Naip1	A	G	13: 100,444,368 (GRCm38)	C124R	probably damaging	Het
Nek1	G	A	8: 61,121,061 (GRCm38)		probably null	Het
Nrn1	C	A	13: 36,730,106 (GRCm38)		probably null	Het
Pde1c	G	T	6: 56,173,666 (GRCm38)	N289K	probably damaging	Het
Pfas	G	A	11: 68,988,277 (GRCm38)		probably benign	Het
Pms2	A	T	5: 143,925,835 (GRCm38)	I587F	probably benign	Het
Ppargc1b	T	C	18: 61,307,684 (GRCm38)	E721G	possibly damaging	Het
Ppp2r1b	A	G	9: 50,878,827 (GRCm38)	I435V	probably benign	Het
Psip1	C	T	4: 83,458,120 (GRCm38)	S494N	probably benign	Het
Ranbp3	T	C	17: 56,710,766 (GRCm38)	V474A	probably benign	Het
Rnf220	C	T	4: 117,273,251 (GRCm38)	C259Y	probably damaging	Het
Sdr16c6	T	C	4: 4,076,603 (GRCm38)	I99V	probably benign	Het
Slc36a1	A	T	11: 55,226,053 (GRCm38)	I303F	probably benign	Het
Slc4a1	C	T	11: 102,359,146 (GRCm38)		probably null	Het
Syncrip	A	T	9: 88,479,809 (GRCm38)	D84E	probably damaging	Het
Tbc1d9b	T	C	11: 50,152,830 (GRCm38)	Y593H	probably damaging	Het
Tenm2	G	T	11: 36,047,030 (GRCm38)	Y1605*	probably null	Het
Tmem135	T	A	7: 89,154,125 (GRCm38)	H280L	probably benign	Het
Tmem229a	T	A	6: 24,955,122 (GRCm38)	Q211L	probably benign	Het
Txlna	T	C	4: 129,640,408 (GRCm38)	D5G	probably damaging	Het
Vmn2r57	T	C	7: 41,448,632 (GRCm38)	I4V	probably benign	Het
Wdfy3	A	G	5: 101,907,587 (GRCm38)	L1539S	probably damaging	Het
Zdhhc14	T	G	17: 5,726,819 (GRCm38)		probably null	Het

Other mutations in Gprin3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00970:Gprin3	APN	6	59,353,837 (GRCm38)	missense	possibly damaging	0.72
IGL02059:Gprin3	APN	6	59,355,325 (GRCm38)	utr 5 prime	probably benign
IGL02080:Gprin3	APN	6	59,354,191 (GRCm38)	missense	possibly damaging	0.91
IGL02183:Gprin3	APN	6	59,353,162 (GRCm38)	missense	possibly damaging	0.87
IGL02267:Gprin3	APN	6	59,354,473 (GRCm38)	missense	probably benign	0.02
IGL03212:Gprin3	APN	6	59,355,028 (GRCm38)	missense	probably benign
creep	UTSW	6	59,353,387 (GRCm38)	missense	probably damaging	0.98
simplex	UTSW	6	59,354,560 (GRCm38)	missense	possibly damaging	0.72
viridae	UTSW	6	59,354,936 (GRCm38)	missense	possibly damaging	0.86
R0505:Gprin3	UTSW	6	59,353,387 (GRCm38)	missense	probably damaging	0.98
R0944:Gprin3	UTSW	6	59,353,915 (GRCm38)	missense	possibly damaging	0.72
R1028:Gprin3	UTSW	6	59,354,609 (GRCm38)	missense	possibly damaging	0.53
R1180:Gprin3	UTSW	6	59,354,936 (GRCm38)	missense	possibly damaging	0.86
R1290:Gprin3	UTSW	6	59,354,464 (GRCm38)	missense	possibly damaging	0.53
R2060:Gprin3	UTSW	6	59,354,519 (GRCm38)	missense	possibly damaging	0.73
R2403:Gprin3	UTSW	6	59,354,149 (GRCm38)	missense	probably benign	0.13
R3830:Gprin3	UTSW	6	59,353,633 (GRCm38)	missense	probably benign	0.12
R3893:Gprin3	UTSW	6	59,354,479 (GRCm38)	missense	probably benign	0.12
R3983:Gprin3	UTSW	6	59,354,560 (GRCm38)	missense	possibly damaging	0.72
R4812:Gprin3	UTSW	6	59,353,365 (GRCm38)	missense	possibly damaging	0.85
R4932:Gprin3	UTSW	6	59,354,173 (GRCm38)	missense	probably benign	0.33
R4944:Gprin3	UTSW	6	59,354,659 (GRCm38)	missense	probably benign	0.00
R5523:Gprin3	UTSW	6	59,353,946 (GRCm38)	nonsense	probably null
R5677:Gprin3	UTSW	6	59,353,892 (GRCm38)	missense	possibly damaging	0.73
R5772:Gprin3	UTSW	6	59,354,413 (GRCm38)	missense	possibly damaging	0.86
R5879:Gprin3	UTSW	6	59,354,713 (GRCm38)	missense	probably benign
R5881:Gprin3	UTSW	6	59,354,786 (GRCm38)	missense	probably benign	0.18
R6044:Gprin3	UTSW	6	59,353,672 (GRCm38)	missense	possibly damaging	0.72
R6272:Gprin3	UTSW	6	59,353,331 (GRCm38)	nonsense	probably null
R7140:Gprin3	UTSW	6	59,355,143 (GRCm38)	missense	possibly damaging	0.85
R7528:Gprin3	UTSW	6	59,354,032 (GRCm38)	missense	possibly damaging	0.85
R7891:Gprin3	UTSW	6	59,353,711 (GRCm38)	missense	probably benign	0.22
R7970:Gprin3	UTSW	6	59,353,165 (GRCm38)	missense	possibly damaging	0.71
R8129:Gprin3	UTSW	6	59,353,859 (GRCm38)	missense	probably benign	0.03
R8190:Gprin3	UTSW	6	59,354,471 (GRCm38)	missense	possibly damaging	0.73
R8291:Gprin3	UTSW	6	59,355,005 (GRCm38)	missense	possibly damaging	0.47
R8466:Gprin3	UTSW	6	59,354,482 (GRCm38)	missense	probably benign	0.33
R8466:Gprin3	UTSW	6	59,354,481 (GRCm38)	missense	possibly damaging	0.73
R9135:Gprin3	UTSW	6	59,353,288 (GRCm38)	missense	probably benign	0.05
R9182:Gprin3	UTSW	6	59,354,212 (GRCm38)	missense	probably benign	0.02
R9762:Gprin3	UTSW	6	59,354,251 (GRCm38)	missense	possibly damaging	0.53

Posted On

2015-12-18