Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02803:Itfg1'

360328

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Itfg1

Ensembl Gene

ENSMUSG00000031703

Gene Name

integrin alpha FG-GAP repeat containing 1

Synonyms

D8Wsu49e, 2310047C21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.179) question?

Stock #

IGL02803

Quality Score

Status

Chromosome

Chromosomal Location

85717578-85840921 bp(-) (GRCm38)

Type of Mutation

splice site (3 bp from exon)

DNA Base Change (assembly)

T to C at 85725511 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000034140 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034140]

AlphaFold

Q99KW9

Predicted Effect

probably null
Transcript: ENSMUST00000034140

SMART Domains

Protein: ENSMUSP00000034140
Gene: ENSMUSG00000031703

Domain	Start	End	E-Value	Type
signal peptide	1	32	N/A	INTRINSIC
SCOP:d1m1xa4	46	232	5e-3	SMART
low complexity region	482	496	N/A	INTRINSIC
transmembrane domain	564	586	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210604

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agmo	C	T	12: 37,252,481	L106F	probably benign	Het
Appl1	A	G	14: 26,951,516	I208T	possibly damaging	Het
Arap2	G	T	5: 62,749,109	A189D	probably benign	Het
Arhgef12	T	C	9: 42,972,028	K1402E	possibly damaging	Het
C7	A	C	15: 5,049,560	F89V	probably damaging	Het
Camsap2	G	A	1: 136,281,123	T877I	probably damaging	Het
Cpt2	T	C	4: 107,907,386	T394A	probably benign	Het
Csnk2a1	G	T	2: 152,274,085		probably benign	Het
Dnah10	C	A	5: 124,798,014	T2528N	probably damaging	Het
Entpd8	G	T	2: 25,085,139	W494L	probably damaging	Het
Fam114a1	T	A	5: 65,005,792		probably benign	Het
Fat4	T	C	3: 38,889,295	V779A	probably damaging	Het
Gckr	T	C	5: 31,298,204	S34P	probably damaging	Het
Golga4	T	C	9: 118,535,460	V297A	probably benign	Het
Gpr65	T	C	12: 98,275,210	S41P	probably damaging	Het
Gps1	G	T	11: 120,786,823	A221S	probably damaging	Het
Heatr1	T	A	13: 12,433,986	S1861T	probably damaging	Het
Hmces	A	G	6: 87,925,729	E184G	probably damaging	Het
Mkl2	C	T	16: 13,403,156	T743I	possibly damaging	Het
Nfe2l3	A	G	6: 51,457,311	S284G	possibly damaging	Het
Nlrp2	C	A	7: 5,328,318	A360S	probably damaging	Het
Nop9	A	G	14: 55,750,076	H298R	probably benign	Het
Olfr1434	A	T	19: 12,283,983	S312C	possibly damaging	Het
Olfr183	T	A	16: 58,999,958	V91E	probably benign	Het
Olfr522	T	C	7: 140,162,374	D192G	possibly damaging	Het
Osgin1	A	G	8: 119,443,267	M158V	probably benign	Het
Patj	C	A	4: 98,426,064	Q374K	probably damaging	Het
Pck1	G	T	2: 173,156,004	G289W	probably damaging	Het
Phkg1	T	G	5: 129,866,054	I219L	possibly damaging	Het
Ppp1r15b	G	A	1: 133,133,343	A533T	probably damaging	Het
Ppwd1	T	C	13: 104,213,684	I398V	probably benign	Het
Prkdc	A	G	16: 15,833,666		probably benign	Het
Psg25	G	A	7: 18,526,287	L229F	possibly damaging	Het
Rps6ka1	T	A	4: 133,880,954	Q24L	probably benign	Het
Sgk3	T	C	1: 9,879,048	I147T	possibly damaging	Het
Slc25a24	T	A	3: 109,155,071	I159N	probably damaging	Het
Slc26a4	T	C	12: 31,522,527		probably null	Het
Slc35f4	T	C	14: 49,304,257	I347V	probably benign	Het
Spag17	A	T	3: 100,109,397	M2163L	probably benign	Het
Stab2	C	T	10: 86,950,269		probably benign	Het
Sult2a8	G	A	7: 14,411,705		probably benign	Het
Syne2	T	C	12: 76,031,546	L4718P	probably damaging	Het
Timd4	G	T	11: 46,815,694	G108W	probably damaging	Het
Timm9	T	C	12: 71,126,374		probably benign	Het
Vmn2r98	G	A	17: 19,066,013	V258I	probably benign	Het
Zcchc9	C	T	13: 91,800,881	V174I	probably benign	Het
Zdbf2	T	C	1: 63,303,077	V205A	possibly damaging	Het

Other mutations in Itfg1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02579:Itfg1	APN	8	85780565	missense	possibly damaging	0.95
R0368:Itfg1	UTSW	8	85764407	missense	probably damaging	1.00
R0755:Itfg1	UTSW	8	85726205	missense	possibly damaging	0.90
R1183:Itfg1	UTSW	8	85780523	missense	probably benign	0.04
R1529:Itfg1	UTSW	8	85810614	missense	probably benign	0.02
R1789:Itfg1	UTSW	8	85725512	critical splice donor site	probably null
R1953:Itfg1	UTSW	8	85831231	missense	probably benign	0.31
R2206:Itfg1	UTSW	8	85776198	missense	probably benign	0.17
R2207:Itfg1	UTSW	8	85776198	missense	probably benign	0.17
R2260:Itfg1	UTSW	8	85722677	missense	probably damaging	1.00
R2358:Itfg1	UTSW	8	85738129	missense	probably damaging	1.00
R2876:Itfg1	UTSW	8	85780510	splice site	probably benign
R2990:Itfg1	UTSW	8	85835049	missense	possibly damaging	0.82
R4484:Itfg1	UTSW	8	85726249	missense	probably damaging	1.00
R4762:Itfg1	UTSW	8	85732441	missense	possibly damaging	0.95
R5146:Itfg1	UTSW	8	85718868	makesense	probably null
R5796:Itfg1	UTSW	8	85718893	missense	probably damaging	1.00
R5805:Itfg1	UTSW	8	85766972	missense	probably benign	0.04
R6084:Itfg1	UTSW	8	85726170	missense	probably benign	0.01
R6187:Itfg1	UTSW	8	85836465	missense	probably damaging	1.00
R6319:Itfg1	UTSW	8	85840629	missense	probably damaging	1.00
R6463:Itfg1	UTSW	8	85736151	missense	probably benign	0.03
R6490:Itfg1	UTSW	8	85740301	missense	probably benign	0.08
R6492:Itfg1	UTSW	8	85740349	missense	probably benign	0.14
R6588:Itfg1	UTSW	8	85736130	missense	probably benign
R6753:Itfg1	UTSW	8	85835078	missense	probably benign	0.04
R7489:Itfg1	UTSW	8	85767001	missense	probably damaging	1.00
R7665:Itfg1	UTSW	8	85764350	missense	probably benign
R7912:Itfg1	UTSW	8	85764280	missense	probably damaging	1.00
R7985:Itfg1	UTSW	8	85725568	missense	probably damaging	1.00
R8927:Itfg1	UTSW	8	85840791	unclassified	probably benign
R8928:Itfg1	UTSW	8	85840791	unclassified	probably benign
R9080:Itfg1	UTSW	8	85740245	missense	possibly damaging	0.82
R9456:Itfg1	UTSW	8	85838937	missense	probably benign	0.01
R9513:Itfg1	UTSW	8	85764246	missense	possibly damaging	0.92
R9577:Itfg1	UTSW	8	85776169	missense	probably benign	0.01
R9761:Itfg1	UTSW	8	85836402	missense	probably benign	0.00
X0067:Itfg1	UTSW	8	85840753	unclassified	probably benign

Posted On

2015-12-18