Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02805:Vmn2r38'

360364

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r38

Ensembl Gene

ENSMUSG00000095773

Gene Name

vomeronasal 2, receptor 38

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02805

Quality Score

Status

Chromosome

Chromosomal Location

9077795-9100764 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 9078546 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 612 (H612L)

Ref Sequence

ENSEMBL: ENSMUSP00000104194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108554]

AlphaFold

G3UYA8

Predicted Effect

probably damaging
Transcript: ENSMUST00000108554
AA Change: H612L

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000104194
Gene: ENSMUSG00000095773
AA Change: H612L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	3.5e-33	PFAM
Pfam:NCD3G	512	565	1.4e-20	PFAM
Pfam:7tm_3	598	833	6.4e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaca	T	C	11: 84,113,959 (GRCm39)		probably benign	Het
Ankdd1b	A	G	13: 96,580,810 (GRCm39)	S163P	probably benign	Het
Ap5z1	G	A	5: 142,456,038 (GRCm39)		probably benign	Het
Asb14	A	G	14: 26,623,144 (GRCm39)	N172S	possibly damaging	Het
Avil	G	A	10: 126,843,486 (GRCm39)	V139I	possibly damaging	Het
C130073F10Rik	A	T	4: 101,748,171 (GRCm39)	M1K	probably null	Het
Ccdc33	T	A	9: 58,005,874 (GRCm39)	I37F	probably benign	Het
Ccdc9	T	C	7: 16,009,199 (GRCm39)	M550V	probably benign	Het
Cfap119	T	C	7: 127,185,566 (GRCm39)	D121G	possibly damaging	Het
Cgn	T	A	3: 94,681,687 (GRCm39)	L469F	probably damaging	Het
Dnaaf3	C	T	7: 4,526,704 (GRCm39)	G458R	possibly damaging	Het
Dscaml1	T	A	9: 45,359,195 (GRCm39)	N151K	probably damaging	Het
Dsel	A	G	1: 111,790,046 (GRCm39)	V163A	probably damaging	Het
Epg5	A	G	18: 78,073,406 (GRCm39)		probably benign	Het
Fanca	A	T	8: 124,016,233 (GRCm39)	I670N	probably damaging	Het
Fsip2	T	C	2: 82,823,839 (GRCm39)	V6524A	probably benign	Het
Gm10985	T	C	3: 53,752,514 (GRCm39)		probably null	Het
Gm1818	C	T	12: 48,602,518 (GRCm39)		noncoding transcript	Het
Hars2	C	T	18: 36,920,630 (GRCm39)	R158*	probably null	Het
Htr5b	A	G	1: 121,455,617 (GRCm39)	V101A	probably damaging	Het
Ipp	A	G	4: 116,386,885 (GRCm39)	I356V	possibly damaging	Het
Itga8	T	A	2: 12,194,291 (GRCm39)	N703I	possibly damaging	Het
Or8b3	T	A	9: 38,315,132 (GRCm39)		probably benign	Het
Ppp6r3	T	C	19: 3,542,428 (GRCm39)	N406D	probably benign	Het
Rbbp6	G	A	7: 122,600,411 (GRCm39)		probably benign	Het
Rgs7	T	C	1: 174,977,262 (GRCm39)	Y114C	probably damaging	Het
Ripor1	A	G	8: 106,344,203 (GRCm39)	T446A	probably damaging	Het
Rnf213	A	G	11: 119,325,892 (GRCm39)	D1562G	probably damaging	Het
Scaf11	A	T	15: 96,318,063 (GRCm39)	D500E	possibly damaging	Het
Spock1	A	G	13: 58,055,391 (GRCm39)	I4T	possibly damaging	Het
Srebf2	C	A	15: 82,054,045 (GRCm39)	N35K	probably benign	Het
Srgap3	G	T	6: 112,704,224 (GRCm39)	H922N	probably damaging	Het
Stk32c	A	C	7: 138,701,762 (GRCm39)	H112Q	probably damaging	Het
Styxl2	T	C	1: 165,926,630 (GRCm39)	E994G	probably damaging	Het
Thumpd3	A	G	6: 113,043,758 (GRCm39)	D391G	probably damaging	Het
Vsig10l	T	G	7: 43,114,666 (GRCm39)	I289S	probably damaging	Het
Wwox	G	A	8: 115,438,753 (GRCm39)	G273E	probably damaging	Het
Zscan4d	T	G	7: 10,898,897 (GRCm39)		probably benign	Het

Other mutations in Vmn2r38

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03199:Vmn2r38	APN	7	9,078,375 (GRCm39)	missense	probably damaging	1.00
R1619:Vmn2r38	UTSW	7	9,078,532 (GRCm39)	missense	probably damaging	1.00
R3154:Vmn2r38	UTSW	7	9,097,689 (GRCm39)	missense	probably benign	0.03
R3909:Vmn2r38	UTSW	7	9,078,553 (GRCm39)	missense	probably damaging	1.00
R4302:Vmn2r38	UTSW	7	9,100,562 (GRCm39)	splice site	probably null
R5106:Vmn2r38	UTSW	7	9,078,169 (GRCm39)	missense	possibly damaging	0.85
R5187:Vmn2r38	UTSW	7	9,100,571 (GRCm39)	missense	probably benign	0.03
R5575:Vmn2r38	UTSW	7	9,078,635 (GRCm39)	nonsense	probably null
R5653:Vmn2r38	UTSW	7	9,100,764 (GRCm39)	start codon destroyed	probably null	1.00
R6156:Vmn2r38	UTSW	7	9,097,611 (GRCm39)	missense	probably damaging	0.99
R6970:Vmn2r38	UTSW	7	9,078,340 (GRCm39)	nonsense	probably null
R7107:Vmn2r38	UTSW	7	9,093,728 (GRCm39)	missense	probably benign	0.00
R7231:Vmn2r38	UTSW	7	9,100,637 (GRCm39)	missense	possibly damaging	0.88
R7419:Vmn2r38	UTSW	7	9,078,354 (GRCm39)	missense	probably damaging	1.00
R7963:Vmn2r38	UTSW	7	9,095,854 (GRCm39)	missense	probably benign	0.17
R8788:Vmn2r38	UTSW	7	9,078,482 (GRCm39)	missense	probably benign	0.02
R9639:Vmn2r38	UTSW	7	9,078,063 (GRCm39)	missense	probably damaging	0.96
R9773:Vmn2r38	UTSW	7	9,097,806 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18