Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02805:Vmn2r38'

360364

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r38

Ensembl Gene

ENSMUSG00000095773

Gene Name

vomeronasal 2, receptor 38

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02805

Quality Score

Status

Chromosome

Chromosomal Location

9073835-9097881 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 9075547 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 612 (H612L)

Ref Sequence

ENSEMBL: ENSMUSP00000104194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108554]

AlphaFold

G3UYA8

Predicted Effect

probably damaging
Transcript: ENSMUST00000108554
AA Change: H612L

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000104194
Gene: ENSMUSG00000095773
AA Change: H612L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	3.5e-33	PFAM
Pfam:NCD3G	512	565	1.4e-20	PFAM
Pfam:7tm_3	598	833	6.4e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaca	T	C	11: 84,223,133		probably benign	Het
Ankdd1b	A	G	13: 96,444,302	S163P	probably benign	Het
Ap5z1	G	A	5: 142,470,283		probably benign	Het
Asb14	A	G	14: 26,901,187	N172S	possibly damaging	Het
Avil	G	A	10: 127,007,617	V139I	possibly damaging	Het
C130073F10Rik	A	T	4: 101,890,974	M1K	probably null	Het
Ccdc189	T	C	7: 127,586,394	D121G	possibly damaging	Het
Ccdc33	T	A	9: 58,098,591	I37F	probably benign	Het
Ccdc9	T	C	7: 16,275,274	M550V	probably benign	Het
Cgn	T	A	3: 94,774,377	L469F	probably damaging	Het
Dnaaf3	C	T	7: 4,523,705	G458R	possibly damaging	Het
Dscaml1	T	A	9: 45,447,897	N151K	probably damaging	Het
Dsel	A	G	1: 111,862,316	V163A	probably damaging	Het
Dusp27	T	C	1: 166,099,061	E994G	probably damaging	Het
Epg5	A	G	18: 78,030,191		probably benign	Het
Fanca	A	T	8: 123,289,494	I670N	probably damaging	Het
Fsip2	T	C	2: 82,993,495	V6524A	probably benign	Het
Gm10985	T	C	3: 53,845,093		probably null	Het
Gm1818	C	T	12: 48,555,735		noncoding transcript	Het
Hars2	C	T	18: 36,787,577	R158*	probably null	Het
Htr5b	A	G	1: 121,527,888	V101A	probably damaging	Het
Ipp	A	G	4: 116,529,688	I356V	possibly damaging	Het
Itga8	T	A	2: 12,189,480	N703I	possibly damaging	Het
Olfr147	T	A	9: 38,403,836		probably benign	Het
Ppp6r3	T	C	19: 3,492,428	N406D	probably benign	Het
Rbbp6	G	A	7: 123,001,188		probably benign	Het
Rgs7	T	C	1: 175,149,696	Y114C	probably damaging	Het
Ripor1	A	G	8: 105,617,571	T446A	probably damaging	Het
Rnf213	A	G	11: 119,435,066	D1562G	probably damaging	Het
Scaf11	A	T	15: 96,420,182	D500E	possibly damaging	Het
Spock1	A	G	13: 57,907,577	I4T	possibly damaging	Het
Srebf2	C	A	15: 82,169,844	N35K	probably benign	Het
Srgap3	G	T	6: 112,727,263	H922N	probably damaging	Het
Stk32c	A	C	7: 139,121,846	H112Q	probably damaging	Het
Thumpd3	A	G	6: 113,066,797	D391G	probably damaging	Het
Vsig10l	T	G	7: 43,465,242	I289S	probably damaging	Het
Wwox	G	A	8: 114,712,013	G273E	probably damaging	Het
Zscan4d	T	G	7: 11,164,970		probably benign	Het

Other mutations in Vmn2r38

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03199:Vmn2r38	APN	7	9075376	missense	probably damaging	1.00
R1619:Vmn2r38	UTSW	7	9075533	missense	probably damaging	1.00
R3154:Vmn2r38	UTSW	7	9094690	missense	probably benign	0.03
R3909:Vmn2r38	UTSW	7	9075554	missense	probably damaging	1.00
R4302:Vmn2r38	UTSW	7	9097563	splice site	probably null
R5106:Vmn2r38	UTSW	7	9075170	missense	possibly damaging	0.85
R5187:Vmn2r38	UTSW	7	9097572	missense	probably benign	0.03
R5575:Vmn2r38	UTSW	7	9075636	nonsense	probably null
R5653:Vmn2r38	UTSW	7	9097765	start codon destroyed	probably null	1.00
R6156:Vmn2r38	UTSW	7	9094612	missense	probably damaging	0.99
R6970:Vmn2r38	UTSW	7	9075341	nonsense	probably null
R7107:Vmn2r38	UTSW	7	9090729	missense	probably benign	0.00
R7231:Vmn2r38	UTSW	7	9097638	missense	possibly damaging	0.88
R7419:Vmn2r38	UTSW	7	9075355	missense	probably damaging	1.00
R7963:Vmn2r38	UTSW	7	9092855	missense	probably benign	0.17
R8788:Vmn2r38	UTSW	7	9075483	missense	probably benign	0.02
R9639:Vmn2r38	UTSW	7	9075064	missense	probably damaging	0.96
R9773:Vmn2r38	UTSW	7	9094807	missense	probably damaging	1.00

Posted On

2015-12-18