Incidental Mutation 'IGL02805:Vmn2r38'
ID360364
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r38
Ensembl Gene ENSMUSG00000095773
Gene Namevomeronasal 2, receptor 38
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02805
Quality Score
Status
Chromosome7
Chromosomal Location9073835-9097881 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 9075547 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 612 (H612L)
Ref Sequence ENSEMBL: ENSMUSP00000104194 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108554]
Predicted Effect probably damaging
Transcript: ENSMUST00000108554
AA Change: H612L

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000104194
Gene: ENSMUSG00000095773
AA Change: H612L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 3.5e-33 PFAM
Pfam:NCD3G 512 565 1.4e-20 PFAM
Pfam:7tm_3 598 833 6.4e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T C 11: 84,223,133 probably benign Het
Ankdd1b A G 13: 96,444,302 S163P probably benign Het
Ap5z1 G A 5: 142,470,283 probably benign Het
Asb14 A G 14: 26,901,187 N172S possibly damaging Het
Avil G A 10: 127,007,617 V139I possibly damaging Het
C130073F10Rik A T 4: 101,890,974 M1K probably null Het
Ccdc189 T C 7: 127,586,394 D121G possibly damaging Het
Ccdc33 T A 9: 58,098,591 I37F probably benign Het
Ccdc9 T C 7: 16,275,274 M550V probably benign Het
Cgn T A 3: 94,774,377 L469F probably damaging Het
Dnaaf3 C T 7: 4,523,705 G458R possibly damaging Het
Dscaml1 T A 9: 45,447,897 N151K probably damaging Het
Dsel A G 1: 111,862,316 V163A probably damaging Het
Dusp27 T C 1: 166,099,061 E994G probably damaging Het
Epg5 A G 18: 78,030,191 probably benign Het
Fanca A T 8: 123,289,494 I670N probably damaging Het
Fsip2 T C 2: 82,993,495 V6524A probably benign Het
Gm10985 T C 3: 53,845,093 probably null Het
Gm1818 C T 12: 48,555,735 noncoding transcript Het
Hars2 C T 18: 36,787,577 R158* probably null Het
Htr5b A G 1: 121,527,888 V101A probably damaging Het
Ipp A G 4: 116,529,688 I356V possibly damaging Het
Itga8 T A 2: 12,189,480 N703I possibly damaging Het
Olfr147 T A 9: 38,403,836 probably benign Het
Ppp6r3 T C 19: 3,492,428 N406D probably benign Het
Rbbp6 G A 7: 123,001,188 probably benign Het
Rgs7 T C 1: 175,149,696 Y114C probably damaging Het
Ripor1 A G 8: 105,617,571 T446A probably damaging Het
Rnf213 A G 11: 119,435,066 D1562G probably damaging Het
Scaf11 A T 15: 96,420,182 D500E possibly damaging Het
Spock1 A G 13: 57,907,577 I4T possibly damaging Het
Srebf2 C A 15: 82,169,844 N35K probably benign Het
Srgap3 G T 6: 112,727,263 H922N probably damaging Het
Stk32c A C 7: 139,121,846 H112Q probably damaging Het
Thumpd3 A G 6: 113,066,797 D391G probably damaging Het
Vsig10l T G 7: 43,465,242 I289S probably damaging Het
Wwox G A 8: 114,712,013 G273E probably damaging Het
Zscan4d T G 7: 11,164,970 probably benign Het
Other mutations in Vmn2r38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03199:Vmn2r38 APN 7 9075376 missense probably damaging 1.00
R1619:Vmn2r38 UTSW 7 9075533 missense probably damaging 1.00
R3154:Vmn2r38 UTSW 7 9094690 missense probably benign 0.03
R3909:Vmn2r38 UTSW 7 9075554 missense probably damaging 1.00
R4302:Vmn2r38 UTSW 7 9097563 splice site probably null
R5106:Vmn2r38 UTSW 7 9075170 missense possibly damaging 0.85
R5187:Vmn2r38 UTSW 7 9097572 missense probably benign 0.03
R5575:Vmn2r38 UTSW 7 9075636 nonsense probably null
R5653:Vmn2r38 UTSW 7 9097765 start codon destroyed probably null 1.00
R6156:Vmn2r38 UTSW 7 9094612 missense probably damaging 0.99
R6970:Vmn2r38 UTSW 7 9075341 nonsense probably null
R7107:Vmn2r38 UTSW 7 9090729 missense probably benign 0.00
R7231:Vmn2r38 UTSW 7 9097638 missense possibly damaging 0.88
R7419:Vmn2r38 UTSW 7 9075355 missense probably damaging 1.00
R7963:Vmn2r38 UTSW 7 9092855 missense probably benign 0.17
R8788:Vmn2r38 UTSW 7 9075483 missense probably benign 0.02
Posted On2015-12-18