Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02805:Vsig10l'

360366

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vsig10l

Ensembl Gene

ENSMUSG00000070604

Gene Name

V-set and immunoglobulin domain containing 10 like

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.230) question?

Stock #

IGL02805

Quality Score

Status

Chromosome

Chromosomal Location

43463151-43472019 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 43465242 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 289 (I289S)

Ref Sequence

ENSEMBL: ENSMUSP00000144692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107977] [ENSMUST00000203042] [ENSMUST00000203633] [ENSMUST00000203769] [ENSMUST00000204680]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000107977
AA Change: I391S

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000103611
Gene: ENSMUSG00000070604
AA Change: I391S

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	28	52	N/A	INTRINSIC
IG	183	285	1.92e0	SMART
IG	298	383	2.15e-3	SMART
IGc2	406	465	4.19e-6	SMART
Blast:IG_like	582	649	1e-13	BLAST
transmembrane domain	764	786	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000203042

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203152

Predicted Effect

probably benign
Transcript: ENSMUST00000203633

SMART Domains

Protein: ENSMUSP00000145061
Gene: ENSMUSG00000107482

Domain	Start	End	E-Value	Type
ETF	26	216	2.7e-65	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000203769
AA Change: I289S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000144692
Gene: ENSMUSG00000070604
AA Change: I289S

Domain	Start	End	E-Value	Type
IG	81	183	8.1e-3	SMART
IG	196	281	9.2e-6	SMART
IGc2	304	363	1.8e-8	SMART
Blast:IG_like	480	547	9e-14	BLAST
transmembrane domain	662	684	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000204680

SMART Domains

Protein: ENSMUSP00000145493
Gene: ENSMUSG00000107482

Domain	Start	End	E-Value	Type
ETF	26	168	2.4e-17	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000205247

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaca	T	C	11: 84,223,133		probably benign	Het
Ankdd1b	A	G	13: 96,444,302	S163P	probably benign	Het
Ap5z1	G	A	5: 142,470,283		probably benign	Het
Asb14	A	G	14: 26,901,187	N172S	possibly damaging	Het
Avil	G	A	10: 127,007,617	V139I	possibly damaging	Het
C130073F10Rik	A	T	4: 101,890,974	M1K	probably null	Het
Ccdc189	T	C	7: 127,586,394	D121G	possibly damaging	Het
Ccdc33	T	A	9: 58,098,591	I37F	probably benign	Het
Ccdc9	T	C	7: 16,275,274	M550V	probably benign	Het
Cgn	T	A	3: 94,774,377	L469F	probably damaging	Het
Dnaaf3	C	T	7: 4,523,705	G458R	possibly damaging	Het
Dscaml1	T	A	9: 45,447,897	N151K	probably damaging	Het
Dsel	A	G	1: 111,862,316	V163A	probably damaging	Het
Dusp27	T	C	1: 166,099,061	E994G	probably damaging	Het
Epg5	A	G	18: 78,030,191		probably benign	Het
Fanca	A	T	8: 123,289,494	I670N	probably damaging	Het
Fsip2	T	C	2: 82,993,495	V6524A	probably benign	Het
Gm10985	T	C	3: 53,845,093		probably null	Het
Gm1818	C	T	12: 48,555,735		noncoding transcript	Het
Hars2	C	T	18: 36,787,577	R158*	probably null	Het
Htr5b	A	G	1: 121,527,888	V101A	probably damaging	Het
Ipp	A	G	4: 116,529,688	I356V	possibly damaging	Het
Itga8	T	A	2: 12,189,480	N703I	possibly damaging	Het
Olfr147	T	A	9: 38,403,836		probably benign	Het
Ppp6r3	T	C	19: 3,492,428	N406D	probably benign	Het
Rbbp6	G	A	7: 123,001,188		probably benign	Het
Rgs7	T	C	1: 175,149,696	Y114C	probably damaging	Het
Ripor1	A	G	8: 105,617,571	T446A	probably damaging	Het
Rnf213	A	G	11: 119,435,066	D1562G	probably damaging	Het
Scaf11	A	T	15: 96,420,182	D500E	possibly damaging	Het
Spock1	A	G	13: 57,907,577	I4T	possibly damaging	Het
Srebf2	C	A	15: 82,169,844	N35K	probably benign	Het
Srgap3	G	T	6: 112,727,263	H922N	probably damaging	Het
Stk32c	A	C	7: 139,121,846	H112Q	probably damaging	Het
Thumpd3	A	G	6: 113,066,797	D391G	probably damaging	Het
Vmn2r38	T	A	7: 9,075,547	H612L	probably damaging	Het
Wwox	G	A	8: 114,712,013	G273E	probably damaging	Het
Zscan4d	T	G	7: 11,164,970		probably benign	Het

Other mutations in Vsig10l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01319:Vsig10l	APN	7	43465254	missense	probably damaging	1.00
IGL01390:Vsig10l	APN	7	43466465	missense	probably damaging	0.97
IGL02401:Vsig10l	APN	7	43464044	missense	probably damaging	1.00
IGL02404:Vsig10l	APN	7	43463747	missense	possibly damaging	0.85
IGL02514:Vsig10l	APN	7	43463914	missense	probably benign	0.02
IGL02636:Vsig10l	APN	7	43463578	missense	possibly damaging	0.53
IGL02823:Vsig10l	APN	7	43466464	missense	probably damaging	1.00
IGL02827:Vsig10l	APN	7	43464869	missense	probably damaging	1.00
R0111:Vsig10l	UTSW	7	43468101	missense	probably damaging	0.97
R0394:Vsig10l	UTSW	7	43465455	missense	probably damaging	0.97
R0465:Vsig10l	UTSW	7	43467442	missense	probably damaging	1.00
R0632:Vsig10l	UTSW	7	43464137	missense	probably damaging	0.97
R1689:Vsig10l	UTSW	7	43465368	missense	possibly damaging	0.93
R1991:Vsig10l	UTSW	7	43467468	missense	possibly damaging	0.89
R2103:Vsig10l	UTSW	7	43467468	missense	possibly damaging	0.89
R2358:Vsig10l	UTSW	7	43468761	missense	probably benign	0.00
R3015:Vsig10l	UTSW	7	43467457	missense	possibly damaging	0.73
R4024:Vsig10l	UTSW	7	43468086	missense	probably benign	0.33
R4031:Vsig10l	UTSW	7	43465374	missense	probably damaging	1.00
R4807:Vsig10l	UTSW	7	43463749	missense	possibly damaging	0.53
R5020:Vsig10l	UTSW	7	43465317	nonsense	probably null
R5261:Vsig10l	UTSW	7	43470850	missense	probably damaging	1.00
R5317:Vsig10l	UTSW	7	43464823	missense	probably damaging	1.00
R5426:Vsig10l	UTSW	7	43464823	missense	probably damaging	0.97
R5656:Vsig10l	UTSW	7	43464151	nonsense	probably null
R5842:Vsig10l	UTSW	7	43468972	missense	probably benign	0.15
R6012:Vsig10l	UTSW	7	43468015	missense	probably damaging	1.00
R6235:Vsig10l	UTSW	7	43468972	missense	probably benign	0.15
R6309:Vsig10l	UTSW	7	43470973	splice site	probably null
R6994:Vsig10l	UTSW	7	43465067	missense	possibly damaging	0.71
R7250:Vsig10l	UTSW	7	43463675	missense	probably benign
R7397:Vsig10l	UTSW	7	43468007	missense	probably damaging	1.00
R7767:Vsig10l	UTSW	7	43463717	missense	probably damaging	0.96
R7956:Vsig10l	UTSW	7	43468070	missense	probably benign
R8086:Vsig10l	UTSW	7	43465452	missense	possibly damaging	0.92
R8139:Vsig10l	UTSW	7	43463729	missense	probably benign	0.00
R8297:Vsig10l	UTSW	7	43464107	missense	possibly damaging	0.50
R8341:Vsig10l	UTSW	7	43463954	missense	probably damaging	1.00
R8519:Vsig10l	UTSW	7	43464902	missense	probably benign	0.33
R8925:Vsig10l	UTSW	7	43466596	missense	probably benign	0.41
R8927:Vsig10l	UTSW	7	43466596	missense	probably benign	0.41
R8948:Vsig10l	UTSW	7	43468199	missense	possibly damaging	0.53
X0028:Vsig10l	UTSW	7	43463364	utr 3 prime	probably benign
X0067:Vsig10l	UTSW	7	43467490	missense	probably damaging	1.00

Posted On

2015-12-18