Incidental Mutation 'IGL02805:Htr5b'
ID360387
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Htr5b
Ensembl Gene ENSMUSG00000050534
Gene Name5-hydroxytryptamine (serotonin) receptor 5B
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02805
Quality Score
Status
Chromosome1
Chromosomal Location121509842-121528465 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 121527888 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 101 (V101A)
Ref Sequence ENSEMBL: ENSMUSP00000057212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055884]
Predicted Effect probably damaging
Transcript: ENSMUST00000055884
AA Change: V101A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000057212
Gene: ENSMUSG00000050534
AA Change: V101A

DomainStartEndE-ValueType
low complexity region 16 38 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 62 366 1e-7 PFAM
Pfam:7tm_1 69 351 1.7e-66 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display a normal phenotype [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T C 11: 84,223,133 probably benign Het
Ankdd1b A G 13: 96,444,302 S163P probably benign Het
Ap5z1 G A 5: 142,470,283 probably benign Het
Asb14 A G 14: 26,901,187 N172S possibly damaging Het
Avil G A 10: 127,007,617 V139I possibly damaging Het
C130073F10Rik A T 4: 101,890,974 M1K probably null Het
Ccdc189 T C 7: 127,586,394 D121G possibly damaging Het
Ccdc33 T A 9: 58,098,591 I37F probably benign Het
Ccdc9 T C 7: 16,275,274 M550V probably benign Het
Cgn T A 3: 94,774,377 L469F probably damaging Het
Dnaaf3 C T 7: 4,523,705 G458R possibly damaging Het
Dscaml1 T A 9: 45,447,897 N151K probably damaging Het
Dsel A G 1: 111,862,316 V163A probably damaging Het
Dusp27 T C 1: 166,099,061 E994G probably damaging Het
Epg5 A G 18: 78,030,191 probably benign Het
Fanca A T 8: 123,289,494 I670N probably damaging Het
Fsip2 T C 2: 82,993,495 V6524A probably benign Het
Gm10985 T C 3: 53,845,093 probably null Het
Gm1818 C T 12: 48,555,735 noncoding transcript Het
Hars2 C T 18: 36,787,577 R158* probably null Het
Ipp A G 4: 116,529,688 I356V possibly damaging Het
Itga8 T A 2: 12,189,480 N703I possibly damaging Het
Olfr147 T A 9: 38,403,836 probably benign Het
Ppp6r3 T C 19: 3,492,428 N406D probably benign Het
Rbbp6 G A 7: 123,001,188 probably benign Het
Rgs7 T C 1: 175,149,696 Y114C probably damaging Het
Ripor1 A G 8: 105,617,571 T446A probably damaging Het
Rnf213 A G 11: 119,435,066 D1562G probably damaging Het
Scaf11 A T 15: 96,420,182 D500E possibly damaging Het
Spock1 A G 13: 57,907,577 I4T possibly damaging Het
Srebf2 C A 15: 82,169,844 N35K probably benign Het
Srgap3 G T 6: 112,727,263 H922N probably damaging Het
Stk32c A C 7: 139,121,846 H112Q probably damaging Het
Thumpd3 A G 6: 113,066,797 D391G probably damaging Het
Vmn2r38 T A 7: 9,075,547 H612L probably damaging Het
Vsig10l T G 7: 43,465,242 I289S probably damaging Het
Wwox G A 8: 114,712,013 G273E probably damaging Het
Zscan4d T G 7: 11,164,970 probably benign Het
Other mutations in Htr5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02160:Htr5b APN 1 121528045 missense possibly damaging 0.66
IGL02375:Htr5b APN 1 121527835 missense probably damaging 1.00
IGL02991:Htr5b UTSW 1 121528027 missense probably benign 0.12
R0387:Htr5b UTSW 1 121527546 missense probably damaging 1.00
R1650:Htr5b UTSW 1 121528162 missense probably benign
R1747:Htr5b UTSW 1 121527918 missense probably damaging 1.00
R2203:Htr5b UTSW 1 121527964 missense probably damaging 1.00
R5492:Htr5b UTSW 1 121527658 missense possibly damaging 0.89
R6782:Htr5b UTSW 1 121510498 missense probably benign 0.00
R7007:Htr5b UTSW 1 121510494 missense probably damaging 1.00
R7249:Htr5b UTSW 1 121510474 missense probably damaging 1.00
R7317:Htr5b UTSW 1 121510428 missense probably damaging 1.00
R7749:Htr5b UTSW 1 121527758 missense probably damaging 0.97
R8186:Htr5b UTSW 1 121528379 start gained probably benign
Z1177:Htr5b UTSW 1 121527739 missense probably damaging 1.00
Posted On2015-12-18