Incidental Mutation 'IGL02805:Or8b3'
ID 360402
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8b3
Ensembl Gene ENSMUSG00000049098
Gene Name olfactory receptor family 8 subfamily B member 3
Synonyms MOR164-1, M3, GA_x6K02T2PVTD-32098059-32099003, Olfr147
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL02805
Quality Score
Status
Chromosome 9
Chromosomal Location 38313007-38315125 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) T to A at 38315132 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149480 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056364] [ENSMUST00000214648]
AlphaFold Q60886
Predicted Effect probably benign
Transcript: ENSMUST00000056364
SMART Domains Protein: ENSMUSP00000051933
Gene: ENSMUSG00000049098

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 1.2e-48 PFAM
Pfam:7tm_1 44 292 2.8e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214648
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T C 11: 84,113,959 (GRCm39) probably benign Het
Ankdd1b A G 13: 96,580,810 (GRCm39) S163P probably benign Het
Ap5z1 G A 5: 142,456,038 (GRCm39) probably benign Het
Asb14 A G 14: 26,623,144 (GRCm39) N172S possibly damaging Het
Avil G A 10: 126,843,486 (GRCm39) V139I possibly damaging Het
C130073F10Rik A T 4: 101,748,171 (GRCm39) M1K probably null Het
Ccdc33 T A 9: 58,005,874 (GRCm39) I37F probably benign Het
Ccdc9 T C 7: 16,009,199 (GRCm39) M550V probably benign Het
Cfap119 T C 7: 127,185,566 (GRCm39) D121G possibly damaging Het
Cgn T A 3: 94,681,687 (GRCm39) L469F probably damaging Het
Dnaaf3 C T 7: 4,526,704 (GRCm39) G458R possibly damaging Het
Dscaml1 T A 9: 45,359,195 (GRCm39) N151K probably damaging Het
Dsel A G 1: 111,790,046 (GRCm39) V163A probably damaging Het
Epg5 A G 18: 78,073,406 (GRCm39) probably benign Het
Fanca A T 8: 124,016,233 (GRCm39) I670N probably damaging Het
Fsip2 T C 2: 82,823,839 (GRCm39) V6524A probably benign Het
Gm10985 T C 3: 53,752,514 (GRCm39) probably null Het
Gm1818 C T 12: 48,602,518 (GRCm39) noncoding transcript Het
Hars2 C T 18: 36,920,630 (GRCm39) R158* probably null Het
Htr5b A G 1: 121,455,617 (GRCm39) V101A probably damaging Het
Ipp A G 4: 116,386,885 (GRCm39) I356V possibly damaging Het
Itga8 T A 2: 12,194,291 (GRCm39) N703I possibly damaging Het
Ppp6r3 T C 19: 3,542,428 (GRCm39) N406D probably benign Het
Rbbp6 G A 7: 122,600,411 (GRCm39) probably benign Het
Rgs7 T C 1: 174,977,262 (GRCm39) Y114C probably damaging Het
Ripor1 A G 8: 106,344,203 (GRCm39) T446A probably damaging Het
Rnf213 A G 11: 119,325,892 (GRCm39) D1562G probably damaging Het
Scaf11 A T 15: 96,318,063 (GRCm39) D500E possibly damaging Het
Spock1 A G 13: 58,055,391 (GRCm39) I4T possibly damaging Het
Srebf2 C A 15: 82,054,045 (GRCm39) N35K probably benign Het
Srgap3 G T 6: 112,704,224 (GRCm39) H922N probably damaging Het
Stk32c A C 7: 138,701,762 (GRCm39) H112Q probably damaging Het
Styxl2 T C 1: 165,926,630 (GRCm39) E994G probably damaging Het
Thumpd3 A G 6: 113,043,758 (GRCm39) D391G probably damaging Het
Vmn2r38 T A 7: 9,078,546 (GRCm39) H612L probably damaging Het
Vsig10l T G 7: 43,114,666 (GRCm39) I289S probably damaging Het
Wwox G A 8: 115,438,753 (GRCm39) G273E probably damaging Het
Zscan4d T G 7: 10,898,897 (GRCm39) probably benign Het
Other mutations in Or8b3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01685:Or8b3 APN 9 38,314,317 (GRCm39) missense possibly damaging 0.67
IGL02109:Or8b3 APN 9 38,314,382 (GRCm39) missense possibly damaging 0.91
IGL02875:Or8b3 APN 9 38,314,472 (GRCm39) missense probably damaging 0.99
R1133:Or8b3 UTSW 9 38,315,027 (GRCm39) missense probably benign 0.00
R1446:Or8b3 UTSW 9 38,314,601 (GRCm39) missense possibly damaging 0.73
R1591:Or8b3 UTSW 9 38,314,232 (GRCm39) missense probably damaging 1.00
R1719:Or8b3 UTSW 9 38,314,550 (GRCm39) missense possibly damaging 0.67
R1895:Or8b3 UTSW 9 38,314,182 (GRCm39) start codon destroyed probably null 0.88
R1946:Or8b3 UTSW 9 38,314,182 (GRCm39) start codon destroyed probably null 0.88
R1981:Or8b3 UTSW 9 38,315,031 (GRCm39) missense probably damaging 0.99
R2033:Or8b3 UTSW 9 38,314,669 (GRCm39) missense probably damaging 0.99
R4856:Or8b3 UTSW 9 38,314,764 (GRCm39) missense probably damaging 1.00
R5322:Or8b3 UTSW 9 38,314,862 (GRCm39) missense probably damaging 1.00
R6017:Or8b3 UTSW 9 38,314,916 (GRCm39) missense probably benign 0.01
R6037:Or8b3 UTSW 9 38,314,601 (GRCm39) missense probably benign 0.07
R6037:Or8b3 UTSW 9 38,314,601 (GRCm39) missense probably benign 0.07
R7032:Or8b3 UTSW 9 38,314,965 (GRCm39) missense possibly damaging 0.53
R7042:Or8b3 UTSW 9 38,314,196 (GRCm39) missense probably damaging 0.98
R7351:Or8b3 UTSW 9 38,314,739 (GRCm39) missense probably damaging 1.00
R7460:Or8b3 UTSW 9 38,314,649 (GRCm39) missense possibly damaging 0.95
R7820:Or8b3 UTSW 9 38,314,862 (GRCm39) missense probably damaging 1.00
R8161:Or8b3 UTSW 9 38,314,803 (GRCm39) missense probably damaging 0.97
R8196:Or8b3 UTSW 9 38,314,904 (GRCm39) missense probably damaging 1.00
R9103:Or8b3 UTSW 9 38,314,518 (GRCm39) missense probably damaging 1.00
R9213:Or8b3 UTSW 9 38,315,047 (GRCm39) nonsense probably null
R9717:Or8b3 UTSW 9 38,314,841 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18