Incidental Mutation 'IGL02811:Olfr724'
ID360598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr724
Ensembl Gene ENSMUSG00000096254
Gene Nameolfactory receptor 724
SynonymsGA_x6K02T2PMLR-5645801-5644872, MOR247-2
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.283) question?
Stock #IGL02811
Quality Score
Status
Chromosome14
Chromosomal Location49960023-49963274 bp(-) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) T to A at 49960133 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075030] [ENSMUST00000213390]
Predicted Effect probably benign
Transcript: ENSMUST00000075030
SMART Domains Protein: ENSMUSP00000074546
Gene: ENSMUSG00000096254

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 1.3e-42 PFAM
Pfam:7TM_GPCR_Srsx 34 302 3e-11 PFAM
Pfam:7tm_1 41 287 5.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213390
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c20 C T 13: 4,512,683 R90H possibly damaging Het
BC048679 A T 7: 81,495,189 probably benign Het
Chd6 T C 2: 160,990,301 R984G probably damaging Het
Cobl A G 11: 12,253,285 I1139T possibly damaging Het
Coq3 A G 4: 21,900,273 R167G probably damaging Het
Crim1 A G 17: 78,350,701 K670E possibly damaging Het
Crtac1 T C 19: 42,333,911 E130G probably damaging Het
Dcbld1 A G 10: 52,319,973 T426A probably benign Het
Dimt1 T C 13: 106,947,667 probably benign Het
Dnal1 G A 12: 84,131,392 probably null Het
Fes T C 7: 80,379,841 Y631C probably damaging Het
Hemk1 A T 9: 107,331,551 V149E probably benign Het
Itga6 T C 2: 71,826,732 V397A probably damaging Het
Kmt2c A T 5: 25,315,028 L2028* probably null Het
Krt33b C A 11: 100,029,569 C86F probably benign Het
Lmx1a A G 1: 167,791,374 I101V probably benign Het
Mlh1 A G 9: 111,271,514 V4A probably benign Het
Mroh2b A G 15: 4,915,236 I440V possibly damaging Het
Mrpl35 A G 6: 71,818,820 Y28H probably benign Het
Oas3 C A 5: 120,764,322 E636D unknown Het
Olfm4 T A 14: 80,021,673 S454T probably damaging Het
Olfr597 T C 7: 103,320,933 I174T probably benign Het
Otoa G T 7: 121,118,655 G365V possibly damaging Het
Pdgfrl G T 8: 40,976,968 R124L probably damaging Het
Rcbtb2 T A 14: 73,174,411 V380E probably damaging Het
Rufy2 A G 10: 63,000,327 D345G probably damaging Het
Shq1 A T 6: 100,630,984 I322N probably damaging Het
Skint4 C A 4: 112,087,003 T4K possibly damaging Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Tbc1d5 A G 17: 50,800,121 I469T probably damaging Het
Thoc3 T C 13: 54,460,175 R319G probably benign Het
Tmem63a A G 1: 180,965,783 I507M probably damaging Het
Usp40 A T 1: 87,995,736 I271N probably damaging Het
Vps13d T C 4: 145,131,765 D2157G possibly damaging Het
Vwa8 T A 14: 78,994,459 V586D probably benign Het
Other mutations in Olfr724
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0829:Olfr724 UTSW 14 49961046 missense probably benign 0.03
R1513:Olfr724 UTSW 14 49961101 critical splice acceptor site probably null
R2016:Olfr724 UTSW 14 49960502 missense probably benign 0.00
R2936:Olfr724 UTSW 14 49960154 missense probably benign 0.03
R3082:Olfr724 UTSW 14 49960704 missense probably damaging 1.00
R3738:Olfr724 UTSW 14 49960556 missense possibly damaging 0.60
R4772:Olfr724 UTSW 14 49960995 small deletion probably benign
R4830:Olfr724 UTSW 14 49960224 missense probably damaging 1.00
R4839:Olfr724 UTSW 14 49960189 missense probably benign 0.41
R5362:Olfr724 UTSW 14 49960529 missense possibly damaging 0.95
R5695:Olfr724 UTSW 14 49960623 missense probably benign 0.00
R6187:Olfr724 UTSW 14 49961069 start codon destroyed probably null 0.99
R7371:Olfr724 UTSW 14 49961106 splice site probably null
R7611:Olfr724 UTSW 14 49960911 missense probably benign 0.03
Posted On2015-12-18