Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02811:Or4l15'

360598

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4l15

Ensembl Gene

ENSMUSG00000096254

Gene Name

olfactory receptor family 4 subfamily L member 15

Synonyms

MOR247-2, Olfr724, GA_x6K02T2PMLR-5645801-5644872

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.220) question?

Stock #

IGL02811

Quality Score

Status

Chromosome

Chromosomal Location

50197548-50198553 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

T to A at 50197590 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149110 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075030] [ENSMUST00000213390]

AlphaFold

K7N5X7

Predicted Effect

probably benign
Transcript: ENSMUST00000075030

SMART Domains

Protein: ENSMUSP00000074546
Gene: ENSMUSG00000096254

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	305	1.3e-42	PFAM
Pfam:7TM_GPCR_Srsx	34	302	3e-11	PFAM
Pfam:7tm_1	41	287	5.3e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213390

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1c20	C	T	13: 4,562,682 (GRCm39)	R90H	possibly damaging	Het
BC048679	A	T	7: 81,144,937 (GRCm39)		probably benign	Het
Chd6	T	C	2: 160,832,221 (GRCm39)	R984G	probably damaging	Het
Cobl	A	G	11: 12,203,285 (GRCm39)	I1139T	possibly damaging	Het
Coq3	A	G	4: 21,900,273 (GRCm39)	R167G	probably damaging	Het
Crim1	A	G	17: 78,658,130 (GRCm39)	K670E	possibly damaging	Het
Crtac1	T	C	19: 42,322,350 (GRCm39)	E130G	probably damaging	Het
Dcbld1	A	G	10: 52,196,069 (GRCm39)	T426A	probably benign	Het
Dimt1	T	C	13: 107,084,175 (GRCm39)		probably benign	Het
Dnal1	G	A	12: 84,178,166 (GRCm39)		probably null	Het
Fes	T	C	7: 80,029,589 (GRCm39)	Y631C	probably damaging	Het
Hemk1	A	T	9: 107,208,750 (GRCm39)	V149E	probably benign	Het
Itga6	T	C	2: 71,657,076 (GRCm39)	V397A	probably damaging	Het
Kmt2c	A	T	5: 25,520,026 (GRCm39)	L2028*	probably null	Het
Krt33b	C	A	11: 99,920,395 (GRCm39)	C86F	probably benign	Het
Lmx1a	A	G	1: 167,618,943 (GRCm39)	I101V	probably benign	Het
Mlh1	A	G	9: 111,100,582 (GRCm39)	V4A	probably benign	Het
Mroh2b	A	G	15: 4,944,718 (GRCm39)	I440V	possibly damaging	Het
Mrpl35	A	G	6: 71,795,804 (GRCm39)	Y28H	probably benign	Het
Oas3	C	A	5: 120,902,387 (GRCm39)	E636D	unknown	Het
Olfm4	T	A	14: 80,259,113 (GRCm39)	S454T	probably damaging	Het
Or52ab2	T	C	7: 102,970,140 (GRCm39)	I174T	probably benign	Het
Otoa	G	T	7: 120,717,878 (GRCm39)	G365V	possibly damaging	Het
Pdgfrl	G	T	8: 41,430,005 (GRCm39)	R124L	probably damaging	Het
Rcbtb2	T	A	14: 73,411,851 (GRCm39)	V380E	probably damaging	Het
Rufy2	A	G	10: 62,836,106 (GRCm39)	D345G	probably damaging	Het
Shq1	A	T	6: 100,607,945 (GRCm39)	I322N	probably damaging	Het
Skint4	C	A	4: 111,944,200 (GRCm39)	T4K	possibly damaging	Het
Stxbp2	A	T	8: 3,691,971 (GRCm39)	I538F	probably benign	Het
Tbc1d5	A	G	17: 51,107,149 (GRCm39)	I469T	probably damaging	Het
Thoc3	T	C	13: 54,607,988 (GRCm39)	R319G	probably benign	Het
Tmem63a	A	G	1: 180,793,348 (GRCm39)	I507M	probably damaging	Het
Usp40	A	T	1: 87,923,458 (GRCm39)	I271N	probably damaging	Het
Vps13d	T	C	4: 144,858,335 (GRCm39)	D2157G	possibly damaging	Het
Vwa8	T	A	14: 79,231,899 (GRCm39)	V586D	probably benign	Het

Other mutations in Or4l15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0829:Or4l15	UTSW	14	50,198,503 (GRCm39)	missense	probably benign	0.03
R1513:Or4l15	UTSW	14	50,198,558 (GRCm39)	critical splice acceptor site	probably null
R2016:Or4l15	UTSW	14	50,197,959 (GRCm39)	missense	probably benign	0.00
R2936:Or4l15	UTSW	14	50,197,611 (GRCm39)	missense	probably benign	0.03
R3082:Or4l15	UTSW	14	50,198,161 (GRCm39)	missense	probably damaging	1.00
R3738:Or4l15	UTSW	14	50,198,013 (GRCm39)	missense	possibly damaging	0.60
R4772:Or4l15	UTSW	14	50,198,452 (GRCm39)	small deletion	probably benign
R4830:Or4l15	UTSW	14	50,197,681 (GRCm39)	missense	probably damaging	1.00
R4839:Or4l15	UTSW	14	50,197,646 (GRCm39)	missense	probably benign	0.41
R5362:Or4l15	UTSW	14	50,197,986 (GRCm39)	missense	possibly damaging	0.95
R5695:Or4l15	UTSW	14	50,198,080 (GRCm39)	missense	probably benign	0.00
R6187:Or4l15	UTSW	14	50,198,526 (GRCm39)	start codon destroyed	probably null	0.99
R7371:Or4l15	UTSW	14	50,198,563 (GRCm39)	splice site	probably null
R7611:Or4l15	UTSW	14	50,198,368 (GRCm39)	missense	probably benign	0.03
R9243:Or4l15	UTSW	14	50,197,881 (GRCm39)	missense	probably benign	0.06

Posted On

2015-12-18