Incidental Mutation 'IGL02813:Mrgprd'
ID360663
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgprd
Ensembl Gene ENSMUSG00000051207
Gene NameMAS-related GPR, member D
SynonymsMrgD, LOC211578
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02813
Quality Score
Status
Chromosome7
Chromosomal Location145314835-145324086 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 145321514 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Valine at position 41 (M41V)
Ref Sequence ENSEMBL: ENSMUSP00000063021 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062163]
Predicted Effect probably benign
Transcript: ENSMUST00000062163
AA Change: M41V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000063021
Gene: ENSMUSG00000051207
AA Change: M41V

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 34 238 4.8e-8 PFAM
Pfam:7tm_1 43 278 7.1e-12 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased sensitivity to cold, heat, and mechanical stimuli. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy1 C A 11: 7,146,591 Q660K possibly damaging Het
Arhgap5 A C 12: 52,516,965 T240P probably benign Het
Arhgef7 C T 8: 11,800,767 probably benign Het
Cttnbp2 C A 6: 18,367,538 V1594F possibly damaging Het
Cyp2a22 G T 7: 26,936,434 Q235K probably benign Het
E330009J07Rik C T 6: 40,418,539 V212I probably benign Het
Ecm1 G A 3: 95,736,786 P169S probably damaging Het
Emilin3 G A 2: 160,908,729 Q320* probably null Het
Ern1 T C 11: 106,423,425 D183G probably damaging Het
Gpat2 T C 2: 127,434,455 V635A possibly damaging Het
Gria1 A G 11: 57,283,584 N564S probably damaging Het
Grtp1 A C 8: 13,186,945 I173S possibly damaging Het
Hsd17b4 A G 18: 50,128,348 probably benign Het
Lrp1b T C 2: 40,679,217 probably null Het
Mark4 A T 7: 19,447,256 probably null Het
Mphosph9 T C 5: 124,315,628 D207G probably benign Het
Myo1g T C 11: 6,518,743 *66W probably null Het
Neto2 C A 8: 85,690,886 D30Y probably benign Het
Nlrp6 A T 7: 140,923,420 I450F possibly damaging Het
Nup155 T A 15: 8,130,121 probably benign Het
Olfr1205 A G 2: 88,831,151 I11M probably benign Het
Pcdhb10 T G 18: 37,413,762 S630R possibly damaging Het
Rwdd4a T C 8: 47,537,361 probably null Het
Slc12a7 T A 13: 73,813,676 probably benign Het
Slc22a20 C T 19: 5,984,858 V192I probably benign Het
Slc9a2 T A 1: 40,742,669 S353T probably damaging Het
Srgap3 A G 6: 112,731,480 F753L probably damaging Het
Tcea1 C T 1: 4,886,756 T93I probably benign Het
Tctex1d1 A G 4: 102,992,572 N64S probably damaging Het
Tecpr2 A T 12: 110,933,192 S665C probably damaging Het
Tor4a C A 2: 25,194,749 E381* probably null Het
Vdr A G 15: 97,869,681 Y143H probably benign Het
Vmn2r91 A C 17: 18,136,086 T672P possibly damaging Het
Wdr41 A G 13: 94,995,245 probably null Het
Other mutations in Mrgprd
AlleleSourceChrCoordTypePredicted EffectPPH Score
H8786:Mrgprd UTSW 7 145322267 missense probably benign 0.00
R0190:Mrgprd UTSW 7 145321702 missense probably benign 0.02
R1689:Mrgprd UTSW 7 145321717 nonsense probably null
R6321:Mrgprd UTSW 7 145322142 missense probably benign
R6891:Mrgprd UTSW 7 145322350 missense probably benign 0.00
R7203:Mrgprd UTSW 7 145322349 missense probably benign 0.06
R7233:Mrgprd UTSW 7 145321935 missense possibly damaging 0.77
R7385:Mrgprd UTSW 7 145321524 missense probably damaging 1.00
R7400:Mrgprd UTSW 7 145321906 missense probably benign 0.21
Z1176:Mrgprd UTSW 7 145321953 missense probably damaging 1.00
Posted On2015-12-18