Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02814:Cyp4f37'

360690

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp4f37

Ensembl Gene

ENSMUSG00000062464

Gene Name

cytochrome P450, family 4, subfamily f, polypeptide 37

Synonyms

Gm9705

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.227) question?

Stock #

IGL02814

Quality Score

Status

Chromosome

Chromosomal Location

32621319-32636184 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 32634671 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 443 (F443S)

Ref Sequence

ENSEMBL: ENSMUSP00000076827 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077639]

AlphaFold

Q3V1F1

Predicted Effect

probably benign
Transcript: ENSMUST00000077639
AA Change: F443S

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000076827
Gene: ENSMUSG00000062464
AA Change: F443S

Domain	Start	End	E-Value	Type
Pfam:p450	52	515	1.1e-136	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700081O15Rik	C	A	19: 7,420,422	N111K	possibly damaging	Het
Abca9	A	T	11: 110,154,467	F347I	possibly damaging	Het
Adcy5	A	G	16: 35,303,649	T1233A	probably benign	Het
Blnk	C	T	19: 40,962,429	D93N	probably damaging	Het
Cadps2	T	C	6: 23,321,707	E1083G	probably damaging	Het
Capn8	C	A	1: 182,598,771	L224M	probably damaging	Het
Cdh4	A	T	2: 179,780,474	E130D	probably benign	Het
Cgn	G	A	3: 94,774,240	T515M	probably benign	Het
Chrna10	C	T	7: 102,112,262	G374D	probably benign	Het
Chrnb1	T	A	11: 69,795,680	Y38F	probably damaging	Het
Cyld	A	G	8: 88,744,897	D621G	probably benign	Het
Dctn1	C	A	6: 83,189,914	A152E	probably damaging	Het
Eml4	T	A	17: 83,441,362	Y228*	probably null	Het
Fbln2	T	A	6: 91,265,857	C846*	probably null	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Gart	T	C	16: 91,623,457	S833G	possibly damaging	Het
Gda	T	C	19: 21,428,475		probably null	Het
Gjb5	C	T	4: 127,355,562	R263Q	probably benign	Het
Gtf2i	T	C	5: 134,286,704	K193E	probably damaging	Het
Hist2h4	C	A	3: 96,263,287	K6N	probably benign	Het
Ints1	C	T	5: 139,772,391	E244K	possibly damaging	Het
Kat14	G	A	2: 144,402,463	S412N	probably benign	Het
Kcnn3	A	T	3: 89,521,175	H236L	possibly damaging	Het
Kif15	T	A	9: 123,003,640	I1005K	possibly damaging	Het
Klrc1	T	C	6: 129,678,892	T7A	possibly damaging	Het
Lcp2	T	C	11: 34,071,033	S130P	probably damaging	Het
Ldha	T	A	7: 46,850,891	Y133*	probably null	Het
Lrp2	A	G	2: 69,506,736	C1231R	probably damaging	Het
Lrrn1	T	A	6: 107,567,352	V37D	probably damaging	Het
Mep1a	T	A	17: 43,477,221	H648L	probably benign	Het
Mmp25	C	T	17: 23,639,762	G272R	probably damaging	Het
Myh15	A	G	16: 49,145,438		probably benign	Het
Myl3	G	T	9: 110,767,991	E140*	probably null	Het
Nlrp4f	A	G	13: 65,185,042	S809P	probably damaging	Het
Nrde2	T	C	12: 100,144,135	I207M	probably null	Het
Olfr1373	C	T	11: 52,144,810	C240Y	probably damaging	Het
Olfr474	T	C	7: 107,954,770	I43T	probably benign	Het
Olfr541	T	C	7: 140,705,133	L294P	probably damaging	Het
Paics	T	G	5: 76,962,473	V245G	probably damaging	Het
Pank1	A	G	19: 34,840,855	F95L	probably damaging	Het
Pde4dip	A	C	3: 97,767,100	C167G	probably damaging	Het
Picalm	C	A	7: 90,191,749	T542K	possibly damaging	Het
Piezo1	A	G	8: 122,498,215	Y651H	probably damaging	Het
Pikfyve	T	A	1: 65,250,194	C1208*	probably null	Het
Pkd1l1	T	A	11: 8,902,582	T634S	probably benign	Het
Rab32	T	C	10: 10,546,427	T183A	probably benign	Het
Rad18	T	C	6: 112,644,622	I206V	possibly damaging	Het
Rbm15b	T	C	9: 106,885,776	I398V	probably benign	Het
Rbm28	T	C	6: 29,159,726	E101G	probably benign	Het
Rsf1	T	C	7: 97,661,227	L388P	probably damaging	Het
Scnn1g	A	G	7: 121,740,365	Y129C	probably damaging	Het
Slc7a13	G	A	4: 19,839,387	C330Y	probably benign	Het
Spock1	A	T	13: 57,587,673	V101E	probably damaging	Het
Sympk	T	A	7: 19,053,273	W1029R	probably damaging	Het
Syne2	T	A	12: 75,945,376	H2008Q	possibly damaging	Het
Tgs1	T	A	4: 3,585,719	Y199N	probably damaging	Het
Trim10	T	A	17: 36,877,336	C481*	probably null	Het
Vmn2r102	A	G	17: 19,677,908	E395G	probably damaging	Het
Wfs1	A	C	5: 36,967,669	V626G	possibly damaging	Het
Zfp689	A	G	7: 127,445,021	S146P	possibly damaging	Het
Zfp786	T	C	6: 47,819,841	H721R	probably damaging	Het

Other mutations in Cyp4f37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Cyp4f37	APN	17	32629053	missense	probably benign	0.20
IGL01994:Cyp4f37	APN	17	32625176	nonsense	probably null
IGL02073:Cyp4f37	APN	17	32627851	missense	possibly damaging	0.59
IGL02145:Cyp4f37	APN	17	32630035	missense	probably benign	0.43
IGL02873:Cyp4f37	APN	17	32625168	missense	probably benign	0.00
IGL02937:Cyp4f37	APN	17	32625189	missense	probably benign	0.00
IGL03170:Cyp4f37	APN	17	32625119	splice site	probably benign
R0625:Cyp4f37	UTSW	17	32634678	missense	probably damaging	1.00
R1774:Cyp4f37	UTSW	17	32629890	missense	possibly damaging	0.59
R1871:Cyp4f37	UTSW	17	32634665	missense	probably damaging	1.00
R2232:Cyp4f37	UTSW	17	32634270	missense	probably benign	0.23
R2847:Cyp4f37	UTSW	17	32629125	missense	probably damaging	1.00
R2848:Cyp4f37	UTSW	17	32629125	missense	probably damaging	1.00
R4027:Cyp4f37	UTSW	17	32631672	missense	probably benign	0.00
R4463:Cyp4f37	UTSW	17	32627736	critical splice acceptor site	probably null
R4517:Cyp4f37	UTSW	17	32631592	missense	probably benign	0.00
R4573:Cyp4f37	UTSW	17	32629087	missense	probably benign	0.23
R4670:Cyp4f37	UTSW	17	32625152	missense	probably benign
R5752:Cyp4f37	UTSW	17	32631332	missense	probably damaging	1.00
R5930:Cyp4f37	UTSW	17	32629983	missense	possibly damaging	0.79
R6248:Cyp4f37	UTSW	17	32629890	missense	possibly damaging	0.59
R7412:Cyp4f37	UTSW	17	32629844	missense	possibly damaging	0.87
R7969:Cyp4f37	UTSW	17	32625207	missense	probably benign	0.00
R8066:Cyp4f37	UTSW	17	32635073	missense	probably benign	0.21
R8187:Cyp4f37	UTSW	17	32635197	missense	probably benign
R8303:Cyp4f37	UTSW	17	32634178	critical splice acceptor site	probably null
R8309:Cyp4f37	UTSW	17	32634978	missense	probably damaging	1.00
R8407:Cyp4f37	UTSW	17	32634184	missense	probably damaging	1.00
R8869:Cyp4f37	UTSW	17	32625122	missense	probably benign	0.01
R9054:Cyp4f37	UTSW	17	32634279	missense	probably benign	0.25
R9565:Cyp4f37	UTSW	17	32625231	missense	possibly damaging	0.79
R9674:Cyp4f37	UTSW	17	32627867	critical splice donor site	probably null
X0057:Cyp4f37	UTSW	17	32625224	missense	probably benign	0.01

Posted On

2015-12-18