Incidental Mutation 'IGL02814:Cyp4f37'
ID 360690
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4f37
Ensembl Gene ENSMUSG00000062464
Gene Name cytochrome P450, family 4, subfamily f, polypeptide 37
Synonyms Gm9705
Accession Numbers
Essential gene? Probably non essential (E-score: 0.222) question?
Stock # IGL02814
Quality Score
Status
Chromosome 17
Chromosomal Location 32840283-32855158 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 32853645 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 443 (F443S)
Ref Sequence ENSEMBL: ENSMUSP00000076827 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077639]
AlphaFold Q3V1F1
Predicted Effect probably benign
Transcript: ENSMUST00000077639
AA Change: F443S

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000076827
Gene: ENSMUSG00000062464
AA Change: F443S

DomainStartEndE-ValueType
Pfam:p450 52 515 1.1e-136 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A T 11: 110,045,293 (GRCm39) F347I possibly damaging Het
Adcy5 A G 16: 35,124,019 (GRCm39) T1233A probably benign Het
Blnk C T 19: 40,950,873 (GRCm39) D93N probably damaging Het
Cadps2 T C 6: 23,321,706 (GRCm39) E1083G probably damaging Het
Capn8 C A 1: 182,426,336 (GRCm39) L224M probably damaging Het
Cdh4 A T 2: 179,422,267 (GRCm39) E130D probably benign Het
Cgn G A 3: 94,681,550 (GRCm39) T515M probably benign Het
Chrna10 C T 7: 101,761,469 (GRCm39) G374D probably benign Het
Chrnb1 T A 11: 69,686,506 (GRCm39) Y38F probably damaging Het
Cyld A G 8: 89,471,525 (GRCm39) D621G probably benign Het
Dctn1 C A 6: 83,166,896 (GRCm39) A152E probably damaging Het
Eml4 T A 17: 83,748,791 (GRCm39) Y228* probably null Het
Fbln2 T A 6: 91,242,839 (GRCm39) C846* probably null Het
Fut2 C T 7: 45,300,193 (GRCm39) G193E possibly damaging Het
Gart T C 16: 91,420,345 (GRCm39) S833G possibly damaging Het
Gda T C 19: 21,405,839 (GRCm39) probably null Het
Gjb5 C T 4: 127,249,355 (GRCm39) R263Q probably benign Het
Gtf2i T C 5: 134,315,558 (GRCm39) K193E probably damaging Het
H4c14 C A 3: 96,170,603 (GRCm39) K6N probably benign Het
Ints1 C T 5: 139,758,146 (GRCm39) E244K possibly damaging Het
Kat14 G A 2: 144,244,383 (GRCm39) S412N probably benign Het
Kcnn3 A T 3: 89,428,482 (GRCm39) H236L possibly damaging Het
Kif15 T A 9: 122,832,705 (GRCm39) I1005K possibly damaging Het
Klrc1 T C 6: 129,655,855 (GRCm39) T7A possibly damaging Het
Lcp2 T C 11: 34,021,033 (GRCm39) S130P probably damaging Het
Ldha T A 7: 46,500,315 (GRCm39) Y133* probably null Het
Lrp2 A G 2: 69,337,080 (GRCm39) C1231R probably damaging Het
Lrrn1 T A 6: 107,544,313 (GRCm39) V37D probably damaging Het
Mep1a T A 17: 43,788,112 (GRCm39) H648L probably benign Het
Mmp25 C T 17: 23,858,736 (GRCm39) G272R probably damaging Het
Myh15 A G 16: 48,965,801 (GRCm39) probably benign Het
Myl3 G T 9: 110,597,059 (GRCm39) E140* probably null Het
Nlrp4f A G 13: 65,332,856 (GRCm39) S809P probably damaging Het
Nrde2 T C 12: 100,110,394 (GRCm39) I207M probably null Het
Or13a26 T C 7: 140,285,046 (GRCm39) L294P probably damaging Het
Or2y8 C T 11: 52,035,637 (GRCm39) C240Y probably damaging Het
Or5p54 T C 7: 107,553,977 (GRCm39) I43T probably benign Het
Paics T G 5: 77,110,320 (GRCm39) V245G probably damaging Het
Pank1 A G 19: 34,818,255 (GRCm39) F95L probably damaging Het
Pde4dip A C 3: 97,674,416 (GRCm39) C167G probably damaging Het
Picalm C A 7: 89,840,957 (GRCm39) T542K possibly damaging Het
Piezo1 A G 8: 123,224,954 (GRCm39) Y651H probably damaging Het
Pikfyve T A 1: 65,289,353 (GRCm39) C1208* probably null Het
Pkd1l1 T A 11: 8,852,582 (GRCm39) T634S probably benign Het
Rab32 T C 10: 10,422,171 (GRCm39) T183A probably benign Het
Rad18 T C 6: 112,621,583 (GRCm39) I206V possibly damaging Het
Rbm15b T C 9: 106,762,975 (GRCm39) I398V probably benign Het
Rbm28 T C 6: 29,159,725 (GRCm39) E101G probably benign Het
Rsf1 T C 7: 97,310,434 (GRCm39) L388P probably damaging Het
Scnn1g A G 7: 121,339,588 (GRCm39) Y129C probably damaging Het
Slc7a13 G A 4: 19,839,387 (GRCm39) C330Y probably benign Het
Spock1 A T 13: 57,735,486 (GRCm39) V101E probably damaging Het
Sympk T A 7: 18,787,198 (GRCm39) W1029R probably damaging Het
Syne2 T A 12: 75,992,150 (GRCm39) H2008Q possibly damaging Het
Tgs1 T A 4: 3,585,719 (GRCm39) Y199N probably damaging Het
Trim10 T A 17: 37,188,228 (GRCm39) C481* probably null Het
Vmn2r102 A G 17: 19,898,170 (GRCm39) E395G probably damaging Het
Wfs1 A C 5: 37,125,013 (GRCm39) V626G possibly damaging Het
Zfp689 A G 7: 127,044,193 (GRCm39) S146P possibly damaging Het
Zfp786 T C 6: 47,796,775 (GRCm39) H721R probably damaging Het
Zfta C A 19: 7,397,787 (GRCm39) N111K possibly damaging Het
Other mutations in Cyp4f37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Cyp4f37 APN 17 32,848,027 (GRCm39) missense probably benign 0.20
IGL01994:Cyp4f37 APN 17 32,844,150 (GRCm39) nonsense probably null
IGL02073:Cyp4f37 APN 17 32,846,825 (GRCm39) missense possibly damaging 0.59
IGL02145:Cyp4f37 APN 17 32,849,009 (GRCm39) missense probably benign 0.43
IGL02873:Cyp4f37 APN 17 32,844,142 (GRCm39) missense probably benign 0.00
IGL02937:Cyp4f37 APN 17 32,844,163 (GRCm39) missense probably benign 0.00
IGL03170:Cyp4f37 APN 17 32,844,093 (GRCm39) splice site probably benign
R0625:Cyp4f37 UTSW 17 32,853,652 (GRCm39) missense probably damaging 1.00
R1774:Cyp4f37 UTSW 17 32,848,864 (GRCm39) missense possibly damaging 0.59
R1871:Cyp4f37 UTSW 17 32,853,639 (GRCm39) missense probably damaging 1.00
R2232:Cyp4f37 UTSW 17 32,853,244 (GRCm39) missense probably benign 0.23
R2847:Cyp4f37 UTSW 17 32,848,099 (GRCm39) missense probably damaging 1.00
R2848:Cyp4f37 UTSW 17 32,848,099 (GRCm39) missense probably damaging 1.00
R4027:Cyp4f37 UTSW 17 32,850,646 (GRCm39) missense probably benign 0.00
R4463:Cyp4f37 UTSW 17 32,846,710 (GRCm39) critical splice acceptor site probably null
R4517:Cyp4f37 UTSW 17 32,850,566 (GRCm39) missense probably benign 0.00
R4573:Cyp4f37 UTSW 17 32,848,061 (GRCm39) missense probably benign 0.23
R4670:Cyp4f37 UTSW 17 32,844,126 (GRCm39) missense probably benign
R5752:Cyp4f37 UTSW 17 32,850,306 (GRCm39) missense probably damaging 1.00
R5930:Cyp4f37 UTSW 17 32,848,957 (GRCm39) missense possibly damaging 0.79
R6248:Cyp4f37 UTSW 17 32,848,864 (GRCm39) missense possibly damaging 0.59
R7412:Cyp4f37 UTSW 17 32,848,818 (GRCm39) missense possibly damaging 0.87
R7969:Cyp4f37 UTSW 17 32,844,181 (GRCm39) missense probably benign 0.00
R8066:Cyp4f37 UTSW 17 32,854,047 (GRCm39) missense probably benign 0.21
R8187:Cyp4f37 UTSW 17 32,854,171 (GRCm39) missense probably benign
R8303:Cyp4f37 UTSW 17 32,853,152 (GRCm39) critical splice acceptor site probably null
R8309:Cyp4f37 UTSW 17 32,853,952 (GRCm39) missense probably damaging 1.00
R8407:Cyp4f37 UTSW 17 32,853,158 (GRCm39) missense probably damaging 1.00
R8869:Cyp4f37 UTSW 17 32,844,096 (GRCm39) missense probably benign 0.01
R9054:Cyp4f37 UTSW 17 32,853,253 (GRCm39) missense probably benign 0.25
R9565:Cyp4f37 UTSW 17 32,844,205 (GRCm39) missense possibly damaging 0.79
R9674:Cyp4f37 UTSW 17 32,846,841 (GRCm39) critical splice donor site probably null
X0057:Cyp4f37 UTSW 17 32,844,198 (GRCm39) missense probably benign 0.01
Posted On 2015-12-18