Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02814:Vmn2r102'

360692

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r102

Ensembl Gene

ENSMUSG00000095961

Gene Name

vomeronasal 2, receptor 102

Synonyms

EG224572

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02814

Quality Score

Status

Chromosome

Chromosomal Location

19660399-19694748 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19677908 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 395 (E395G)

Ref Sequence

ENSEMBL: ENSMUSP00000126559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171741]

AlphaFold

L7N279

Predicted Effect

probably damaging
Transcript: ENSMUST00000171741
AA Change: E395G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: E395G

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	448	5.2e-38	PFAM
Pfam:NCD3G	509	562	1.1e-21	PFAM
Pfam:7tm_3	595	830	1.8e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700081O15Rik	C	A	19: 7,420,422	N111K	possibly damaging	Het
Abca9	A	T	11: 110,154,467	F347I	possibly damaging	Het
Adcy5	A	G	16: 35,303,649	T1233A	probably benign	Het
Blnk	C	T	19: 40,962,429	D93N	probably damaging	Het
Cadps2	T	C	6: 23,321,707	E1083G	probably damaging	Het
Capn8	C	A	1: 182,598,771	L224M	probably damaging	Het
Cdh4	A	T	2: 179,780,474	E130D	probably benign	Het
Cgn	G	A	3: 94,774,240	T515M	probably benign	Het
Chrna10	C	T	7: 102,112,262	G374D	probably benign	Het
Chrnb1	T	A	11: 69,795,680	Y38F	probably damaging	Het
Cyld	A	G	8: 88,744,897	D621G	probably benign	Het
Cyp4f37	T	C	17: 32,634,671	F443S	probably benign	Het
Dctn1	C	A	6: 83,189,914	A152E	probably damaging	Het
Eml4	T	A	17: 83,441,362	Y228*	probably null	Het
Fbln2	T	A	6: 91,265,857	C846*	probably null	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Gart	T	C	16: 91,623,457	S833G	possibly damaging	Het
Gda	T	C	19: 21,428,475		probably null	Het
Gjb5	C	T	4: 127,355,562	R263Q	probably benign	Het
Gtf2i	T	C	5: 134,286,704	K193E	probably damaging	Het
Hist2h4	C	A	3: 96,263,287	K6N	probably benign	Het
Ints1	C	T	5: 139,772,391	E244K	possibly damaging	Het
Kat14	G	A	2: 144,402,463	S412N	probably benign	Het
Kcnn3	A	T	3: 89,521,175	H236L	possibly damaging	Het
Kif15	T	A	9: 123,003,640	I1005K	possibly damaging	Het
Klrc1	T	C	6: 129,678,892	T7A	possibly damaging	Het
Lcp2	T	C	11: 34,071,033	S130P	probably damaging	Het
Ldha	T	A	7: 46,850,891	Y133*	probably null	Het
Lrp2	A	G	2: 69,506,736	C1231R	probably damaging	Het
Lrrn1	T	A	6: 107,567,352	V37D	probably damaging	Het
Mep1a	T	A	17: 43,477,221	H648L	probably benign	Het
Mmp25	C	T	17: 23,639,762	G272R	probably damaging	Het
Myh15	A	G	16: 49,145,438		probably benign	Het
Myl3	G	T	9: 110,767,991	E140*	probably null	Het
Nlrp4f	A	G	13: 65,185,042	S809P	probably damaging	Het
Nrde2	T	C	12: 100,144,135	I207M	probably null	Het
Olfr1373	C	T	11: 52,144,810	C240Y	probably damaging	Het
Olfr474	T	C	7: 107,954,770	I43T	probably benign	Het
Olfr541	T	C	7: 140,705,133	L294P	probably damaging	Het
Paics	T	G	5: 76,962,473	V245G	probably damaging	Het
Pank1	A	G	19: 34,840,855	F95L	probably damaging	Het
Pde4dip	A	C	3: 97,767,100	C167G	probably damaging	Het
Picalm	C	A	7: 90,191,749	T542K	possibly damaging	Het
Piezo1	A	G	8: 122,498,215	Y651H	probably damaging	Het
Pikfyve	T	A	1: 65,250,194	C1208*	probably null	Het
Pkd1l1	T	A	11: 8,902,582	T634S	probably benign	Het
Rab32	T	C	10: 10,546,427	T183A	probably benign	Het
Rad18	T	C	6: 112,644,622	I206V	possibly damaging	Het
Rbm15b	T	C	9: 106,885,776	I398V	probably benign	Het
Rbm28	T	C	6: 29,159,726	E101G	probably benign	Het
Rsf1	T	C	7: 97,661,227	L388P	probably damaging	Het
Scnn1g	A	G	7: 121,740,365	Y129C	probably damaging	Het
Slc7a13	G	A	4: 19,839,387	C330Y	probably benign	Het
Spock1	A	T	13: 57,587,673	V101E	probably damaging	Het
Sympk	T	A	7: 19,053,273	W1029R	probably damaging	Het
Syne2	T	A	12: 75,945,376	H2008Q	possibly damaging	Het
Tgs1	T	A	4: 3,585,719	Y199N	probably damaging	Het
Trim10	T	A	17: 36,877,336	C481*	probably null	Het
Wfs1	A	C	5: 36,967,669	V626G	possibly damaging	Het
Zfp689	A	G	7: 127,445,021	S146P	possibly damaging	Het
Zfp786	T	C	6: 47,819,841	H721R	probably damaging	Het

Other mutations in Vmn2r102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00944:Vmn2r102	APN	17	19678892	missense	probably damaging	1.00
IGL00974:Vmn2r102	APN	17	19677509	missense	possibly damaging	0.93
IGL00978:Vmn2r102	APN	17	19678923	splice site	probably null
IGL01589:Vmn2r102	APN	17	19678804	missense	probably benign
IGL01738:Vmn2r102	APN	17	19677758	missense	probably damaging	1.00
IGL01994:Vmn2r102	APN	17	19660469	missense	probably benign	0.00
IGL02066:Vmn2r102	APN	17	19693929	missense	probably benign	0.01
IGL02525:Vmn2r102	APN	17	19681185	missense	probably benign
IGL02589:Vmn2r102	APN	17	19681218	missense	probably damaging	1.00
IGL03028:Vmn2r102	APN	17	19694066	missense	possibly damaging	0.92
IGL03162:Vmn2r102	APN	17	19694024	missense	probably damaging	1.00
PIT4431001:Vmn2r102	UTSW	17	19676696	missense	possibly damaging	0.68
R0042:Vmn2r102	UTSW	17	19660589	missense	probably damaging	0.98
R0131:Vmn2r102	UTSW	17	19678763	missense	probably benign	0.42
R0131:Vmn2r102	UTSW	17	19678763	missense	probably benign	0.42
R0132:Vmn2r102	UTSW	17	19678763	missense	probably benign	0.42
R0268:Vmn2r102	UTSW	17	19677850	missense	probably benign	0.00
R0441:Vmn2r102	UTSW	17	19694368	missense	probably damaging	1.00
R0583:Vmn2r102	UTSW	17	19676781	missense	probably benign	0.01
R0600:Vmn2r102	UTSW	17	19678015	missense	probably benign	0.00
R0606:Vmn2r102	UTSW	17	19678844	missense	possibly damaging	0.93
R0674:Vmn2r102	UTSW	17	19677867	missense	probably benign	0.00
R0709:Vmn2r102	UTSW	17	19677619	missense	probably benign	0.01
R0879:Vmn2r102	UTSW	17	19694192	missense	probably damaging	1.00
R1349:Vmn2r102	UTSW	17	19660625	splice site	probably benign
R1473:Vmn2r102	UTSW	17	19694581	missense	probably benign	0.00
R1630:Vmn2r102	UTSW	17	19678770	missense	possibly damaging	0.60
R1727:Vmn2r102	UTSW	17	19677508	missense	probably damaging	0.99
R1759:Vmn2r102	UTSW	17	19694493	missense	probably damaging	1.00
R1809:Vmn2r102	UTSW	17	19677619	missense	probably benign	0.01
R2013:Vmn2r102	UTSW	17	19676744	missense	probably benign	0.03
R2086:Vmn2r102	UTSW	17	19676687	missense	probably damaging	1.00
R2241:Vmn2r102	UTSW	17	19676741	missense	probably benign	0.00
R2378:Vmn2r102	UTSW	17	19694668	missense	probably damaging	1.00
R3814:Vmn2r102	UTSW	17	19678831	missense	probably damaging	0.98
R3827:Vmn2r102	UTSW	17	19694525	missense	probably damaging	1.00
R4159:Vmn2r102	UTSW	17	19677826	missense	probably damaging	1.00
R4505:Vmn2r102	UTSW	17	19660583	missense	probably benign	0.00
R4515:Vmn2r102	UTSW	17	19681213	missense	probably damaging	1.00
R4517:Vmn2r102	UTSW	17	19681213	missense	probably damaging	1.00
R4534:Vmn2r102	UTSW	17	19694713	missense	probably benign
R4535:Vmn2r102	UTSW	17	19694713	missense	probably benign
R4662:Vmn2r102	UTSW	17	19681162	missense	probably damaging	1.00
R4708:Vmn2r102	UTSW	17	19694314	missense	probably benign	0.00
R4734:Vmn2r102	UTSW	17	19677533	missense	probably damaging	1.00
R4834:Vmn2r102	UTSW	17	19677941	missense	probably damaging	0.99
R4927:Vmn2r102	UTSW	17	19660399	start codon destroyed	probably benign	0.00
R5077:Vmn2r102	UTSW	17	19677572	missense	probably benign	0.20
R5181:Vmn2r102	UTSW	17	19676741	missense	probably benign	0.00
R5277:Vmn2r102	UTSW	17	19694131	missense	possibly damaging	0.49
R5418:Vmn2r102	UTSW	17	19694153	missense	probably damaging	1.00
R5810:Vmn2r102	UTSW	17	19677542	missense	probably benign	0.20
R5864:Vmn2r102	UTSW	17	19694681	missense	possibly damaging	0.55
R6168:Vmn2r102	UTSW	17	19694140	missense	possibly damaging	0.83
R6266:Vmn2r102	UTSW	17	19678745	missense	probably benign
R6432:Vmn2r102	UTSW	17	19681221	missense	possibly damaging	0.61
R6487:Vmn2r102	UTSW	17	19677907	missense	probably damaging	1.00
R6597:Vmn2r102	UTSW	17	19694188	missense	probably damaging	0.99
R6797:Vmn2r102	UTSW	17	19660432	nonsense	probably null
R7009:Vmn2r102	UTSW	17	19694194	missense	probably damaging	0.99
R7098:Vmn2r102	UTSW	17	19694408	missense	probably damaging	1.00
R7134:Vmn2r102	UTSW	17	19677487	missense	probably benign	0.01
R7463:Vmn2r102	UTSW	17	19676624	missense	probably damaging	1.00
R7511:Vmn2r102	UTSW	17	19681143	missense	probably damaging	1.00
R7512:Vmn2r102	UTSW	17	19694101	missense	probably damaging	1.00
R7556:Vmn2r102	UTSW	17	19677831	missense	probably benign
R8126:Vmn2r102	UTSW	17	19660450	missense	probably benign	0.02
R8385:Vmn2r102	UTSW	17	19693826	missense	possibly damaging	0.89
R8410:Vmn2r102	UTSW	17	19677934	missense	possibly damaging	0.85
R9045:Vmn2r102	UTSW	17	19660579	missense	probably benign	0.00
R9267:Vmn2r102	UTSW	17	19676666	missense	probably damaging	1.00
R9325:Vmn2r102	UTSW	17	19677296	missense	probably damaging	1.00
R9363:Vmn2r102	UTSW	17	19677352	missense	probably benign	0.04
R9524:Vmn2r102	UTSW	17	19677302	missense	possibly damaging	0.74
R9747:Vmn2r102	UTSW	17	19677867	missense	probably benign	0.00
Z1176:Vmn2r102	UTSW	17	19694043	nonsense	probably null

Posted On

2015-12-18