Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02814:Trim10'

360708

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim10

Ensembl Gene

ENSMUSG00000073400

Gene Name

tripartite motif-containing 10

Synonyms

Rnf9, Herf1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

IGL02814

Quality Score

Status

Chromosome

Chromosomal Location

36869574-36877833 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 36877336 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 481 (C481*)

Ref Sequence

ENSEMBL: ENSMUSP00000057928 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060524] [ENSMUST00000087158] [ENSMUST00000172711]

AlphaFold

Q9WUH5

Predicted Effect

probably null
Transcript: ENSMUST00000060524
AA Change: C481*

SMART Domains

Protein: ENSMUSP00000057928
Gene: ENSMUSG00000073400
AA Change: C481*

Domain	Start	End	E-Value	Type
RING	16	60	1.2e-7	SMART
BBOX	94	135	5.38e-10	SMART
coiled coil region	152	175	N/A	INTRINSIC
low complexity region	187	207	N/A	INTRINSIC
PRY	309	361	1.04e-25	SMART
SPRY	362	485	1.51e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000087158

SMART Domains

Protein: ENSMUSP00000084400
Gene: ENSMUSG00000073399

Domain	Start	End	E-Value	Type
RING	12	54	6e-8	SMART
Pfam:zf-B_box	65	105	1.1e-6	PFAM
coiled coil region	106	150	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000172711

SMART Domains

Protein: ENSMUSP00000133581
Gene: ENSMUSG00000073399

Domain	Start	End	E-Value	Type
RING	12	54	6e-8	SMART
Pfam:zf-B_box	65	105	3.4e-7	PFAM
coiled coil region	106	150	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700081O15Rik	C	A	19: 7,420,422	N111K	possibly damaging	Het
Abca9	A	T	11: 110,154,467	F347I	possibly damaging	Het
Adcy5	A	G	16: 35,303,649	T1233A	probably benign	Het
Blnk	C	T	19: 40,962,429	D93N	probably damaging	Het
Cadps2	T	C	6: 23,321,707	E1083G	probably damaging	Het
Capn8	C	A	1: 182,598,771	L224M	probably damaging	Het
Cdh4	A	T	2: 179,780,474	E130D	probably benign	Het
Cgn	G	A	3: 94,774,240	T515M	probably benign	Het
Chrna10	C	T	7: 102,112,262	G374D	probably benign	Het
Chrnb1	T	A	11: 69,795,680	Y38F	probably damaging	Het
Cyld	A	G	8: 88,744,897	D621G	probably benign	Het
Cyp4f37	T	C	17: 32,634,671	F443S	probably benign	Het
Dctn1	C	A	6: 83,189,914	A152E	probably damaging	Het
Eml4	T	A	17: 83,441,362	Y228*	probably null	Het
Fbln2	T	A	6: 91,265,857	C846*	probably null	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Gart	T	C	16: 91,623,457	S833G	possibly damaging	Het
Gda	T	C	19: 21,428,475		probably null	Het
Gjb5	C	T	4: 127,355,562	R263Q	probably benign	Het
Gtf2i	T	C	5: 134,286,704	K193E	probably damaging	Het
Hist2h4	C	A	3: 96,263,287	K6N	probably benign	Het
Ints1	C	T	5: 139,772,391	E244K	possibly damaging	Het
Kat14	G	A	2: 144,402,463	S412N	probably benign	Het
Kcnn3	A	T	3: 89,521,175	H236L	possibly damaging	Het
Kif15	T	A	9: 123,003,640	I1005K	possibly damaging	Het
Klrc1	T	C	6: 129,678,892	T7A	possibly damaging	Het
Lcp2	T	C	11: 34,071,033	S130P	probably damaging	Het
Ldha	T	A	7: 46,850,891	Y133*	probably null	Het
Lrp2	A	G	2: 69,506,736	C1231R	probably damaging	Het
Lrrn1	T	A	6: 107,567,352	V37D	probably damaging	Het
Mep1a	T	A	17: 43,477,221	H648L	probably benign	Het
Mmp25	C	T	17: 23,639,762	G272R	probably damaging	Het
Myh15	A	G	16: 49,145,438		probably benign	Het
Myl3	G	T	9: 110,767,991	E140*	probably null	Het
Nlrp4f	A	G	13: 65,185,042	S809P	probably damaging	Het
Nrde2	T	C	12: 100,144,135	I207M	probably null	Het
Olfr1373	C	T	11: 52,144,810	C240Y	probably damaging	Het
Olfr474	T	C	7: 107,954,770	I43T	probably benign	Het
Olfr541	T	C	7: 140,705,133	L294P	probably damaging	Het
Paics	T	G	5: 76,962,473	V245G	probably damaging	Het
Pank1	A	G	19: 34,840,855	F95L	probably damaging	Het
Pde4dip	A	C	3: 97,767,100	C167G	probably damaging	Het
Picalm	C	A	7: 90,191,749	T542K	possibly damaging	Het
Piezo1	A	G	8: 122,498,215	Y651H	probably damaging	Het
Pikfyve	T	A	1: 65,250,194	C1208*	probably null	Het
Pkd1l1	T	A	11: 8,902,582	T634S	probably benign	Het
Rab32	T	C	10: 10,546,427	T183A	probably benign	Het
Rad18	T	C	6: 112,644,622	I206V	possibly damaging	Het
Rbm15b	T	C	9: 106,885,776	I398V	probably benign	Het
Rbm28	T	C	6: 29,159,726	E101G	probably benign	Het
Rsf1	T	C	7: 97,661,227	L388P	probably damaging	Het
Scnn1g	A	G	7: 121,740,365	Y129C	probably damaging	Het
Slc7a13	G	A	4: 19,839,387	C330Y	probably benign	Het
Spock1	A	T	13: 57,587,673	V101E	probably damaging	Het
Sympk	T	A	7: 19,053,273	W1029R	probably damaging	Het
Syne2	T	A	12: 75,945,376	H2008Q	possibly damaging	Het
Tgs1	T	A	4: 3,585,719	Y199N	probably damaging	Het
Vmn2r102	A	G	17: 19,677,908	E395G	probably damaging	Het
Wfs1	A	C	5: 36,967,669	V626G	possibly damaging	Het
Zfp689	A	G	7: 127,445,021	S146P	possibly damaging	Het
Zfp786	T	C	6: 47,819,841	H721R	probably damaging	Het

Other mutations in Trim10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00493:Trim10	APN	17	36877248	missense	probably benign	0.03
IGL00501:Trim10	APN	17	36877047	missense	probably benign	0.08
IGL00846:Trim10	APN	17	36871692	missense	probably damaging	1.00
IGL01536:Trim10	APN	17	36877288	splice site	probably null
IGL03135:Trim10	APN	17	36874221	missense	possibly damaging	0.78
IGL03144:Trim10	APN	17	36876848	missense	probably damaging	1.00
IGL03298:Trim10	APN	17	36877025	missense	possibly damaging	0.87
PIT4378001:Trim10	UTSW	17	36877128	missense	probably damaging	0.98
R0102:Trim10	UTSW	17	36870182	missense	probably damaging	1.00
R0102:Trim10	UTSW	17	36870182	missense	probably damaging	1.00
R0834:Trim10	UTSW	17	36872391	missense	probably benign	0.00
R1517:Trim10	UTSW	17	36872454	missense	probably damaging	1.00
R1691:Trim10	UTSW	17	36876899	missense	probably damaging	1.00
R1696:Trim10	UTSW	17	36877181	nonsense	probably null
R2149:Trim10	UTSW	17	36877014	missense	probably benign	0.18
R3153:Trim10	UTSW	17	36871688	missense	probably damaging	1.00
R3154:Trim10	UTSW	17	36871688	missense	probably damaging	1.00
R5156:Trim10	UTSW	17	36877056	missense	probably damaging	0.99
R5327:Trim10	UTSW	17	36870189	missense	probably damaging	1.00
R5361:Trim10	UTSW	17	36875436	missense	probably benign	0.03
R5758:Trim10	UTSW	17	36877152	missense	possibly damaging	0.80
R5764:Trim10	UTSW	17	36870181	missense	probably damaging	0.97
R6032:Trim10	UTSW	17	36871714	missense	possibly damaging	0.87
R6032:Trim10	UTSW	17	36871714	missense	possibly damaging	0.87
R6179:Trim10	UTSW	17	36877031	missense	probably damaging	1.00
R6709:Trim10	UTSW	17	36872370	missense	probably damaging	0.99
R7172:Trim10	UTSW	17	36870063	missense	possibly damaging	0.78
R7197:Trim10	UTSW	17	36876954	missense	probably damaging	1.00
R7390:Trim10	UTSW	17	36869881	start codon destroyed	probably null	0.98
R7391:Trim10	UTSW	17	36869881	start codon destroyed	probably null	0.98
R7696:Trim10	UTSW	17	36871752	missense	probably damaging	1.00
R8830:Trim10	UTSW	17	36869954	missense	probably damaging	1.00
R8867:Trim10	UTSW	17	36870156	missense	probably benign	0.00
R8970:Trim10	UTSW	17	36873276	missense	probably benign	0.00
R9376:Trim10	UTSW	17	36873276	missense	probably benign	0.00
R9635:Trim10	UTSW	17	36876998	missense	probably damaging	1.00

Posted On

2015-12-18