Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02814:Trim10'

360708

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim10

Ensembl Gene

ENSMUSG00000073400

Gene Name

tripartite motif-containing 10

Synonyms

Rnf9, Herf1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL02814

Quality Score

Status

Chromosome

Chromosomal Location

37180466-37188725 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 37188228 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 481 (C481*)

Ref Sequence

ENSEMBL: ENSMUSP00000057928 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060524] [ENSMUST00000087158] [ENSMUST00000172711]

AlphaFold

Q9WUH5

Predicted Effect

probably null
Transcript: ENSMUST00000060524
AA Change: C481*

SMART Domains

Protein: ENSMUSP00000057928
Gene: ENSMUSG00000073400
AA Change: C481*

Domain	Start	End	E-Value	Type
RING	16	60	1.2e-7	SMART
BBOX	94	135	5.38e-10	SMART
coiled coil region	152	175	N/A	INTRINSIC
low complexity region	187	207	N/A	INTRINSIC
PRY	309	361	1.04e-25	SMART
SPRY	362	485	1.51e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000087158

SMART Domains

Protein: ENSMUSP00000084400
Gene: ENSMUSG00000073399

Domain	Start	End	E-Value	Type
RING	12	54	6e-8	SMART
Pfam:zf-B_box	65	105	1.1e-6	PFAM
coiled coil region	106	150	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000172711

SMART Domains

Protein: ENSMUSP00000133581
Gene: ENSMUSG00000073399

Domain	Start	End	E-Value	Type
RING	12	54	6e-8	SMART
Pfam:zf-B_box	65	105	3.4e-7	PFAM
coiled coil region	106	150	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	T	11: 110,045,293 (GRCm39)	F347I	possibly damaging	Het
Adcy5	A	G	16: 35,124,019 (GRCm39)	T1233A	probably benign	Het
Blnk	C	T	19: 40,950,873 (GRCm39)	D93N	probably damaging	Het
Cadps2	T	C	6: 23,321,706 (GRCm39)	E1083G	probably damaging	Het
Capn8	C	A	1: 182,426,336 (GRCm39)	L224M	probably damaging	Het
Cdh4	A	T	2: 179,422,267 (GRCm39)	E130D	probably benign	Het
Cgn	G	A	3: 94,681,550 (GRCm39)	T515M	probably benign	Het
Chrna10	C	T	7: 101,761,469 (GRCm39)	G374D	probably benign	Het
Chrnb1	T	A	11: 69,686,506 (GRCm39)	Y38F	probably damaging	Het
Cyld	A	G	8: 89,471,525 (GRCm39)	D621G	probably benign	Het
Cyp4f37	T	C	17: 32,853,645 (GRCm39)	F443S	probably benign	Het
Dctn1	C	A	6: 83,166,896 (GRCm39)	A152E	probably damaging	Het
Eml4	T	A	17: 83,748,791 (GRCm39)	Y228*	probably null	Het
Fbln2	T	A	6: 91,242,839 (GRCm39)	C846*	probably null	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
Gart	T	C	16: 91,420,345 (GRCm39)	S833G	possibly damaging	Het
Gda	T	C	19: 21,405,839 (GRCm39)		probably null	Het
Gjb5	C	T	4: 127,249,355 (GRCm39)	R263Q	probably benign	Het
Gtf2i	T	C	5: 134,315,558 (GRCm39)	K193E	probably damaging	Het
H4c14	C	A	3: 96,170,603 (GRCm39)	K6N	probably benign	Het
Ints1	C	T	5: 139,758,146 (GRCm39)	E244K	possibly damaging	Het
Kat14	G	A	2: 144,244,383 (GRCm39)	S412N	probably benign	Het
Kcnn3	A	T	3: 89,428,482 (GRCm39)	H236L	possibly damaging	Het
Kif15	T	A	9: 122,832,705 (GRCm39)	I1005K	possibly damaging	Het
Klrc1	T	C	6: 129,655,855 (GRCm39)	T7A	possibly damaging	Het
Lcp2	T	C	11: 34,021,033 (GRCm39)	S130P	probably damaging	Het
Ldha	T	A	7: 46,500,315 (GRCm39)	Y133*	probably null	Het
Lrp2	A	G	2: 69,337,080 (GRCm39)	C1231R	probably damaging	Het
Lrrn1	T	A	6: 107,544,313 (GRCm39)	V37D	probably damaging	Het
Mep1a	T	A	17: 43,788,112 (GRCm39)	H648L	probably benign	Het
Mmp25	C	T	17: 23,858,736 (GRCm39)	G272R	probably damaging	Het
Myh15	A	G	16: 48,965,801 (GRCm39)		probably benign	Het
Myl3	G	T	9: 110,597,059 (GRCm39)	E140*	probably null	Het
Nlrp4f	A	G	13: 65,332,856 (GRCm39)	S809P	probably damaging	Het
Nrde2	T	C	12: 100,110,394 (GRCm39)	I207M	probably null	Het
Or13a26	T	C	7: 140,285,046 (GRCm39)	L294P	probably damaging	Het
Or2y8	C	T	11: 52,035,637 (GRCm39)	C240Y	probably damaging	Het
Or5p54	T	C	7: 107,553,977 (GRCm39)	I43T	probably benign	Het
Paics	T	G	5: 77,110,320 (GRCm39)	V245G	probably damaging	Het
Pank1	A	G	19: 34,818,255 (GRCm39)	F95L	probably damaging	Het
Pde4dip	A	C	3: 97,674,416 (GRCm39)	C167G	probably damaging	Het
Picalm	C	A	7: 89,840,957 (GRCm39)	T542K	possibly damaging	Het
Piezo1	A	G	8: 123,224,954 (GRCm39)	Y651H	probably damaging	Het
Pikfyve	T	A	1: 65,289,353 (GRCm39)	C1208*	probably null	Het
Pkd1l1	T	A	11: 8,852,582 (GRCm39)	T634S	probably benign	Het
Rab32	T	C	10: 10,422,171 (GRCm39)	T183A	probably benign	Het
Rad18	T	C	6: 112,621,583 (GRCm39)	I206V	possibly damaging	Het
Rbm15b	T	C	9: 106,762,975 (GRCm39)	I398V	probably benign	Het
Rbm28	T	C	6: 29,159,725 (GRCm39)	E101G	probably benign	Het
Rsf1	T	C	7: 97,310,434 (GRCm39)	L388P	probably damaging	Het
Scnn1g	A	G	7: 121,339,588 (GRCm39)	Y129C	probably damaging	Het
Slc7a13	G	A	4: 19,839,387 (GRCm39)	C330Y	probably benign	Het
Spock1	A	T	13: 57,735,486 (GRCm39)	V101E	probably damaging	Het
Sympk	T	A	7: 18,787,198 (GRCm39)	W1029R	probably damaging	Het
Syne2	T	A	12: 75,992,150 (GRCm39)	H2008Q	possibly damaging	Het
Tgs1	T	A	4: 3,585,719 (GRCm39)	Y199N	probably damaging	Het
Vmn2r102	A	G	17: 19,898,170 (GRCm39)	E395G	probably damaging	Het
Wfs1	A	C	5: 37,125,013 (GRCm39)	V626G	possibly damaging	Het
Zfp689	A	G	7: 127,044,193 (GRCm39)	S146P	possibly damaging	Het
Zfp786	T	C	6: 47,796,775 (GRCm39)	H721R	probably damaging	Het
Zfta	C	A	19: 7,397,787 (GRCm39)	N111K	possibly damaging	Het

Other mutations in Trim10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00493:Trim10	APN	17	37,188,140 (GRCm39)	missense	probably benign	0.03
IGL00501:Trim10	APN	17	37,187,939 (GRCm39)	missense	probably benign	0.08
IGL00846:Trim10	APN	17	37,182,584 (GRCm39)	missense	probably damaging	1.00
IGL01536:Trim10	APN	17	37,188,180 (GRCm39)	splice site	probably null
IGL03135:Trim10	APN	17	37,185,113 (GRCm39)	missense	possibly damaging	0.78
IGL03144:Trim10	APN	17	37,187,740 (GRCm39)	missense	probably damaging	1.00
IGL03298:Trim10	APN	17	37,187,917 (GRCm39)	missense	possibly damaging	0.87
PIT4378001:Trim10	UTSW	17	37,188,020 (GRCm39)	missense	probably damaging	0.98
R0102:Trim10	UTSW	17	37,181,074 (GRCm39)	missense	probably damaging	1.00
R0102:Trim10	UTSW	17	37,181,074 (GRCm39)	missense	probably damaging	1.00
R0834:Trim10	UTSW	17	37,183,283 (GRCm39)	missense	probably benign	0.00
R1517:Trim10	UTSW	17	37,183,346 (GRCm39)	missense	probably damaging	1.00
R1691:Trim10	UTSW	17	37,187,791 (GRCm39)	missense	probably damaging	1.00
R1696:Trim10	UTSW	17	37,188,073 (GRCm39)	nonsense	probably null
R2149:Trim10	UTSW	17	37,187,906 (GRCm39)	missense	probably benign	0.18
R3153:Trim10	UTSW	17	37,182,580 (GRCm39)	missense	probably damaging	1.00
R3154:Trim10	UTSW	17	37,182,580 (GRCm39)	missense	probably damaging	1.00
R5156:Trim10	UTSW	17	37,187,948 (GRCm39)	missense	probably damaging	0.99
R5327:Trim10	UTSW	17	37,181,081 (GRCm39)	missense	probably damaging	1.00
R5361:Trim10	UTSW	17	37,186,328 (GRCm39)	missense	probably benign	0.03
R5758:Trim10	UTSW	17	37,188,044 (GRCm39)	missense	possibly damaging	0.80
R5764:Trim10	UTSW	17	37,181,073 (GRCm39)	missense	probably damaging	0.97
R6032:Trim10	UTSW	17	37,182,606 (GRCm39)	missense	possibly damaging	0.87
R6032:Trim10	UTSW	17	37,182,606 (GRCm39)	missense	possibly damaging	0.87
R6179:Trim10	UTSW	17	37,187,923 (GRCm39)	missense	probably damaging	1.00
R6709:Trim10	UTSW	17	37,183,262 (GRCm39)	missense	probably damaging	0.99
R7172:Trim10	UTSW	17	37,180,955 (GRCm39)	missense	possibly damaging	0.78
R7197:Trim10	UTSW	17	37,187,846 (GRCm39)	missense	probably damaging	1.00
R7390:Trim10	UTSW	17	37,180,773 (GRCm39)	start codon destroyed	probably null	0.98
R7391:Trim10	UTSW	17	37,180,773 (GRCm39)	start codon destroyed	probably null	0.98
R7696:Trim10	UTSW	17	37,182,644 (GRCm39)	missense	probably damaging	1.00
R8830:Trim10	UTSW	17	37,180,846 (GRCm39)	missense	probably damaging	1.00
R8867:Trim10	UTSW	17	37,181,048 (GRCm39)	missense	probably benign	0.00
R8970:Trim10	UTSW	17	37,184,168 (GRCm39)	missense	probably benign	0.00
R9376:Trim10	UTSW	17	37,184,168 (GRCm39)	missense	probably benign	0.00
R9635:Trim10	UTSW	17	37,187,890 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18