Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02814:Zfp786'

360741

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp786

Ensembl Gene

ENSMUSG00000051499

Gene Name

zinc finger protein 786

Synonyms

A730012O14Rik

Accession Numbers

Genbank: NM_177882; MGI: 3026883

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

IGL02814

Quality Score

Status

Chromosome

Chromosomal Location

47819266-47830867 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 47819841 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 721 (H721R)

Ref Sequence

ENSEMBL: ENSMUSP00000057495 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058844]

AlphaFold

Q8BV42

Predicted Effect

probably damaging
Transcript: ENSMUST00000058844
AA Change: H721R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000057495
Gene: ENSMUSG00000051499
AA Change: H721R

Domain	Start	End	E-Value	Type
KRAB	9	69	2.6e-22	SMART
low complexity region	156	164	N/A	INTRINSIC
ZnF_C2H2	240	262	5.34e-1	SMART
ZnF_C2H2	268	295	1.41e2	SMART
ZnF_C2H2	420	440	1.21e2	SMART
ZnF_C2H2	448	470	3.52e-1	SMART
ZnF_C2H2	476	498	1.89e-1	SMART
ZnF_C2H2	504	526	1.69e-3	SMART
ZnF_C2H2	532	554	5.59e-4	SMART
ZnF_C2H2	560	582	4.79e-3	SMART
ZnF_C2H2	588	610	3.69e-4	SMART
ZnF_C2H2	616	638	3.63e-3	SMART
ZnF_C2H2	644	665	5.92e0	SMART
ZnF_C2H2	671	693	2.57e-3	SMART
ZnF_C2H2	699	721	1.38e-3	SMART
ZnF_C2H2	727	749	1.45e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000080603

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143979

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700081O15Rik	C	A	19: 7,420,422	N111K	possibly damaging	Het
Abca9	A	T	11: 110,154,467	F347I	possibly damaging	Het
Adcy5	A	G	16: 35,303,649	T1233A	probably benign	Het
Blnk	C	T	19: 40,962,429	D93N	probably damaging	Het
Cadps2	T	C	6: 23,321,707	E1083G	probably damaging	Het
Capn8	C	A	1: 182,598,771	L224M	probably damaging	Het
Cdh4	A	T	2: 179,780,474	E130D	probably benign	Het
Cgn	G	A	3: 94,774,240	T515M	probably benign	Het
Chrna10	C	T	7: 102,112,262	G374D	probably benign	Het
Chrnb1	T	A	11: 69,795,680	Y38F	probably damaging	Het
Cyld	A	G	8: 88,744,897	D621G	probably benign	Het
Cyp4f37	T	C	17: 32,634,671	F443S	probably benign	Het
Dctn1	C	A	6: 83,189,914	A152E	probably damaging	Het
Eml4	T	A	17: 83,441,362	Y228*	probably null	Het
Fbln2	T	A	6: 91,265,857	C846*	probably null	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Gart	T	C	16: 91,623,457	S833G	possibly damaging	Het
Gda	T	C	19: 21,428,475		probably null	Het
Gjb5	C	T	4: 127,355,562	R263Q	probably benign	Het
Gtf2i	T	C	5: 134,286,704	K193E	probably damaging	Het
Hist2h4	C	A	3: 96,263,287	K6N	probably benign	Het
Ints1	C	T	5: 139,772,391	E244K	possibly damaging	Het
Kat14	G	A	2: 144,402,463	S412N	probably benign	Het
Kcnn3	A	T	3: 89,521,175	H236L	possibly damaging	Het
Kif15	T	A	9: 123,003,640	I1005K	possibly damaging	Het
Klrc1	T	C	6: 129,678,892	T7A	possibly damaging	Het
Lcp2	T	C	11: 34,071,033	S130P	probably damaging	Het
Ldha	T	A	7: 46,850,891	Y133*	probably null	Het
Lrp2	A	G	2: 69,506,736	C1231R	probably damaging	Het
Lrrn1	T	A	6: 107,567,352	V37D	probably damaging	Het
Mep1a	T	A	17: 43,477,221	H648L	probably benign	Het
Mmp25	C	T	17: 23,639,762	G272R	probably damaging	Het
Myh15	A	G	16: 49,145,438		probably benign	Het
Myl3	G	T	9: 110,767,991	E140*	probably null	Het
Nlrp4f	A	G	13: 65,185,042	S809P	probably damaging	Het
Nrde2	T	C	12: 100,144,135	I207M	probably null	Het
Olfr1373	C	T	11: 52,144,810	C240Y	probably damaging	Het
Olfr474	T	C	7: 107,954,770	I43T	probably benign	Het
Olfr541	T	C	7: 140,705,133	L294P	probably damaging	Het
Paics	T	G	5: 76,962,473	V245G	probably damaging	Het
Pank1	A	G	19: 34,840,855	F95L	probably damaging	Het
Pde4dip	A	C	3: 97,767,100	C167G	probably damaging	Het
Picalm	C	A	7: 90,191,749	T542K	possibly damaging	Het
Piezo1	A	G	8: 122,498,215	Y651H	probably damaging	Het
Pikfyve	T	A	1: 65,250,194	C1208*	probably null	Het
Pkd1l1	T	A	11: 8,902,582	T634S	probably benign	Het
Rab32	T	C	10: 10,546,427	T183A	probably benign	Het
Rad18	T	C	6: 112,644,622	I206V	possibly damaging	Het
Rbm15b	T	C	9: 106,885,776	I398V	probably benign	Het
Rbm28	T	C	6: 29,159,726	E101G	probably benign	Het
Rsf1	T	C	7: 97,661,227	L388P	probably damaging	Het
Scnn1g	A	G	7: 121,740,365	Y129C	probably damaging	Het
Slc7a13	G	A	4: 19,839,387	C330Y	probably benign	Het
Spock1	A	T	13: 57,587,673	V101E	probably damaging	Het
Sympk	T	A	7: 19,053,273	W1029R	probably damaging	Het
Syne2	T	A	12: 75,945,376	H2008Q	possibly damaging	Het
Tgs1	T	A	4: 3,585,719	Y199N	probably damaging	Het
Trim10	T	A	17: 36,877,336	C481*	probably null	Het
Vmn2r102	A	G	17: 19,677,908	E395G	probably damaging	Het
Wfs1	A	C	5: 36,967,669	V626G	possibly damaging	Het
Zfp689	A	G	7: 127,445,021	S146P	possibly damaging	Het

Other mutations in Zfp786

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00593:Zfp786	APN	6	47819671	makesense	probably null
IGL02442:Zfp786	APN	6	47821367	missense	probably benign	0.00
IGL02674:Zfp786	APN	6	47820493	missense	probably benign	0.22
IGL03072:Zfp786	APN	6	47821243	missense	probably benign	0.01
IGL03294:Zfp786	APN	6	47821324	nonsense	probably null
IGL03393:Zfp786	APN	6	47821524	missense	possibly damaging	0.88
3-1:Zfp786	UTSW	6	47820445	missense	probably damaging	1.00
PIT4581001:Zfp786	UTSW	6	47819822	missense	probably damaging	1.00
R1071:Zfp786	UTSW	6	47821305	missense	possibly damaging	0.91
R1426:Zfp786	UTSW	6	47825079	missense	probably benign	0.17
R1976:Zfp786	UTSW	6	47819757	missense	probably damaging	1.00
R2114:Zfp786	UTSW	6	47826997	missense	probably damaging	1.00
R2115:Zfp786	UTSW	6	47826997	missense	probably damaging	1.00
R2117:Zfp786	UTSW	6	47826997	missense	probably damaging	1.00
R2176:Zfp786	UTSW	6	47820971	missense	possibly damaging	0.65
R2304:Zfp786	UTSW	6	47820699	missense	probably damaging	1.00
R3110:Zfp786	UTSW	6	47820226	missense	probably damaging	1.00
R3112:Zfp786	UTSW	6	47820226	missense	probably damaging	1.00
R3623:Zfp786	UTSW	6	47821423	missense	probably benign	0.00
R4654:Zfp786	UTSW	6	47820934	missense	probably benign	0.01
R4741:Zfp786	UTSW	6	47820691	missense	probably damaging	1.00
R4927:Zfp786	UTSW	6	47820153	missense	probably benign	0.43
R4936:Zfp786	UTSW	6	47821268	nonsense	probably null
R5084:Zfp786	UTSW	6	47820019	missense	probably benign	0.00
R5445:Zfp786	UTSW	6	47819685	missense	probably damaging	1.00
R6662:Zfp786	UTSW	6	47826986	missense	probably damaging	1.00
R7290:Zfp786	UTSW	6	47819995	missense	probably damaging	1.00
R7561:Zfp786	UTSW	6	47819733	missense	probably benign	0.02
R8038:Zfp786	UTSW	6	47821254	missense	probably benign	0.01
R8090:Zfp786	UTSW	6	47820009	missense	probably damaging	1.00
R8250:Zfp786	UTSW	6	47820795	missense	possibly damaging	0.85
R8438:Zfp786	UTSW	6	47820000	missense	probably damaging	1.00
R8516:Zfp786	UTSW	6	47820543	missense	probably damaging	1.00
R8868:Zfp786	UTSW	6	47825081	missense	probably damaging	0.99
R9596:Zfp786	UTSW	6	47820472	nonsense	probably null
R9788:Zfp786	UTSW	6	47820882	missense	probably benign	0.00

Posted On

2015-12-18