Incidental Mutation 'IGL02819:Tatdn3'
ID 360915
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tatdn3
Ensembl Gene ENSMUSG00000026632
Gene Name TatD DNase domain containing 3
Synonyms 1500010M24Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02819
Quality Score
Status
Chromosome 1
Chromosomal Location 190778023-190795129 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 190787541 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 114 (A114S)
Ref Sequence ENSEMBL: ENSMUSP00000106516 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027945] [ENSMUST00000085633] [ENSMUST00000110891] [ENSMUST00000110893]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000027945
AA Change: A114S

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000027945
Gene: ENSMUSG00000026632
AA Change: A114S

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 263 5e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000085633
AA Change: A114S

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000082773
Gene: ENSMUSG00000026632
AA Change: A114S

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 170 1.1e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110891
AA Change: A114S

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000106516
Gene: ENSMUSG00000026632
AA Change: A114S

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 231 2.3e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110893
AA Change: A114S

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000106518
Gene: ENSMUSG00000026632
AA Change: A114S

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 264 1.8e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124497
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143876
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153757
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156527
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833439L19Rik C T 13: 54,712,033 (GRCm39) probably benign Het
Abcb8 T A 5: 24,611,422 (GRCm39) N470K probably benign Het
Adamtsl3 A T 7: 82,223,329 (GRCm39) N1037Y probably damaging Het
Adcy3 T C 12: 4,256,986 (GRCm39) probably benign Het
Ankrd35 A G 3: 96,597,524 (GRCm39) D983G possibly damaging Het
Asf1a A G 10: 53,483,920 (GRCm39) T118A probably benign Het
Atp2a3 T C 11: 72,868,033 (GRCm39) Y389H probably damaging Het
Atp5f1b T C 10: 127,919,821 (GRCm39) I63T probably damaging Het
C2cd5 A G 6: 143,028,946 (GRCm39) Y98H probably benign Het
Caprin2 A G 6: 148,749,756 (GRCm39) V518A probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Clcn2 C A 16: 20,528,006 (GRCm39) E487* probably null Het
Cog6 T A 3: 52,916,966 (GRCm39) K184M probably damaging Het
Cpn1 A G 19: 43,956,907 (GRCm39) Y286H probably damaging Het
Cpne9 A T 6: 113,277,624 (GRCm39) S448C probably damaging Het
Csnk2a1 G T 2: 152,116,005 (GRCm39) probably benign Het
Cys1 T C 12: 24,717,169 (GRCm39) E132G possibly damaging Het
Depdc7 T C 2: 104,555,071 (GRCm39) M280V probably benign Het
Fhad1 C T 4: 141,646,069 (GRCm39) D298N probably benign Het
Golga1 T A 2: 38,929,090 (GRCm39) N318Y probably null Het
Hsd3b6 A G 3: 98,718,262 (GRCm39) V34A probably benign Het
Krt9 A G 11: 100,082,346 (GRCm39) I193T probably damaging Het
Lama4 A T 10: 38,902,565 (GRCm39) I180F possibly damaging Het
Lamc1 T C 1: 153,126,407 (GRCm39) T458A probably damaging Het
Lin28b A T 10: 45,346,155 (GRCm39) M1K probably null Het
Myo16 T C 8: 10,372,600 (GRCm39) C100R probably damaging Het
Nt5c3 A T 6: 56,860,718 (GRCm39) M279K probably damaging Het
Ppfia2 A G 10: 106,742,255 (GRCm39) Y1016C probably damaging Het
Rpl6 A G 5: 121,345,264 (GRCm39) probably benign Het
Rpn2 G T 2: 157,158,130 (GRCm39) probably null Het
Rspry1 T C 8: 95,380,884 (GRCm39) V396A probably benign Het
Serpina3i C T 12: 104,234,761 (GRCm39) T364I probably damaging Het
Shprh A G 10: 11,030,509 (GRCm39) K242R possibly damaging Het
Slit3 A G 11: 35,062,417 (GRCm39) N72S possibly damaging Het
Syt17 G A 7: 118,009,143 (GRCm39) probably benign Het
Tjp2 A G 19: 24,091,469 (GRCm39) V564A probably damaging Het
Tmem117 T C 15: 94,777,253 (GRCm39) probably benign Het
Tnfrsf8 T C 4: 144,995,703 (GRCm39) E452G probably damaging Het
Tns1 T C 1: 73,976,407 (GRCm39) D1147G probably damaging Het
Traf6 T C 2: 101,515,134 (GRCm39) S97P probably damaging Het
Ttc28 A T 5: 111,414,449 (GRCm39) E1321D probably benign Het
Other mutations in Tatdn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Tatdn3 APN 1 190,787,578 (GRCm39) splice site probably benign
IGL02898:Tatdn3 APN 1 190,778,507 (GRCm39) makesense probably null
R0718:Tatdn3 UTSW 1 190,785,046 (GRCm39) splice site probably benign
R0892:Tatdn3 UTSW 1 190,795,002 (GRCm39) missense probably benign 0.22
R1635:Tatdn3 UTSW 1 190,792,373 (GRCm39) missense probably benign
R2018:Tatdn3 UTSW 1 190,781,477 (GRCm39) critical splice donor site probably null
R2088:Tatdn3 UTSW 1 190,785,073 (GRCm39) missense possibly damaging 0.59
R2243:Tatdn3 UTSW 1 190,785,097 (GRCm39) missense probably damaging 1.00
R3933:Tatdn3 UTSW 1 190,778,521 (GRCm39) splice site probably null
R4676:Tatdn3 UTSW 1 190,781,531 (GRCm39) missense probably damaging 1.00
R5047:Tatdn3 UTSW 1 190,778,475 (GRCm39) missense probably damaging 1.00
R5923:Tatdn3 UTSW 1 190,781,507 (GRCm39) missense probably damaging 1.00
R6044:Tatdn3 UTSW 1 190,788,558 (GRCm39) critical splice donor site probably null
R6066:Tatdn3 UTSW 1 190,778,465 (GRCm39) missense probably benign 0.24
R7770:Tatdn3 UTSW 1 190,791,053 (GRCm39) missense probably benign 0.05
R8331:Tatdn3 UTSW 1 190,778,408 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18