Incidental Mutation 'IGL02819:Csnk2a1'
ID360939
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Csnk2a1
Ensembl Gene ENSMUSG00000074698
Gene Namecasein kinase 2, alpha 1 polypeptide
SynonymsCsnk2a1-rs4
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02819
Quality Score
Status
Chromosome2
Chromosomal Location152226839-152281852 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to T at 152274085 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000096829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099224]
Predicted Effect probably benign
Transcript: ENSMUST00000099224
SMART Domains Protein: ENSMUSP00000096829
Gene: ENSMUSG00000074698

DomainStartEndE-ValueType
S_TKc 39 324 1.88e-78 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136063
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
PHENOTYPE: Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833439L19Rik C T 13: 54,564,220 probably benign Het
Abcb8 T A 5: 24,406,424 N470K probably benign Het
Adamtsl3 A T 7: 82,574,121 N1037Y probably damaging Het
Adcy3 T C 12: 4,206,986 probably benign Het
Ankrd35 A G 3: 96,690,208 D983G possibly damaging Het
Asf1a A G 10: 53,607,824 T118A probably benign Het
Atp2a3 T C 11: 72,977,207 Y389H probably damaging Het
Atp5b T C 10: 128,083,952 I63T probably damaging Het
C2cd5 A G 6: 143,083,220 Y98H probably benign Het
Caprin2 A G 6: 148,848,258 V518A probably damaging Het
Ces1d C A 8: 93,169,718 probably null Het
Clcn2 C A 16: 20,709,256 E487* probably null Het
Cog6 T A 3: 53,009,545 K184M probably damaging Het
Cpn1 A G 19: 43,968,468 Y286H probably damaging Het
Cpne9 A T 6: 113,300,663 S448C probably damaging Het
Cys1 T C 12: 24,667,170 E132G possibly damaging Het
Depdc7 T C 2: 104,724,726 M280V probably benign Het
Fhad1 C T 4: 141,918,758 D298N probably benign Het
Golga1 T A 2: 39,039,078 N318Y probably null Het
Hsd3b6 A G 3: 98,810,946 V34A probably benign Het
Krt9 A G 11: 100,191,520 I193T probably damaging Het
Lama4 A T 10: 39,026,569 I180F possibly damaging Het
Lamc1 T C 1: 153,250,661 T458A probably damaging Het
Lin28b A T 10: 45,470,059 M1K probably null Het
Myo16 T C 8: 10,322,600 C100R probably damaging Het
Nt5c3 A T 6: 56,883,733 M279K probably damaging Het
Ppfia2 A G 10: 106,906,394 Y1016C probably damaging Het
Rpl6 A G 5: 121,207,201 probably benign Het
Rpn2 G T 2: 157,316,210 probably null Het
Rspry1 T C 8: 94,654,256 V396A probably benign Het
Serpina3i C T 12: 104,268,502 T364I probably damaging Het
Shprh A G 10: 11,154,765 K242R possibly damaging Het
Slit3 A G 11: 35,171,590 N72S possibly damaging Het
Syt17 G A 7: 118,409,920 probably benign Het
Tatdn3 C A 1: 191,055,344 A114S probably benign Het
Tjp2 A G 19: 24,114,105 V564A probably damaging Het
Tmem117 T C 15: 94,879,372 probably benign Het
Tnfrsf8 T C 4: 145,269,133 E452G probably damaging Het
Tns1 T C 1: 73,937,248 D1147G probably damaging Het
Traf6 T C 2: 101,684,789 S97P probably damaging Het
Ttc28 A T 5: 111,266,583 E1321D probably benign Het
Other mutations in Csnk2a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01571:Csnk2a1 APN 2 152275406 missense probably damaging 1.00
IGL02003:Csnk2a1 APN 2 152276970 nonsense probably null
IGL02043:Csnk2a1 APN 2 152274150 missense probably damaging 1.00
IGL02803:Csnk2a1 APN 2 152274085 splice site probably benign
IGL02815:Csnk2a1 APN 2 152274085 splice site probably benign
IGL02818:Csnk2a1 APN 2 152274085 splice site probably benign
R1454:Csnk2a1 UTSW 2 152257427 missense probably damaging 1.00
R1725:Csnk2a1 UTSW 2 152257972 missense probably damaging 0.98
R2086:Csnk2a1 UTSW 2 152254281 missense probably benign 0.01
R3113:Csnk2a1 UTSW 2 152263214 missense probably damaging 1.00
R4003:Csnk2a1 UTSW 2 152250575 missense probably damaging 0.97
R4021:Csnk2a1 UTSW 2 152258689 missense probably damaging 0.96
R6702:Csnk2a1 UTSW 2 152258688 missense probably benign 0.35
R6703:Csnk2a1 UTSW 2 152258688 missense probably benign 0.35
R6849:Csnk2a1 UTSW 2 152250564 missense probably benign
R7021:Csnk2a1 UTSW 2 152260812 missense probably damaging 1.00
R7061:Csnk2a1 UTSW 2 152274171 missense probably benign 0.08
R7381:Csnk2a1 UTSW 2 152258694 missense probably benign 0.05
R8799:Csnk2a1 UTSW 2 152257966 missense probably damaging 1.00
Posted On2015-12-18