Incidental Mutation 'IGL02819:Csnk2a1'
ID 360939
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Csnk2a1
Ensembl Gene ENSMUSG00000074698
Gene Name casein kinase 2, alpha 1 polypeptide
Synonyms CK2, Csnk2a1-rs4
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02819
Quality Score
Chromosome 2
Chromosomal Location 152068759-152123772 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to T at 152116005 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000096829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099224]
AlphaFold Q60737
Predicted Effect probably benign
Transcript: ENSMUST00000099224
SMART Domains Protein: ENSMUSP00000096829
Gene: ENSMUSG00000074698

S_TKc 39 324 1.88e-78 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136063
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
PHENOTYPE: Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833439L19Rik C T 13: 54,712,033 (GRCm39) probably benign Het
Abcb8 T A 5: 24,611,422 (GRCm39) N470K probably benign Het
Adamtsl3 A T 7: 82,223,329 (GRCm39) N1037Y probably damaging Het
Adcy3 T C 12: 4,256,986 (GRCm39) probably benign Het
Ankrd35 A G 3: 96,597,524 (GRCm39) D983G possibly damaging Het
Asf1a A G 10: 53,483,920 (GRCm39) T118A probably benign Het
Atp2a3 T C 11: 72,868,033 (GRCm39) Y389H probably damaging Het
Atp5f1b T C 10: 127,919,821 (GRCm39) I63T probably damaging Het
C2cd5 A G 6: 143,028,946 (GRCm39) Y98H probably benign Het
Caprin2 A G 6: 148,749,756 (GRCm39) V518A probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Clcn2 C A 16: 20,528,006 (GRCm39) E487* probably null Het
Cog6 T A 3: 52,916,966 (GRCm39) K184M probably damaging Het
Cpn1 A G 19: 43,956,907 (GRCm39) Y286H probably damaging Het
Cpne9 A T 6: 113,277,624 (GRCm39) S448C probably damaging Het
Cys1 T C 12: 24,717,169 (GRCm39) E132G possibly damaging Het
Depdc7 T C 2: 104,555,071 (GRCm39) M280V probably benign Het
Fhad1 C T 4: 141,646,069 (GRCm39) D298N probably benign Het
Golga1 T A 2: 38,929,090 (GRCm39) N318Y probably null Het
Hsd3b6 A G 3: 98,718,262 (GRCm39) V34A probably benign Het
Krt9 A G 11: 100,082,346 (GRCm39) I193T probably damaging Het
Lama4 A T 10: 38,902,565 (GRCm39) I180F possibly damaging Het
Lamc1 T C 1: 153,126,407 (GRCm39) T458A probably damaging Het
Lin28b A T 10: 45,346,155 (GRCm39) M1K probably null Het
Myo16 T C 8: 10,372,600 (GRCm39) C100R probably damaging Het
Nt5c3 A T 6: 56,860,718 (GRCm39) M279K probably damaging Het
Ppfia2 A G 10: 106,742,255 (GRCm39) Y1016C probably damaging Het
Rpl6 A G 5: 121,345,264 (GRCm39) probably benign Het
Rpn2 G T 2: 157,158,130 (GRCm39) probably null Het
Rspry1 T C 8: 95,380,884 (GRCm39) V396A probably benign Het
Serpina3i C T 12: 104,234,761 (GRCm39) T364I probably damaging Het
Shprh A G 10: 11,030,509 (GRCm39) K242R possibly damaging Het
Slit3 A G 11: 35,062,417 (GRCm39) N72S possibly damaging Het
Syt17 G A 7: 118,009,143 (GRCm39) probably benign Het
Tatdn3 C A 1: 190,787,541 (GRCm39) A114S probably benign Het
Tjp2 A G 19: 24,091,469 (GRCm39) V564A probably damaging Het
Tmem117 T C 15: 94,777,253 (GRCm39) probably benign Het
Tnfrsf8 T C 4: 144,995,703 (GRCm39) E452G probably damaging Het
Tns1 T C 1: 73,976,407 (GRCm39) D1147G probably damaging Het
Traf6 T C 2: 101,515,134 (GRCm39) S97P probably damaging Het
Ttc28 A T 5: 111,414,449 (GRCm39) E1321D probably benign Het
Other mutations in Csnk2a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01571:Csnk2a1 APN 2 152,117,326 (GRCm39) missense probably damaging 1.00
IGL02003:Csnk2a1 APN 2 152,118,890 (GRCm39) nonsense probably null
IGL02043:Csnk2a1 APN 2 152,116,070 (GRCm39) missense probably damaging 1.00
IGL02803:Csnk2a1 APN 2 152,116,005 (GRCm39) splice site probably benign
IGL02815:Csnk2a1 APN 2 152,116,005 (GRCm39) splice site probably benign
IGL02818:Csnk2a1 APN 2 152,116,005 (GRCm39) splice site probably benign
R1454:Csnk2a1 UTSW 2 152,099,347 (GRCm39) missense probably damaging 1.00
R1725:Csnk2a1 UTSW 2 152,099,892 (GRCm39) missense probably damaging 0.98
R2086:Csnk2a1 UTSW 2 152,096,201 (GRCm39) missense probably benign 0.01
R3113:Csnk2a1 UTSW 2 152,105,134 (GRCm39) missense probably damaging 1.00
R4003:Csnk2a1 UTSW 2 152,092,495 (GRCm39) missense probably damaging 0.97
R4021:Csnk2a1 UTSW 2 152,100,609 (GRCm39) missense probably damaging 0.96
R6702:Csnk2a1 UTSW 2 152,100,608 (GRCm39) missense probably benign 0.35
R6703:Csnk2a1 UTSW 2 152,100,608 (GRCm39) missense probably benign 0.35
R6849:Csnk2a1 UTSW 2 152,092,484 (GRCm39) missense probably benign
R7021:Csnk2a1 UTSW 2 152,102,732 (GRCm39) missense probably damaging 1.00
R7061:Csnk2a1 UTSW 2 152,116,091 (GRCm39) missense probably benign 0.08
R7381:Csnk2a1 UTSW 2 152,100,614 (GRCm39) missense probably benign 0.05
R8799:Csnk2a1 UTSW 2 152,099,886 (GRCm39) missense probably damaging 1.00
R8990:Csnk2a1 UTSW 2 152,096,177 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18