Incidental Mutation 'IGL02820:Mettl7a1'
ID360980
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl7a1
Ensembl Gene ENSMUSG00000054619
Gene Namemethyltransferase like 7A1
SynonymsMettl7a, 3300001H21Rik, 2210414H16Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.277) question?
Stock #IGL02820
Quality Score
Status
Chromosome15
Chromosomal Location100304140-100328662 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 100305052 bp
ZygosityHeterozygous
Amino Acid Change Serine to Stop codon at position 51 (S51*)
Ref Sequence ENSEMBL: ENSMUSP00000155621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067752] [ENSMUST00000229217] [ENSMUST00000229574] [ENSMUST00000229588] [ENSMUST00000230018] [ENSMUST00000230252] [ENSMUST00000230472] [ENSMUST00000231166]
Predicted Effect probably null
Transcript: ENSMUST00000067752
AA Change: S69*
SMART Domains Protein: ENSMUSP00000065271
Gene: ENSMUSG00000054619
AA Change: S69*

DomainStartEndE-ValueType
Pfam:Ubie_methyltran 31 195 7.7e-12 PFAM
Pfam:Methyltransf_23 47 221 7e-20 PFAM
Pfam:Methyltransf_31 68 223 1.5e-15 PFAM
Pfam:Methyltransf_18 71 176 1e-9 PFAM
Pfam:Methyltransf_25 74 168 4e-12 PFAM
Pfam:Methyltransf_12 75 170 8.6e-16 PFAM
Pfam:Methyltransf_11 75 172 6.6e-23 PFAM
Pfam:Methyltransf_8 117 197 1.1e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000229217
AA Change: S51*
Predicted Effect silent
Transcript: ENSMUST00000229574
Predicted Effect probably null
Transcript: ENSMUST00000229588
AA Change: S69*
Predicted Effect probably benign
Transcript: ENSMUST00000230018
Predicted Effect probably null
Transcript: ENSMUST00000230252
AA Change: S24*
Predicted Effect probably null
Transcript: ENSMUST00000230472
AA Change: S51*
Predicted Effect silent
Transcript: ENSMUST00000231166
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624G23Rik T C 12: 24,074,416 Y86C probably benign Het
Adgra2 G A 8: 27,117,507 V47M probably damaging Het
Anks1b T C 10: 90,077,059 C349R possibly damaging Het
Anks4b A T 7: 120,182,691 probably benign Het
Apobec2 A G 17: 48,423,267 S124P probably damaging Het
Brd8 G A 18: 34,607,301 S493L probably benign Het
Cbln3 A G 14: 55,883,487 Y126H probably damaging Het
Ccdc138 T C 10: 58,528,899 probably benign Het
Cckbr C T 7: 105,434,031 A147V probably damaging Het
Ceacam2 T A 7: 25,519,986 H283L probably damaging Het
Clasp1 A G 1: 118,551,104 D718G possibly damaging Het
Clmn A T 12: 104,773,234 Y979N probably damaging Het
Ddias T C 7: 92,859,343 T455A probably benign Het
Dennd5b T C 6: 149,019,342 R851G probably null Het
Dock1 T C 7: 135,167,215 V1771A probably benign Het
Dysf T A 6: 84,100,205 L694Q probably damaging Het
Faim2 T C 15: 99,521,257 Y77C probably benign Het
Fbxw22 A T 9: 109,386,664 I172N probably damaging Het
Fhad1 C T 4: 141,918,758 D298N probably benign Het
Fyb T G 15: 6,658,559 V800G possibly damaging Het
Gcm1 T C 9: 78,064,562 F262L probably benign Het
Gm21983 T C 7: 27,180,180 M121V probably benign Het
Gm9996 A T 10: 29,143,661 probably benign Het
Gstm3 A T 3: 107,968,758 probably benign Het
Gsto2 G T 19: 47,874,959 E91D probably damaging Het
Hs6st3 G T 14: 119,139,080 M222I possibly damaging Het
Ighv3-6 T C 12: 114,288,230 D90G probably damaging Het
Itgb1bp1 C T 12: 21,276,853 A40T possibly damaging Het
Kcns3 C T 12: 11,091,871 E276K probably benign Het
Lamc3 C T 2: 31,923,022 R1007C probably damaging Het
Lnx2 A T 5: 147,042,067 M125K probably damaging Het
Lyst T A 13: 13,638,058 N1018K probably benign Het
Mctp2 T A 7: 72,245,542 S186C probably damaging Het
Olfr352 A T 2: 36,869,859 T98S probably benign Het
Polg T C 7: 79,459,771 T433A possibly damaging Het
Rdh13 C T 7: 4,435,060 V127M probably damaging Het
Rdh16 A G 10: 127,813,601 T309A probably benign Het
Reep5 A T 18: 34,373,259 D21E probably benign Het
Rptn A T 3: 93,396,920 N520I probably benign Het
Rttn T C 18: 89,028,998 L928P probably damaging Het
Slc44a2 A G 9: 21,342,977 I212V probably benign Het
Snupn A G 9: 56,963,048 T71A probably benign Het
Ssu2 T C 6: 112,382,392 N89S probably benign Het
Thsd7a A G 6: 12,321,072 S1535P probably damaging Het
Uba7 A T 9: 107,981,516 S849C probably benign Het
Vmn2r80 A G 10: 79,171,605 T472A probably benign Het
Wdr6 A G 9: 108,578,544 I17T probably benign Het
Wdr66 A G 5: 123,254,636 probably benign Het
Xkr9 G A 1: 13,700,949 V230I probably benign Het
Other mutations in Mettl7a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0943:Mettl7a1 UTSW 15 100304958 missense probably benign 0.19
R2258:Mettl7a1 UTSW 15 100313168 missense probably benign 0.43
R2259:Mettl7a1 UTSW 15 100313168 missense probably benign 0.43
R4260:Mettl7a1 UTSW 15 100313070 missense probably benign 0.12
R4625:Mettl7a1 UTSW 15 100313058 missense probably damaging 1.00
R4932:Mettl7a1 UTSW 15 100305106 missense probably benign 0.26
R7802:Mettl7a1 UTSW 15 100305301 missense possibly damaging 0.80
R7839:Mettl7a1 UTSW 15 100305076 missense possibly damaging 0.65
Posted On2015-12-18