Incidental Mutation 'IGL02822:Aldh1a7'
ID 361046
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Aldh1a7
Ensembl Gene ENSMUSG00000024747
Gene Name aldehyde dehydrogenase family 1, subfamily A7
Synonyms Aldh-pb, Ahd2-like
Accession Numbers
Essential gene? Probably non essential (E-score: 0.231) question?
Stock # IGL02822
Quality Score
Status
Chromosome 19
Chromosomal Location 20670318-20704920 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20679630 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 382 (V382A)
Ref Sequence ENSEMBL: ENSMUSP00000025656 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025656]
AlphaFold O35945
Predicted Effect possibly damaging
Transcript: ENSMUST00000025656
AA Change: V382A

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000025656
Gene: ENSMUSG00000024747
AA Change: V382A

DomainStartEndE-ValueType
Pfam:Aldedh 29 492 2.5e-185 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110057P08Rik T C 16: 88,971,683 (GRCm39) C2R unknown Het
Asap2 T C 12: 21,315,911 (GRCm39) V943A probably damaging Het
Bod1l C T 5: 41,951,688 (GRCm39) V2908M possibly damaging Het
Casd1 C T 6: 4,630,017 (GRCm39) T471I probably damaging Het
Cd200l1 T C 16: 45,262,968 (GRCm39) Y57C probably damaging Het
Col20a1 T C 2: 180,638,600 (GRCm39) Y405H probably damaging Het
Elp1 A G 4: 56,774,520 (GRCm39) probably null Het
Evi5l T C 8: 4,237,248 (GRCm39) I117T probably damaging Het
Fbxw5 A G 2: 25,393,022 (GRCm39) N164S probably benign Het
Fga A G 3: 82,938,789 (GRCm39) E388G probably damaging Het
Fgfr1 A G 8: 26,047,818 (GRCm39) T55A probably benign Het
Gdpd4 T C 7: 97,621,131 (GRCm39) V148A possibly damaging Het
Gsap T A 5: 21,422,442 (GRCm39) V137D probably damaging Het
Hsdl2 A G 4: 59,601,379 (GRCm39) H117R possibly damaging Het
Htr4 T A 18: 62,561,255 (GRCm39) probably benign Het
Ifitm1 T C 7: 140,548,191 (GRCm39) V8A possibly damaging Het
Kdelr1 A G 7: 45,523,288 (GRCm39) probably benign Het
Klra6 G T 6: 129,993,673 (GRCm39) Y199* probably null Het
Matcap1 T C 8: 106,011,330 (GRCm39) Y268C probably damaging Het
Mmp21 C T 7: 133,277,828 (GRCm39) D333N possibly damaging Het
Mocs1 T C 17: 49,746,597 (GRCm39) F189S probably damaging Het
Myo18b C T 5: 112,923,211 (GRCm39) A1849T probably damaging Het
Naca C A 10: 127,875,214 (GRCm39) probably benign Het
Nbea A T 3: 55,926,868 (GRCm39) H778Q possibly damaging Het
Nlrp4c C T 7: 6,068,726 (GRCm39) P209L probably damaging Het
Or10q1b A G 19: 13,683,019 (GRCm39) D276G probably benign Het
Or14j1 T C 17: 38,146,534 (GRCm39) Y215H possibly damaging Het
Or4a81 A G 2: 89,619,444 (GRCm39) L84P possibly damaging Het
Osbpl9 A G 4: 108,930,118 (GRCm39) S258P probably damaging Het
Pclaf A G 9: 65,808,875 (GRCm39) E108G possibly damaging Het
Pira13 T A 7: 3,819,917 (GRCm39) T549S possibly damaging Het
Pla2r1 C A 2: 60,285,517 (GRCm39) C699F probably damaging Het
Pnkp A G 7: 44,511,848 (GRCm39) Y120C probably damaging Het
Psme4 T A 11: 30,798,204 (GRCm39) probably benign Het
Rad54l2 A G 9: 106,587,606 (GRCm39) S720P probably damaging Het
Rasa1 T C 13: 85,400,633 (GRCm39) H301R probably damaging Het
Spg11 C A 2: 121,905,015 (GRCm39) W1316L probably damaging Het
Ube2t C T 1: 134,901,688 (GRCm39) probably benign Het
Vmn2r94 T A 17: 18,463,882 (GRCm39) I803F probably benign Het
Other mutations in Aldh1a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Aldh1a7 APN 19 20,677,410 (GRCm39) missense probably damaging 1.00
IGL01132:Aldh1a7 APN 19 20,704,404 (GRCm39) missense possibly damaging 0.76
IGL01630:Aldh1a7 APN 19 20,673,693 (GRCm39) splice site probably benign
IGL01901:Aldh1a7 APN 19 20,695,103 (GRCm39) missense probably damaging 0.99
IGL02324:Aldh1a7 APN 19 20,704,368 (GRCm39) missense probably damaging 1.00
IGL03162:Aldh1a7 APN 19 20,685,645 (GRCm39) missense probably benign 0.21
PIT4514001:Aldh1a7 UTSW 19 20,679,604 (GRCm39) missense probably benign 0.07
R0125:Aldh1a7 UTSW 19 20,704,430 (GRCm39) splice site probably benign
R0268:Aldh1a7 UTSW 19 20,686,866 (GRCm39) critical splice acceptor site probably null
R0833:Aldh1a7 UTSW 19 20,679,607 (GRCm39) missense probably damaging 1.00
R1665:Aldh1a7 UTSW 19 20,704,825 (GRCm39) missense probably benign
R1709:Aldh1a7 UTSW 19 20,693,316 (GRCm39) missense probably damaging 1.00
R1772:Aldh1a7 UTSW 19 20,693,383 (GRCm39) missense probably damaging 1.00
R1917:Aldh1a7 UTSW 19 20,704,819 (GRCm39) missense probably benign
R2570:Aldh1a7 UTSW 19 20,677,320 (GRCm39) missense probably benign 0.35
R3778:Aldh1a7 UTSW 19 20,696,675 (GRCm39) missense possibly damaging 0.70
R3832:Aldh1a7 UTSW 19 20,685,602 (GRCm39) missense probably damaging 1.00
R3894:Aldh1a7 UTSW 19 20,673,762 (GRCm39) nonsense probably null
R4601:Aldh1a7 UTSW 19 20,693,343 (GRCm39) missense probably damaging 0.98
R4948:Aldh1a7 UTSW 19 20,704,374 (GRCm39) missense possibly damaging 0.77
R5562:Aldh1a7 UTSW 19 20,679,628 (GRCm39) nonsense probably null
R5606:Aldh1a7 UTSW 19 20,699,731 (GRCm39) missense probably damaging 1.00
R5641:Aldh1a7 UTSW 19 20,693,293 (GRCm39) missense probably benign 0.00
R5808:Aldh1a7 UTSW 19 20,685,561 (GRCm39) missense possibly damaging 0.79
R6646:Aldh1a7 UTSW 19 20,677,275 (GRCm39) missense possibly damaging 0.94
R6759:Aldh1a7 UTSW 19 20,677,320 (GRCm39) missense possibly damaging 0.89
R7034:Aldh1a7 UTSW 19 20,685,542 (GRCm39) missense possibly damaging 0.95
R7036:Aldh1a7 UTSW 19 20,685,542 (GRCm39) missense possibly damaging 0.95
R7150:Aldh1a7 UTSW 19 20,693,382 (GRCm39) missense probably damaging 1.00
R7255:Aldh1a7 UTSW 19 20,692,092 (GRCm39) missense probably damaging 1.00
R7875:Aldh1a7 UTSW 19 20,693,343 (GRCm39) missense possibly damaging 0.90
R7964:Aldh1a7 UTSW 19 20,693,406 (GRCm39) missense probably benign 0.05
R7964:Aldh1a7 UTSW 19 20,677,371 (GRCm39) missense probably damaging 0.99
R7984:Aldh1a7 UTSW 19 20,686,764 (GRCm39) missense probably damaging 0.98
R8547:Aldh1a7 UTSW 19 20,692,067 (GRCm39) missense possibly damaging 0.93
X0022:Aldh1a7 UTSW 19 20,696,679 (GRCm39) missense probably benign 0.01
Posted On 2015-12-18