Incidental Mutation 'IGL02823:Prl7a2'
| ID |
361091 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Prl7a2
|
| Ensembl Gene |
ENSMUSG00000046899 |
| Gene Name |
prolactin family 7, subfamily a, member 2 |
| Synonyms |
Prlpf, PLP-F |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.050)
|
| Stock # |
IGL02823
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
27842567-27852019 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 27846734 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 93
(Y93C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000006660
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006660]
|
| AlphaFold |
O54831 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000006660
AA Change: Y93C
PolyPhen 2
Score 0.947 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000006660
Gene: ENSMUSG00000046899
AA Change: Y93C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Hormone_1
|
17 |
244 |
6.9e-45 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
C |
13: 77,410,074 (GRCm39) |
S194P |
probably damaging |
Het |
| Abca7 |
T |
A |
10: 79,844,656 (GRCm39) |
D1488E |
probably damaging |
Het |
| Abhd18 |
A |
G |
3: 40,887,953 (GRCm39) |
|
probably benign |
Het |
| Atp6ap1l |
A |
G |
13: 91,047,644 (GRCm39) |
V56A |
probably benign |
Het |
| Atrip |
A |
G |
9: 108,890,246 (GRCm39) |
Y631H |
probably damaging |
Het |
| C9orf72 |
A |
T |
4: 35,213,031 (GRCm39) |
C215S |
probably damaging |
Het |
| Dst |
A |
T |
1: 34,231,164 (GRCm39) |
H3097L |
possibly damaging |
Het |
| Ear1 |
G |
T |
14: 44,056,502 (GRCm39) |
S122* |
probably null |
Het |
| Eif2a |
G |
T |
3: 58,456,092 (GRCm39) |
A364S |
probably benign |
Het |
| Eps8l2 |
A |
T |
7: 140,921,988 (GRCm39) |
D22V |
probably damaging |
Het |
| Fndc7 |
A |
G |
3: 108,776,487 (GRCm39) |
F432S |
probably damaging |
Het |
| Gemin5 |
T |
C |
11: 58,058,531 (GRCm39) |
|
probably benign |
Het |
| Grxcr2 |
T |
C |
18: 42,125,046 (GRCm39) |
K121E |
probably damaging |
Het |
| Gucy1a2 |
T |
C |
9: 3,894,656 (GRCm39) |
I713T |
possibly damaging |
Het |
| Hs3st1 |
A |
G |
5: 39,772,100 (GRCm39) |
L181P |
probably damaging |
Het |
| Ksr1 |
C |
A |
11: 78,912,229 (GRCm39) |
V627L |
probably benign |
Het |
| Lama2 |
T |
C |
10: 26,877,141 (GRCm39) |
N2682D |
probably damaging |
Het |
| Lratd2 |
T |
C |
15: 60,694,972 (GRCm39) |
D258G |
probably damaging |
Het |
| Map3k19 |
G |
T |
1: 127,750,001 (GRCm39) |
H1117N |
probably benign |
Het |
| Mdc1 |
C |
T |
17: 36,163,815 (GRCm39) |
A1121V |
probably damaging |
Het |
| Nlrp1a |
C |
T |
11: 70,983,249 (GRCm39) |
S1239N |
probably damaging |
Het |
| Or2w3 |
T |
C |
11: 58,556,793 (GRCm39) |
M136T |
possibly damaging |
Het |
| Prkra |
G |
T |
2: 76,460,768 (GRCm39) |
A310E |
probably damaging |
Het |
| Prl2c1 |
T |
C |
13: 28,040,416 (GRCm39) |
|
probably benign |
Het |
| Prob1 |
A |
T |
18: 35,785,800 (GRCm39) |
V818E |
possibly damaging |
Het |
| Rbbp8 |
A |
G |
18: 11,865,270 (GRCm39) |
S720G |
possibly damaging |
Het |
| Rexo4 |
T |
C |
2: 26,852,489 (GRCm39) |
T149A |
probably benign |
Het |
| Slc39a2 |
T |
A |
14: 52,132,869 (GRCm39) |
Y271N |
probably damaging |
Het |
| Sprr2d |
T |
A |
3: 92,247,734 (GRCm39) |
C58* |
probably null |
Het |
| Srebf2 |
G |
A |
15: 82,083,975 (GRCm39) |
G965D |
possibly damaging |
Het |
| Tcof1 |
T |
C |
18: 60,949,120 (GRCm39) |
E1265G |
probably benign |
Het |
| Terf2 |
T |
C |
8: 107,799,257 (GRCm39) |
N389S |
possibly damaging |
Het |
| Vsig10l |
T |
C |
7: 43,115,888 (GRCm39) |
S410P |
probably damaging |
Het |
| Vwa3b |
A |
T |
1: 37,225,985 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Prl7a2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01484:Prl7a2
|
APN |
13 |
27,843,191 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02424:Prl7a2
|
APN |
13 |
27,851,953 (GRCm39) |
missense |
probably null |
0.08 |
|
IGL02734:Prl7a2
|
APN |
13 |
27,843,190 (GRCm39) |
missense |
probably benign |
0.38 |
|
PIT4260001:Prl7a2
|
UTSW |
13 |
27,843,259 (GRCm39) |
nonsense |
probably null |
|
|
R0733:Prl7a2
|
UTSW |
13 |
27,846,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1371:Prl7a2
|
UTSW |
13 |
27,846,750 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1778:Prl7a2
|
UTSW |
13 |
27,843,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1857:Prl7a2
|
UTSW |
13 |
27,843,163 (GRCm39) |
nonsense |
probably null |
|
|
R2063:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2064:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2065:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2067:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2068:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2176:Prl7a2
|
UTSW |
13 |
27,843,089 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2213:Prl7a2
|
UTSW |
13 |
27,849,051 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4111:Prl7a2
|
UTSW |
13 |
27,849,050 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R4459:Prl7a2
|
UTSW |
13 |
27,849,979 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4483:Prl7a2
|
UTSW |
13 |
27,844,930 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4722:Prl7a2
|
UTSW |
13 |
27,844,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5360:Prl7a2
|
UTSW |
13 |
27,843,143 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5778:Prl7a2
|
UTSW |
13 |
27,844,983 (GRCm39) |
nonsense |
probably null |
|
|
R6667:Prl7a2
|
UTSW |
13 |
27,845,024 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7107:Prl7a2
|
UTSW |
13 |
27,843,076 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7600:Prl7a2
|
UTSW |
13 |
27,843,264 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8298:Prl7a2
|
UTSW |
13 |
27,844,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8447:Prl7a2
|
UTSW |
13 |
27,849,941 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9009:Prl7a2
|
UTSW |
13 |
27,849,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9331:Prl7a2
|
UTSW |
13 |
27,849,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9624:Prl7a2
|
UTSW |
13 |
27,849,869 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-12-18 |
Incidental Mutation