Incidental Mutation 'IGL02823:Olfr322'
ID361103
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr322
Ensembl Gene ENSMUSG00000063549
Gene Nameolfactory receptor 322
SynonymsGA_x6K02T2NKPP-754816-754257, OTTMUSG00000005755, Olfr216, Olfr322-ps1, Olfr179, GA_x6K02SYUPNB-557-3, MOR256-64, GA_x6K02SYUNE5-2-727
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02823
Quality Score
Status
Chromosome11
Chromosomal Location58658782-58669528 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 58665967 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 136 (M136T)
Ref Sequence ENSEMBL: ENSMUSP00000149062 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072030] [ENSMUST00000213232] [ENSMUST00000213793] [ENSMUST00000214392] [ENSMUST00000214400] [ENSMUST00000216442] [ENSMUST00000217399]
Predicted Effect possibly damaging
Transcript: ENSMUST00000072030
AA Change: M136T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000071913
Gene: ENSMUSG00000063549
AA Change: M136T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 25 305 2.7e-6 PFAM
Pfam:7tm_4 31 308 3.5e-48 PFAM
Pfam:7tm_1 41 290 3.2e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157597
Predicted Effect possibly damaging
Transcript: ENSMUST00000213232
AA Change: M136T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213793
AA Change: M136T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214392
AA Change: M136T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214400
AA Change: M136T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216442
AA Change: M136T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217399
AA Change: M136T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T C 13: 77,261,955 S194P probably damaging Het
3110043O21Rik A T 4: 35,213,031 C215S probably damaging Het
Abca7 T A 10: 80,008,822 D1488E probably damaging Het
Abhd18 A G 3: 40,933,518 probably benign Het
Atp6ap1l A G 13: 90,899,525 V56A probably benign Het
Atrip A G 9: 109,061,178 Y631H probably damaging Het
Dst A T 1: 34,192,083 H3097L possibly damaging Het
Ear1 G T 14: 43,819,045 S122* probably null Het
Eif2a G T 3: 58,548,671 A364S probably benign Het
Eps8l2 A T 7: 141,342,075 D22V probably damaging Het
Fam84b T C 15: 60,823,123 D258G probably damaging Het
Fndc7 A G 3: 108,869,171 F432S probably damaging Het
Gemin5 T C 11: 58,167,705 probably benign Het
Grxcr2 T C 18: 41,991,981 K121E probably damaging Het
Gucy1a2 T C 9: 3,894,656 I713T possibly damaging Het
Hs3st1 A G 5: 39,614,757 L181P probably damaging Het
Ksr1 C A 11: 79,021,403 V627L probably benign Het
Lama2 T C 10: 27,001,145 N2682D probably damaging Het
Map3k19 G T 1: 127,822,264 H1117N probably benign Het
Mdc1 C T 17: 35,852,923 A1121V probably damaging Het
Nlrp1a C T 11: 71,092,423 S1239N probably damaging Het
Prkra G T 2: 76,630,424 A310E probably damaging Het
Prl2c1 T C 13: 27,856,433 probably benign Het
Prl7a2 T C 13: 27,662,751 Y93C possibly damaging Het
Prob1 A T 18: 35,652,747 V818E possibly damaging Het
Rbbp8 A G 18: 11,732,213 S720G possibly damaging Het
Rexo4 T C 2: 26,962,477 T149A probably benign Het
Slc39a2 T A 14: 51,895,412 Y271N probably damaging Het
Sprr2d T A 3: 92,340,427 C58* probably null Het
Srebf2 G A 15: 82,199,774 G965D possibly damaging Het
Tcof1 T C 18: 60,816,048 E1265G probably benign Het
Terf2 T C 8: 107,072,625 N389S possibly damaging Het
Vsig10l T C 7: 43,466,464 S410P probably damaging Het
Vwa3b A T 1: 37,186,904 probably benign Het
Other mutations in Olfr322
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01960:Olfr322 APN 11 58665865 missense probably benign 0.05
IGL02514:Olfr322 APN 11 58665643 missense probably damaging 1.00
R0449:Olfr322 UTSW 11 58665963 missense probably benign 0.02
R0600:Olfr322 UTSW 11 58666160 missense probably damaging 1.00
R0865:Olfr322 UTSW 11 58665652 missense possibly damaging 0.84
R1601:Olfr322 UTSW 11 58666077 missense probably damaging 0.97
R2062:Olfr322 UTSW 11 58665982 missense probably damaging 1.00
R5642:Olfr322 UTSW 11 58666399 missense possibly damaging 0.55
R6232:Olfr322 UTSW 11 58665931 missense possibly damaging 0.95
R7383:Olfr322 UTSW 11 58666185 missense possibly damaging 0.94
Posted On2015-12-18