Incidental Mutation 'IGL02825:Mapk11'
ID 361160
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mapk11
Ensembl Gene ENSMUSG00000053137
Gene Name mitogen-activated protein kinase 11
Synonyms p38beta, Sapk2, Prkm11, P38b
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02825
Quality Score
Status
Chromosome 15
Chromosomal Location 89026685-89033809 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 89030585 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 103 (Y103H)
Ref Sequence ENSEMBL: ENSMUSP00000086204 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088823]
AlphaFold Q9WUI1
Predicted Effect probably damaging
Transcript: ENSMUST00000088823
AA Change: Y103H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000086204
Gene: ENSMUSG00000053137
AA Change: Y103H

DomainStartEndE-ValueType
S_TKc 24 308 1.67e-84 SMART
low complexity region 313 325 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228967
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230634
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230734
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abo A G 2: 26,733,710 (GRCm39) V163A possibly damaging Het
Ap1b1 G T 11: 4,983,738 (GRCm39) A664S possibly damaging Het
B3gnt4 T C 5: 123,649,114 (GRCm39) F160L possibly damaging Het
Brd3 T C 2: 27,339,275 (GRCm39) E685G probably damaging Het
Cacna2d2 C T 9: 107,401,659 (GRCm39) R746C probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Chl1 T A 6: 103,645,764 (GRCm39) V268E possibly damaging Het
Cpb1 T A 3: 20,303,889 (GRCm39) I392F probably damaging Het
Dnai1 T C 4: 41,625,101 (GRCm39) probably benign Het
Dync2h1 T C 9: 6,955,901 (GRCm39) probably benign Het
Edc4 T C 8: 106,617,243 (GRCm39) S1021P probably damaging Het
Exoc7 A C 11: 116,188,411 (GRCm39) L296R probably damaging Het
Fgd5 A G 6: 92,015,068 (GRCm39) probably null Het
Gm28042 T A 2: 119,862,125 (GRCm39) M232K probably damaging Het
Ints1 A T 5: 139,750,494 (GRCm39) S888T probably benign Het
Kirrel1 A T 3: 86,996,595 (GRCm39) probably benign Het
Lrp1 C T 10: 127,378,474 (GRCm39) R4037Q probably damaging Het
Lrrc37 G A 11: 103,507,894 (GRCm39) probably benign Het
Lrrn3 A T 12: 41,502,592 (GRCm39) V575D probably damaging Het
Mrpl19 G T 6: 81,942,796 (GRCm39) T38K probably benign Het
Nefl A T 14: 68,321,795 (GRCm39) K128N possibly damaging Het
Olfm1 A G 2: 28,119,090 (GRCm39) N242D probably damaging Het
Oprd1 T A 4: 131,844,670 (GRCm39) T113S probably damaging Het
Or10d1 A T 9: 39,483,877 (GRCm39) I226N probably damaging Het
Or52s19 T C 7: 103,007,568 (GRCm39) I278V probably benign Het
Pds5b C T 5: 150,652,435 (GRCm39) T234I possibly damaging Het
Prpf3 A T 3: 95,760,792 (GRCm39) C37S probably damaging Het
Rpgrip1l G A 8: 92,031,433 (GRCm39) T148M possibly damaging Het
Rph3a T C 5: 121,083,509 (GRCm39) K587R possibly damaging Het
Scn3b T C 9: 40,188,441 (GRCm39) C5R probably damaging Het
Sirpa C T 2: 129,457,372 (GRCm39) P149S probably damaging Het
Slco1a1 A T 6: 141,864,343 (GRCm39) C486S probably damaging Het
Spin1 C A 13: 51,277,332 (GRCm39) probably benign Het
Stom C A 2: 35,211,644 (GRCm39) V126F probably damaging Het
Tom1 A G 8: 75,783,883 (GRCm39) D64G probably damaging Het
Trbv4 T A 6: 41,036,613 (GRCm39) L46Q probably damaging Het
Trhr A T 15: 44,092,921 (GRCm39) D386V possibly damaging Het
Vmn2r101 T A 17: 19,810,132 (GRCm39) I306N probably benign Het
Vmn2r51 C T 7: 9,832,046 (GRCm39) probably benign Het
Vmn2r63 A G 7: 42,576,274 (GRCm39) probably null Het
Zfp277 T C 12: 40,367,175 (GRCm39) K494E probably benign Het
Zranb3 A T 1: 127,887,489 (GRCm39) S979R probably benign Het
Other mutations in Mapk11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01744:Mapk11 APN 15 89,031,046 (GRCm39) splice site probably benign
IGL02164:Mapk11 APN 15 89,029,651 (GRCm39) critical splice acceptor site probably null
E0370:Mapk11 UTSW 15 89,030,716 (GRCm39) missense probably damaging 1.00
R1764:Mapk11 UTSW 15 89,028,594 (GRCm39) critical splice donor site probably null
R2158:Mapk11 UTSW 15 89,030,575 (GRCm39) missense probably damaging 0.98
R3149:Mapk11 UTSW 15 89,029,653 (GRCm39) splice site probably null
R3150:Mapk11 UTSW 15 89,029,653 (GRCm39) splice site probably null
R3730:Mapk11 UTSW 15 89,029,318 (GRCm39) missense probably benign 0.27
R4319:Mapk11 UTSW 15 89,030,946 (GRCm39) missense probably damaging 1.00
R4424:Mapk11 UTSW 15 89,029,576 (GRCm39) critical splice donor site probably null
R4632:Mapk11 UTSW 15 89,030,579 (GRCm39) missense probably damaging 1.00
R4783:Mapk11 UTSW 15 89,033,691 (GRCm39) missense probably damaging 0.98
R4937:Mapk11 UTSW 15 89,030,685 (GRCm39) missense probably benign
R5422:Mapk11 UTSW 15 89,030,488 (GRCm39) missense probably damaging 1.00
R5511:Mapk11 UTSW 15 89,029,380 (GRCm39) critical splice acceptor site probably null
R5914:Mapk11 UTSW 15 89,030,038 (GRCm39) missense probably benign 0.21
R5972:Mapk11 UTSW 15 89,028,387 (GRCm39) missense probably benign 0.34
R7290:Mapk11 UTSW 15 89,028,511 (GRCm39) missense probably damaging 1.00
R8244:Mapk11 UTSW 15 89,030,007 (GRCm39) missense possibly damaging 0.73
R8974:Mapk11 UTSW 15 89,028,014 (GRCm39) missense probably benign 0.00
R9276:Mapk11 UTSW 15 89,029,372 (GRCm39) missense probably damaging 1.00
R9432:Mapk11 UTSW 15 89,028,631 (GRCm39) missense probably benign 0.01
Posted On 2015-12-18