Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02826:Tmem215'

361195

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem215

Ensembl Gene

ENSMUSG00000046593

Gene Name

transmembrane protein 215

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02826

Quality Score

Status

Chromosome

Chromosomal Location

40472180-40477168 bp(+) (GRCm38)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 40474632 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Tryptophan at position 236 (*236W)

Ref Sequence

ENSEMBL: ENSMUSP00000136595 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049655] [ENSMUST00000179526]

AlphaFold

A7E1Z1

Predicted Effect

probably null
Transcript: ENSMUST00000049655
AA Change: *236W

SMART Domains

Protein: ENSMUSP00000052129
Gene: ENSMUSG00000046593
AA Change: *236W

Domain	Start	End	E-Value	Type
transmembrane domain	13	32	N/A	INTRINSIC
transmembrane domain	37	59	N/A	INTRINSIC
low complexity region	168	179	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000179526
AA Change: *236W

SMART Domains

Protein: ENSMUSP00000136595
Gene: ENSMUSG00000046593
AA Change: *236W

Domain	Start	End	E-Value	Type
Pfam:TMEM215	1	235	2.5e-117	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110004E09Rik	A	C	16: 90,926,062	D261E	probably benign	Het
1810041L15Rik	A	G	15: 84,420,129		probably benign	Het
4930404N11Rik	A	G	10: 81,364,736		probably benign	Het
A3galt2	T	C	4: 128,761,509		probably benign	Het
Alk	C	T	17: 71,869,536	G1591D	probably damaging	Het
Angptl2	T	C	2: 33,228,315	S34P	probably benign	Het
Atp2a2	A	G	5: 122,489,291	V137A	probably benign	Het
Atp8b5	A	G	4: 43,366,770	M845V	probably damaging	Het
Camk1d	A	G	2: 5,565,760	V30A	possibly damaging	Het
Ceacam19	G	A	7: 19,882,610	T193I	probably benign	Het
Chst15	T	A	7: 132,266,746	D315V	probably damaging	Het
Cux1	G	T	5: 136,308,003	P885Q	probably damaging	Het
Cyth1	C	T	11: 118,185,481	E88K	possibly damaging	Het
Dido1	A	G	2: 180,683,958	V479A	probably benign	Het
Dlc1	G	T	8: 36,570,275		probably benign	Het
H2-Ab1	G	A	17: 34,264,911	R82Q	probably damaging	Het
Hps6	T	A	19: 46,006,041	*806K	probably null	Het
Ilf3	T	C	9: 21,398,044	S486P	probably benign	Het
Kdm1b	C	A	13: 47,080,467	T759K	probably damaging	Het
Kirrel	C	A	3: 87,088,485	V381F	probably damaging	Het
Kmt2b	A	T	7: 30,577,144	V1701E	probably damaging	Het
Lrmda	T	C	14: 22,828,737	Y100H	probably damaging	Het
Mastl	T	C	2: 23,145,409	I169V	probably damaging	Het
Mroh2b	A	G	15: 4,962,148	E1576G	probably damaging	Het
Nek3	A	T	8: 22,160,368		probably null	Het
Nipal3	G	T	4: 135,468,550	Y247*	probably null	Het
Nt5e	A	C	9: 88,355,705	K229N	probably damaging	Het
Olfr237-ps1	A	G	6: 43,153,577	I91V	possibly damaging	Het
Olfr974	G	T	9: 39,942,958	G233C	probably damaging	Het
Opa1	A	G	16: 29,610,887	M290V	probably null	Het
Parp2	T	A	14: 50,815,415	I155K	probably benign	Het
Pde4dip	G	T	3: 97,767,087	A171E	probably damaging	Het
Prom2	C	T	2: 127,531,116	E678K	probably benign	Het
Rab12	A	G	17: 66,498,116		probably benign	Het
Rgs8	A	T	1: 153,670,799	T13S	probably damaging	Het
Setd3	A	G	12: 108,112,124		probably benign	Het
Slx4ip	G	A	2: 137,004,973	V53I	probably damaging	Het
Stil	A	G	4: 115,024,098	D613G	probably benign	Het
Tjp3	T	A	10: 81,273,689	S858C	probably damaging	Het
Ttbk1	A	G	17: 46,470,660	V389A	probably benign	Het
Wdfy4	A	G	14: 32,971,750	F2706S	possibly damaging	Het
Xpo4	C	A	14: 57,629,420	V222L	possibly damaging	Het
Zfc3h1	A	G	10: 115,400,904	S428G	probably benign	Het
Zfp286	T	C	11: 62,787,960	Q47R	probably damaging	Het
Zfp318	A	G	17: 46,398,754	K468E	probably damaging	Het

Other mutations in Tmem215

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02028:Tmem215	APN	4	40473940	missense	possibly damaging	0.75
IGL02380:Tmem215	APN	4	40474534	missense	probably benign	0.19
R1531:Tmem215	UTSW	4	40473965	missense	probably damaging	1.00
R4941:Tmem215	UTSW	4	40474520	missense	probably damaging	0.97
R5636:Tmem215	UTSW	4	40474394	missense	probably damaging	0.99
R6820:Tmem215	UTSW	4	40473926	start codon destroyed	probably null	0.88
R7767:Tmem215	UTSW	4	40474042	missense	possibly damaging	0.75
R8958:Tmem215	UTSW	4	40474376	missense	probably benign	0.03
R9035:Tmem215	UTSW	4	40473945	missense	probably damaging	0.99

Posted On

2015-12-18