Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02826:Tmem215'

361195

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem215

Ensembl Gene

ENSMUSG00000046593

Gene Name

transmembrane protein 215

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02826

Quality Score

Status

Chromosome

Chromosomal Location

40472180-40477168 bp(+) (GRCm38)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 40474632 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Tryptophan at position 236 (*236W)

Ref Sequence

ENSEMBL: ENSMUSP00000136595 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049655] [ENSMUST00000179526]

AlphaFold

A7E1Z1

Predicted Effect

probably null
Transcript: ENSMUST00000049655
AA Change: *236W

SMART Domains

Protein: ENSMUSP00000052129
Gene: ENSMUSG00000046593
AA Change: *236W

Domain	Start	End	E-Value	Type
transmembrane domain	13	32	N/A	INTRINSIC
transmembrane domain	37	59	N/A	INTRINSIC
low complexity region	168	179	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000179526
AA Change: *236W

SMART Domains

Protein: ENSMUSP00000136595
Gene: ENSMUSG00000046593
AA Change: *236W

Domain	Start	End	E-Value	Type
Pfam:TMEM215	1	235	2.5e-117	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A3galt2	T	C	4: 128,761,509 (GRCm38)		probably benign	Het
Alk	C	T	17: 71,869,536 (GRCm38)	G1591D	probably damaging	Het
Angptl2	T	C	2: 33,228,315 (GRCm38)	S34P	probably benign	Het
Atp2a2	A	G	5: 122,489,291 (GRCm38)	V137A	probably benign	Het
Atp8b5	A	G	4: 43,366,770 (GRCm38)	M845V	probably damaging	Het
Camk1d	A	G	2: 5,565,760 (GRCm38)	V30A	possibly damaging	Het
Ceacam19	G	A	7: 19,882,610 (GRCm38)	T193I	probably benign	Het
Cfap298	A	C	16: 90,926,062 (GRCm38)	D261E	probably benign	Het
Chst15	T	A	7: 132,266,746 (GRCm38)	D315V	probably damaging	Het
Cux1	G	T	5: 136,308,003 (GRCm38)	P885Q	probably damaging	Het
Cyth1	C	T	11: 118,185,481 (GRCm38)	E88K	possibly damaging	Het
Dido1	A	G	2: 180,683,958 (GRCm38)	V479A	probably benign	Het
Dlc1	G	T	8: 36,570,275 (GRCm38)		probably benign	Het
H2-Ab1	G	A	17: 34,264,911 (GRCm38)	R82Q	probably damaging	Het
Hps6	T	A	19: 46,006,041 (GRCm38)	*806K	probably null	Het
Ilf3	T	C	9: 21,398,044 (GRCm38)	S486P	probably benign	Het
Kdm1b	C	A	13: 47,080,467 (GRCm38)	T759K	probably damaging	Het
Kirrel1	C	A	3: 87,088,485 (GRCm38)	V381F	probably damaging	Het
Kmt2b	A	T	7: 30,577,144 (GRCm38)	V1701E	probably damaging	Het
Lrmda	T	C	14: 22,828,737 (GRCm38)	Y100H	probably damaging	Het
Mastl	T	C	2: 23,145,409 (GRCm38)	I169V	probably damaging	Het
Mroh2b	A	G	15: 4,962,148 (GRCm38)	E1576G	probably damaging	Het
Nek3	A	T	8: 22,160,368 (GRCm38)		probably null	Het
Nipal3	G	T	4: 135,468,550 (GRCm38)	Y247*	probably null	Het
Nt5e	A	C	9: 88,355,705 (GRCm38)	K229N	probably damaging	Het
Olfr237-ps1	A	G	6: 43,153,577 (GRCm38)	I91V	possibly damaging	Het
Opa1	A	G	16: 29,610,887 (GRCm38)	M290V	probably null	Het
Or8d6	G	T	9: 39,942,958 (GRCm38)	G233C	probably damaging	Het
Parp2	T	A	14: 50,815,415 (GRCm38)	I155K	probably benign	Het
Pde4dip	G	T	3: 97,767,087 (GRCm38)	A171E	probably damaging	Het
Prom2	C	T	2: 127,531,116 (GRCm38)	E678K	probably benign	Het
Rab12	A	G	17: 66,498,116 (GRCm38)		probably benign	Het
Rgs8	A	T	1: 153,670,799 (GRCm38)	T13S	probably damaging	Het
Setd3	A	G	12: 108,112,124 (GRCm38)		probably benign	Het
Shisal1	A	G	15: 84,420,129 (GRCm38)		probably benign	Het
Slx4ip	G	A	2: 137,004,973 (GRCm38)	V53I	probably damaging	Het
Stil	A	G	4: 115,024,098 (GRCm38)	D613G	probably benign	Het
Tektip1	A	G	10: 81,364,736 (GRCm38)		probably benign	Het
Tjp3	T	A	10: 81,273,689 (GRCm38)	S858C	probably damaging	Het
Ttbk1	A	G	17: 46,470,660 (GRCm38)	V389A	probably benign	Het
Wdfy4	A	G	14: 32,971,750 (GRCm38)	F2706S	possibly damaging	Het
Xpo4	C	A	14: 57,629,420 (GRCm38)	V222L	possibly damaging	Het
Zfc3h1	A	G	10: 115,400,904 (GRCm38)	S428G	probably benign	Het
Zfp286	T	C	11: 62,787,960 (GRCm38)	Q47R	probably damaging	Het
Zfp318	A	G	17: 46,398,754 (GRCm38)	K468E	probably damaging	Het

Other mutations in Tmem215

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02028:Tmem215	APN	4	40,473,940 (GRCm38)	missense	possibly damaging	0.75
IGL02380:Tmem215	APN	4	40,474,534 (GRCm38)	missense	probably benign	0.19
R1531:Tmem215	UTSW	4	40,473,965 (GRCm38)	missense	probably damaging	1.00
R4941:Tmem215	UTSW	4	40,474,520 (GRCm38)	missense	probably damaging	0.97
R5636:Tmem215	UTSW	4	40,474,394 (GRCm38)	missense	probably damaging	0.99
R6820:Tmem215	UTSW	4	40,473,926 (GRCm38)	start codon destroyed	probably null	0.88
R7767:Tmem215	UTSW	4	40,474,042 (GRCm38)	missense	possibly damaging	0.75
R8958:Tmem215	UTSW	4	40,474,376 (GRCm38)	missense	probably benign	0.03
R9035:Tmem215	UTSW	4	40,473,945 (GRCm38)	missense	probably damaging	0.99

Posted On

2015-12-18