Incidental Mutation 'IGL02826:Tmem215'
ID361195
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem215
Ensembl Gene ENSMUSG00000046593
Gene Nametransmembrane protein 215
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02826
Quality Score
Status
Chromosome4
Chromosomal Location40472180-40477168 bp(+) (GRCm38)
Type of Mutationmakesense
DNA Base Change (assembly) A to G at 40474632 bp
ZygosityHeterozygous
Amino Acid Change Stop codon to Tryptophan at position 236 (*236W)
Ref Sequence ENSEMBL: ENSMUSP00000136595 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049655] [ENSMUST00000179526]
Predicted Effect probably null
Transcript: ENSMUST00000049655
AA Change: *236W
SMART Domains Protein: ENSMUSP00000052129
Gene: ENSMUSG00000046593
AA Change: *236W

DomainStartEndE-ValueType
transmembrane domain 13 32 N/A INTRINSIC
transmembrane domain 37 59 N/A INTRINSIC
low complexity region 168 179 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000179526
AA Change: *236W
SMART Domains Protein: ENSMUSP00000136595
Gene: ENSMUSG00000046593
AA Change: *236W

DomainStartEndE-ValueType
Pfam:TMEM215 1 235 2.5e-117 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004E09Rik A C 16: 90,926,062 D261E probably benign Het
1810041L15Rik A G 15: 84,420,129 probably benign Het
4930404N11Rik A G 10: 81,364,736 probably benign Het
A3galt2 T C 4: 128,761,509 probably benign Het
Alk C T 17: 71,869,536 G1591D probably damaging Het
Angptl2 T C 2: 33,228,315 S34P probably benign Het
Atp2a2 A G 5: 122,489,291 V137A probably benign Het
Atp8b5 A G 4: 43,366,770 M845V probably damaging Het
Camk1d A G 2: 5,565,760 V30A possibly damaging Het
Ceacam19 G A 7: 19,882,610 T193I probably benign Het
Chst15 T A 7: 132,266,746 D315V probably damaging Het
Cux1 G T 5: 136,308,003 P885Q probably damaging Het
Cyth1 C T 11: 118,185,481 E88K possibly damaging Het
Dido1 A G 2: 180,683,958 V479A probably benign Het
Dlc1 G T 8: 36,570,275 probably benign Het
H2-Ab1 G A 17: 34,264,911 R82Q probably damaging Het
Hps6 T A 19: 46,006,041 *806K probably null Het
Ilf3 T C 9: 21,398,044 S486P probably benign Het
Kdm1b C A 13: 47,080,467 T759K probably damaging Het
Kirrel C A 3: 87,088,485 V381F probably damaging Het
Kmt2b A T 7: 30,577,144 V1701E probably damaging Het
Lrmda T C 14: 22,828,737 Y100H probably damaging Het
Mastl T C 2: 23,145,409 I169V probably damaging Het
Mroh2b A G 15: 4,962,148 E1576G probably damaging Het
Nek3 A T 8: 22,160,368 probably null Het
Nipal3 G T 4: 135,468,550 Y247* probably null Het
Nt5e A C 9: 88,355,705 K229N probably damaging Het
Olfr237-ps1 A G 6: 43,153,577 I91V possibly damaging Het
Olfr974 G T 9: 39,942,958 G233C probably damaging Het
Opa1 A G 16: 29,610,887 M290V probably null Het
Parp2 T A 14: 50,815,415 I155K probably benign Het
Pde4dip G T 3: 97,767,087 A171E probably damaging Het
Prom2 C T 2: 127,531,116 E678K probably benign Het
Rab12 A G 17: 66,498,116 probably benign Het
Rgs8 A T 1: 153,670,799 T13S probably damaging Het
Setd3 A G 12: 108,112,124 probably benign Het
Slx4ip G A 2: 137,004,973 V53I probably damaging Het
Stil A G 4: 115,024,098 D613G probably benign Het
Tjp3 T A 10: 81,273,689 S858C probably damaging Het
Ttbk1 A G 17: 46,470,660 V389A probably benign Het
Wdfy4 A G 14: 32,971,750 F2706S possibly damaging Het
Xpo4 C A 14: 57,629,420 V222L possibly damaging Het
Zfc3h1 A G 10: 115,400,904 S428G probably benign Het
Zfp286 T C 11: 62,787,960 Q47R probably damaging Het
Zfp318 A G 17: 46,398,754 K468E probably damaging Het
Other mutations in Tmem215
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02028:Tmem215 APN 4 40473940 missense possibly damaging 0.75
IGL02380:Tmem215 APN 4 40474534 missense probably benign 0.19
R1531:Tmem215 UTSW 4 40473965 missense probably damaging 1.00
R4941:Tmem215 UTSW 4 40474520 missense probably damaging 0.97
R5636:Tmem215 UTSW 4 40474394 missense probably damaging 0.99
R6820:Tmem215 UTSW 4 40473926 start codon destroyed probably null 0.88
R7767:Tmem215 UTSW 4 40474042 missense possibly damaging 0.75
Posted On2015-12-18