Incidental Mutation 'IGL02826:Mroh2b'
ID 361222
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mroh2b
Ensembl Gene ENSMUSG00000022155
Gene Name maestro heat-like repeat family member 2B
Synonyms 4930455B06Rik, Heatr7b2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # IGL02826
Quality Score
Status
Chromosome 15
Chromosomal Location 4898737-4962205 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 4962148 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 1576 (E1576G)
Ref Sequence ENSEMBL: ENSMUSP00000036148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045736]
AlphaFold Q7M6Y6
Predicted Effect probably damaging
Transcript: ENSMUST00000045736
AA Change: E1576G

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000036148
Gene: ENSMUSG00000022155
AA Change: E1576G

DomainStartEndE-ValueType
low complexity region 124 135 N/A INTRINSIC
low complexity region 824 842 N/A INTRINSIC
SCOP:d1gw5a_ 937 1443 7e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226849
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228458
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004E09Rik A C 16: 90,926,062 (GRCm38) D261E probably benign Het
1810041L15Rik A G 15: 84,420,129 (GRCm38) probably benign Het
4930404N11Rik A G 10: 81,364,736 (GRCm38) probably benign Het
A3galt2 T C 4: 128,761,509 (GRCm38) probably benign Het
Alk C T 17: 71,869,536 (GRCm38) G1591D probably damaging Het
Angptl2 T C 2: 33,228,315 (GRCm38) S34P probably benign Het
Atp2a2 A G 5: 122,489,291 (GRCm38) V137A probably benign Het
Atp8b5 A G 4: 43,366,770 (GRCm38) M845V probably damaging Het
Camk1d A G 2: 5,565,760 (GRCm38) V30A possibly damaging Het
Ceacam19 G A 7: 19,882,610 (GRCm38) T193I probably benign Het
Chst15 T A 7: 132,266,746 (GRCm38) D315V probably damaging Het
Cux1 G T 5: 136,308,003 (GRCm38) P885Q probably damaging Het
Cyth1 C T 11: 118,185,481 (GRCm38) E88K possibly damaging Het
Dido1 A G 2: 180,683,958 (GRCm38) V479A probably benign Het
Dlc1 G T 8: 36,570,275 (GRCm38) probably benign Het
H2-Ab1 G A 17: 34,264,911 (GRCm38) R82Q probably damaging Het
Hps6 T A 19: 46,006,041 (GRCm38) *806K probably null Het
Ilf3 T C 9: 21,398,044 (GRCm38) S486P probably benign Het
Kdm1b C A 13: 47,080,467 (GRCm38) T759K probably damaging Het
Kirrel C A 3: 87,088,485 (GRCm38) V381F probably damaging Het
Kmt2b A T 7: 30,577,144 (GRCm38) V1701E probably damaging Het
Lrmda T C 14: 22,828,737 (GRCm38) Y100H probably damaging Het
Mastl T C 2: 23,145,409 (GRCm38) I169V probably damaging Het
Nek3 A T 8: 22,160,368 (GRCm38) probably null Het
Nipal3 G T 4: 135,468,550 (GRCm38) Y247* probably null Het
Nt5e A C 9: 88,355,705 (GRCm38) K229N probably damaging Het
Olfr237-ps1 A G 6: 43,153,577 (GRCm38) I91V possibly damaging Het
Olfr974 G T 9: 39,942,958 (GRCm38) G233C probably damaging Het
Opa1 A G 16: 29,610,887 (GRCm38) M290V probably null Het
Parp2 T A 14: 50,815,415 (GRCm38) I155K probably benign Het
Pde4dip G T 3: 97,767,087 (GRCm38) A171E probably damaging Het
Prom2 C T 2: 127,531,116 (GRCm38) E678K probably benign Het
Rab12 A G 17: 66,498,116 (GRCm38) probably benign Het
Rgs8 A T 1: 153,670,799 (GRCm38) T13S probably damaging Het
Setd3 A G 12: 108,112,124 (GRCm38) probably benign Het
Slx4ip G A 2: 137,004,973 (GRCm38) V53I probably damaging Het
Stil A G 4: 115,024,098 (GRCm38) D613G probably benign Het
Tjp3 T A 10: 81,273,689 (GRCm38) S858C probably damaging Het
Tmem215 A G 4: 40,474,632 (GRCm38) *236W probably null Het
Ttbk1 A G 17: 46,470,660 (GRCm38) V389A probably benign Het
Wdfy4 A G 14: 32,971,750 (GRCm38) F2706S possibly damaging Het
Xpo4 C A 14: 57,629,420 (GRCm38) V222L possibly damaging Het
Zfc3h1 A G 10: 115,400,904 (GRCm38) S428G probably benign Het
Zfp286 T C 11: 62,787,960 (GRCm38) Q47R probably damaging Het
Zfp318 A G 17: 46,398,754 (GRCm38) K468E probably damaging Het
Other mutations in Mroh2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00503:Mroh2b APN 15 4,899,197 (GRCm38) missense probably benign
IGL00507:Mroh2b APN 15 4,962,127 (GRCm38) missense probably damaging 1.00
IGL00548:Mroh2b APN 15 4,931,316 (GRCm38) missense probably benign 0.35
IGL00902:Mroh2b APN 15 4,915,222 (GRCm38) missense probably damaging 1.00
IGL00944:Mroh2b APN 15 4,951,127 (GRCm38) splice site probably benign
IGL00954:Mroh2b APN 15 4,903,054 (GRCm38) missense probably damaging 0.99
IGL01015:Mroh2b APN 15 4,941,542 (GRCm38) missense probably damaging 1.00
IGL01134:Mroh2b APN 15 4,915,152 (GRCm38) missense probably benign 0.00
IGL01337:Mroh2b APN 15 4,905,024 (GRCm38) missense probably benign 0.38
IGL01780:Mroh2b APN 15 4,912,000 (GRCm38) missense probably benign 0.01
IGL01919:Mroh2b APN 15 4,923,688 (GRCm38) missense probably benign 0.10
IGL02069:Mroh2b APN 15 4,904,324 (GRCm38) splice site probably benign
IGL02146:Mroh2b APN 15 4,951,294 (GRCm38) splice site probably null
IGL02221:Mroh2b APN 15 4,923,641 (GRCm38) missense probably damaging 1.00
IGL02281:Mroh2b APN 15 4,952,263 (GRCm38) missense probably benign 0.04
IGL02350:Mroh2b APN 15 4,912,000 (GRCm38) missense probably benign 0.01
IGL02357:Mroh2b APN 15 4,912,000 (GRCm38) missense probably benign 0.01
IGL02401:Mroh2b APN 15 4,900,501 (GRCm38) missense possibly damaging 0.71
IGL02427:Mroh2b APN 15 4,951,560 (GRCm38) splice site probably benign
IGL02432:Mroh2b APN 15 4,914,186 (GRCm38) missense probably benign
IGL02582:Mroh2b APN 15 4,908,515 (GRCm38) missense probably damaging 0.98
IGL02632:Mroh2b APN 15 4,931,101 (GRCm38) missense probably damaging 0.99
IGL02741:Mroh2b APN 15 4,905,632 (GRCm38) missense probably benign
IGL02811:Mroh2b APN 15 4,915,236 (GRCm38) missense possibly damaging 0.55
IGL03412:Mroh2b APN 15 4,944,372 (GRCm38) missense probably benign 0.14
PIT4468001:Mroh2b UTSW 15 4,912,812 (GRCm38) missense probably damaging 1.00
R0024:Mroh2b UTSW 15 4,925,627 (GRCm38) missense probably damaging 1.00
R0333:Mroh2b UTSW 15 4,931,118 (GRCm38) missense probably damaging 1.00
R0433:Mroh2b UTSW 15 4,941,634 (GRCm38) missense probably benign 0.01
R0530:Mroh2b UTSW 15 4,934,395 (GRCm38) missense probably damaging 0.97
R1411:Mroh2b UTSW 15 4,918,317 (GRCm38) missense probably damaging 1.00
R1457:Mroh2b UTSW 15 4,925,684 (GRCm38) missense probably damaging 1.00
R1466:Mroh2b UTSW 15 4,925,684 (GRCm38) missense probably damaging 1.00
R1466:Mroh2b UTSW 15 4,925,684 (GRCm38) missense probably damaging 1.00
R1472:Mroh2b UTSW 15 4,948,655 (GRCm38) missense probably benign 0.00
R1525:Mroh2b UTSW 15 4,951,130 (GRCm38) splice site probably null
R1584:Mroh2b UTSW 15 4,925,684 (GRCm38) missense probably damaging 1.00
R1605:Mroh2b UTSW 15 4,945,090 (GRCm38) missense probably benign 0.08
R1657:Mroh2b UTSW 15 4,931,043 (GRCm38) nonsense probably null
R1671:Mroh2b UTSW 15 4,951,294 (GRCm38) splice site probably null
R1698:Mroh2b UTSW 15 4,914,140 (GRCm38) missense probably benign 0.02
R2002:Mroh2b UTSW 15 4,925,684 (GRCm38) missense probably damaging 1.00
R2005:Mroh2b UTSW 15 4,917,158 (GRCm38) missense probably damaging 1.00
R2077:Mroh2b UTSW 15 4,944,966 (GRCm38) missense probably damaging 1.00
R2179:Mroh2b UTSW 15 4,921,446 (GRCm38) critical splice donor site probably null
R2183:Mroh2b UTSW 15 4,918,225 (GRCm38) splice site probably null
R3713:Mroh2b UTSW 15 4,943,649 (GRCm38) missense probably benign 0.01
R3714:Mroh2b UTSW 15 4,943,649 (GRCm38) missense probably benign 0.01
R3747:Mroh2b UTSW 15 4,952,246 (GRCm38) nonsense probably null
R3748:Mroh2b UTSW 15 4,952,246 (GRCm38) nonsense probably null
R3749:Mroh2b UTSW 15 4,952,246 (GRCm38) nonsense probably null
R3750:Mroh2b UTSW 15 4,952,246 (GRCm38) nonsense probably null
R3792:Mroh2b UTSW 15 4,923,620 (GRCm38) missense probably damaging 1.00
R3872:Mroh2b UTSW 15 4,925,061 (GRCm38) nonsense probably null
R4021:Mroh2b UTSW 15 4,925,100 (GRCm38) missense possibly damaging 0.75
R4329:Mroh2b UTSW 15 4,931,379 (GRCm38) missense probably damaging 0.99
R4456:Mroh2b UTSW 15 4,947,925 (GRCm38) missense probably benign 0.21
R4592:Mroh2b UTSW 15 4,918,290 (GRCm38) missense probably damaging 1.00
R4836:Mroh2b UTSW 15 4,904,270 (GRCm38) missense probably damaging 1.00
R5050:Mroh2b UTSW 15 4,900,450 (GRCm38) missense possibly damaging 0.82
R5230:Mroh2b UTSW 15 4,941,522 (GRCm38) missense probably benign 0.07
R5342:Mroh2b UTSW 15 4,914,133 (GRCm38) nonsense probably null
R5353:Mroh2b UTSW 15 4,917,178 (GRCm38) missense probably damaging 1.00
R5368:Mroh2b UTSW 15 4,905,572 (GRCm38) missense probably damaging 1.00
R5424:Mroh2b UTSW 15 4,941,612 (GRCm38) missense probably damaging 0.98
R5484:Mroh2b UTSW 15 4,908,981 (GRCm38) missense possibly damaging 0.92
R5999:Mroh2b UTSW 15 4,912,884 (GRCm38) splice site probably null
R6046:Mroh2b UTSW 15 4,951,281 (GRCm38) missense probably benign 0.01
R6081:Mroh2b UTSW 15 4,944,377 (GRCm38) missense probably damaging 1.00
R6162:Mroh2b UTSW 15 4,915,225 (GRCm38) missense probably damaging 1.00
R6165:Mroh2b UTSW 15 4,918,350 (GRCm38) missense probably benign 0.23
R6240:Mroh2b UTSW 15 4,934,644 (GRCm38) missense probably benign 0.38
R6487:Mroh2b UTSW 15 4,947,239 (GRCm38) missense probably damaging 1.00
R6539:Mroh2b UTSW 15 4,905,574 (GRCm38) missense probably damaging 1.00
R6616:Mroh2b UTSW 15 4,953,282 (GRCm38) missense probably benign 0.36
R6663:Mroh2b UTSW 15 4,947,935 (GRCm38) missense probably benign 0.21
R6820:Mroh2b UTSW 15 4,953,274 (GRCm38) missense probably damaging 1.00
R6900:Mroh2b UTSW 15 4,908,987 (GRCm38) missense probably benign 0.00
R6990:Mroh2b UTSW 15 4,912,802 (GRCm38) missense possibly damaging 0.55
R7067:Mroh2b UTSW 15 4,900,504 (GRCm38) missense probably benign 0.35
R7092:Mroh2b UTSW 15 4,934,678 (GRCm38) missense possibly damaging 0.92
R7102:Mroh2b UTSW 15 4,948,003 (GRCm38) missense probably benign 0.06
R7264:Mroh2b UTSW 15 4,921,362 (GRCm38) missense possibly damaging 0.81
R7436:Mroh2b UTSW 15 4,941,554 (GRCm38) missense probably benign 0.21
R7462:Mroh2b UTSW 15 4,908,627 (GRCm38) missense probably damaging 1.00
R7529:Mroh2b UTSW 15 4,949,009 (GRCm38) missense probably damaging 1.00
R7575:Mroh2b UTSW 15 4,934,605 (GRCm38) missense probably damaging 1.00
R7579:Mroh2b UTSW 15 4,931,061 (GRCm38) missense probably benign 0.09
R7605:Mroh2b UTSW 15 4,945,023 (GRCm38) missense probably damaging 1.00
R7624:Mroh2b UTSW 15 4,917,131 (GRCm38) missense probably damaging 1.00
R7797:Mroh2b UTSW 15 4,949,105 (GRCm38) missense probably benign 0.36
R7848:Mroh2b UTSW 15 4,938,379 (GRCm38) nonsense probably null
R7952:Mroh2b UTSW 15 4,951,211 (GRCm38) missense probably damaging 1.00
R7995:Mroh2b UTSW 15 4,921,357 (GRCm38) nonsense probably null
R8088:Mroh2b UTSW 15 4,900,503 (GRCm38) missense possibly damaging 0.57
R8207:Mroh2b UTSW 15 4,938,410 (GRCm38) missense possibly damaging 0.95
R8242:Mroh2b UTSW 15 4,909,040 (GRCm38) missense probably benign 0.04
R8248:Mroh2b UTSW 15 4,931,104 (GRCm38) missense probably benign 0.40
R8258:Mroh2b UTSW 15 4,911,909 (GRCm38) missense probably benign 0.01
R8259:Mroh2b UTSW 15 4,911,909 (GRCm38) missense probably benign 0.01
R8304:Mroh2b UTSW 15 4,925,637 (GRCm38) missense probably damaging 0.99
R8316:Mroh2b UTSW 15 4,951,264 (GRCm38) nonsense probably null
R8345:Mroh2b UTSW 15 4,944,326 (GRCm38) missense probably benign 0.09
R8507:Mroh2b UTSW 15 4,949,090 (GRCm38) missense probably damaging 1.00
R8728:Mroh2b UTSW 15 4,905,640 (GRCm38) missense probably damaging 1.00
R8747:Mroh2b UTSW 15 4,935,300 (GRCm38) missense probably damaging 0.99
R8798:Mroh2b UTSW 15 4,948,709 (GRCm38) missense probably damaging 1.00
R8814:Mroh2b UTSW 15 4,941,625 (GRCm38) missense possibly damaging 0.61
R8856:Mroh2b UTSW 15 4,931,028 (GRCm38) nonsense probably null
R8910:Mroh2b UTSW 15 4,931,373 (GRCm38) missense probably benign 0.01
R8913:Mroh2b UTSW 15 4,917,528 (GRCm38) intron probably benign
R8941:Mroh2b UTSW 15 4,962,124 (GRCm38) missense possibly damaging 0.86
R9014:Mroh2b UTSW 15 4,899,188 (GRCm38) start codon destroyed probably null 0.95
R9086:Mroh2b UTSW 15 4,953,272 (GRCm38) critical splice acceptor site probably null
R9101:Mroh2b UTSW 15 4,900,453 (GRCm38) missense probably benign 0.20
R9118:Mroh2b UTSW 15 4,962,091 (GRCm38) missense possibly damaging 0.86
R9393:Mroh2b UTSW 15 4,951,184 (GRCm38) missense probably benign
R9429:Mroh2b UTSW 15 4,934,425 (GRCm38) missense probably damaging 1.00
R9431:Mroh2b UTSW 15 4,934,470 (GRCm38) missense probably damaging 1.00
R9443:Mroh2b UTSW 15 4,944,339 (GRCm38) missense probably damaging 1.00
R9447:Mroh2b UTSW 15 4,931,341 (GRCm38) missense probably damaging 1.00
R9497:Mroh2b UTSW 15 4,921,363 (GRCm38) missense probably damaging 0.98
R9588:Mroh2b UTSW 15 4,948,648 (GRCm38) missense probably benign 0.00
R9631:Mroh2b UTSW 15 4,917,074 (GRCm38) missense probably damaging 0.97
R9686:Mroh2b UTSW 15 4,945,123 (GRCm38) missense probably benign 0.34
R9774:Mroh2b UTSW 15 4,914,131 (GRCm38) missense probably benign 0.08
X0067:Mroh2b UTSW 15 4,951,591 (GRCm38) missense possibly damaging 0.90
Z1177:Mroh2b UTSW 15 4,905,005 (GRCm38) missense probably damaging 1.00
Posted On 2015-12-18