Incidental Mutation 'IGL02827:Ifna14'
ID361239
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifna14
Ensembl Gene ENSMUSG00000095896
Gene Nameinterferon alpha 14
SynonymsOTTMUSG00000007662
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL02827
Quality Score
Status
Chromosome4
Chromosomal Location88571229-88571798 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 88571364 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Asparagine at position 145 (K145N)
Ref Sequence ENSEMBL: ENSMUSP00000099872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102808]
Predicted Effect probably benign
Transcript: ENSMUST00000102808
AA Change: K145N

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000099872
Gene: ENSMUSG00000095896
AA Change: K145N

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 2.41e-68 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T C 10: 80,009,865 S1554P probably damaging Het
Actn2 A T 13: 12,275,199 L152Q probably damaging Het
Afg3l2 T C 18: 67,425,945 I369V probably damaging Het
Aqp6 G A 15: 99,603,011 G199S probably damaging Het
Asgr2 A G 11: 70,096,897 I74V probably benign Het
Cebpz T C 17: 78,929,331 R702G probably damaging Het
Cers1 C T 8: 70,321,527 P145S probably damaging Het
Ddx21 T C 10: 62,598,374 K202R probably benign Het
Gm13119 C T 4: 144,363,761 A457V probably damaging Het
Gphn A T 12: 78,609,220 D407V probably damaging Het
Hnf1b A G 11: 83,855,926 K123E probably damaging Het
Ifitm10 T C 7: 142,328,580 D151G unknown Het
Lamc2 C T 1: 153,139,781 C602Y probably damaging Het
Mrps25 T C 6: 92,175,182 E119G probably benign Het
Olfr1331 A T 4: 118,868,960 M60L probably damaging Het
Olfr1366 A G 13: 21,537,358 S216P probably benign Het
Pgm5 C A 19: 24,709,295 R516L probably benign Het
Rmnd5b A G 11: 51,628,022 L48P possibly damaging Het
Samd4b G A 7: 28,414,121 R140C probably damaging Het
Sema3d T C 5: 12,585,118 I717T probably benign Het
Sh3tc2 G A 18: 62,013,159 S1203N probably benign Het
Smpdl3a A G 10: 57,802,496 T132A probably damaging Het
Stard13 T C 5: 151,063,126 I188M probably benign Het
Stk17b T C 1: 53,776,542 T33A probably benign Het
Stxbp3 A T 3: 108,809,895 I264N probably damaging Het
Tmem60 T A 5: 20,886,624 F129Y probably damaging Het
Trpm1 A G 7: 64,219,160 D404G probably null Het
Unc79 A C 12: 103,074,846 S713R possibly damaging Het
Uox A C 3: 146,597,196 probably benign Het
Vmn2r68 T C 7: 85,237,592 D38G probably damaging Het
Vps13a T C 19: 16,641,634 D2856G possibly damaging Het
Vsig10l T C 7: 43,464,869 L205P probably damaging Het
Other mutations in Ifna14
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2398:Ifna14 UTSW 4 88571626 missense possibly damaging 0.56
R4578:Ifna14 UTSW 4 88571510 missense possibly damaging 0.81
R4666:Ifna14 UTSW 4 88571336 missense probably benign 0.01
R5163:Ifna14 UTSW 4 88571362 missense probably damaging 1.00
R5199:Ifna14 UTSW 4 88571362 missense probably damaging 1.00
Posted On2015-12-18