Incidental Mutation 'IGL02827:Ifna14'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifna14
Ensembl Gene ENSMUSG00000095896
Gene Nameinterferon alpha 14
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL02827
Quality Score
Chromosomal Location88571229-88571798 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 88571364 bp
Amino Acid Change Lysine to Asparagine at position 145 (K145N)
Ref Sequence ENSEMBL: ENSMUSP00000099872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102808]
Predicted Effect probably benign
Transcript: ENSMUST00000102808
AA Change: K145N

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000099872
Gene: ENSMUSG00000095896
AA Change: K145N

signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 2.41e-68 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T C 10: 80,009,865 S1554P probably damaging Het
Actn2 A T 13: 12,275,199 L152Q probably damaging Het
Afg3l2 T C 18: 67,425,945 I369V probably damaging Het
Aqp6 G A 15: 99,603,011 G199S probably damaging Het
Asgr2 A G 11: 70,096,897 I74V probably benign Het
Cebpz T C 17: 78,929,331 R702G probably damaging Het
Cers1 C T 8: 70,321,527 P145S probably damaging Het
Ddx21 T C 10: 62,598,374 K202R probably benign Het
Gm13119 C T 4: 144,363,761 A457V probably damaging Het
Gphn A T 12: 78,609,220 D407V probably damaging Het
Hnf1b A G 11: 83,855,926 K123E probably damaging Het
Ifitm10 T C 7: 142,328,580 D151G unknown Het
Lamc2 C T 1: 153,139,781 C602Y probably damaging Het
Mrps25 T C 6: 92,175,182 E119G probably benign Het
Olfr1331 A T 4: 118,868,960 M60L probably damaging Het
Olfr1366 A G 13: 21,537,358 S216P probably benign Het
Pgm5 C A 19: 24,709,295 R516L probably benign Het
Rmnd5b A G 11: 51,628,022 L48P possibly damaging Het
Samd4b G A 7: 28,414,121 R140C probably damaging Het
Sema3d T C 5: 12,585,118 I717T probably benign Het
Sh3tc2 G A 18: 62,013,159 S1203N probably benign Het
Smpdl3a A G 10: 57,802,496 T132A probably damaging Het
Stard13 T C 5: 151,063,126 I188M probably benign Het
Stk17b T C 1: 53,776,542 T33A probably benign Het
Stxbp3 A T 3: 108,809,895 I264N probably damaging Het
Tmem60 T A 5: 20,886,624 F129Y probably damaging Het
Trpm1 A G 7: 64,219,160 D404G probably null Het
Unc79 A C 12: 103,074,846 S713R possibly damaging Het
Uox A C 3: 146,597,196 probably benign Het
Vmn2r68 T C 7: 85,237,592 D38G probably damaging Het
Vps13a T C 19: 16,641,634 D2856G possibly damaging Het
Vsig10l T C 7: 43,464,869 L205P probably damaging Het
Other mutations in Ifna14
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2398:Ifna14 UTSW 4 88571626 missense possibly damaging 0.56
R4578:Ifna14 UTSW 4 88571510 missense possibly damaging 0.81
R4666:Ifna14 UTSW 4 88571336 missense probably benign 0.01
R5163:Ifna14 UTSW 4 88571362 missense probably damaging 1.00
R5199:Ifna14 UTSW 4 88571362 missense probably damaging 1.00
Posted On2015-12-18