Incidental Mutation 'IGL02828:Vmn2r105'
| ID |
361278 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r105
|
| Ensembl Gene |
ENSMUSG00000091670 |
| Gene Name |
vomeronasal 2, receptor 105 |
| Synonyms |
EG627743 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02828
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
20428492-20455134 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20429345 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 577
(V577A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129762
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167382]
|
| AlphaFold |
E9Q3A5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167382
AA Change: V577A
PolyPhen 2
Score 0.801 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: V577A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
85 |
469 |
6.5e-42 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
3.2e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.5e-51 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
G |
A |
11: 109,871,720 (GRCm39) |
T86I |
probably damaging |
Het |
| Adam28 |
C |
T |
14: 68,884,319 (GRCm39) |
S93N |
possibly damaging |
Het |
| Adamts6 |
T |
C |
13: 104,433,978 (GRCm39) |
Y136H |
probably damaging |
Het |
| Ahdc1 |
A |
T |
4: 132,790,232 (GRCm39) |
K491I |
possibly damaging |
Het |
| Alb |
C |
A |
5: 90,615,247 (GRCm39) |
A253E |
probably benign |
Het |
| Asb18 |
A |
G |
1: 89,923,932 (GRCm39) |
|
probably null |
Het |
| Asxl3 |
T |
A |
18: 22,657,718 (GRCm39) |
N1909K |
possibly damaging |
Het |
| Atosa |
G |
T |
9: 74,913,714 (GRCm39) |
A123S |
probably damaging |
Het |
| Atp12a |
T |
A |
14: 56,613,599 (GRCm39) |
V457D |
possibly damaging |
Het |
| Atxn7 |
G |
T |
14: 14,090,056 (GRCm38) |
G334W |
probably damaging |
Het |
| Catsperb |
T |
A |
12: 101,447,041 (GRCm39) |
I223K |
probably benign |
Het |
| Clec2h |
T |
A |
6: 128,652,885 (GRCm39) |
H217Q |
probably benign |
Het |
| Col6a3 |
T |
C |
1: 90,724,281 (GRCm39) |
E1416G |
probably damaging |
Het |
| Dcaf1 |
T |
A |
9: 106,721,501 (GRCm39) |
|
probably benign |
Het |
| Ddr2 |
C |
T |
1: 169,816,082 (GRCm39) |
A542T |
probably benign |
Het |
| Ebf3 |
T |
C |
7: 136,909,247 (GRCm39) |
N174S |
probably damaging |
Het |
| Ecpas |
A |
G |
4: 58,875,512 (GRCm39) |
S151P |
possibly damaging |
Het |
| Ephb2 |
A |
G |
4: 136,498,461 (GRCm39) |
I206T |
probably benign |
Het |
| Fbxo39 |
T |
A |
11: 72,208,041 (GRCm39) |
I131N |
possibly damaging |
Het |
| Fdxacb1 |
G |
A |
9: 50,682,864 (GRCm39) |
V276I |
possibly damaging |
Het |
| Gpr146 |
A |
T |
5: 139,378,576 (GRCm39) |
Y126F |
probably damaging |
Het |
| Hivep3 |
A |
T |
4: 119,954,929 (GRCm39) |
K1082* |
probably null |
Het |
| Ifnar1 |
T |
A |
16: 91,302,304 (GRCm39) |
|
probably null |
Het |
| Kap |
A |
G |
6: 133,829,057 (GRCm39) |
V25A |
probably benign |
Het |
| Klhl2 |
C |
A |
8: 65,232,791 (GRCm39) |
R162L |
probably damaging |
Het |
| Kmt2a |
A |
G |
9: 44,733,244 (GRCm39) |
|
probably benign |
Het |
| Lrp4 |
A |
G |
2: 91,305,639 (GRCm39) |
N303S |
probably benign |
Het |
| Mtpap |
A |
T |
18: 4,386,207 (GRCm39) |
N276Y |
probably damaging |
Het |
| Nlrp5 |
G |
A |
7: 23,120,885 (GRCm39) |
G684S |
possibly damaging |
Het |
| Or10g3b |
T |
C |
14: 52,586,799 (GRCm39) |
R235G |
probably benign |
Het |
| Or14a256 |
A |
T |
7: 86,265,277 (GRCm39) |
V192E |
possibly damaging |
Het |
| Pak2 |
A |
T |
16: 31,840,674 (GRCm39) |
L469H |
probably damaging |
Het |
| Pcdhb15 |
T |
A |
18: 37,606,903 (GRCm39) |
L45Q |
probably damaging |
Het |
| Pi4ka |
A |
T |
16: 17,098,575 (GRCm39) |
|
probably benign |
Het |
| Picalm |
A |
G |
7: 89,826,709 (GRCm39) |
T386A |
probably benign |
Het |
| Pkd1l2 |
T |
C |
8: 117,756,298 (GRCm39) |
T1645A |
probably benign |
Het |
| Plekhm2 |
A |
T |
4: 141,356,941 (GRCm39) |
V754E |
probably damaging |
Het |
| Pramel25 |
A |
T |
4: 143,521,695 (GRCm39) |
D437V |
possibly damaging |
Het |
| Rbl1 |
T |
A |
2: 157,041,384 (GRCm39) |
E81V |
probably damaging |
Het |
| Rbp4 |
C |
A |
19: 38,106,717 (GRCm39) |
|
probably null |
Het |
| Rdh12 |
T |
C |
12: 79,265,459 (GRCm39) |
V211A |
probably damaging |
Het |
| Ret |
G |
A |
6: 118,153,168 (GRCm39) |
A500V |
probably benign |
Het |
| Rin1 |
T |
C |
19: 5,103,118 (GRCm39) |
F469S |
possibly damaging |
Het |
| Rmc1 |
C |
A |
18: 12,322,278 (GRCm39) |
A577D |
possibly damaging |
Het |
| Rsc1a1 |
G |
T |
4: 141,411,479 (GRCm39) |
P478T |
probably damaging |
Het |
| Setd2 |
A |
T |
9: 110,390,282 (GRCm39) |
Y1579F |
probably benign |
Het |
| Sh3bp5 |
A |
T |
14: 31,156,106 (GRCm39) |
|
probably benign |
Het |
| Slc22a13 |
G |
T |
9: 119,024,773 (GRCm39) |
L235I |
probably benign |
Het |
| Slc6a11 |
A |
T |
6: 114,111,948 (GRCm39) |
T172S |
possibly damaging |
Het |
| Slitrk1 |
G |
T |
14: 109,149,048 (GRCm39) |
S554R |
possibly damaging |
Het |
| Tg |
G |
A |
15: 66,554,243 (GRCm39) |
G553S |
probably damaging |
Het |
| Tmem26 |
G |
A |
10: 68,611,215 (GRCm39) |
|
probably null |
Het |
| Trpm2 |
A |
T |
10: 77,754,820 (GRCm39) |
L1222Q |
probably benign |
Het |
| Vdac2 |
T |
C |
14: 21,893,957 (GRCm39) |
V249A |
probably benign |
Het |
| Vmn1r170 |
T |
C |
7: 23,305,943 (GRCm39) |
V115A |
probably damaging |
Het |
| Xpo1 |
A |
G |
11: 23,232,593 (GRCm39) |
E371G |
probably damaging |
Het |
| Zfp106 |
A |
C |
2: 120,362,178 (GRCm39) |
H980Q |
possibly damaging |
Het |
|
| Other mutations in Vmn2r105 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01433:Vmn2r105
|
APN |
17 |
20,448,817 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01909:Vmn2r105
|
APN |
17 |
20,444,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01925:Vmn2r105
|
APN |
17 |
20,428,973 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02021:Vmn2r105
|
APN |
17 |
20,448,157 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02838:Vmn2r105
|
APN |
17 |
20,447,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03343:Vmn2r105
|
APN |
17 |
20,446,631 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Vmn2r105
|
UTSW |
17 |
20,447,741 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0096:Vmn2r105
|
UTSW |
17 |
20,447,741 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0212:Vmn2r105
|
UTSW |
17 |
20,428,827 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0268:Vmn2r105
|
UTSW |
17 |
20,428,938 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0271:Vmn2r105
|
UTSW |
17 |
20,454,965 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0613:Vmn2r105
|
UTSW |
17 |
20,428,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,448,119 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,447,973 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1162:Vmn2r105
|
UTSW |
17 |
20,447,973 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1263:Vmn2r105
|
UTSW |
17 |
20,428,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1363:Vmn2r105
|
UTSW |
17 |
20,428,932 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1464:Vmn2r105
|
UTSW |
17 |
20,449,004 (GRCm39) |
splice site |
probably benign |
|
|
R2029:Vmn2r105
|
UTSW |
17 |
20,444,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2420:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2421:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2422:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2570:Vmn2r105
|
UTSW |
17 |
20,447,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3847:Vmn2r105
|
UTSW |
17 |
20,428,952 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3848:Vmn2r105
|
UTSW |
17 |
20,428,952 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4030:Vmn2r105
|
UTSW |
17 |
20,429,016 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4275:Vmn2r105
|
UTSW |
17 |
20,448,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4551:Vmn2r105
|
UTSW |
17 |
20,446,613 (GRCm39) |
missense |
probably benign |
|
|
R4801:Vmn2r105
|
UTSW |
17 |
20,447,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4802:Vmn2r105
|
UTSW |
17 |
20,447,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4816:Vmn2r105
|
UTSW |
17 |
20,428,953 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4929:Vmn2r105
|
UTSW |
17 |
20,448,280 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5022:Vmn2r105
|
UTSW |
17 |
20,428,676 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5475:Vmn2r105
|
UTSW |
17 |
20,455,044 (GRCm39) |
missense |
probably benign |
|
|
R5576:Vmn2r105
|
UTSW |
17 |
20,444,836 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5795:Vmn2r105
|
UTSW |
17 |
20,448,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5895:Vmn2r105
|
UTSW |
17 |
20,448,929 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6017:Vmn2r105
|
UTSW |
17 |
20,428,889 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6210:Vmn2r105
|
UTSW |
17 |
20,448,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6491:Vmn2r105
|
UTSW |
17 |
20,447,992 (GRCm39) |
nonsense |
probably null |
|
|
R6542:Vmn2r105
|
UTSW |
17 |
20,448,803 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6729:Vmn2r105
|
UTSW |
17 |
20,428,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7020:Vmn2r105
|
UTSW |
17 |
20,429,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Vmn2r105
|
UTSW |
17 |
20,428,874 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7488:Vmn2r105
|
UTSW |
17 |
20,429,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7491:Vmn2r105
|
UTSW |
17 |
20,448,827 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7555:Vmn2r105
|
UTSW |
17 |
20,447,937 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7863:Vmn2r105
|
UTSW |
17 |
20,428,937 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8137:Vmn2r105
|
UTSW |
17 |
20,454,966 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8166:Vmn2r105
|
UTSW |
17 |
20,428,904 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8186:Vmn2r105
|
UTSW |
17 |
20,444,880 (GRCm39) |
nonsense |
probably null |
|
|
R8214:Vmn2r105
|
UTSW |
17 |
20,448,775 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8497:Vmn2r105
|
UTSW |
17 |
20,455,134 (GRCm39) |
start codon destroyed |
probably null |
0.75 |
|
R8850:Vmn2r105
|
UTSW |
17 |
20,428,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8880:Vmn2r105
|
UTSW |
17 |
20,429,229 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9272:Vmn2r105
|
UTSW |
17 |
20,447,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9506:Vmn2r105
|
UTSW |
17 |
20,429,404 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9549:Vmn2r105
|
UTSW |
17 |
20,448,023 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Posted On |
2015-12-18 |
Incidental Mutation